Catarina Duarte / Food and health @ IBET

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Presentation given by Catarina Duarte from the Chemistry and Biology Technological Institute (New University of Lisbon) in the framework of the Emergence Forum Barcelona

Biocat organized the Barcelona Emergence Forum (April 10-11th, 2014, Congress Palace, Montjuïc) supported by the TRANSBIO SUDOE, a translational cooperation project dedicated to innovation in life sciences in South-West Europe. The Barcelona Emergence Forum contributed to bringing together Academics, Companies, Investment Entities, Technology Platforms and Technology Transfer Offices from Spain, France and Portugal to set up collaborative projects on Human Health & Agro-food Innovation.
More information at: http://www.b2match.eu/emergenceforum2014

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Catarina Duarte / Food and health @ IBET

  1. 1. Food and Health @ iBET Catarina Duarte Nutraceuticals and controlled Delivery Lab IBET/ ITQB-UNL Oeiras, Portugal
  2. 2. To create value for our partners leveraging scientific & technological knowledge in Biology and Chemistry To push for faster utilization of the new biotechnological tools in business activities; To provide joint research advanced training – OPEN INSTITUTION - Research conducted through a close partnership with ITQB To provide a support infrastructure for academia & companies in biotechnological processes and manufacturing in Portugal; To support start up/spin off companies at the incubation stage of their activities Mission : www.ibet.pt Oeiras, Lisbon
  3. 3. BIAL │ IBERFAR │ JOSÉ de MELLO SAÚDE GRUPO AZEVEDOS │ MEDINFAR │ TECNIMEDE PHARMACEUTICALSAND HEALHCARE AGROFOODAND FORESTRYINDUSTRIES AMORIM CORK INVESTIGAÇÃO E SERVIÇOS │ NUTRINVESTE RAR│ SUMOL+COMPAL ACADEMICINSTITUTIONS ESBUC – ESCOLA SUPERIOR DE BIOTECNOLOGIA (UCP) FCT-UNL – FACULDADE DE CIÊNCIAS E TECNOLOGIA (UNL) ITQB – INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA (UNL) FACULDADE DE CIÊNCIAS MÉDICAS (UNL) REITORIA DA UNIVERSIDADE NOVA DE LISBOA FCT – FUNDAÇÃO PARA A CIÊNCIA E TECNOLOGIA FLAD – FUNDAÇÃO LUSO-AMERICANA PARA O DESENVOLVIMENTO IAPMEI – INSTITUTO DE APOIO ÀS PEQUENAS E MÉDIAS EMPRESAS IICT – INSTITUTO DE INVESTIGAÇÃO CIENTÍFICA TROPICAL INIAV – INST. NACIONAL DE INVESTIG. AGRÁRIA E VETERINÁRIA FOUNDATIONSAND INSTITUTES In total, iBET is 60% privately owned Non-for-profit Member of the LAO (ITQB, IGC, iBET, CEDOC)
  4. 4. 16 fully equipped laboratories Pilot Plant cGMP Analytical Services Unit cGMP CMO (GeniBET) Human resources: 18 PhDs 4 Engineers 67 Researchers 14 Lab Technicians
  5. 5. FLEXIBILITY & CONFIDENTIALITY SPECIFIC NEEDS • Contract Research Projects • “Umbrella Research Contracts” (plus per project based contracts) • Satellite Laboratories (Merck Serono and Bayer Healthcare) • Joint Research for Advanced Training (MSc, PhD, publications submitted after both parties approval)
  6. 6. iBET is a certified Service Provider Agro-forestry Biopharmaceuticals and novel therapies cGMP Analytical services and Bioassays Food in Health Food, Water and Energy Nexus Protein stability, structure and drug design
  7. 7. BioactivityChemical Characterization and Metabolism Process Tecnology Analytical characterization: Phytochemicals Carbohydrates Proteins Sensory analysis Metabolism: • in vitro and in vivo digestion and bioavailability • metabolomic Extraction and Fractionation (green and sustainable processes) Fermentation Formulation (development of bioactive and bioavailable forms) Scale-up (extraction, fermentation, drying) Toxicity assessment Health benefits (cell models, yeast models, …) Preservative effects Molecurar Structure - Bioactivy Food and Health
  8. 8. Chemical Characterization and Metabolism Analytical characterization: Phytochemicals Carbohydrates Proteins Sensory analysis Metabolism: • in vitro and in vivo digestion and bioavailability • metabolomic Molecurar Structure - Bioactivy Food and Health Spectrophotometric assays Chromatographic techniques • Total polyphenols content • Total flavonoids content • Total phenolic acids content • Total procyanidin content • Total anthocyanin content • Total betalain content • Analysis of carotenoids • TLC • UPLC •HPLC-DAD-FD-ED • GC-MS • FTIR • NMR
  9. 9. Food and Health Process Tecnology • Conventional Extraction (with biocompatible solvents) • Pressurized Liquid Extraction • Supercritical Fluid Technology • Adsorption processes (molecular imprinted polymers) Bioactive rich fractions (e.g. polyphenols, carotenoids, phytosterols, terpenes,...) Natural colours Natural flavours Natural preservatives Application in food, cosmetic or pharma industries Extraction /Fraccionation of Natural Compounds
  10. 10. Food and Health Process Tecnology Materials Processing – particle formation, encapsulation and impregnation Fundamental studies Design & optimization of Delivery Systems DDS Characterization (morphology, particle size, pharmacokinetics,…) Nanotoxicity Supercritical fluid Technology Solid material processing with ScCO2 Particle formation technologies Impregnation by adsorption Molecular Imprinting Spray drying Spray chilling Fluidized-bed spray “Conventional” Techniques
  11. 11. Food and Health Bioactivity Characterization and pre-clinical Bioactivity evaluation of bioproducts Enzymatic assays Cell-based assays Chemical assays  In vitro chemical and cell based assays for pre-clinical studies (antioxidant, anti-inflammatory, anti-proliferative,, neuroprotection, cardioprotective, anti-diabetes…)  Transport and permeability studies (in vitro)  Bioavailability evaluation after digestion (in vitro) Molecurar Structure - Bioactivy
  12. 12. Catarina Duarte Contacts: cduarte@ibet.pt http://www.ibet.pt/services/food-health

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