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By: Brian
Hemophilia A:    Also known as classic hemophilia or Factor VIII    Deficiency    People with this type of hemophilia have...
Hemophilia A:    Also known as classic hemophilia    People with this type of hemophilia have low    levels of a blood clo...
Hemophilia B:   Also known as Christmas disease   People with this type of hemophilia have low levels of   a blood clottin...
The two different types of hemophilia arecaused by permanent gene changes(mutations). Mutations in the FVIII genecause Hem...
Hemophilia A is more common than Hemophilia B.One in 5000-10000 males around the world haveHemophilia A. One in 20,000- 34...
Perpetuated oozing after injuries   repeated bleeding after first bleeding   Easy or spontaneous bruising   Perpetuated bl...
Hemophilia A&B are diagnosed by measuring factor clottingactivity. Individuals who have Hemophilia A have low factor VIIIc...
Is Hemophilia inherited?Hemophilia A and hemophilia B are inherited in an X-linked recessivepattern. The genes associated ...
Is there a cure for Hemophilia?Right now, there is no cure for Hemophilia but, there are sometreatments being used dependi...
• Pediatric Von Willibrands Disease
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Hemophilia

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a powerpoint on hemophilia i needed to make.
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Transcript of "Hemophilia"

  1. 1. By: Brian
  2. 2. Hemophilia A: Also known as classic hemophilia or Factor VIII Deficiency People with this type of hemophilia have low levels of a blood clotting factor called figure 8 (FVIII)Hemophilia B: Also known as Christmas disease or Factor IX Deficiency People with this type of hemophilia have low levels of a blood clotting factor called figure 9 (FIX) -The two different types of hemophilia are caused by permanent gene changes (mutations). Mutations in the FVIII gene cause Hemophilia A. Mutations in the FIX gene cause Hemophilia B.
  3. 3. Hemophilia A: Also known as classic hemophilia People with this type of hemophilia have low levels of a blood clotting factor called figure 8 (FVIII)-Severe Hemophilia A: Spontaneous joint ordeep muscle bleeding. Usually diagnosed withinfirst two years of life.-Moderate Hemophilia A: spontaneous bleeding,delayed oozing after minor injury, and usuallydiagnosed before they are 5 to 6 years old.- Mild Hemophilia A: Do NOT have spontaneousbleeding but unusual bleeding occurs withsurgery and tooth extractions. People are usuallydiagnosed with this in later life.
  4. 4. Hemophilia B: Also known as Christmas disease People with this type of hemophilia have low levels of a blood clotting factor called figure 9 (FIX)-Severe Hemophilia B: Spontaneous joint or deep musclebleeding is the most frequent symptom. People areusually diagnosed in the first 2 years of life.-Moderate Hemophilia B: spontaneous bleeding, delayedoozing after minor injury, and usually diagnosed beforethey are 5 to 6 years old- Mild Hemophilia B: Do NOT have spontaneous bleedingbut unusual bleeding occurs with surgery and toothextractions. People are usually diagnosed with this inlater life.
  5. 5. The two different types of hemophilia arecaused by permanent gene changes(mutations). Mutations in the FVIII genecause Hemophilia A. Mutations in the FIXgene cause Hemophilia B.
  6. 6. Hemophilia A is more common than Hemophilia B.One in 5000-10000 males around the world haveHemophilia A. One in 20,000- 34,500 males aroundthe world have Hemophilia B.
  7. 7. Perpetuated oozing after injuries repeated bleeding after first bleeding Easy or spontaneous bruising Perpetuated bleeding- The most frequent symptom for Hemophilia’s typesA&B is spontaneous joint bleeding.
  8. 8. Hemophilia A&B are diagnosed by measuring factor clottingactivity. Individuals who have Hemophilia A have low factor VIIIclotting activity. Individuals who have hemophilia B have lowfactor IX clotting activity. Genetic testing is also available for thefactor VIII gene and the factor IX gene. Genetic testing of the FVIIIgene finds a disease-causing mutation in up to 98 percent ofindividuals who have hemophilia A. Genetic testing of the FIXgene finds disease-causing mutations in more than 99 percent ofindividuals who have hemophilia B. Genetic testing is usuallyused to identify women who are carriers of a type FVIII or FIXgene mutation, and to diagnose hemophilia in a fetus during apregnancy. It is sometimes used to diagnose individuals who havemild symptoms of hemophilia A or B.
  9. 9. Is Hemophilia inherited?Hemophilia A and hemophilia B are inherited in an X-linked recessivepattern. The genes associated with these conditions are located on the Xchromosome, which is one of the two sex chromosomes. In males (whohave only one X chromosome), one changed copy of the gene in each cellis sufficient to cause the condition. In females (who have two Xchromosomes), a mutation would have to occur in both copies of the geneto cause the disorder. Because it is unlikely that females will have twochanged copies of this gene, it is very rare for females to have hemophilia.A characteristic of X-linked inheritance is that fathers cannot pass X-linkedtraits to their sons. In X-linked recessive inheritance, a female withone changed copy of the gene in each cell is called a carrier. Carrierfemales have about half the usual amount of clotting factor VIII or clottingfactor IX, which is generally enough for normal blood clotting. However,about 10 percent of carrier females have less than half the normal amountof one of these clotting factors; these individuals are at risk for unusualbleeding, particularly after an injury, surgery, or tooth extraction.
  10. 10. Is there a cure for Hemophilia?Right now, there is no cure for Hemophilia but, there are sometreatments being used depending on the` severity of hemophilia
  11. 11. • Pediatric Von Willibrands Disease
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