3D liver microtissuesToxicology Products » Liver-specific morphology and high functionality over 21 days » Chronic in vitro toxicity studies possible » Assay-ready, no cell culturing needed » No scaffolds, so no unwanted artifacts » Supplied in automation-friendly 96 well-format
What are 3D liver microtissues?Liver microtissues are multicellular spheroids of hepatocyte cells either in monoculture, or specially de-signed in co-culture systems. These scaffold-free tissue models display remarkably similar histomorpho-logical, functional and microenvironmental features to in vivo liver tissue.3D liver microtissues are ideal for toxicology and metabolic analysis and are far more likely to be predic-tive of adverse toxicological effects compared to sandwich cultures. At last these valuable 3D modelsare conveniently available on demand in large quantities, ready-for-use in high-throughput applications. How are InSphero 3D tumor microtissues made? InSphero’s GravityPLUS process gently coerces cells to assemble into microtissues in a very reproducible 2D/3D cell culture comparison mass-production process. This process generates assay-ready 96 well plates, each containing one micro- 2D Sandwich 3D Microtissue tissue per well. By combining hepatocytes with other cells, such as liver-derived non-parenchymal cells,Scaffold Yes No highly organotypic liver microtissues can be produced that retain liver-specific morphology and functio-Co-culture – +++ nality for more than 21 days.Long term functionality + +++Bile canalicular network ++ +++Cell-cell contacts + +++Differentiation + +++High-throughput analysis + +++High-content analysis ++ ++
Services Overview For feasibility studies or compound testing offers using our rat-liver microtissues please contact our sales department at firstname.lastname@example.org Product OverviewAssay-ready liver microtissuesAssay-ready microtissues delivered in a specially coated, non-adhesive, 96-well V-bottom plate:Cat. # Name Description Cell sourceMT-02-001-04 rLiMT Rat liver microtissues formed by primary Wistar hepatocytes in co-culture with non-parenchymal cells InSphero AGMT-02-002-01 hLiMT Human liver microtissues formed by fresh Lonza Technoparkstrasse 1 human hepatocytes (homotypic culture) CH-8005 ZurichMT-02-002-03 hLiMT Human liver microtissues formed by cryo- Lonza Switzerland preserved human hepatocytes in co-culture with normal human dermal fibroblasts www.insphero.com Phone: +41-44-515049-0 e-mail: email@example.comAll technical and pricing information subject to change.All products are for research use only. They are not intended for any animalor human therapeutic or diagnostic use unless otherwise stated.