Natural Product for Skin Care+ Increases Migration, Proliferation And Survival of Skin Cells

Uploaded on


  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads


Total Views
On Slideshare
From Embeds
Number of Embeds



Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

    No notes for slide


  • 1. Natural Product for Skin Care+ Increases Migration,Proliferation And Survival of Skin CellsThe naturally occuring skin treatment active ingredient supplied by the Helix Aspersa Müller hascome a long way in the last 30 years since 1981 undergoing 3 generations of collection method. is leading the pack with its newest and also greatest improvement in theprocurement of this precious immune secretion.Existing research concentration of PHYSICIAN Tomic-Canic is molecular and also cellularsystems of cut treatment and also its inhibition with the long-lasting aim to deliver bench-sideanalysis back to patients at the bedside. Her study includes human and diabetic types oflaceration recovery, wound genomics studies, generating key cells from patients injury biopsies,local sustained gene delivery, cellular assays of laceration recovery, as well as histology as wellas immunohistochemistry of skin.The "how" of cell growth control. Each cell that is growing binds seemingly insignificant amountsof positive regulatory proteins called growth factors that promote cell division. The naturallyoccuring serum, made from glyco biomolecules, that powers all skintreatment creams nourishes as well as revitalizes the cells of the skin, and also has actuallybeen the object of intense study by researchers as well as skin specialists enrolled by a few ofthe most prominent dermatology services on the planet, holds potential as mediator elements ininjury treatment and also stem cell regenerative medicine. Below is an extract from a terrific poston the matter: Human skin stem cells (epithelial stem cells) located at the basal layer of theepidermis (the upper layer of the skin) and within the hair follicles replenish & maintain thenatural balance of cells within the epidermis layer of the skin. They also regenerate tissuedamaged from injury or excess solar exposure. To do their feat properly stem cells need tocommunicate with each other and there must also be good communication between theirinternal organelles. This is the function of glyco (sugar) molecules, and the recognition of theirrole by the sweet science of glycobiology has led to think of them as messenger molecules thatare able to bridge communication between cells and within cells. "Glycans control the societalinteractions of cells," noted Michael Tiemeyer, University of Georgia professor of biochemistryand molecular biology. "They control how cells interact with each other and how they interactwith their environment." What has slowly become clear to biochemists is that these sugars playas vital a role in making the cell work as do the proteins. They combine to form giant moleculessuch as carbohydrates and cellulose; they are already known to regulate hormones, organizeembryonic development, direct the movement of cells and proteins throughout the body, and 1/5
  • 2. regulate the immune system. As of 2012, we are aware of only LOréal Research recognizingthe importance of the latest discoveries in glycobiology. Yves Saint Laurent launched ForeverYouth Liberator, a new facial skincare which contains synthetic versions of 3 glycans to"stimulate the skins youth-promoting functions".This is after 24 years of discoveries in this new field of biology and chemistry. So if you havebeen with us since we launched the first generation of skincare products made with snail serum,more than 13 years ago, you may understand that the naturally occurring serum that powers ourskin care products should be looked upon as a benchmark by the cosmetic industry. The topicalapplication of the serum collected from live snails nourishes the fibroblasts in the basal layer ofthe skin and they preserve the vitality and youthful appearance of skin. This results in newer,stronger & longer lasting skin cells, more resistant to UV exposure & all around healthier.The serum is the main active ingredient in all our creams and we also offer a highlyconcentrated "skin serum" for intense treatment of damaged skin, BIOSKINREVITALIZER,made with the organic secretions of snails and with a hydrating Seaweed extract and HyaluronicAcid base, a pioneering & must-have addition on the journey to younger looking skin. GlycoMolecules Support the Immune System Our IMMUNE SYSTEM is a complex biologicalsubsystem made up of molecules, proteins, cells, and organs that function together to recognizeand defend against disease producing bacteria, viruses, fungi, and cells that have undergonemalignant transformation.The aging process decreases tissue function and our regenerative capacity. This is associatedwith a decline in the number of adult or somatic stem cells and their ability to divide and repairwithin multiple tissues. This process is called senescence. Senescence is the biological slowingdown of cellular division as dictated by stem cells & genetic instruction. It is a sort of biologicalclock & a natural component of aging. Stem cells are the natural architects of reparation. Foundin all multicellular organisms, they can self-replicate and differentiate into diverse specializedcell types in order to propagate the growth of an existing cell type.The potential therapeutic application of stem cells to reduce the burden of aging and stimulatetissue regeneration after trauma is very promising. Regenerative medicine products arebeginning to change medical practice today. Human tissue engineered skin and tissueengineered cartilage were amongst the first to be used for the treatment of chronic wounds andburns, and joint degeneration and injury, respectively. Other regenerative techniques are beingdeveloped to repair bone, the cornea, the bladder and several other common medicalconditions. An innovative technology that isolates, purifies and multiplies a patients ownfibroblast cells (a type of skin cell that makes collagen) for injection has been developed andcan be used for acne scarring and other therapeutic skin treatments. 2/5
  • 3. An artists impression of cell multiplication via http://alexanderandturner.comBecause the cells originate from the patient rather than a foreign source, the chance of anallergic reaction is extremely small, and results in patients have been shown to last for as manyas seven years, without the recurring return treatments required by conventional fillers. (As withevery invention there are risks involved and the procedure is very new so all of them may nothave been detected, thus be sure you do your due diligence before recurring to that procedure).Small fibroblast samples are taken from behind the patients ear and sent to the FibrocellScience lab. Over a period of approximately 90 days, hundreds of millions of fibroblasts arecultured and then frozen until needed for treatment. The recommended course of laVívadministration is a series of three treatments, typically three to six weeks apart. Additionalinformation about laVív, including complete Prescribing Information, is available Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) Are MajorPlayers In Tissue Repair Much research is currently ongoing to identify the factors andmolecular mediators of stem cell self-renewal to reach these goals.Over the last two decades, fibroblast growth factors (FGFs) and their receptors (FGFRs) havestood up as major players in both embryonic development and tissue repair. Moreover, manystudies point to somatic stem cells as major targets of FGF signaling in both tissue homeostasisand repair. FGFs appear to promote self-renewing proliferation and inhibit cellular senescencein nearly all tissues tested to date. Roles of FGF signaling in stem cell self-renewal, senescence 3/5
  • 4. and aging Daniel L.Coutu 1 & Jacques Galipeau 2 1-Stem Cell Dynamics Research Unit,Helmholtz Zentrum München, 85764 Munich (Germany) 2-Departments of Hematology &Medical Oncology, and Pediatrics, Emory University, Winship Cancer Institute, Atlanta 30322,GA (USA) The process of aging is a systemic degenerative process caused by intrinsic (genetic,epigenetic) and extrinsic (environmental) factors. It affects multiple organs, mainly those with ahigh metabolic demand or those actively dividing and replicating their chromosomes and thoserequiring constant or frequent regeneration. As such, aging is associated with a decrease in theregenerative properties of many tissues including bone, skin, muscle, brain and more. Adultstem cells constantly provide replacement cells for tissue homeostasis and repair while at thesame time maintaining a pool of stem cells by the process of self-renewal, where after celldivision takes place at least one daughter cell is still a stem cell whereas the other is either astem cell (symmetric division) or a differentiated progeny (asymmetric division).The stem cell pool only regresses when a symmetric division giving rise to two differentiatedprogeny occurs, or when the stem cell undergoes cellular senescence (these two processes notbeing exclusive). In recent years, a number of studies have identified fibroblast growth factors(FGFs) and their receptors (FGFRs) as key regulators of both senescence and self-renewal in avariety of stem cell types. The Fibroblast growth factors (FGFs) comprise a large family ofgrowth and differentiation factors with essential functions in development, metabolism, andrepair of various tissues and organs. Dysregulation of FGF signaling is associated with a widevariety of human diseases, including several developmental/genetic diseases, metabolicdisorders, and malignancies.FGFs (23 known members) and FGFRs (5 known members, expressed as multiple splicevariants) have long been known for their important roles in embryonic development. However,the vast number of somewhat redundant ligands and receptor variants, as well as thepromiscuous ligand usage by the receptors has made it difficult to study the roles ofFGFs-FGFRs using genetic methods. Furthermore, FGF signaling is modulated by tissuespecific heparan-sulfate proteoglycans (HSPGs) that either inhibit or amplify FGFR activation.The divergent effects of FGF signaling also appear to depend on the state of differentiation ofthe cells, the repertoire of FGFRs they express, and the presence of other growth factors orcytokines.Nevertheless, as further tools and reagents are developed, a more comprehensive image isstarting to emerge. Since FGF signaling is so potent at inducing stem cell self-renewal andinhibiting their senescence, therapeutic targeting of FGF signaling components by recombinantproteins, gene therapy or small molecules could well be used to reverse some of the effects ofaging. In fact, various FGFs are currently being tested therapeutically for a number ofage-related disorders such as cardiovascular diseases, diabetes, osteoarthritis, chronic kidneydisease, Parkinsons disease and mood disorders (reviewed in Beenken A, Mohammadi M: TheFGF family: biology, pathophysiology and therapy. Nature Reviews Drug discovery 2009,8:235-53. Also see 4/5
  • 5. Natural Product for Skin Care+ Increases Migration, Proliferation And Survival of Skin Cells 5/5Powered by TCPDF (