Minerals iron ppt BIOCHEMISTRY vkunder637@gmail.com

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Minerals iron ppt BIOCHEMISTRY vkunder637@gmail.com

  1. 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  2. 2. Sources RDA Metabolism Functions Disorders
  3. 3. Green leafy vegetables Liver and meat Egg Jaggery Pulses Cereals
  4. 4. 10-20 mg/day Adult 40mg/day Pregnancy
  5. 5. Absorption Transport Storage Excretion
  6. 6. Site Small intestine Forms Heme Non-haem Efficiency About 10% of total food iron is absorbed
  7. 7. Factors decreasing iron absorption Phytates and phosphate Antacid, achlorhydria Gastrointestinal diseases Factors increasing iron absorption Ferrous form Ascorbic acid Cysteine HCl
  8. 8. Ferric Iron Fe+++ Ferrous Iron Fe++ Heme iron Vit C Ferricreductase Fe++ Fe+++ Ferritin Apoferritin Heme iron Fe++ Fe++ Fe+++ Transferrin Fe+++ Lumen Mucosal cell Blood CeruloplasminApotransferrin Ferroxidase Ferroreductase
  9. 9. Mucosal block theory
  10. 10. Storage Form Ferritin Hemosiderin Storage Site Liver Intestine Spleen Bone marrow
  11. 11. Normal excretion Very little About 1mg/day Stool 0.7mg/day Physiological loss Menstruation 20-30mg/cycle Delivery 750mg
  12. 12. Heme compounds Non-haem compounds Iron is a component of several functionally important compounds
  13. 13. Haem compounds Haemoglobin Myoglobin Cytochrome Catalase Non-haem compounds Succinate dehydrogenase Xanthine oxidase Iron sulfur proteins
  14. 14. Iron deficiency Iron excess
  15. 15. Causes Features Lab findings Treatment
  16. 16. Decreased intake of iron Malnutrition Decreased absorption of iron Achlorhydria and chronic diarrhea Increased loss of Iron Bleeding, hookworm infestation Increased iron requirement Pregnancy, infancy
  17. 17. Pallor Fatigue Dizziness Dyspnea Palpitation Angular stomatitis Pica
  18. 18. Decreased hemoglobin Microcytic hypochromic anemia Decreased serum iron Increased serum total iron binding capacity Decreased plasma ferritin
  19. 19. Treatment of underlying causes Treating Hookworm Controlling bleeding Administration of iron preparations Orally I.V
  20. 20. Haemosiderosis Increase in iron stores as haemosiderin Without associated with tissue injury Haemochromatosis Excessive deposition of iron in the tissue Associated with tissue injury

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