Minerals phosphorus ppt BIOCHEMISTRY vkunder637@gmail.com

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Minerals phosphorus ppt BIOCHEMISTRY vkunder637@gmail.com

  1. 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  2. 2. Sources RDA Metabolism Functions Disorders
  3. 3. 800mg/day
  4. 4. Absorption Factors affecting absorption Excretion
  5. 5. Site Efficiency Upper small intestine 70% absorbed
  6. 6. Phosphorus absorption increased by • Bile salts Acidity PTH and vitamin D Calcium Phosphorus absorption decreased by • High Ca: P ratio Phytates Alkalinity Magnesium and aluminium
  7. 7. Urine 2/3 of ingested phosphate 0.6gm/day Stool Due to non- absorption 0.2 – 0.5 gm/day Factors affecting renal excretion ↑ PTH
  8. 8. Formation of bone and teeth Production of high energy compounds DNA and RNA synthesis Synthesis of coenzymes Synthesis of phosphoproteins and phospholipids Activation of enzymes by phosphorylation Acid base balance
  9. 9. Human body contain about 840gm of phosphorus 80% present in bone and teeth 20% in other tissue Plasma phosphorus : 3 – 4mg/100ml
  10. 10. 3 -4mg/dlADULT 5 – 6mg/dlCHILDREN
  11. 11. 3 HORMONES 1,25(OH)2D3 PTH Calcitonin
  12. 12. 1,25(OH)2D3 Increases absorption from intestine Increases the mobilization from bone Increases the renal reabsorption Increases plasma phosphorus
  13. 13. PTH Decreases the renal reabsorption Decreases plasma phosphorus
  14. 14. Calcitonin Inhibits bone resorption Decreases the renal reabsorption Decreases plasma phosphorus
  15. 15. Hypophosphatemia Hyperphosphatemia
  16. 16. Causes Features Treatment
  17. 17. Decreased intake Decreased absorption Increased loss
  18. 18. • Hemolytic anemia • Leukocyte dysfunction • Platelet dysfunction Acute • Anorexia • Weakness • Pain in the muscle and bones • Fractures Chronic
  19. 19. Management of underlying disease Administration of phosphate
  20. 20. Causes Featurs Treatment
  21. 21. Increased intestinal absorption Decreased renal excretion Extracellular shift of phosphorus Hemolysis
  22. 22. Features of underlying diseases Soft tissue calcification
  23. 23. Treatment of underlying disorders Dialysis in renal failure Administration of aluminum hydroxide

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