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Boehringer Ingelheim
delivering more health to patients and families for more than 125 years
Who We Are




                 For more than125 years
                  Boehringer Ingelheim
                  has been committed to
                     the research and
                      development of
                   innovative medicines
                 that improve the lives of
                     patients and their
                          families

2
Who We Are




        We think long        Our products      We’re committed
       term and invest     help patients and     to doing the
      heavily in science     their families       right thing




3
More than 125 Years of Innovating for Patients and Families



                                         Founded 1885
                                         in Ingelheim, Germany


                     Family-owned                        Privately-held
                        global company                  for more than 125 years


      Products marketed in                $17.1 billion                           44,000
     150+ countries                         2011 net sales                  employees worldwide


                                                                 Focus on
                     23.5 % of sales                       Human
                      invested back                    Pharmaceuticals
                        into R&D                       & Animal Health

4
125 Years of Innovating for Patients and Their Families


       1885                                                                                       2010
Albert Boehringer
  buys a small
   tartaric acid                          1941
                                       Revolutionary
                                                                             2002                 First new
     factory in
                                       aludrin® for                                              product in
    Ingelheim,
                                     asthma treatment                                            category in
     Germany
                                        introduced                                                50+ years

                                                                            34,221 employees




                                                        22,254 employees
       28 employees                                                                              44,000 employees

                                                             1985                   2003                   2011
                      1912
              First pharmaceutical                      100th Anniversary
                                                                                Inhaler device
              product laudanon®
                                                                                  registered           First approved
                for pain launched
                                                                                 Biopharma                  product
                                                                                 production                from BI’s
                                                                                 investment            alliance with Eli
                                                                                                            Lilly and
  5                                                                                                        Company
Our World Net Sales




                                   29 June 2012
PLEASE INSERT Presentation title              6
Research and Development Centers Around the World




             Laval (Canada)
             Infectious Disease                                    Biberach &
                                                              Ingelheim (Germany)
                                                               Cardiometabolic Diseases
                                                                 Respiratory Diseases
                                                                Neurological Diseases




                                    Ridgefield (USA)
                                  Immunology & Inflammation
                                   Cardiometabolic Diseases                           Vienna (Austria)
                                                                                          Oncology




7
Focused on Innovation


                                           Metabolic
                                           Diseases

         Immunology &
          Inflammation                                                  Oncology




        Respiratory                                                       Infectious
         Diseases                                                          Diseases




                         Central Nervous
                                                       Cardiovascular
                          System (CNS)
                                                          Diseases
                            Disorders
8
Focused on Innovation:
Marketed Prescription Medications




9
Focused on Research Innovation:
 Investigating New Treatments for Patients

     Therapeutic Areas       Phase III          Phase II


                              Afatinib
         Oncology                              Volasertib
                            Nintedanib


      Type 2 Diabetes      Empagliflozin




                             Olodaterol
        Respiratory      Tiotropium (Asthma)
                             Nintedanib


        Hepatitis C          BI201335          BI 207127

10
A Great Place to Work



                                      Human Rights Campaign
                                       Best Places to Work




                         2011 Top 50 Company for
                            Female Executives

                                                       Best Employers
                                                             for
                                                      Healthy Lifestyles

     Top Employers

                                    Trainer’s
                                  Choice Award

11
We Care for Our Employees


         Fitness center and   Health/wellness
             programs           programs




            Workplace            On-site
            flexibility         childcare
12
We Care for Our Communities



        We are a family company with a 125-year heritage of providing more health for our communities.
         Our caring culture embraces a broad range of activities that include:


                                             Corporate Social Responsibility
                                             •    Boehringer Ingelheim AmeriCares Free Clinic
                                             •    Science Horizons Regional Science Fair
                                             •    United Way Day of Caring

                                             Volunteerism
                                             •    Our employees are passionate about helping
                                                  improve the lives of people in our community
                                             •    In 2011 U.S. employees volunteered more than
                                                  15,000 hours of their time
13
BI Cares Foundation



     In keeping with our commitment to do the most good for the most people,
       we work hard to ensure our medicines are accessible to eligible patients
     who need them, including senior citizens and families on limited incomes.

                                                      Through the
                                             BI Cares Foundation
                                         our Patient Assistance Programs help
                                          those in need obtain medications
                                                     free of charge.

                                                        In 2011,
                                               more than 63,000
                                          eligible patients received assistance
                                                through these programs.
14
Where We Are in the United States


     BI Vetmedica, Inc.                          Ben Venue Laboratories, Inc.
       St. Joseph, MO                              Bedford Laboratories™
      (Animal Health)                                    Bedford, OH
                                                     (Sterile Injectables)




             Established in U.S. in 1971
         More than 10,000 U.S. Employees
          Headquartered in Ridgefield, CT
                                                                  BI Pharmaceuticals, Inc.
               Seven U.S. Subsidiaries                                 Ridgefield, CT
                                                         (Prescription Medicines, Consumer Health
                                                              Care, Research & Development)


                            BI Fremont, Inc.
                              Fremont, CA
                          (Biopharmaceuticals)




                  BI Roxane, Inc.                                    BI Chemicals, Inc.
                Roxane Laboratories                                    Petersburg, VA
                  Columbus, OH                               (Active Pharmaceutical Ingredient
             (Generics and Distribution)                              Manufacturing)
15
Where We Are in the United States




            Worldwide Center of
        Excellence in immunology,
        inflammatory disease, and
          cardiovascular research
                                       Boehringer Ingelheim
           Consumer Health Care      Pharmaceuticals, Inc. (BIPI)
          Marketers of Zantac® and
              Dulcolax® products      Ridgefield, CT headquarters

          Prescription medicines     Southbury, CT training facility
             Clinical Research
               Development               Field-based salesforce
                 Marketing
                                           3,500 employees




16
Where We Are in the United States




           A leading producer of
       advanced, high-quality active
                                        Boehringer Ingelheim Chemicals, Inc.
          human pharmaceutical
        ingredients (APIs) for BI and              Petersburg, VA
           third-party customers
                                                   350 employees




17
Where We Are in the United States




        Ben Venue Laboratories, Inc.
      Contract Marketing
      • A leading manufacturer of liquid and
        freeze-dried sterile injectable drugs for
        the global pharmaceutical industry
      • BVL offers one of the largest contract
        lyophilization capacities worldwide         Ben Venue Laboratories, Inc.

             Bedford Laboratories                      Bedford Laboratories

      • Markets specialty multisource injectable            Bedford, OH
        products to hospitals in North America
      • Offers 92 products in 279                    More than 1,400 Employees
        presentations, including seven sole
        source generics
      • Most comprehensive line of generic
        injectable oncology products in North
        America



18
Where We Are in the United States




           Brand Production Site

       • Spiriva®         • Combivent®
       • Mirapex®         • Micardis®
                                            Boehringer Ingelheim Roxane, Inc.
       • Viramune®        • Aptivus®
                                                      Columbus, OH
          Multisource Launch Site
                                                     900 Employees
       • Prescription Medicines, Generics
         and Consumer Health Care
       • Two Distribution Centers
         (Columbus and Reno)




19
Where We Are in the United States



        Solid/Liquid/Inhalation Generics

         16 – 20 abbreviated new drug
          applications filed per year

        8 – 12 product launches per year

              Market Strategy:             Roxane Laboratories
               Differentiation
                                              Columbus, OH
       • Paragraph IV filings
                                              120 Employees
       • Complex formulations/clinical
         trials
       • Internal Intellecutal Property
       • Potent Compounds
       • DEA Quota Controlled
         Substances



20
Where We Are in the United States




                                                                  Boehringer Ingelheim Vetmedica, Inc.

                                                                             St. Joseph, MO

     • Biological research, development and manufacturing                      Elwood, KS

     • Dedicated to improving lives and well-being of animals                Sioux Center, IA

     • High-quality products for cattle, swine, horses and pets                 Ames, IA

     • Acquired significant portion of Fort Dodge Animal Health              Fort Dodge, IA
       business in 2009
                                                                            1,900 employees

21
Where We Are in the United States




                                                                  Boehringer Ingelheim Fremont, Inc.

                                                                             Fremont, CA
          • Key manufacturing site for BI Biopharmaceutical
            Contract Manufacturing in the U.S.                              300 Employees

          • State-of-the-art facility with 200,000 + sq. ft for
            laboratories, manufacturing and process development
          • Key product is Amgen’s Vectibix®




22

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2012 U.S. Corporate Overview

  • 1. Boehringer Ingelheim delivering more health to patients and families for more than 125 years
  • 2. Who We Are For more than125 years Boehringer Ingelheim has been committed to the research and development of innovative medicines that improve the lives of patients and their families 2
  • 3. Who We Are We think long Our products We’re committed term and invest help patients and to doing the heavily in science their families right thing 3
  • 4. More than 125 Years of Innovating for Patients and Families Founded 1885 in Ingelheim, Germany Family-owned Privately-held global company for more than 125 years Products marketed in $17.1 billion 44,000 150+ countries 2011 net sales employees worldwide Focus on 23.5 % of sales Human invested back Pharmaceuticals into R&D & Animal Health 4
  • 5. 125 Years of Innovating for Patients and Their Families 1885 2010 Albert Boehringer buys a small tartaric acid 1941 Revolutionary 2002 First new factory in aludrin® for product in Ingelheim, asthma treatment category in Germany introduced 50+ years 34,221 employees 22,254 employees 28 employees 44,000 employees 1985 2003 2011 1912 First pharmaceutical 100th Anniversary Inhaler device product laudanon® registered First approved for pain launched Biopharma product production from BI’s investment alliance with Eli Lilly and 5 Company
  • 6. Our World Net Sales 29 June 2012 PLEASE INSERT Presentation title 6
  • 7. Research and Development Centers Around the World Laval (Canada) Infectious Disease Biberach & Ingelheim (Germany) Cardiometabolic Diseases Respiratory Diseases Neurological Diseases Ridgefield (USA) Immunology & Inflammation Cardiometabolic Diseases Vienna (Austria) Oncology 7
  • 8. Focused on Innovation Metabolic Diseases Immunology & Inflammation Oncology Respiratory Infectious Diseases Diseases Central Nervous Cardiovascular System (CNS) Diseases Disorders 8
  • 9. Focused on Innovation: Marketed Prescription Medications 9
  • 10. Focused on Research Innovation: Investigating New Treatments for Patients Therapeutic Areas Phase III Phase II Afatinib Oncology Volasertib Nintedanib Type 2 Diabetes Empagliflozin Olodaterol Respiratory Tiotropium (Asthma) Nintedanib Hepatitis C BI201335 BI 207127 10
  • 11. A Great Place to Work Human Rights Campaign Best Places to Work 2011 Top 50 Company for Female Executives Best Employers for Healthy Lifestyles Top Employers Trainer’s Choice Award 11
  • 12. We Care for Our Employees Fitness center and Health/wellness programs programs Workplace On-site flexibility childcare 12
  • 13. We Care for Our Communities We are a family company with a 125-year heritage of providing more health for our communities. Our caring culture embraces a broad range of activities that include: Corporate Social Responsibility • Boehringer Ingelheim AmeriCares Free Clinic • Science Horizons Regional Science Fair • United Way Day of Caring Volunteerism • Our employees are passionate about helping improve the lives of people in our community • In 2011 U.S. employees volunteered more than 15,000 hours of their time 13
  • 14. BI Cares Foundation In keeping with our commitment to do the most good for the most people, we work hard to ensure our medicines are accessible to eligible patients who need them, including senior citizens and families on limited incomes. Through the BI Cares Foundation our Patient Assistance Programs help those in need obtain medications free of charge. In 2011, more than 63,000 eligible patients received assistance through these programs. 14
  • 15. Where We Are in the United States BI Vetmedica, Inc. Ben Venue Laboratories, Inc. St. Joseph, MO Bedford Laboratories™ (Animal Health) Bedford, OH (Sterile Injectables) Established in U.S. in 1971 More than 10,000 U.S. Employees Headquartered in Ridgefield, CT BI Pharmaceuticals, Inc. Seven U.S. Subsidiaries Ridgefield, CT (Prescription Medicines, Consumer Health Care, Research & Development) BI Fremont, Inc. Fremont, CA (Biopharmaceuticals) BI Roxane, Inc. BI Chemicals, Inc. Roxane Laboratories Petersburg, VA Columbus, OH (Active Pharmaceutical Ingredient (Generics and Distribution) Manufacturing) 15
  • 16. Where We Are in the United States Worldwide Center of Excellence in immunology, inflammatory disease, and cardiovascular research Boehringer Ingelheim Consumer Health Care Pharmaceuticals, Inc. (BIPI) Marketers of Zantac® and Dulcolax® products Ridgefield, CT headquarters Prescription medicines Southbury, CT training facility Clinical Research Development Field-based salesforce Marketing 3,500 employees 16
  • 17. Where We Are in the United States A leading producer of advanced, high-quality active Boehringer Ingelheim Chemicals, Inc. human pharmaceutical ingredients (APIs) for BI and Petersburg, VA third-party customers 350 employees 17
  • 18. Where We Are in the United States Ben Venue Laboratories, Inc. Contract Marketing • A leading manufacturer of liquid and freeze-dried sterile injectable drugs for the global pharmaceutical industry • BVL offers one of the largest contract lyophilization capacities worldwide Ben Venue Laboratories, Inc. Bedford Laboratories Bedford Laboratories • Markets specialty multisource injectable Bedford, OH products to hospitals in North America • Offers 92 products in 279 More than 1,400 Employees presentations, including seven sole source generics • Most comprehensive line of generic injectable oncology products in North America 18
  • 19. Where We Are in the United States Brand Production Site • Spiriva® • Combivent® • Mirapex® • Micardis® Boehringer Ingelheim Roxane, Inc. • Viramune® • Aptivus® Columbus, OH Multisource Launch Site 900 Employees • Prescription Medicines, Generics and Consumer Health Care • Two Distribution Centers (Columbus and Reno) 19
  • 20. Where We Are in the United States Solid/Liquid/Inhalation Generics 16 – 20 abbreviated new drug applications filed per year 8 – 12 product launches per year Market Strategy: Roxane Laboratories Differentiation Columbus, OH • Paragraph IV filings 120 Employees • Complex formulations/clinical trials • Internal Intellecutal Property • Potent Compounds • DEA Quota Controlled Substances 20
  • 21. Where We Are in the United States Boehringer Ingelheim Vetmedica, Inc. St. Joseph, MO • Biological research, development and manufacturing Elwood, KS • Dedicated to improving lives and well-being of animals Sioux Center, IA • High-quality products for cattle, swine, horses and pets Ames, IA • Acquired significant portion of Fort Dodge Animal Health Fort Dodge, IA business in 2009 1,900 employees 21
  • 22. Where We Are in the United States Boehringer Ingelheim Fremont, Inc. Fremont, CA • Key manufacturing site for BI Biopharmaceutical Contract Manufacturing in the U.S. 300 Employees • State-of-the-art facility with 200,000 + sq. ft for laboratories, manufacturing and process development • Key product is Amgen’s Vectibix® 22