Nature Reviews Drug Discovery | AOP, published online 18 August 2006; doi:10.1038/nrd2131




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PE R S PEC T I V E S

  Exploratory                 Discovery              Preclinical        Clinical development        ...
PE R S PEC T I V E S

 Box 1 | The Medicines for Malaria Venture
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PE R S PEC T I V E S

 Table 1 | Public–private partnerships engaged in drug and vaccine development                      ...
PE R S PEC T I V E S

    Knowledge-based work requires lots            Table 2 | Public–private partnerships and their pa...
PE R S PEC T I V E S

 Table 3 | Public–private partnerships lower the critical mass required to discover and develop new ...
PE R S PEC T I V E S

welcome the opportunity to put their skills         enough. As Darren Carroll, former CEO of        ...
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Can Open Source R&D Reinvigorate Drug Research

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This is an article published in Nature that looks at the relevance of the open-source model to pharmaceutical research, and recommends a combination of open-sourcing and outsourcing as a complement to the existing model

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Can Open Source R&D Reinvigorate Drug Research

  1. 1. Nature Reviews Drug Discovery | AOP, published online 18 August 2006; doi:10.1038/nrd2131 PERSPECTIVES Subversion help over a million people OUTLOOK collaborate on more than 100,000 projects. Can open-source R&D reinvigorate But other areas, such as life sciences, have spawned open-source initiatives of their own. The impetus to create open-source soft- drug research? ware often comes from developers looking for challenge. They agree on an attractive project, Bernard Munos form a team and produce a ‘bare-bones’ pro- gram with basic functionality. Then, they offer Abstract | The low number of novel therapeutics approved by the US FDA in recent it at no cost on the Internet under a public- years continues to cause great concern about productivity and declining innovation. domain license (there are many different Can open-source drug research and development, using principles pioneered by types of open-source license; some, notably the ‘copyleft’ or General Public License (GPL), the highly successful open-source software movement, help revive the industry? require those who download a program to share any improvements they make). If the Open-source research, which started as a involved? What are the better targets? Once project draws interest, others add features and counterculture movement in the software these questions are answered, laboratory and post their code on the project’s webpage for industry 15 years ago, has since grown into a clinical studies can be outsourced to institu- fellow programmers to critique. New code of business model whose best-known product, tions with the requisite capacity through the sufficient quality is added to the authorized Linux, has become a credible alternative to help of matchmaking software. version of the program. Microsoft’s Windows. Now, with biology The resulting model is a hybrid in which Open-source’s chief benefit is to cross- increasingly becoming an information- a part of R&D is open-sourced while the fertilize minds and tap creativity quickly, orientated science, some have suggested rest is outsourced. To function, however, cheaply and on a scale that is beyond the reach that what worked for software might be part it needs strong project leadership and of scientists working in the ‘ivory towers’ of of the answer to the spiralling cost of drug expertise in the minutia of drug R&D, academia or behind the ‘corporate moats’ R&D. With this in mind, this article exam- which mostly exist in big pharmaceutical of industry. Hollingsworth1,2 has shown that ines the relevance to pharmaceutical R&D firms. This suggests that, far from being innovation spikes when diverse minds interact of the open-source model developed by the a threat to conventional drug R&D, frequently in an unstructured manner. By software industry. In this context, open- open-source could be a way to leverage drawing talent from all around the world, source no longer refers to source code, but big pharma’s capabilities in order to tackle open-source research takes these dynamics instead to the open origin of contributors. challenges that the blockbuster model can- to a new scale. And by making innovation Open-source R&D has already made not address economically, such as neglected immediately available to all, it speeds up the inroads into bioinformatics and research diseases. As pharmacogenomics takes hold, accumulation and application of knowledge. tools for drug hunters. However, key it might also be a way to address market Outsiders are often puzzled by the open- differences between software and biology, niches that cannot support blockbusters. source idea. Why would anyone work for such as regulatory requirements, have free? Simply put, because some people value limited its application to drug development. A brief primer on open-source non-cash compensation more than money. Nevertheless, in the past 5 years a new Open-source R&D is a novel approach to They volunteer their expertise to satisfy ideal- breed of organizations called public–private research that lets scientists join hands freely ism or curiosity, seek new challenges, hone partnerships (PPPs) have adapted the across organizations, disciplines and borders skills, build a reputation or enhance careers. open-source concept and combined it with to solve problems in which they share an Feldman3 quotes the example of Australian outsourcing to create a new, low-cost interest. The movement’s icon is Linux, the programmers who, within hours of Netscape’s business model, which they have applied operating system started in the early 1990s by release of its browser code, attached an with encouraging results to the discovery student Linus Torvalds, who used the nascent ‘add-on’ to enable secure internet transactions. of new treatments for neglected diseases. Internet to circulate it to fellow computer No money changed hands, but the authors Advances in data mining, visualization enthusiasts. Soon they were busy adding fea- received respect from the programming com- and networking now make it feasible to go tures and improving the code, with Torvalds munity and the satisfaction of turning out an one step further. It is possible to offer scien- overseeing the process. Fifteen years later, elegant and useful piece of software. tists a computerized toolbox that lets them this grassroots experiment has blossomed Companies are learning to use open- harness the creativity of numerous volunteers into a new culture that is spreading to other source to their advantage, and many now to address the key questions that are holding disciplines. It is most prominent in computer allow their employees to participate on com- back innovation. For example, what is the software development, for which dedicated pany time. They might use it to gain market aetiology of a disease? What are the pathways websites such as such as SourceForge or share against entrenched competitors, or NATURE REVIEWS | DRUG DISCOVERY A DVA NCE ON L I N E PU BL ICAT ION | 1
  2. 2. PE R S PEC T I V E S Exploratory Discovery Preclinical Clinical development the achievements of others, and errors can be patched without requiring the rewrite of Lead Lead identification optimization Transition Phase I Phase II Phase III the whole program. With drugs, one care- less worker can compromise years of work costing tens of million of dollars. OZ + PQP Chlorproguanil- Isoquine Finally, the two industries follow different PSAC Dihydrofolate Novel RBx11160/ dapsone (improved antagonist reductase macrolides aminoquinoline) OZ277 (Lapdap) intellectual property regimes. Software is + piperaquine -artesunate (CDA) protected by copyrights that arise automati- Pf enoyl-ACP New 4(1H)- cally as code is written, even if nothing is AQ-13 new Paediatric reductase dicationic pyridones (Fab i) molecules Backups aminoquinoline coartem filed. Drug research is protected by patents that are costly to file and maintain, and Pf protein for which meeting the legal standards that Falcipain Cyclofarnesyl farnesyl- Pyronaridine– (cysteine define innovation is much harder. sequiterpenes transferase artesunate protease) (Pf-PFT) Next Entantio- Open-source biomedical research generation selective 8-amino- EuArtekin (dihydroartemisinin–piperaquine) Early efforts. Despite these differences, the antimalarials quinolines open-source idea has entered biomedical Novel research6. The first inroads were made in bio- imidazolidine informatics7,8 , as might have been expected. -diones These efforts resulted in a collection of pro- grams such as Biojava, BioPerl, BioPython, MMV active support ended MMV/GSK portfolio New projects to be added Bio-SPICE, BioRuby and Simple Molecular Figure 1 | Portfolio of the Medicines for Malaria Venture. PSAC, plasmodial surface anion Mechanics for Proteins9, and inspired other channel. initiatives such as the Human Genome Project, the SNP Consortium, the Alliance to entice developers to create applications has been accumulated. That knowledge for Cellular Signaling, BioForge, GMOD for their product, possibly in the hope of acquisition can take years or decades, with no and Massachusetts Institute of Technology’s turning it into a ‘platform’. Some of them way to know at the outset whether the store BioBricks (some of these have the transpar- have been quite successful at turning open- of knowledge at hand is nearly sufficient or ency and feel of open-source, although the source into profits. Red Hat, for instance, will require years of painstaking additional resources needed to get involved do not allow has attained a US$5-billion market cap from research before innovation can thrive. all volunteers to participate; however, we still selling support services for Linux. Software development is also simpler: call them ‘open-source’). it spans only a few disciplines and has no Can it work for drugs? equivalent to clinical trials. For the most An old idea. One could argue that there has If biomedical scientists could adapt the part, a single programmer can master all the long been an active, if invisible, collabora- open-source model, it could make a huge skills needed to write a program from start tive process akin to open-source in drug difference to such projects as developing to finish. By contrast, drug development development, as, for some diseases, half drugs for neglected diseases, for which requires coordination of multiple specialties of all prescriptions are for off-label uses10 . needs are great but funds are scarce4 . Only with little overlap. Biomedical knowledge, Somehow, physicians share their ideas and 10% of R&D resources are spent on illnesses which grows at the rate of 1,000 publications experiences informally to uncover novel that represent 90% of the burden of disease. per day, must be peer-reviewed and repli- uses for existing medicines. For instance, Open-source drug R&D might not change cated before it is accepted. All this is slow oncologists routinely use drugs approved for that equation, but could make it possible and enormously expensive. one kind of cancer to treat other types. In a to get much more from that 10%. Drug R&D can go off-track more easily recent study, DeMonaco11 found that 59% of There are, however, significant barriers to than software programming. Biologists drug therapy innovations were discovered the deployment of open-source approaches can get mired in the complexity of biology by practicing clinicians via field discovery. to drug R&D5. One is economic. All it takes without ever making much progress towards The way by which physicians uncover these to write open-source software is a laptop and a drug — chemists handed the wrong target new indications is quick and inexpensive an internet connection. With drug research, cannot do much good no matter how hard compared with Phase III trials. From an eco- someone must pay for laboratory expenses they try; inadequate toxicology can derail nomic and medical standpoint, there would and clinical trials. And the costs are high, at a compound late in development, or even be merit in exploiting these clinical observa- more than US$800 million for the discovery after launch. One misstep along the way can tions and sharing them with physicians as a and development of a novel drug by most render all downstream work useless. complement to, or replacement for, some of estimates. In contrast to drug developers, software the traditional clinical development. Research dynamics between the two indus- publishers are lightly regulated. They do tries also differ. Software development does not need FDA approval. The quality stand- Public–private partnerships. Taking a different not have a discovery phase. Once the objective ards they face are far less onerous than the approach, a new kind of organization, known is set, programmers set to work and make minutia of Good Laboratory Practice as the public–private partnership (PPP), has steady progress towards their goal. By contrast, (GLP), Good Clinical Practice (GCP) and recently developed a clever virtual business drug discovery cannot flourish until a certain Good Manufacturing Practice (GMP). model that emulates the collaborative features amount of knowledge about the target disease One sloppy programmer seldom jeopardizes of the open-source concept12 . An example is 2 | A DVA NCE ON L I N E PU BL ICAT ION www.nature.com/reviews/drugdisc
  3. 3. PE R S PEC T I V E S Box 1 | The Medicines for Malaria Venture markets (for example, to treat travellers). Its alliance with GlaxoSmithKline supports 25 scientists funded equally by the partners. CEO The Initiative on Public–Private Partnerships for Health reckons that there Chief Finance Officer and are about 24 PPPs engaged in drug and Administrative Assistant Donor Relations vaccine R&D (TABLE 1). Most of them were created in the past 7 years and share a com- Communication Human Resources Officer mon profile13. First, they focus on neglected and Advocacy Officer diseases. Second, they operate as virtual drug companies, with a small staff getting project Chief Scientific Officer Director, International Ops ideas from outside, vetting them through a committee of experts and outsourcing R&D to a network of institutions. Third, they man- Director, Drug Discovery Director, Clinical age growing portfolios of projects ranging and Technology Development from discovery through to Phase III trials. Fourth, they have been able to function on Contracts Officer Director, Clinical lean budgets with a cumulative spending Development that seldom exceeds US$50 million. This makes them attractive vehicles to fund Associate Director, research in areas that are not economical for Administrative Assistant Clinical Development traditional drug R&D. Management team By the end of 2005, PPPs had attracted The Medicines for Malaria Venture (MMV) is run by a staff of 13. Its CEO reports to a Board of 12 funding in excess of US$1.5 billion. Directors who represent funding organizations. An Expert Scientific Advisory Committee, which Foundations have given about US$1.15 billion includes chemists, biologists, clinicians, malariologists and drug development experts, advises on (with the Gates Foundation alone contributing project selection and research strategy. The Management Team’s responsibilities are to: more than US$950 million), governments • Encourage the submission of research proposals US$244 million and private entities US$36 • Select proposals and negotiate with partners million. In addition, donors have committed • Set up project-management teams and monitor progress another US$3.5 billion which will be • Organize manufacturing and marketing • Earn appropriate returns from marketed products disbursed as needed by The Global Fund to • Raise funds Fight AIDS, Tuberculosis and Malaria. • Communicate with government agencies Backers Open-source versus alliance networks. It can • Gates Foundation be argued that the 25,000 alliances wrought • BHP Billiton by the 8,000 pharma and biotech companies • ExxonMobil over the past 15 years add up to a vast open- • Global Forum for Health Research innovation system that mimics the collabo- • International Federation of Pharmaceutical Manufacturers Associations rative features of the open-source model. • Netherlands Minister for Development Cooperation Some scholars have countered, however, that • Rockefeller Foundation alliances are less effective than open-source • Swiss Agency for Development and Cooperation research at promoting innovation. This is • United Kingdom Department for International Development because open-source networks are richer in • United States Agency for International Development • World Bank ‘weak links’ (loose relationships), whereas • Wellcome Trust alliances pride themselves on the strength • World Health Organization of the connections between partners. DeBresson14 has shown that weak links bring novel ideas into the fray whereas strong links the Medicines for Malaria Venture (MMV), R&D to a network of 300 scientists at 40 insti- tend to reinforce orthodoxies. which was established in 1999 to discover and tutions (universities, big pharma, biotechs develop new, affordable antimalarial drugs. and research institutes). Funding comes from PPPs and big pharmas. TABLE 2 lists some of Established as a nonprofit entity with a staff public and philanthropic partners (BOX 1). the projects and organizations coordinated of only 13 people, it has assembled a portfolio After each step, the Scientific Advisory by PPPs. As can be seen, GlaxoSmithKline of 19 projects ranging from discovery to Committee reviews the data and decides features prominently, with Bristol-Myers Phase III (FIG. 1). whether to proceed or terminate the project. Squibb, Novartis, Bayer, Sanofi-Aventis and MMV gets its projects through open MMV’s cumulative spend from 2000 through Ranbaxy involved to a lesser extent. calls — anyone with an idea can contribute. 2005 is about US$100 million, 90% of which An Expert Scientific Advisory Committee funded actual research. MMV plans to out- Lessons learned reviews the submissions and selects the source manufacturing to low-cost partners, PPPs have advantages and drawbacks projects that will be funded. Each is managed sell drugs at cost to developing countries, and compared with traditional R&D15. Advantages by a project manager who outsources the market them through partners in developed include the following. NATURE REVIEWS | DRUG DISCOVERY A DVA NCE ON L I N E PU BL ICAT ION | 3
  4. 4. PE R S PEC T I V E S Table 1 | Public–private partnerships engaged in drug and vaccine development Speed. Lean PPPs can decide quickly, partly because they do not have layers of committees Name Focus Year created to satisfy. In addition, because they tap their Aeras Global TB Vaccine Foundation Tuberculosis 1997 partner’s unused capacity, they can advance BIO Ventures for Global Health Biotech drugs for neglected 2004 swiftly as there is often a qualified laboratory diseases somewhere that can do the work without Consortium for Industrial Collaboration in Development of new 1995 having to wait in someone else’s queue. Contraceptive Research contraceptives Contraceptive Research and Development Improving reproductive health in 1986 There are also some disadvantages to PPPs, developing countries which include the following. Dengue Vaccine Project Dengue fever 1989 Funding. US$5 billion has been committed Drugs for Neglected Diseases Initiative Sleeping sickness, visceral 2003 leishmaniasis, Chagas disease to PPPs ($1.5 billion disbursed). However, despite the thriftiness of PPPs, there is European Malaria Vaccine Initiative Malaria 1998 concern that these funds will be stretched Gates Foundation–UNC Partnership for African trypanosomiasis, 2000 as more projects move into late, expensive Development of New Drugs leishmaniasis clinical development. Global Alliance for TB Tuberculosis 2000 Global Microbicide Project New microcides for women 2000 Sustainability. PPPs have not demon- strated the sustainability of their business Human Hookworm Vaccine Initiative Hookworm 2000 model. Some of their projects come from Infectious Disease Research Institute Tuberculosis, leishmaniasis, 1993 companies that had shelved them because Chagas disease, malaria, leprosy of insufficient commercial prospects. To and Buruli ulcer survive, PPPs will need to replenish their Institute for One World Health Visceral leishmaniasis, cutaneous 2000 portfolios. There are also worries that, in leishmaniasis, Chagas disease, paediatric secretory diarrhoea some areas of science, the pool of contribu- tors might be too thin to perform the work International AIDS Vaccine Initiative AIDS 1996 that must be done. International Partnership for Microbicides HIV 2002 Japanese Pharmaceutical, Ministry of Malaria 1999 TABLE 3 shows that the PPP R&D model Health, WHO Malaria Drug Partnership has worked reasonably well. Some of this Lapdap Antimalarial Product Development Malaria 1998 success comes from targeting low-hanging fruits in diseases that have long been Lassa Fever Initiative Lassa fever 2001 neglected, but it also suggests that the PPP Malaria Vaccine Initiative Malaria 1999 model can be a potent tool in finding new Medicines for Malaria Venture Malaria 1999 cures. Whether the PPP business model Meningitis Meningitis 2001 becomes a transformational force or remains a non-threatening niche depends Microbicides Development Programme HIV 2001 on how it ultimately performs against Pediatric Dengue Vaccine Initiative Dengue 2001 traditional pharmaceutical R&D. To PneumoADIP Pneumococcal vaccines 2004 succeed, it must go beyond tools and soft- UNC, University of North Carolina; WHO, World Health Organization. ware and tackle large projects where it will rival the big firms that are helping it today. Yet, this rivalry need not be a zero-sum Agility. Virtual R&D makes it easier to Risk sharing. The open-innovation game. On the contrary, there is a place for terminate projects that no longer look model of PPPs makes it easier for scientists collaborative and proprietary research in promising. The project manager does not to collaborate on pre-commercial research drug R&D, just as in software16 . If open- have to deal with entrenched advocates such as biomarkers or cell signalling. source drug R&D takes hold, what will manoeuvering to save their project or move probably emerge is not the replacement of it underground. Affordability. PPPs lower the critical mass one model by another, but an ecology in required to be a pharmaceutical company. By which big pharma, biotech and collabora- Creativity. PPPs enable experts from dif- leveraging external expertise and capabilities, tive research compete and collaborate at ferent countries, specialties and styles of they allow small organizations to do much of the same time, feeding off each other thought to leverage each other’s ideas. They what was once the domain of large companies. synergistically, while moving towards harness the problem-solving skills of a much therapies along their own distinctive paths. greater population than is typically available Impact. PPPs engage scientists in developing to traditional research organizations. nations who have first-hand experience in A template for open-source drug R&D many neglected diseases. It helps them build Can the PPP model succeed beyond Focus. PPPs focus on one or few diseases. their clinical research capacity, which in turn neglected diseases? To answer this, it helps to This helps them build deep expertise for better leverages the effectiveness of their public break down drug R&D into knowledge-based decisions (for example, target selection). health systems. activities and rule-based tasks. 4 | A DVA NCE ON L I N E PU BL ICAT ION www.nature.com/reviews/drugdisc
  5. 5. PE R S PEC T I V E S Knowledge-based work requires lots Table 2 | Public–private partnerships and their partners of intelligence and intuition, but little infrastructure. Examples include identifying Project Industry partner University/public Other PPP health partner targets, understanding metabolic networks, and designing clinical trials or computer- Medicines for Malaria Venture ized disease models. It is about scientists Improved 4-aminoquinoline GlaxoSmithKline University of Liverpool leveraging each other’s ideas, and using Farnesyl transferase inhibitors Bristol-Myers Squibb University of Washington tools to gain deeper insights that might lead Manzamine derivatives University of Mississipi to breakthroughs. This work is ideally suited to the open-source model. Cysteine protease inhibitors GlaxoSmithKline UCSF Rule-based work requires physical assets Fatty acid biosynthesis Texas A&M, A. Einstein, (laboratories, equipment, patients and so on) inhibition Jacobus and money. It is tightly scripted and must Pyridone GlaxoSmithKline conform to rigid regulatory requirements. New di-cationic molecules Immtech University of North It is about organization, discipline and Carolina implementation. Examples include toxicol- Dihydrofolate reductase Biotec Thailand ogy studies, Chemistry Manufacturing and inhibition Controls (CMC) studies, and the conduct of clinical trials. Rule-based work is ideally Artesunate derivatives GlaxoSmithKline, TDR, DNDi Shin Poong suited to outsourcing, and much of it is already outsourced to contract research Artemisone Bayer University of Hong Kong organizations. Synthetic peroxide Ranbaxy University of Nebraska This division of labour suggests a busi- Intravenous artesunate Walter Reed ness model template in which part of the Coartem in infants Novartis TDR R&D value chain is open-sourced, while the rest is outsourced, with the following TB Alliance features. Pyridones and quinolizines Taejon, Yonsei Isoniazid analogue Wellesley College Template features: operating principles PA-824 NIH, Johns Hopkins Open-sourcing. The open-source part of our model should allow anyone who can Mocifloxaxin Bayer CDC, Johns Hopkins contribute to join. Volunteers should be Institute for One World Health able to log on to a website, find the page(s) Paromomycin TDR that matches their area of expertise, peruse challenges to be solved, review others’ con- Azole Yale tributions, download computerized tools TDR and start working towards contributions of Miltefosine Zentaris their own. As they progress, they can pub- Oral eflornithine Aventis lish their findings in scientific journals and CDC, Centers for Disease Control and Prevention; DNDi, Drugs for Neglected Diseases Initiative; NIH, discuss their insights in on-line forums. National Institutes of Health; TDR, UNICEF–UNDP–World Bank–WHO Special Programme for Research Over time, the better ones will gain authority and Training in Tropical Diseases. and become the de facto leaders of their open-source community. is a group of senior executives that rules Projects origination. There is a permanent Outsourcing. Work to be outsourced on important operational issues such open call for new projects. Scientists are should be posted on a website for all to see. as fundraising, budgets, project funding, invited to submit ideas online for review by Scientists and organizations qualified for the key hires and selection of partners. the SAC. job can bid, and the sponsor picks the best It also approves recommendations from candidate for each task. the Scientific Advisory Committee. The Portfolio management. The SAC is Scientific Advisory Committee (SAC) is a responsible for maintaining an adequate and Template features: procedures group of external experts from academia balanced pipeline of projects. Governance. Three decision-making bodies and industry. It sets R&D strategy, proposes provide leadership and guidance: the Board new projects, reviews existing ones and Project management. Each project is man- of Directors, the Steering Committee recommends termination of those that no aged by a Project Team led by a member and the Scientific Advisory Committee. longer deserve support. of the organization, and staffed by external The Board of Directors includes senior experts in drug discovery, clinical research executives and outsiders who represent Scope. This template calls for focusing and regulation. The Project Team is respon- shareholders and stakeholders. It approves on single diseases or related illnesses. sible for developing the budget and timeline, strategy and ensures that management An organization working on unrelated overseeing outsourced tasks and ensuring performance is consistent with the organi- diseases should establish separate websites compliance with GxP. One of its crucial zation’s mission. The Steering Committee for each one. duties is selecting what will be open-sourced NATURE REVIEWS | DRUG DISCOVERY A DVA NCE ON L I N E PU BL ICAT ION | 5
  6. 6. PE R S PEC T I V E S Table 3 | Public–private partnerships lower the critical mass required to discover and develop new cures Organization Focus Staff Pipeline Number of Discovery PK Clinical Cumulative projects spending through 2005 (US$ million) Medicines for Malaria 13 19 12 1 6 103 Malaria Venture TB Alliance Tuberculosis 18 12 8 1 3 20 Drugs for Neglected Trypanosomiasis, visceral 36 20 9 4 7 20 Disease Initiative leishmaniasis, Chagas disease OneWorld Health Leishmaniasis, malaria, Chagas 40 5 1 3 1 ? disease, diarrhoeal diseases International AIDS HIV/AIDS 169 6 – 1 5 120 Vaccine Initiative Malaria Vaccines Malaria 32 10 4 2 4 ? Initiative Source: Annual reports. PK, pharmacokinetics. and what will be outsourced. The project can lead to a patentable invention will need to post tasks, and experts to register their leader is accountable for generating the data to exercise caution with disclosures until the skills, and Innocentive, an online problem- used to decide whether to fund the next step. invention has been reduced to practice and solving tool that lets a company post a Commitment to a project is limited to the patent applications have been filed, just as challenge with a reward: whoever finds the current step, until the data warrants commit- would be necessary in a traditional research solution gets the money. ting funds for the next one. Open-sourced setting. It is generally accepted that open tasks are posted on the project’s website, communication promotes advancement Template features: costs each on its own page, and outsourced ones of science, but needs to be balanced by the PPPs have been able to function on very low are posted on a companion matchmaking need to protect the rights of inventors. budgets for several reasons (TABLE 4). First, website such as Innocentive, or Scienteur. The same applies to open-source activities. they have few people, low overhead costs Outsourcing bids are reviewed by the Project and no fixed assets. They rely on someone Team, which issues recommendations Template features: tools else’s unused capacity, and the market seems to the SAC. The discovery toolbox. As of February 2006, to price such capacity at marginal instead 349 genomes have been published and of full cost. Second, they outsource much of Intellectual property ownership. There is another 1,575 are being sequenced. A new their work where it is cheaper to do so and often a misperception that open-source generation of smart, computerized tools do most of their trials in developing coun- initiatives are hostile to patents and bent is becoming available to mine data, comb tries. Third, they concentrate on infectious on putting discoveries in the public domain. the literature, map metabolic networks, diseases for which costs are lower. Fourth, The reality is more nuanced. Most open- perform in silico modelling, visualize bind- they receive in-kind donations. source activities occur at a pre-commercial ing sites, identify chemical leads, design R&D stage, when the ideas and hypotheses molecules and predict toxicity. These tools Will it work? debated fall short of the legal standards that should be packaged into a convenient Despite the promise of open-source drug define inventions in patent law. They are an toolbox, together with access to major R&D, both its pioneers, and the veterans on-going scientific conversation that can be databases, and offered to volunteers willing of open-source software, point to several likened to a global instant-messaging system to contribute their expertise. potentially troublesome issues that could linking scientists interested in a topic. In that affect the success of the open-source model. sense, open-source is no more threatening Outsourcing software. Several programs to patents than other forms of scientific already exist to match projects with talent Availability of talent. Typical open-source publishing. A scientist who engages in that and capacity. Two examples are Scienteur, projects do not require a large number of conversation and comes up with an idea that a free e-marketplace that allows companies contributors. Data from the software indus- try suggests that the ideal number ranges from 6 to 20 people. Yet much of the drug Table 4 | R&D costs for public–private partnerships (US$ million) R&D expertise resides in an industry that Stage MMV TB Alliance DNDi IAVI Big Pharma has a strong proprietary culture. Employees Discovery and PK 8.3 18.6 16.2 20.0 26.0 are routinely asked to assign their intellectual Phase I 1.6 0.6 Unpublished 2.0 15.2 output, including that created on their own time, to their employers17. This could stifle Phase II 1.2 3.4 Unpublished 5.0 23.5 talent supply in key areas. Two developments, Phase III 9.5 22.6 Unpublished 30.0 86.3 however, might give open-source drug R&D Total clinical 12.2 26.6 24.2 37.0 125.0 the permanent talent pool it needs. First, Source: REF. 19. DNDi, Drugs for Neglected Diseases Initiative; IAVI, International AIDS Vaccine Initiative; thousands of highly trained pharmaceutical MMV, Medicines for Malaria Venture. scientists are nearing retirement and might 6 | A DVA NCE ON L I N E PU BL ICAT ION www.nature.com/reviews/drugdisc
  7. 7. PE R S PEC T I V E S welcome the opportunity to put their skills enough. As Darren Carroll, former CEO of 3. Feldman, R. The open-source biotechnology movement: is it patent misuse? Minn. J. L. Sci. Tech. 6,1 (2004). to good use. Second, drug companies might Innocentive, puts it, “If you build it, they will 4. Cukier, K. N. Community property: Open-source be persuaded to ease restrictions on their not come!”. It takes a sustained effort to get the proponents plant the seeds of a new patent landscape. Acumen 1, 54–60 (2003). employee’s involvement. There is indeed little word out and build trust with stakeholders. 5. Rai, A. Open and collaborative research: a new model conflict of interest in being a cancer scientist It also takes a leader who can connect with for biomedicine. Duke Law School, Legal Studies Research Paper Series, Research Paper 61 (2004). by day and an anthrax researcher at night, people, understand their motivation and foster 6. Maurer, S. New institutions for doing science: from and firms might gain valuable goodwill from trust. Linux attracts thousands of contributors databases to open biology. Presented at University of Maastricht, November 24–25 (2003). letting employees seek cures for diseases in because they identify with Torvalds’ ideals and 7. DeLano, W. L., The case for open-source software in drug which they have no interest. trust him to do the right thing. Open-source discovery. Drug Discov. Today10, 213–217 (2005). 8. Geldenhuys, W. J., Gaasch, K. E., Watson, M., drug R&D must build such leaders. Allen, D. D. & Van der Schyf, C. J. Optimizing the use Availability of data and standards. Open- of open-source software applications in drug discovery. Drug Discov. Today 11, 127–132 (2006). source scientists cannot accomplish much Web interface. The design of the project’s 9. Eisenmenger, F., Hansmann, U. H. E., Hayryan, S. & unless they can access data. Biological data website is crucial. 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PLoS Med. 1, e56 (2004). use a reasonably small number of them, but something as complex as drug R&D gets 13. Gardner, C. & Garner, C. Technology Licensing to chemists are further from such consensus. parceled out around the world, quality nontraditional partners: non-profit health product development organizations for better global health. Both the lack of standards and the scarcity of assurance can become an issue. Oversight, Industry Higher Education 19, 241–247 (2005). data in certain areas can cause problematic due-diligence, audits, good practices and 14. DeBresson, C. & Amesse, F. Networks of innovators: a review and introduction to the issue. Res. Policy 20, choke points in an open-source R&D effort. prior experience can be used to ensure quality. 363–379 (1991). International Organization for Standardization 15. Nwaka, S. & Ridley, R. Virtual drug discovery and development for neglected diseases through public– Availability of tools. Open-source scientists standards could also help in the future. private partnerships. Nature Rev. Drug Discov. 2, need open-source tools to practice their 919–928 (2003). 16. Hope, J. Open-Source Biotechnology. Ph.D. Thesis, craft. Until recently, such tools were plentiful Selectivity. Not all projects will be equally Australian National Univ. (2004). in bioinformatics, but less so in chemistry, suitable. Cancer might draw contributors, 17. Stahl, M. T. Open-source software: not quite endsville. Drug Discov. Today 10, 219–222 (2005). which has long been dominated by com- but hair loss might not. 18. Collins, F. S. The NIH Roadmap: new pathways to mercial software. This is changing. The 2004 discovery — empowering small molecule research. Office of Portfolio Analysis and Strategic Initiatives launch of PubChem has brought online a Conclusion: a new ecology of drug R&D? (National Institutes of Health, Bethesda, 2006). powerful suite of tools that allows scientists Is there still room for big pharma in open- 19. Towse, A. & Renowden, O. in Combating Diseases Associated with Poverty: Financing Strategies for to connect chemical information with source R&D? One must stress that ‘virtual’ Product Development and the Potential Role of biomedical research and clinical informa- does not mean ‘leaderless’. To succeed, Public–Private Partnerships (eds Widdus, R. & White, K.) [online], <http://www.globalforumhealth. tion in an unprecedented way. Non-profit open-source R&D will need deep expertise org/filesupld/ippph_cd/06.PDF> (Initiative on scientists can now access small-molecule in the minutia of drug R&D, which today Public–Private Partnerships for Health, London, 2004). high-throughput screening, chemistry and resides overwhelmingly in the pharma- Acknowledgements informatics on a scale previously available ceutical industry. There might be many I thank A. Tashjian (Harvard School of Public Health and only to industry. They can even get grants to volunteers, but they must be shepherded Harvard Medical School), B. Smith (Center for Biosecurity, University of Pittsburgh Medical Center) and M. Munos turn their online discoveries into assays for towards a goal. Such stewardship is a core (Gardner Carton & Douglas) for valuable feedback on high-throughput screening18 . Other tools competency of pharmaceutical companies. previous versions of the manuscript. such as eMolecules, Jmol or the Chemistry Our model is not a substitute for them, but Competing interests statement B.M. works for Eli Lilly & Co., which has sponsored the Development Kit are adding powerful a way to leverage their capabilities to tackle Scienteur and Innocentive ventures mentioned in this article. chemical search and visualization capabilities unmet medical needs, such as the diseases of This declaration of potential competing financial interests is also available in the Web version. to the open-source scientist’s toolbox. poverty, orphan diseases and niche markets. Pharmaceutical companies stand to gain FURTHER INFORMATION Intellectual leadership. Just as putting ingre- from co-opting the open-source model and SourceForge: http://sourceforge.net/ dients into a vat does not necessarily cause allowing it to flourish in ‘coopetition’ with BioForge: www.bioforge.net PubChem: http://pubchem.ncbi.nlm.nih.gov them to react, connecting smart people online traditional R&D, to handle the diseases or eMolecule: www.emolecules.com does not guarantee they will produce anything R&D steps for which it is best suited. Jmol: http://jmol.sourceforge.net CDK: http://almost.cubic.uni-koeln.de/cdk valuable. In both cases, a catalyst is needed. Emboss: http://emboss.sourceforge.net/ For open-source drug R&D, the presence of Bernard Munos is at Eli Lilly & Co., Lilly Corporate Medicines for Malaria Venture: www.mmv.org Center, 1085, Indianapolis, Indiana 46285, USA. The Initiative on Public-Private Partnerships for Health: a subgroup of highly innovative contributors e-mail: bhmunos@stanfordalumni.org www.ippph.org who can tune in the on-going conversation Global Fund to Fight AIDS, Tuberculosis and Malaria: doi:10.1038/nrd2131 www.theglobalfund.org and fuel it with their own creative insights acts Published online 18 August 2006 Aeras, Global TB Vaccine Foundation: www.aeras.org as such a catalyst. Without it, the conversation Drugs for Neglected Diseases Initiative: www.dndi.org 1. Hollingsworth, J. R. & Hollingsworth, E. J. in Practicing Global Alliance for TB: www.tballiance.org could remain shallow and fizzle out. Interdisciplinarity (eds Weingart, P. & Stehr, N.) Institute for One World Health: www.oneworldhealth.org 215–244 (Univ. Toronto Press, Toronto, 2000). International AIDS Vaccine Initiative: www.iavi.org 2. Hollingsworth, J. R. in Creating a Tradition of Malaria Vaccine Initiative: www.malariavaccine.org Momentum. Enticing people to join is a Biomedical Research (ed. Stapleton, D.) 17–63 Access to this interactive links box is free online. challenge. A good website helps, but it’s not (Rockefeller Univ. Press, New York, 2004). NATURE REVIEWS | DRUG DISCOVERY A DVA NCE ON L I N E PU BL ICAT ION | 7

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