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Miquel Borràs / Research and technology transfer in experimental toxicology and ecotoxicology

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Presentation given by Miquel Borràs from Barcelona Science Park in the framework of the Emergence Forum Barcelona …

Presentation given by Miquel Borràs from Barcelona Science Park in the framework of the Emergence Forum Barcelona

Biocat organized the Barcelona Emergence Forum (April 10-11th, 2014, Congress Palace, Montjuïc) supported by the TRANSBIO SUDOE, a translational cooperation project dedicated to innovation in life sciences in South-West Europe. The Barcelona Emergence Forum contributed to bringing together Academics, Companies, Investment Entities, Technology Platforms and Technology Transfer Offices from Spain, France and Portugal to set up collaborative projects on Human Health & Agro-food Innovation.
More information at: http://www.b2match.eu/emergenceforum2014

Published in: Healthcare, Technology, Business

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  • 1. www.pcb.ub.cat/utox-pcb www.pcb.ub.cat/ceretox UTOX | UNITOF EXPERIMENTALTOXICOLOGYAND ECOTOXICOLOGY CERETOX | CENTER OF RESEARCH INTOXICOLOGY
  • 2. 1  Description  Mission, Vision and Values  The Team  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise •The Unit of ExperimentalToxicology and Ecotoxicology is a Technological Platform of PCB, starting in 2002 •Committed to cover our own expenses, by means of • public funded competitive projects • contract research or services with private or public customers •Initial offer: our previous know-how • “conventional” in vivo toxicology (my own experience in the pharmaceutical industry) • Ecosurveillance field studies with sentinel species and biomarkers (our experience at the Faculty of Biology)
  • 3. 2  Description  Mission, Vision and Values  The Team  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise Very soon we realize that: • It is simply not possible to perform regulatory toxicology with only three people and without any quality certification • Not many people will be willing to pay for long-term, scientifically interesting but non-regulatory ecotoxicological field studies •Competition is very hard!
  • 4. 3  Description  Mission, Vision and Values  The Team  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise So, we needed to find a technological offer ad hoc, • Alternative • Innovative • with little or none competition • with a high added value And we ought to: •Win the trust of our customers (confidentiality, professionality, seriousness in the terms for deliverables) • Provide some special adds (proximity, flexibility, disponibility, readiness for any interaction) • HAVEA QUALITY PLAN!! • have a Marketing Plan •AND SET UP SOMEALLIANCES!!
  • 5. 4  Description  Mission, Vision and Values  The Team  Contact | Location  Facilities | Equipment UTOX | The Unit of Experimental Toxicology and Ecotoxicology is a platform of the Barcelona Science Park (PCB), the objective of which is to serve as a support resource for UB groups, companies located in the PCB and other public or private research centers; and, on the other hand, to carry out its own research projects or projects in collaboration with other partners. The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise UTOX | UNIT OF EXPERIMENTALTOXICOLOGY AND ECOTOXICOLOGY · PCB UTF | UNIT OFTOXICOLOGY OF PHARMACY · UB + = UTF | The Unit of Toxicology of the Pharmacy school of the University of Barcelona cooperates and supports other UB groups, companies and other public and private centers of research in terms of technology transfer and know-how, besides its teaching and research activity. CERETOX | The Center of Research in Toxicology (TECNIO agent) comprises the UTOX and UTF units, and is specialized in the Technology transfer in Toxicology, making available to the industry the know-how of the group performing toxicological laboratory and field studies.
  • 6. 5  Description  Mission,Vision andValues  The Team  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise MISSION|Support to the industry and health/environment care sector for the safe development of news products and for the improvement of process, by means of the transfer of toxicology. VISION|To provide advice on, design and perform customized toxicology studies (based on the specific regulatory and quality needs and requirements in each case), covering the areas of ‘non regulatory’ as well as ‘pre-clinical’Toxicology. VALUES| Know-how | Quality (GLP) | Innovation | Adaptability | Proximity
  • 7. 6  Description  Mission, Vision and Values  TheTeam  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise THETEAM | The nucleus of the team consists of a total of 7 + 5 persons: PhDs, university graduates and technicians from several different origins and training (biologists and pharmacists primarily). The team expands every year with university, master or pre-doctoral students, from different scientific backgrounds and countries, who complement their training and projects in the center, by means of temporary stays. Director UTOX Miquel Borràs Customer&Administrative service AlceColoma Director UTF Joan M. Llobet Study staff UTOX David Ramos Joan Serret Roser Cruz Lab coordinator UTOX Joaquín de Lapuente Lab responsible UTOX JavierGonzález Lab coordinator UTF Jesús Gómez Lab responsible UTF Ester Piqué Study staff UTF Núria Boix
  • 8. 7  Description  Mission, Vision and Values  The Team  Contact | Location  Facilities | Equipment The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise FACILITIES | INTERNAL EXTERNAL >HISTOLOGY SERVICE >SERUM BIOCHEMISTRY EQUIPMENT / LIQUID BIOCHEMISTRY ANALYZER >HEMATHOLOGY ANALYZER >MICROSCOPY & FLUORESCENCE MICROSCOPY ... Access to Transmision Electronic Microscope Service · IRB ... Access to Confocal Microscope Service · IRB >CELL CULTURES >ECOMODUL (Ecotoxicity studies under GLP conditions) >ELECTROPHORESIS EQUIPMENT & PCR >HPLC & SPECTROPHOTOMETER >TECHNOLOGICAL PLATFORMS · PCB Proteomics Drug Discovery Combinatorial Chemistry PRAAL >COMMON SCIENTIFIC SERVICES· PCB >RADIOACTIVITY · PCB >CCiT – Scientific and Technological Centers · UB Genomics Cytometry >PATTERNS / CERTIFIED MATERIALS · Research Quality Service·UB >ANIMAL FACILITY SERVICE · PCB & UB EQUIPMENT | Dealing at a time as a PCB platform and a TECNIO member formed by two units from two different institutions, the center has access to both facilities, equipment and expertise of the PCB and the UB, and to the activities and grants of ACC1Ó.
  • 9. 8  AccreditationACC1Ó  Good Laboratory Practices certificate The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise | Because of being a member of TECNIO, the center has the certificate of Quality Management according to the accreditation process of the IT network, based on the requirements of the ISO9001 and Model EFQM (European Foundation for the Quality Management) standards.
  • 10. 9  AccreditationACC1Ó  Good Laboratory Practices certificate The Center Quality Toxicology  Assays Toxicology  Sectors Technology Transfer Research  Projects | Papers Expertise | TYPEOF STUDIES Toxicity studies (2) Mutagenicity studies (3) Environmental toxicity studies (4) (aquatic and terrestrial organisms) | AREAS OFAPPLICATION Human and Veterinary drugs Medical devices Cosmetics GLPs
  • 11. 10  InVivo Toxicology  In Vitro Toxicology  Ecotoxicology  Nanotoxicology  Analitical Toxicology | Histopathology  Risk Assessment | Expert Reports The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise INVIVO TOXICOLOGY | AcuteToxicity (Up&Down protocol) AcuteToxicity (Classic method) (Oral, intraperitoneal, dermic, intracutaneous,intramuscular, intravenous, inhalatory) AbnormalToxicity Subacute Toxicity (14 days) SubacuteToxicity (28 days) Subchronic Toxicity (90 days ) Chronic Toxicity (6 months) Fertility and Embrionary Development Fetal Development (Teratogenicity) Peri and Postnatal Development Sensitization(LLNA) Guinea Pig Maximisation Test Irritation on Oral/Vaginal/Rectal Mucosa Primary Dermal Irritation Intradermic Reactivity Test Acute Ocular Irritation Pirogenicity Test PalatabilityTest (Choice test) Mortality Test (rodenticides) Toxicological Proof of Concept Micronucleus Test in vivo Comet Test in vivo
  • 12. 11 The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise  In Vivo Toxicology  InVitro Toxicology  Ecotoxicology  Nanotoxicology  Analitical Toxicology | Histopathology  Risk Assessment | Expert Reports INVITRO TOXICOLOGY| Embryonic Stem Cell Test (EST) MicroMass Test Whole Embryo Culture (WEC) FET: Fish Embryo Test CitoxicityTest (3T3 NRU, MTT, WST-1, LDH) Micronucleus Test in vitro Comet Test in vitro Ames test Mammalian Cell Gene Mutation Test (MLA) Cell Transformation Assay (CTA) Cariotyping Detection of estrogenic ebdocrine disruptors (Vitellogenin Assay) Hemolisis Test The Stably Transfected Human Estrogen Receptor Transcriptional Activation Assay Corrosion assasy in human skin model (EPISKIN) RHPE Despigmentation PhototoxicityAssay Hemolisis Test + Protein Denaturation (RBC) Ocular Irritation Assay (RhT) Dermic Absorption Assay
  • 13. 12  ToxicologiyIn Vivo  Toxicology In Vitro  Ecotoxicology  Nanotoxicology  Analitical Toxicology | Histopathology  Risk Assessment | Expert Reports ECOTOXICOLOGY| Sentinel species Biomarkers of exposure and effect Nitrogen Transformation Assay Earthworm lethality Test Earthworm reproduction Test Terrestrial Plants Seeding and Growth Test Algae Growth Inhibition Test Daphnia sp. Acute Immobilization Test Daphnia sp Reproduction Test Fish Acute Toxicity Fish Embryo TeratogenicityTest Frog embryo teratogenesis assay-Xenopus (FETAX) The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise
  • 14. 13  Toxicologiy In Vivo  Toxicology In Vitro  Ecotoxicology  Nanotoxicology  Analitical Toxicology | Histopathology  Risk Assessment | Expert Reports NANOTOXICOLOGY| The current expansion of nanotechnology and of the range of its practical applications allows to foresee a substantial increase in the levels of exposure (intentional or accidental) to nanoparticles of anthropogenic origin for both humans and the environment. It is therefore essential to establish the basis for the assessment of risk in both areas , which means having relevant data both for exposure and toxicity (hazard). Moreover, the same considerations apply when nanotechnology is used for drug delivery, even of already-known products. The presentation to targets at a nano-scale can modulate their toxicity in a way that can not be predicted a priori . The study of the distribution of nanoparticles in the body and the dynamics of their internalization into cells become, therefore , a topic of the highest importance. Similarly, the protocols of conventional toxicological testing techniques must be adapted to the study of these new materials. The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise
  • 15. 14  Toxicology In Vivo  Toxicology In Vitro  Ecotoxicology  Nanotoxicology  AnaliticalToxicology | Histopathology  Risk Assessment | Expert Reports ANALITICALTOXICOLOGY | HISTOPATHOLOGY Hematology Serum Biochemistry Paraffin blocks preparation and cutting, cryotomy Histological slides staining and mounting Differencial stains Immunohistochemistry Histopathologic Diagnosis The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise
  • 16. 15 The Center Quality Toxicology Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise  Toxicology In Vivo  Toxicology In Vitro  Ecotoxicology  Nanotoxicology  AnaliticalToxicology | Histopathology  RiskAssessment | Expert Reports RISKASSESSMENT | EXPERT REPORTS
  • 17. 16  Pharma & Biotechnology  Cosmetics  Medical Devices  Veterinarian  Food  Chemical Industry The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise PHARMA & BIOTECHNOLOGY|
  • 18. 17  Pharma & Biotechnology  Cosmetics  Medical Devices  Veterinarian  Food  Chemical Industry COSMETICS| The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise
  • 19. 18  Pharma & Biotechnology  Cosmetics  Medical Devices  Veterinarian  Food  Chemical Industry The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise MEDICAL DEVICES |
  • 20. 19  Pharma & Biotechnology  Cosmetics  Medical Devices  Veterinary  Food  Chemical Industry The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise VETERINARY |
  • 21. 20  Pharma & Biotechnology  Cosmetics  Medical Devices  Veterinarian  Food  Chemical Industry The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise FOOD |
  • 22. 21  TECNIO  AppliedToxicology:AddedValor | Process Improvement The Center Quality Toxicology  Techniques Toxicology  Sectors TechnologyTransfer Research  Projects | Publications Expertise TECNIO | APPLIEDTOXICOLOGY | TECNIO is the brand that identifies technology centers and university groups expert in industrial research and technology transfer in Catalonia. TECNIO brings together the best technology centers and research universities of Catalonia.  Access to R & D differential capabilities.  Range of knowledge and technologies that are not in the market and, therefore, are key factors for improving the competitive position of the company.  Respond to the technological needs of the company to help develop and improve new products and services.  To add value to the product.  Promote internationalization of companies through participation in international programs to support R & D.
  • 23. 22  Public Projects  Scientific Publications The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise PUBLIC PROJECTS | Recently finished | We have participated and actively participate in the different types of calls, regional, national and international: ACC1Ó (VALTEC, INNOEMPRESA and others) / PLAN NACIONAL / CDTI / INNPACTO / CONNECT-EU / ERA.Net RUS / FP6 / FP7 / FP8 (H2020), and others. > “Integrated assessment of health risks of environmental stressors in Europe (INTARESE)” FP6 project, IP: David Briggs (Imperial College of Science, Technology and Medicine of London) > “Evaluación de los efectos sobre la reproducción masculina tras la exposición subcrónica y de los efectos en la maduración testicular tras la exposición maternal subcrónica peri y postnatal. Estudios en rata subadulta (EXTASIS)” FIS project, IP: Joan M. Llobet (GRET/CERETOX (UB/PCB),Barcelona) > “Desarrollos tecnológicos hacia un Ciclo del Agua Urbano Autosostenible (SOSTAQUA) “ CENIT project, IP: Josep Flores (AGBAR, Barcelona) “Hacia una nanotecnología sostenible, responsable y segura (NANOSOST)” Singular & Strategic project, IP: Julià Santpere (IQS-URL, Barcelona) > “Desarrollo de nuevas estrategias para la optimización de la tecnología de biorremediación y aporte de información para una mejor caracterización química y ecotoxicológica de suelos contaminados por hidrocarburos” Ministry of Environment project, IP: Anna M. Solanas (UB, Barcelona) > “Medicina personalizada en oncología (ONCOLÓGICA)” CENIT project, IP: ORYZON (Barcelona)
  • 24. 23  Public Projects  Scientific Publications The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise PUBLIC PROJECTS | Open | > “NANOBIO-NANOMED” CONNECT-EU network, IP: Institut de Bioenginyeria de Catalunya (IBEC, Barcelona) > “Cyano-bridged coordination polymer nanoparticles (COPONAMRI)” ERA.Net RUS call in Collaborative S&T projects, IP: Yannick Guari (Université Montpellier II, France) > “Industrial Implementation of Processes to Render RSC Safer in Manufacturing Processes (SILICOAT)” FP7 project, IP: Instituto de Tecnología Cerámica (Castellón) > “Health and Environment-wide Associations based on Large population Surveys (HEALS). FP7 project, IP: Isabella Anesi-Maesano (Université Pierre et Marie Curie, Paris) and Denis Sarigiannis (Aristotle University, Thessaloniki)
  • 25. 24  Public Projects  Scientific Publications The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise PUBLIC PROJECTS | Submitted | > NIH-EMBRYNANOTOX: Molecular biomarkers for the assessment of embryotoxicity and developmental toxicity of nanomaterials with in vitro alternative methods. NIH (USA, PA-11-260 NIH founding opportunities,2013) / UMH > LIFE-EMBRYNANOTOX: Improving knowledge in the assessment of embryo and developmental toxicity of nanomaterials using molecular endpoints. European Comission (LIFE13 ENV/ES/000511) / UMH > PN – EMBRYONANOX: Biomarcadores genómicos, proteómicos y morfológicos para la evaluación in vitro de la embriotoxicidad de nanomateriales con aplicaciones biomédicas. Ministerio de Economía y Competitividad / UMH (Plan Estatal de Investigación Científica y Técnica y de Innovación - Programa Estatalde Fomento de la Investigación Científica y Técnica de Retos, 2013) > “Desarrollo de sílices precipitadas con alta capacidad de absorción” CDTI / Empresa Industrias Químicas del Ebro, S.A (convocatoria del CDTI para la presentación de proyectos de I+D cofinanciados por el mecanismo financiero del espacio económico europeo (EEA-GRANTS)dentro del programa de Ciencia y Tecnología en Medio ambiente y Cambio climático, 2013) > Projecte “Estudi de toxicitat sistèmica bacteriana” ACC1Ó - Generalitat de Catalunya (convocatòria VALTEC/UAB 2013)0 > “Estudi preclínic - Screening toxicològic” ACC1Ó - Generalitat de Catalunya (convocatòria VALTEC/IBEC 2013) > Aprofitament de residus vegetals de la restauració, ja seleccionats i de gran volum. ACC1Ó (Generalitat) i Ministerio de Industria y Turismo – Programa INNOEMPRESA(2013)/ EUROPEADE NEGOCIOS SPAIN ONLINE S.L. > SFERA: Safety of Food via combined Exposure and Risk Assessment. 8FP (H2020-SFS-2014-2) / ARISTOTELIOPANEPISTIMIO THESSALONIKIS > ITN-MULTIHERANANO 8FP (H2020-MSCA-ITN-2014) > E – BIOTIDE: Bioactivity and osseointegration enhancement of Ti dental implants by innovative coatings EUROSTARS Programme 2014 / FLUBETECH S.L.
  • 26. 25  Public Projects  Scientific publications and other academic activities The Center Quality Toxicology Techniques Toxicology  Sectors Technology Transfer Research  Projects | Publications Expertise SCIENTIFIC PUBLICATIONSAND OTHER ACADEMICACTIVITIES| In these 12 years, • we have participated in 12 competitive projects national and international • we have participated in more than 50 publications • we have participated in over 40 conferences and seminars • we have contributed to the formation of more than 90 people who have made stays in our laboratory. We have also worked with over 60 different clients, public and private, and have collaborated with many groups at the University of Barcelona, other Catalan universities and institutions throughout Spain and Europe as well as some of South America and Africa.
  • 27. www.pcb.ub.cat/utox-pcb www.pcb.ub.cat/ceretox Parc Científic de Barcelona – Edifici Clúster Campus Diagonal. Universitat de Barcelona c/ Baldiri Reixac, 10-12 - 08028 Barcelona mborras@pcb.ub.cat | +93 403 71 93 https://www.youtube.com/user/UTOXiPCB http://www.linkedin.com/groups/Unidad-Toxicologia-PCB-4469364?trk=my_groups-b-grp-v