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VitaminB12
Chemistry
It is made up of Tetrapyrrole ring system
called as corrin ring with a central cobalt
(Co) atom.
3-4 μg/day.
Vitamin Bl2 combines with intrinsic factor to
form Vitamin B12 - IF complex.
Vitamin B12 intrinsic factor complex is
absor...
Unlike other water
soluble vitamins, vitamin
B12 is stored in the liver
and other tissues
Whole liver contains
about 2mg o...
Methyl cobalamin
Deoxy adenosylcobalamin
Vitamin B12 act as coenzyme.
Methyl cobalamin is the coenzyme of methionine synthase .
Deoxy adenosylcobalamin is the coen...
Causes
• Nutritional
• Decrease in absorption
• IF deficiency
• Gastric atrophy
• Pregnancy
• Fish tapeworm
• Megaloblastic
anemia
• Pernicious anemia
Hamatopoitic
•Numbness and tingling of
the hands and feet
•Subacute combined
de...
Serum B12 Schilling test
Peripheral
smear
Homosystinuria
Thank you
|
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com
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Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com

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Transcript of "Watre soluble vitamin B12 ppt Lecture 5 BIOCHEMISTRY vkunder637@gmail.com"

  1. 1. VitaminB12
  2. 2. Chemistry It is made up of Tetrapyrrole ring system called as corrin ring with a central cobalt (Co) atom.
  3. 3. 3-4 μg/day.
  4. 4. Vitamin Bl2 combines with intrinsic factor to form Vitamin B12 - IF complex. Vitamin B12 intrinsic factor complex is absorbed in the ileum. In the illeal cells the intrinsic factor is released and the B12 is transferred to a plasma transport protein transcobalamin II.
  5. 5. Unlike other water soluble vitamins, vitamin B12 is stored in the liver and other tissues Whole liver contains about 2mg of B12, which is sufficient for 2-3 years.
  6. 6. Methyl cobalamin Deoxy adenosylcobalamin
  7. 7. Vitamin B12 act as coenzyme. Methyl cobalamin is the coenzyme of methionine synthase . Deoxy adenosylcobalamin is the coenzyme of methyl malonyl-CoA mutase Therapeutic function Vitamin B12 is effective in lowering concentration of plasma homocysteine of coronary artery disease patients.
  8. 8. Causes • Nutritional • Decrease in absorption • IF deficiency • Gastric atrophy • Pregnancy • Fish tapeworm
  9. 9. • Megaloblastic anemia • Pernicious anemia Hamatopoitic •Numbness and tingling of the hands and feet •Subacute combined degeneration Neurological •Hyperhomocysteinemia •Achlorhydria Others
  10. 10. Serum B12 Schilling test Peripheral smear Homosystinuria
  11. 11. Thank you |
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