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FLUORINE, SELENIUM, M
ANGANESE, MOLYBDENU
M, COBALT
Dr. Vijay Marakala, MBBS, MD.
Assistant professor
BIOCHEMISTRY
SIMS & ...
FLUORINE
Source RDA Functions
Deficiency Toxicity
FLUORINE - SOURCE
Drinking
water
Depends
upon fluorine
content in the
soil
FLUORINE - RDA
1ppm
FLUORINE - FUNCTIONS
Increases hardness of bone and teeth
Required for normal dentition
Prevents dental caries
FLUORINE - DEFICIENCY
Cause Drinking water that is low in fluorine
content
Feature Dental caries
Drinking water containing...
FLUORINE - TOXICITY
Cause
Drinking water with
fluorine more than 5ppm
Features
Dental fluorosis and
skeletal fluorosis
FLUORINE - TOXICITY
Dental
fluorosis
Mottling of enamel
Discoloration of teeth
Skeletal
fluorosis
Bowed legs
Bending of sp...
SELENIUM
SELENIUM - SOURCES
Sea
foods
Meat Liver
Kidney Plants
SELENIUM - RDA
100
µg/day
SELENIUM –FUNCTIONS
Glutathione
peroxidase
• As an
antioxidant
Deiodinase
• Converts T4 to
T3
Selenocysteine
• 21st amino
...
SELENIUM – DEFICIENCY
Causes
• Low soil content
of selenium
• Parenteral
nutrition
Features
• Cirrhosis of liver
• Cardiom...
SELENIUM - TOXICITY
• Rare
• Seen in people who handle metal
polishes and antirust compounds
Cause
• Hair loss
• Dermatiti...
MANGANESE
MANGANESE – SOURCE & RDA
Whole grain cereals
Vegetables
Nuts
MANGANESE - FUNCTIONS
Pyruvate
carboxylase
• Gluconeogenesis
Acetyl CoA
carboxylase
• Fatty acid
synthesis
Superoxide
dism...
MOLYBDENUM
MOLYBDENUM – SOURCES & RDA
Milk
Beans
cereals
RDA
200
µg/day
MOLYBDENUM - FUNCTIONS
Xanthine
oxidase
• Catabolism of
purines
Sulfite oxidase
• It oxidizes
sulfite to
sulfate
COBALT
COBALT - FUNCTIONS
Methycobalmine
• Homocysteine
methy
transferse
Deoxyadenosyl
cobalamine
• L- methyl
malonylCoA
mutase
Minerals Fluorine, selenium, manganese, molybdenum, ppt BIOCHEMISTRY vkunder637@gmail.com
Minerals Fluorine, selenium, manganese, molybdenum, ppt BIOCHEMISTRY vkunder637@gmail.com
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Minerals Fluorine, selenium, manganese, molybdenum, ppt BIOCHEMISTRY vkunder637@gmail.com

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  • 1ppm=1gram of fluoride in million gm of water=1mg/1000ml
  • Transcript of "Minerals Fluorine, selenium, manganese, molybdenum, ppt BIOCHEMISTRY vkunder637@gmail.com"

    1. 1. FLUORINE, SELENIUM, M ANGANESE, MOLYBDENU M, COBALT Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
    2. 2. FLUORINE Source RDA Functions Deficiency Toxicity
    3. 3. FLUORINE - SOURCE Drinking water Depends upon fluorine content in the soil
    4. 4. FLUORINE - RDA 1ppm
    5. 5. FLUORINE - FUNCTIONS Increases hardness of bone and teeth Required for normal dentition Prevents dental caries
    6. 6. FLUORINE - DEFICIENCY Cause Drinking water that is low in fluorine content Feature Dental caries Drinking water containing less than 0.5ppm of fluoride
    7. 7. FLUORINE - TOXICITY Cause Drinking water with fluorine more than 5ppm Features Dental fluorosis and skeletal fluorosis
    8. 8. FLUORINE - TOXICITY Dental fluorosis Mottling of enamel Discoloration of teeth Skeletal fluorosis Bowed legs Bending of spine Osteoporesis
    9. 9. SELENIUM
    10. 10. SELENIUM - SOURCES Sea foods Meat Liver Kidney Plants
    11. 11. SELENIUM - RDA 100 µg/day
    12. 12. SELENIUM –FUNCTIONS Glutathione peroxidase • As an antioxidant Deiodinase • Converts T4 to T3 Selenocysteine • 21st amino acid
    13. 13. SELENIUM – DEFICIENCY Causes • Low soil content of selenium • Parenteral nutrition Features • Cirrhosis of liver • Cardiomyopathy • Muscular dystrophy
    14. 14. SELENIUM - TOXICITY • Rare • Seen in people who handle metal polishes and antirust compounds Cause • Hair loss • DermatitisFeatures
    15. 15. MANGANESE
    16. 16. MANGANESE – SOURCE & RDA Whole grain cereals Vegetables Nuts
    17. 17. MANGANESE - FUNCTIONS Pyruvate carboxylase • Gluconeogenesis Acetyl CoA carboxylase • Fatty acid synthesis Superoxide dismutase • Suppression of oxidative stress
    18. 18. MOLYBDENUM
    19. 19. MOLYBDENUM – SOURCES & RDA Milk Beans cereals RDA 200 µg/day
    20. 20. MOLYBDENUM - FUNCTIONS Xanthine oxidase • Catabolism of purines Sulfite oxidase • It oxidizes sulfite to sulfate
    21. 21. COBALT
    22. 22. COBALT - FUNCTIONS Methycobalmine • Homocysteine methy transferse Deoxyadenosyl cobalamine • L- methyl malonylCoA mutase
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