Electron transport chain ppt BIOCHEMISTRY
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Electron transport chain ppt BIOCHEMISTRY

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  • mechanism by which electrons are passed along a series of carrier molecules, releasing energy for the synthesis of ATP.

Electron transport chain ppt BIOCHEMISTRY Electron transport chain ppt BIOCHEMISTRY Presentation Transcript

  • {OR RESPIRATORY CHAIN Dr Vijay Marakala Assistant professor Biochemistry SIMS&RC
  • CONTENTS What is ETC Localization of ETC Function of ETC Components of ETC Reaction of ETC Oxidative phosphorylation Mechanism of oxidative phosphorylation
  • Reducing equivalents
  • What is ETC?
  • Localization of ETC
  • Function of ETC ETC collects and oxidizes reducing equivalents with liberation of energy in the form of ATP
  • Components of ETC Q=Ubiquinone or coenzyme Q
  • Complex-I NADH - Q oxidoreductase NADH FMN Fe-S CoQ
  • Complex-II Succinate Q oxidoreductase Succinate FAD Fe-S CoQ
  • Complex-III Q- Cytochrome c oxidoreductase CoQ Fe-S Cyt.b Cyt.c1 Cyt.c
  • Complex-IV Cytochrome oxidase or Cytochrome aa3 Cyt.c Cyt.aa3 O2
  • Reactions of ETC Accepts and transfers one hydride ionNAD+ • One H+ and 2e- Accepts and donates two hydrogenFMN/ FAD/ Q • H2 = 2H+ and 2e- Accepts and transfers only one electronCyt/Fe-S • One e- Remember
  • Reactions of ETC Sequence of reactions NADH+ H+ donates electrons and protons Formation of FMNH2 Collection of electrons from FMNH2 by Fe-S protein Collection of reducing equivalents by Co Q Removal of electrons by cytochromes Reduction of oxygen to water
  • Formation of ATP Coupling site for ATP synthesis
  • Fo F1 ATPase F0 F1 Also called ATP synthase. Embedded in the inner membrane
  • Mechanism of oxidative phosphorylation CHEMIOSMOTIC THEORY Peter Mitchell 1920-1992
  • Electrochemical gradient
  • Proton motive force
  • { {P:O ratio  No of ATP synthesized per atom of oxygen[1/2O2] Respiratory control  The regulation of the rate of oxidative phosphorylation by ADP level is called respiratory control P:O ratio and Respiratory control