Vitamin E & K Lecture 3 BIOCHEMISTRY
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Vitamin E & K Lecture 3 BIOCHEMISTRY

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Vitamin E & K Lecture 3 BIOCHEMISTRY Vitamin E & K Lecture 3 BIOCHEMISTRY Presentation Transcript

  • Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  • Chemistry Sources RDA Metabolism Functions Deficiency Toxicity
  • Tocopherols α-tocopherol β-tocopherol γ-tocopherol δ-tocopherol Tocotrienols α-tocotrienols β-tocotrienols γ-tocotrienols δ-tocotrienols
  • RDA 8 – 10 mg/day The daily requirement increases with increase in dietary intake of PUFA
  • Absorption Upper SI Along with lipids Transport Chylomicron VLDL and LDL Storage Adipose tissue liver
  • As a biological antioxidant Prevents lipid peroxidation of biological membrane Prevents peroxidation of vitamin A & PUFA Reproductive functions & prevents sterility Vitamin E
  • Selenium complements the antioxidant effects of vitamin E and reduces the requirement of vitamin E
  • Causes Inadequate intake Impaired absorption Features Hemolytic anaemia in the new born Muscle weakness Spinocerebellar ataxia and impaired vision
  • Pylloquinone Present in plants Vitamin K1 Menaquinone Produced by intestinal bacteria Vitamin K2 Menadione Synthetic form Vitamin K3
  • 80µg/day
  • Absorption Upper SI Along with lipids Transport Chylomicron LDL Storage Liver
  • Role in blood coagulation • Cofactor for gamma carboxylation of glutamic acid in clotting factors II, VIII, IX and X Role in bone mineralization • Cofactor for gamma carboxylation of glutamic acid in osteocalcin
  • Causes In newborn Impaired absorption Sterile bacterial flora Features Bleeding Prolonged prothrombin time
  • Dicumarol Warfarin