2 nd most common cancer, after lung cancer (and melanomas) (the WHO) Strongly related to age, less than 5% of cases are women under 40 yrs 1.3 million women diagnosed annually worldwide
Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare. Risk factors
After the mammogram… Or other disease such as mastitis
Round, ellipse, moon, rough
Primary tumor is a tumor growing at the anatomical site where tumor progression began and proceeded to yield a cancerous mass. Metastasis(Pleural effusion) is excess fluid that accumulates in the pleural cavity, the fluid-filled space that surrounds the lungs. Cancer cells can break away, leak, or spill from a primary tumor, enter lymphatic and blood vessels, circulate through the bloodstream. Metastasis is one of three hallmarks of malignancy.
Fig. 2. Morphologies of breast cancer cell lines cultured in 2D and 3D. (Top) Images of 4 representative breast cancer cell lines cultured as 2D monolayer, (middle) and in 3D lrBM grouped by 3D morphological classification: Round, Mass, Grape-like and Stellate. (Bottom) 3D cultures were stained for F-actin and nuclei were counterstained with DAPI. Scale bars: top panel, 100$m; middle panel, 50$m; bottom panel, 20$m. Adapted from ref. .
Presented by Dannise Jangyoung Marcus Bongsoo Breast Cancer Diagnostics
Treatment is based on the diagnostics of cell lines (Examples of invasive ductal carcinoma)
Lasfargues, EY et al. 1958. Cultivation of human breast carcinomas. Borras, M et al. 1997. Estrogen receptor negative/progesterone receptor-positive evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers. Cell line Origin of cell Estrogen receptors Progesterone receptors ERBB2 Amplification BT-20 Primary No No No BT-474 Primary Yes Yes Yes MCF-7 Metastasis Yes Yes No SK-BR-3 Metastasis No No Yes