Drugs that Require an Antidote/Treatment

Phentolamine Antimuscarinic, anticholinergic agents Phentolamine Antidepressants (MAO inhibitors and tryamine-containing foods may lead to hypertensive crisis including symptoms of chest pain, severe headache, nuchal rigidity, nausea and vomiting, photosensitivity, and enlarged pupils) Atropine, Pralidoxime Anticholinesterases (Cholinergics), organophosphates N-acetylcysteine Acetaminophen (Paracetamol) Antidote/Treatments Drug/Toxin

Digoxin immune Fasb (Digibind), Stop digitalis, normalize K; lidocaine, anti-dig FAB fragments ( Digitoxin) Digitalis Immune FAB Digoxin, digitoxin, Digitalis Amyl nitrite, sodium nitrite, sodium thiosulfate Cyanide Glucagon Beta blockers Flumazenil Benzodiazepines Antidote/Treatments Drug/Toxin

CaEDTA, Edetate calcium disodium, dimeraprol, penicillamine , succimer Lead Deferoxamine Iron Mesna Ifosfamide (Adverse effects cause hemorrhagic cystitis) Leucovorin calcium Fluorouracil (5FU) Antidote/Treatments Drug/Toxin

Methelyn blue Methemoglobin Leucovorin calcium Methotrexate (Adverse effects cause folic acid deficiency) Ethanol, dialysis, fomepizole Methanol, ethylene glycol (antifreeze) Calcium Gluconate Magnesium Sulfate Sodium Bicarbonate Lithium Carbonate (Eskalith) Antidote/Treatments Drug/Toxin

Phytonadione (Vitamin K), fresh frozen plasma Anticoagulant: Warfarin (Coumadin) NaHCO3 (nonspecific), Physostigmine Tricyclic antidepressants (Anafranil, Tofranil) Aminocaproic Acid ( Amicar) Thrombolytics: t-PA, (Streptokinase, Urokinase) Nalmefene, Naloxone Hydrochloride (Narcan), Naltrexone Opioids, Narcotic Analgesics: Demerol and Morphine Sulfate, Heroin Antidote/Treatments Drug/Toxin

Alkalinize urine, dialysis Salicylates Dimercaprol (BAL), succimer Arsenic, mercurym gold Penicillamine Copper, arsenic, gold 100% O2, hyperbaric O2 Carbon Monoxide Protamine Sulfate Anticoagulant: Heparin Antidote/Treatments Drug/Toxin

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