BOND KING
Small gram- negative coco bacillary organism(0.5-0.7um by 0.6-1.5 um)In smear they occurs singly , in pairs or in short ...
Human pathogens1.Brucella melintensis2.Brucia abortus3.Brucella suis4.Brucella canisClinical manifestation and pathogenesi...
Preferential hosts are* B.abortus – cattle(cows)* B.melintensis – sheep and goat* B.suis – swine (pig)* B.canis – dogs
Human become infected by:-1. Inhaling the organisms.2. Direct infection with infected materials including  - Animal carcas...
A common risk factor is consumption of imported cheese made from unpasturized goat’s milkLocal adenopathy often occurs w...
Organisms may be seen within phagocytesSigns and symptoms are often variable and non-specific, with chills, fever, sweat...
 Most often recovered from blood and bone marrow  and less often from material obtained from spleen and  liver abcesses....
TreatmentCombination of- tetracycline- Aminoglycosidase- rifampin- trimetheoprin sulfamethoxazole (for prolonged  period ...
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Brucella

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immunology by BOND king

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Brucella

  1. 1. BOND KING
  2. 2. Small gram- negative coco bacillary organism(0.5-0.7um by 0.6-1.5 um)In smear they occurs singly , in pairs or in short chain.Described as having the appearance of sandNon-motile, strictly aerobic and catalase and usually oxidase positive organisms.Growth is often enhanced by the persence of 5% to 10% CO2 and requires complex media.
  3. 3. Human pathogens1.Brucella melintensis2.Brucia abortus3.Brucella suis4.Brucella canisClinical manifestation and pathogenesisBrucella spp. Are intracellular parasite that infect a wide range of animal species and have also been found in some insect and ticks.
  4. 4. Preferential hosts are* B.abortus – cattle(cows)* B.melintensis – sheep and goat* B.suis – swine (pig)* B.canis – dogs
  5. 5. Human become infected by:-1. Inhaling the organisms.2. Direct infection with infected materials including - Animal carcasses - Fetal membrane - vaginal discharges - fetuses - skin or mucous membrane - ingestion of unpasturized milk or milk products from infected animals
  6. 6. A common risk factor is consumption of imported cheese made from unpasturized goat’s milkLocal adenopathy often occurs with dissemination and secondary localization in the RES (reticulo endothelial system) and formation of granulomas in the liver, spleen, bone, genitourinary tract, lungs and soft tissue. *Adenopathy (enlargement of glandular tissue specially lymph nodes)
  7. 7. Organisms may be seen within phagocytesSigns and symptoms are often variable and non-specific, with chills, fever, sweats and anorexia.The fever is characteristically (dirulant) undulant.
  8. 8.  Most often recovered from blood and bone marrow and less often from material obtained from spleen and liver abcesses. They grow on standard laboratory media. - brucella - blood - chocolate - trypticase soy agar Some strains will grow on mac conkey agar. Can be done serologically (1: 160) Recent brucellosis when a four fold or greater rise in titer occurs during the first month or two of illness.
  9. 9. TreatmentCombination of- tetracycline- Aminoglycosidase- rifampin- trimetheoprin sulfamethoxazole (for prolonged period of time).

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