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Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
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Lipid metabolism ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com

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  • 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  • 2. Definition Significance Synthesis Utilization Ketosis
  • 3. DEFINITION Ketone bodies are metabolic products that are produced in excess during excessive breakdown of fatty acids.
  • 4. Acetone Acetoacetate β- hydroxybutyrate
  • 5. Alternate sources to glucose for energy Production of ketone bodies under conditions of cellular energy deprivation Utilization of ketone bodies by the brain
  • 6. Site Pathway Regulation
  • 7. Ketone bodies are synthesized only in liver
  • 8. Level 1 Lipolysis INSULIN GLUCAGON Level 2 Entry of fatty acid to mitochondria CAT-I Level 3 Oxidation of acetyl CoA OXALOACETATE
  • 9. Ketone bodies are not oxidized in the liver. Utilized in extrahepatic tissues such as brain, heart, skeletal muscle and kidney
  • 10. β-Hydroxybutyrate CoA transferase Thiolase KETOLYSIS
  • 11. Ketosis is a disorder of excessive production of ketone bodies
  • 12. • Carbohydrate deprivation Prolonged starvation • Impaired uptake of glucose by the peripheral tissues Uncontrolled diabetes mellitus
  • 13. Ketonemia Ketonuria Acetone breath Metabolic acidosis Hyperkalemia
  • 14. • In plasma β hydroxybutyrate • In urine • Rothera’s test Acetoacetate
  • 15. Provision of glucose to the tissues Starvation – carbohydrate ingestion Diabetes mellitus – glucose and insulin Correction of acid-base and electrolyte imbalance Bicarbonate administration Reverses hyperkalemia

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