Tumor markers ppt BIOCHEMISTRY
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Tumor markers ppt BIOCHEMISTRY

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Tumor markers ppt BIOCHEMISTRY Tumor markers ppt BIOCHEMISTRY Presentation Transcript

  • Definition Clinical uses Classification Examples
  • Substance found in increased amounts in the blood, other body fluids and tissues that may suggest the presence of cancer Definition
  • Diagnosis Prognosis Monitor treatment Detection of recurrence Screening
  • Hormones Oncofetal Antigens Enzymes Tumor- Associated Proteins
  • Human chorionic gonadotropin • Gestational trophoblastic disease • Gonadal germ cell tumor Calcitonin • Medullary cancer of the thyroid Catecholamines • Pheochromocytoma
  • Oncofetal antigens • Hepatocellular carcinoma, • Gonadal germ cell tumor α-Fetoprotein • Adenocarcinomas of the colon, pancreas, lung, breast, ovary Carcinoembryonic antigen
  • • Prostate cancer Prostatic acid phosphatase • Small cell cancer of the lung, • Neuroblastoma Neuron-specific enolase • Lymphoma, • Ewing's sarcoma Lactate dehydrogenase
  • Tumor-Associated Proteins Prostate- specific antigen Prostate cancer Monoclonal immunoglobulin Myeloma CA-125 Ovarian cancer CA19-9 Colon, pancreatic, breast cancer
  • The crucial link between anatomy and molecular pathways From anatomy… via serological tumor markers … to molecular pathways Lung KIT Breast EGF R Prostate HER 2 Colon BRAF