co-processed excipients ppt


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co-processed excipients ppt

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  2. 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar EXCIPIENTS M. Pharm. (Sem. I) (H.O.D. Pharmaceutics) 2
  3. 3. Contents………… Definition of excipients Need of excipients Ideal characteristics of excipients Roles of excipients Classification of excipients Excipients used in solid dosage forms Excipients used in liquid dosage formsExcipients used in semi-solid dosage forms Co-processed excipients Co-processing methodology Conclusion References 3
  4. 4. What are Excipients? 4
  5. 5. Need of ExcipientsDirect clinical use of the active drug substances is rare due to the number of reasons: API handling is difficult or impossible. Accurate drug dosing is difficult or impossible. API may cause local irritations or injury. 5
  6. 6. Cont...... API can have unpleasant organoleptic properties. API can be degraded at the site of administration. 6
  7. 7. Ideal characteristics of excipients It should be non toxic. It should be physically and chemically stable. It should be commercially available. It should have pleasant organoleptic properties. Economic. 7
  8. 8. Roles of excipients in different dosage forms Impart consistency and volume Improve stability Increase solubility Enhance bioavailability Increase patient compliance and acceptability Impart weight 8
  9. 9. Classification of excipients  Primary excipients : Diluents Binders Disintegrants Lubricants Antiadhesives Glidents  Secondary excipients : Flavoring agents Sweetening agents 9
  10. 10. Commonly used excipients in solid dosageforms Diluents Binders Disintegrants Lubricants Antiadhesives Glidents 10
  11. 11. Commonly used excipients in liquid dosage forms SUSPENSION EMULSION Vehicle Vehicle Flocculating agents Antimicrobial agentsAntimicrobial agents AntioxidantsSweetening agents Flavoring agentsSuspending agents Preservatives 11
  12. 12. Commonly used excipients in semi-solid dosage formsBasesPreservativesAntioxidantsChelating agents 12
  13. 13. Co-Processed Excipients 13
  14. 14. Manufacturing problems in solid Product weight variation. Content non uniformity during mixing. Loss of excipients. dosage forms Poor disintegration time of product. 14
  15. 15. Particle Properties Achieving Excipient Functionality Particle property Achieving Excipient functionalityParticle size Flow ability, compressibility, disintegration, dissolution rate.Particle size distribution Segregation potential.Particle shape Flow ability, content uniformity, compressibility.Particle porosity Compressibility, solubility. 15
  16. 16. Co-processing methodologyExcipient selection on the basis of material characteristics Selection of proportion of excipients Homogenous dispersion or solution Co-drying Co-processed excipient 16
  17. 17. Manufacturing of co-processed excipietse.g. Dicalcium phosphate (diluent) and magnesium stearate (lubricant) Steps: 1. Solubalisation 2. Solvent evaporation 3. Drying 4. Sifting 17
  18. 18. Properties of co-processed excipients Absence of chemical change Improved flow properties Improved compressibility Reduced lubricant sensitivity 18
  19. 19. Advantages Provide a single excipient with multiple functionalities. Better mouth feel and improved palatibility. Removal of undesirable properties. Improvement of organoleptic properties. 19
  20. 20. Evaluation parameters for co-processed excipients  Particle size distribution- The particle size distribution can be calculated by statistical method. 20
  21. 21. Cont......  Carr’s index- Carr’s index can be calculated by-Carr’s index= Tapped Density-Bulk Density 100 Tapped Density ˟ 21
  22. 22. Cont......  Hausner Ratio-Hausner ratio can be calculated by-Hausner Ratio= Tapped Density Bulk Density 22
  23. 23. REFERENCESAulton’s Pharmaceutics, the design and manufacture of medicines, third edition by Michael E. Aulton. Page no: 298-301.B. M. Mithal, A textbook of Pharmaceutical formulation, vallabh prakashan. Page no. 57-120.Remington- The science & practice of Pharmacy. Page no. 896-910.Ansel’s Pharmaceutical dosage form. Page no.198- 199, 240-242. excipients 24
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