Bernard Dumas / Screening and identification of new natural compounds for plant protection against biotic stresses
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Bernard Dumas / Screening and identification of new natural compounds for plant protection against biotic stresses

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Presentation given by Bernard Dumas from University Toulouse III, Paul Sabatier, in the framework of the Emergence Forum Barcelona ...

Presentation given by Bernard Dumas from University Toulouse III, Paul Sabatier, in the framework of the Emergence Forum Barcelona

Biocat organized the Barcelona Emergence Forum (April 10-11th, 2014, Congress Palace, Montjuïc) supported by the TRANSBIO SUDOE, a translational cooperation project dedicated to innovation in life sciences in South-West Europe. The Barcelona Emergence Forum contributed to bringing together Academics, Companies, Investment Entities, Technology Platforms and Technology Transfer Offices from Spain, France and Portugal to set up collaborative projects on Human Health & Agro-food Innovation.
More information at: http://www.b2match.eu/emergenceforum2014

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Bernard Dumas / Screening and identification of new natural compounds for plant protection against biotic stresses Bernard Dumas / Screening and identification of new natural compounds for plant protection against biotic stresses Presentation Transcript

  • Screening and identification of new natural compounds for plant protection against biotic stresses Dr Bernard DUMAS Research Director CNRS Plant-Microbe Interactions team UMR 5546 CNRS-Université Paul Sabatier Toulouse III , France
  • Plant diseases: strong economical and environmental impacts Fungal diseases: major cause of yield losses (>30%) Massive use of fongicides  Toxic compounds targeted to pathogens  Environmental and health concerns  Development of resistant strains Biological control as an alternative strategy to control plant diseases Biological control: The use of living organisms, or products derived from living organisms, for pest control
  • Plant diseases: strong economical and environmental impacts  World market of pesticides (fungicides, insecticides, herbicides) : 44 billions $  Strong increase of the biopesticide market Source: IUPP
  • Commercial products against fungal diseases  Microorganisms (~15) (antagonisms) Rhizobacteria : Bacillus sp., Pseudomonas fluorescens… Fungi: Trichoderma sp., Coniothyrium minitans, Ampelomyces quisqualis….. Natural products (active compounds known): β-1,3-glucan (Iodus2)….  Inducers of plant defense (5) Natural extracts (active compounds unkown): Giant knotweed (Milsana), Fenugrec seeds (Stifenia)… In France, about 20 active compounds are registrated Problem: Low and variable efficacy Solution: Identification of new active compounds, improvement of the formulation
  • Phase I : Molecular characterization of active compounds  Identification, mode of action, first toxicity evaluation… Phase II : Product development  Industrial production, formulation, field tests…. Phase III : Regulatory process  Toxicity studies, environmental impact… Phase IV : Commercial development From the identification of active compounds to the development of commercial products Development costs:  Chemical: ~250 million $  Biological product: ?
  • Neoprotec (2010 – 2014): a collaborative project to develop new biological products
  • Identification of active compounds from natural extracts  Development of high-throughput screening tests on model plants (Arabidopsis, tobacco….)  Mode of action: high-troughput gene expression assays using a « plant immunity chip » (96 biomarkers) to monitor immune responses Samples (treated plants) Primers (Biomarkers) 9216 Q-PCR (4h) BioMark™ HD System (Fluidigm) Compounds active on plant immune responses
  • Take-home messages  Strong need of environmentally-friendly strategies to control plant diseases  Biocontrol products (living microorganisms, natural extracts) can offer alternative solutions  Development of high-throughput screening tests to identify compounds able to stimulate natural plant immune responses  Identification of new formulations to improve the stability and efficacy of active compounds in the field
  • Acknowledgements  Sophie Vergnes  The Plant-Microbe Interactions team, LRSV Industrial partners