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Membrane transport ppt BIOCHEMISTRY

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  • 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  • 2. • Cell membrane is the boundary between inside & outside… IN food carbohydrates sugars, proteins amino acids lipids salts, O2, H2O OUT waste ammonia salts CO2 H2O products IN OUT NO!
  • 3. • Biological membrane are semipermeable Channel proteins Carrier proteins Lipid bilayer interstices
  • 4. Passive transport Active transport
  • 5. • Transport of solute molecules from across membrane • It is a down hill transport and requires no energy Simple diffusion Facilitated diffusion 2 types
  • 6. • Move from HIGH to LOW concentration – “passive transport” – no energy needed Diffusion Through the channel protein and lipid bilayer interstices. E.g., Transport of O2, CO2, N2, ethanol and urea
  • 7. Passive transport protein Lower concentration Higher concentration of Protein channel
  • 8. E.g., Transport of glucose and most amino acids Through carrier protein conformational change
  • 9. • Molecule moves . • Needs an external Primary active transport • Energy is derived directly from hydrolysis of ATP Secondary active transport • ATP provides the energy for transport indirectly Two types
  • 10. Sodium-Potassium pump High Na+ Low Na+ Low K+ High K+
  • 11. • ATP provides the energy for transport indirectly. • Uses an energy of an electrochemical gradient or membrane potential produced originally by primary active transport process by using ATP Co-transport or Symport Both the substances move across in same direction Sodium- glucose cotransport Counter transport or antiport Each substance moves in opposite direction Sodium-calcium counter transport
  • 12. Voltage gated channels are opened by membrane depolarization Membrane potential change (voltage difference) switches the ion channel to open Voltage gated sodium channels Voltage gated potassium channels
  • 13. ENDOCYTOSIS Pinocytosis (cellular drinking) Phagocytosis (cellular eating) EXOCYTOSIS Exocytic vesicles
  • 14. Vesicle forming
  • 15. Vesicle Fluid outside cell Protein Cytoplasm
  • 16. • Water moves rapidly into & out of cells – evidence that there were water channels 1991 | 2003 Peter Agre John Hopkins Roderick MacKinnon Rockefeller