Joan Tibau / Pig production & biomedical models: synergies and opportunities


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Presentation given by Joan Tibau from the Agraric Technology and Research Insitute (IRTA) in the framework of the Emergence Forum Barcelona

Biocat organized the Barcelona Emergence Forum (April 10-11th, 2014, Congress Palace, Montjuïc) supported by the TRANSBIO SUDOE, a translational cooperation project dedicated to innovation in life sciences in South-West Europe. The Barcelona Emergence Forum contributed to bringing together Academics, Companies, Investment Entities, Technology Platforms and Technology Transfer Offices from Spain, France and Portugal to set up collaborative projects on Human Health & Agro-food Innovation.
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Joan Tibau / Pig production & biomedical models: synergies and opportunities

  1. 1. Pig production & biomedical models: synergies and opportunities IRTA EXPERIENCES/FACILITIES & CAPACITIES PROPOSALS TO . FOOD / PHARMA INDUSTRY . MEDICAL RESEARCH ORGANISATIONS & COMPANIES TRANSBIO SUDOE Emergence Forum April, 9-11th 2014 Barcelona. Dr. Joan Tibau i Font . IRTA – Animal Breeding Genetics
  2. 2. Why pigs as animal model in biomedical research? Important livestock for food supply & ideal biological model for human diseases/dysfunctions. Efficient and precise genetic engineering -> great promise in agriculture and biomedicine. (One-step generation of knockout pigs by zygote injection of CRISPR/Cas system . Tang Hai et al . 2014 .Cell Research 31-01-014.) More human similarities than drosophila, rats, mouse, rabbits… Natural genetic diversity /variability/adaptability… (flexibility # models).. Evolutionary proximity to humans ( genomics).. -> Omnivore, body and organ size , physiology, live long, reproduction .. Common interest Human health Production efficiency Human health
  3. 3. Pig kariotype Human kariotype Human,3 Pig,13
  4. 4. IRTA - CURRENT STUDIES RELATING HUMANS AND PIGS • Appetite and feed preference studies . Social and eating behaviour. • Pig as a model for human obesity/metabolic syndrome studies. • Epigenetic studies in the human cardio metabolic risk in paediatrics. • Phenotypic , genetic and GXE studies of pig populations (breed, diet, age, sex,..) • Genomics and metabolomics of lipid metabolism (cholesterol) • Modelling human obesity : alometric growth curves and fat deposition in pigs . • Genomic and transcriptomic studies of swine sex –related hormones . • Neurotransmitters, stress and intake. • Microbiological studies in gut. Diet & animal health.
  5. 5. SERVICES & FACILITIES • Formulation and production special diets : powdered milk (Ordesa) and feed mill . • Experimental pig populations with full breeding control : ( Minipigs: Specipig ). • Individual growth, behaviour and feed intake (in experimental facilities with specialised personnel). • Evolution of live body composition and tissue development using computer axial tomography (TAC). • Blood, faeces and urine samples in live animals • Organ/tissues samples -> biochemical, histological, transcriptomics, proteomics and metabolomics analysis. -> (animal/human) growth/ physiology/ health biomarkers
  6. 6. Research and Development Collaborative Platform : Food, pharmaceutical and medical industry and academia join research. Human health Pig Production Transition : Lactation-> Omnivore Appetite : Brain <-> Gut …. Palatability Digestive tract inflamation Feed Efficiency Brain activity <-> Food Activity/ Regeneration Eating Behavior/Welfare Epigenetics Mother /children obesity-diabetes Production/Reproduction Longevity/ performances Fat mobilization -> milk Metabolic syndrome Heart/liver/blood biomarkers Fat/meat /product quality PIG AS MODEL ORGANISM : fields of preferential /common interest METAPIGS