The evolutionary conserved neurobiology of operant learning
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Presentation at the 2016 annual meeting of the Mind and Brain College of the University of Lisbon on the multiple learning systems interacting during operant learning.
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The evolutionary conserved neurobiology of operant learning
- 2. Tone Food Tone: Conditioned stimulus – CS Food: Unconditioned Stimulus – US
- 5. > 530 Mya CREB CRE Long- term memory cAMP PKA Cytoplasm Nucleus Nt DNA rutabaga Modified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008)
- 6. CS US Tone Food Lever- pressing Food Behavior Reinforcement
- 8. > 530 Mya CREB CRE Long- term memory cAMP PKA Cytoplasm Nucleus Nt DNA rutabaga Modified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008)
- 11. Behavioral variability in a constant stimulus situation:
- 13. > 530 Mya CREB CRE Long- term memory cAMP PKA Cytoplasm Nucleus Nt DNA rutabaga Modified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008)
- 14. Brembs & Plendl (2008) Torque HeatColors Torque Heat rut-AC dependent Synaptic Plasticity Protein Kinase C world self rut2080 wtb rut2080 wtb HS noHS PKCi PKCi HS noHS PKCi PKCi
- 15. PKC but not rut-AC involved in Aplysia self-learning Aplysia californica F. Lorenzetti, D. Baxter, J. Byrne (2008): Neuron 59, 815-828
- 16. PKC involved in self-motion learning Rochefort C, Arabo A, André M, Poucet B, Save E, Rondi-Reig L. (2011) Science 334(6054):385-389
- 19. Torque Heat Colomb & Brembs, 2016
- 20. Action – Outcome Evaluation Torque Heat
- 21. Generate spontaneous actions (trying out)
- 22. Shape behavior by evaluating sensory feedbac
- 23. Action – Outcome Evaluation FoxP2
- 28. > 530 Mya Aplysia (Mollusks) Drosophila (Arthropods) Humans/mice/birds (Chordates) ??? cAMP PKA Cytoplasm Nucleus Nt DNA Type II cyclase PKC FoxP
- 29. Why have more than one learning system?
- 30. F1 2005
- 31. PI = (tc - th) / (tc + th)
- 32. Brembs & Heisenberg (2000) L & M ‘Master’: operant ‘Replay’: classical
- 34. Training Test composite: turning + color turning
- 35. Training Test composite: turning + color turning WT WT 16min MB Impaired OK OK Self-Learning Test
- 36. Training Test composite: turning + color turning color WT WT 16min MB Impaired OK OK Self-Learning Test WT WT 16min MB OK Impaired Impaired World-Learning Test
- 37. Training Test composite: turning + color turning color WT 8min WT 16min MB Impaired OK OK Self-Learning Test WT 8min WT 16min MB OK Impaired Impaired World-Learning Test habit formation
- 38. Training Test composite: turning + color turning color WT 8min WT 16min FoxP 16min Impaired OK Impaired Self-Learning Test WT 8min WT 16min MB OK Impaired Impaired World-Learning Test
- 39. Training Test composite: turning + color turning color WT 8min WT 16min MB 8min Impaired OK OK Self-Learning Test WT 8min WT 16min MB 8min OK Impaired Impaired World-Learning Test Brembs, 2009 MB247 or 17D driving TNT
- 40. Brembs (2009) Curr Biol Colomb & Brembs (2010) Commun Integr Biol Brembs (2010) Proc Roy Soc Brembs (2011) Behav Proc
- 41. Spontaneous Activity independent of sensory input e.g. exploration Mixed Complex stimuli/variable actions Behavioral set Endogenous evoked responses Closed loop Evoked Fixed stimulus/response at fixed latency e.g. reflex, habit Stimulus-response coupling Predictability
- 42. Spontaneous Activity independent of sensory input e.g. exploration Mixed Complex stimuli/variable actions Behavioral set Endogenous evoked responses Closed loop Evoked Fixed stimulus/response at fixed latency e.g. reflex, habit Stimulus-response coupling Predictability/Efficiency