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Transcription ppt BIOCHEMISTRY Presentation Transcript

  • 1. TRANSCRIPTION Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  • 2. TRANSCRIPTION Definition Similarity and Differentiation Basic requirements Stages Post- transcriptional processing
  • 3. TRANSCRIPTION [RNA SYNTHESIS] Synthesis of RNA using DNA as a template
  • 4. TRANSCRIPTION mRNA rRNA tRNA SnRNA
  • 5. TRANSCRIPTION Similarities • 3 stages • Synthesis occurs in the 5’→3’ direction • Follows Watson-Crick base pairing Differences • Ribonucleotides are used in RNA synthesis • Uracil replaces Thymine • Primer is not required • Only a very small portion of genome is transcribed
  • 6. TRANSCRIPTION BASIC REQUIREMENTS Template Substrate Enzyme
  • 7. TRANSCRIPTION
  • 8. TRANSCRIPTION ATP GTP CTP UTP
  • 9. TRANSCRIPTION - Basic requirements -ENZYME DNA dependent RNA polymerase or RNA polymerase Three RNA polymerase RNAP-I RNA-II RNA-III EUKARYOTIC Single RNA polymerase PROKARYOTIC
  • 10. TRANSCRIPTION PROKARYOTIC RNA POLYMERASE
  • 11. TRANSCRIPTION - STAGES INITIATION ELONGATION TERMINATION
  • 12. TRANSCRIPTION – STAGES: PROMOTOR REGION
  • 13. TRANSCRIPTION – STAGES:
  • 14. TRANSCRIPTION – STAGES:
  • 15. TRANSCRIPTION – STAGES:
  • 16. TRANSCRIPTION – STAGES:
  • 17. TRANSCRIPTION-STAGES:
  • 18. TRANSCRIPTION-STAGES:
  • 19. TRANSCRIPTION-STAGES:
  • 20. TRANSCRIPTION-STAGES: Rho- dependent termination Rho- independent termination 2 mechanisms
  • 21. TRANSCRIPTION-STAGES: 2 mechanisms
  • 22. TRANSCRIPTION-STAGES: 2 mechanisms
  • 23. TRANSCRIPTION IN EUKARYOTES Main differences RNA Polymerase Promoter sites Enhancers, Silencers and TF
  • 24. TRANSCRIPTION IN EUKARYOTES RNA polymerase-I RNA polymerase-II RNA polymerase-III EUKARYOTIC RNA POLYMERASE
  • 25. TRANSCRIPTION IN EUKARYOTES
  • 26. TRANSCRIPTION IN EUKARYOTES ENHANCER