Chemist talks to class of 5th graders

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A pharmaceutical Chemist shares a view of organic chemistry and his role preparing enantiomeric drugs for clinical trials. Dr. Welch is also on the Titan Explorer team looking for signs of life on other planets

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Chemist talks to class of 5th graders

  1. 1. Atoms, Molecules and Chemistry Dr. Chris Welch, Ph.D. Process Research Analysis & Preparative Separations Cranbury Elementary Cranbury, NJ April 2005
  2. 2. Atoms Democritus (c. 460–c. 370 B.C.) matter is made of discrete indivisible particles, or atoms
  3. 3. Dimitri Mendeleev (1834-1907)
  4. 4. Molecules Jacobus Henricus van't Hoff 1852 -1911 Friedrich August Kekulé 1829- 1896
  5. 5. Molecules COOH O CH3 O aspirin
  6. 6. O H COOH C O CH3 O OCH3 aspirin vanillin OH
  7. 7. O O CH3 CH3 H3C N N N HN N N O N O N CH3 CH3 caffeine theobromine
  8. 8. H3C CH3 CH3 H CH3 CH3 H H H cholesterol HO
  9. 9. H3C CH3 CH3 CH3 H3C CH3 CH3 CH3 CH3 beta carotene CH3 CH3 CH3 H3C CH3 H C O all-trans Retinal CH3 (vitamin A)
  10. 10. bd pq analyte enantiomers k’1 = t1 - to to Less stable More stable adsorbate adsorbate k’2 = t2 - to to α= k’2 k’1 CSP
  11. 11. N Ph O HO H OH N N N N MeO O H O O N CF3 1 5.6 kg of 2 obtained from 19 runs 1 290 g/injection 0.9 0.8 < 5 hours 0.7 1.9 kkd ‘dimer’ 0.6 UV @ 320 nm 400L/kg 0.5 0.4 0.3 0.2 0.1 F F F F1 2 3 4 A B 0 0 2 4 6 8 10 12 14 16 T im e (m in )
  12. 12. O S H NH O O O O methine hydrogen methine hydrogen amide hydrogen hydrogen bond carbonyl oxygen (S) L-828,198 (S) - 1 π- π interaction (S,S) Whelk-O CSP (3R, 4S) - 2 1:1 complex 1:1 complex
  13. 13. ChiMERA Project (Chiral Measurements for Extraterrestrial Robotic Analyses) A U of Arizona-Caltech-JPL-MRL Partnership Team Lead: Pat Beauchamp, Jet Propulsion Laboratory University Lead: Jonathan I. Lunine, Lunar and Planetary Laboratory, The University of Arizona Team Jack Beauchamp, Beckman Institute and Dept. of Chemistry, Caltech Dennis Dougherty, Dept. of Chemistry, Caltech Gene MacDonald, Jet Propulsion Laboratory Mark Smith, Department of Chemistry, U of A Chris Welch, Merck and Co.
  14. 14. Cassini Orbiter releasing Huygens probe
  15. 15. Huygens Probe
  16. 16. Huygens GC/MS 17 kg
  17. 17. Titan Organics Explorer follow-up to Cassini-Huygens? Aerover approach Aerobot approach
  18. 18. Conclusion Atoms are cool. Molecules are fun. There are many new things waiting to be discovered in…. CHEMISTRY, the central science.

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