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Antibiotics That Require Frequent Monitoring

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Antibiotics That Require Frequent Monitoring

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Antibiotics That Require Frequent Monitoring Antibiotics That Require Frequent Monitoring Presentation Transcript

  • Antibiotics that Require Frequent Monitoring (Aminoglycosides)
  • 35 mcg/ml Peaks 5 mcg/ml Troughs Amikacin Drugs
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  • 10 mcg/ml Peaks 2 mcg/ml Troughs Gentamicin Drugs
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  • 35 mcg/ml Peaks 5 mcg/ml Troughs Kanamycin Drugs
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  • 16 mcg/ml Peaks 2 mcg/ml Troughs Neomycin Drugs
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  • 25 mcg/ml Peaks Varies Troughs Streptomycin Drugs
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  • 20 mcg/ml Peaks 2 mcg/ml Troughs Tobramycin Drugs
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  • 25 mcg/ml Peaks 5-10 mcg/ml Troughs Vancomycin Drugs
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    • Aminoglycosides must be monitored carefully for side effects including ototoxicity (vestibular and cochlear), nephrotoxicity , neurotoxicity , and hypersensitivity reactions. Monitor patients for tinnitus, vertigo, hearing loss, rash, dizziness, or difficulty urinating. 
    • Renal lab tests that must be monitored include urinalysis, specific gravity, BUN, creatinine, and creatinine clearance. 
    • Liver lab tests that must be monitored include , AST (SGOT), ALT (SGPT), serum alkaline phosphatase, bilirubin, creatinien, and LDH concentrations.
    • Trough# levels are referred to as the minimum drug concentration that proceeds the administration of a single dose of medication. Trough levels should be drawn just prior to the next dose
    • Peak* levels are referred to as the maximum drug concentration that follows the administration of a single dose of medication. Peak levels should be drawn 1 hour after IM injections and 30 minutes after a 30-minute IV infusion is completed. 
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