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Hormone action ppt BIOCHEMISTRY
 

Hormone action ppt BIOCHEMISTRY

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    Hormone action ppt BIOCHEMISTRY Hormone action ppt BIOCHEMISTRY Presentation Transcript

    • Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
    • Polypeptides Steroids Amino acid derivatives Insulin glucagon somatotropin FSH LH vasopressin Oxytocin thyrotropin ACTH Estrogen testosterone cortisol Aldosterone corticosterone Progesterone Epinephrine norepinephrine dopamine Thyroxine, T3 and T4 Melatonin Serotonin
    • Rule: All peptide hormones are synthesized as inactive “pre-pro” precursors Rule: A signal peptide must be cleaved off to activate the mature form of the hormone
    • Hormones transmit the signals through specific receptors
    • Definition: The series events and components that take part in transmitting a hormonal signal to a the interior of the cell Membrane or cytosolic Receptor Signal Initiator Target molecule Signal mediator Action
    • T3 T4 TSH Autoantibodies Free T4
    • Reference range • 110-190ng/dl Increased T3 • Hyperthyroidism Decreased T3 • Hypothyroidism
    • Reference range • 5-12µg/dl Increased T4 • Hyperthyroidism Decreased T4 • Hypothyroidism
    • Reference range • 0.5-12µU/ml Increased TSH • Hyporthyroidism Decreased TSH • Hyperthyroidism
    • Direct measure of free hormones 07 – 2ng/dl Estimation is more sensitive
    • Antibodies to TSH receptors •Graves disease Antimicrosomal antibody •Hashimoto’s thyroiditis