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Hemophilia gene

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  • 1. HemophiliaGenetics of the F8C Gene
  • 2. F8C GeneHemophilia is correlated to defects in the F8C gene.The F8C gene is found on the X chromosome
  • 3. InheritanceHemophilia is an X-linked recessive disorder that affects one in 10,000 males and very few femalesSince females have two X chromosomes, they are often carriers of the gene
  • 4. HemophiliaPersons who inherit the F8C gene lack a clotting factor to prevent bleedingEven simple cuts may be a serious problem for these people
  • 5. Famous Pedigree of Hemophiliacs & Carriers Q u e e n V ic t o r ia ( c a r r ie r o f h e m o p h ilia A ) D a u g h te r # 1 D a u g h te r # 2 ( C a r r ie r ) ( C a r r ie r ) m a r r ie d R u s s ia n r o y a lt y m a r r ie d S p a n is h r o y a lt y r e c e s s iv e g e n e p a s s e d fr o mR u s s i a n c z a r s f a m i l y t o G e r m a n s
  • 6. Russian Royal Family