MOVEMENT
MAJOR FUNCTIONS1. SUPPORT   framework for body2. MOVEMENT   ~point of attachment for skeletal     muscles   ~joints
3. PROTECTION    ~ soft tissues        (brain, spinal cord, heart, etc.)
4. STORAGE    ~ minerals:       (Ca, P, Na, K )       for use when needed…
5. FORMATION OF BLOOD CELLS    ~Hematopoiesis:       red marrow produces blood       cells for circulation
TWO MAJOR TYPES OF            BONE TISSUE• COMPACT BONE –Give bone hard, durable quality –Outer layers of bone –Functions ...
COMPACT BONE
• SPONGY BONE  - Less dense than compact bone  – Contains red marrow:          stem cellsblood cell                      ...
Types of Joints• The type of joints that are particularly important for  physical activity and sport are:   – BALL AND SOC...
– GLIDING JOINT - these occur in the many small bones  of the hand and feet. They allow a slight sliding motion  forwards ...
• TASK:• the picture shows:• 1: Shoulder joint -ball and  socket• 2: Elbow joint - hinge joint• can you name another  ball...
FOUR MAJOR TYPES OF BONES1.   LONG BONES2.   SHORT BONES3.   FLAT BONES4.   IRREGULAR BONES
LONG BONES• Greater in length than width• Absorb stress from body weight• Upper/lower appendages
Long bone structure1. Diaphysis- shaft with compact bone &   medullary cavity2. Epiphysis- ends, articular cartilage & com...
SHORT BONES• ~ equal length/width• Wrists, ankles
FLAT BONES• Thin, flat in structure• Skull, ribs, sternum
IRREGULAR BONES• Variety of shapes• Vertebral column / bones of face
The Muscular System
Muscular System Functions•   MOVEMENT•   Maintain Posture•   Stabilize Joints•   Generate HEAT    – 40% body mass    – 80%...
Muscle Tissue• Tissue Review:  – Cardiac Cardiovascular System     • Involuntary, Striated  – Smooth  Cardiovascular, Di...
Muscles are…•   Excitable (irritable)•   Contractile•   Extensible•   Elastic•   Myo-, Mys, Sarco- (muscle prefixes)
Skeletal Muscle Tissue• MUSCLE CELL STRUCTURE  – Arrangement: large, long FIBERS     • Fiber = muscle cell  – Two major pr...
Skeletal Muscle Structure• Striated  – Due to actin/myosin• Elongated  – Varied lengths• Multinucleated
Muscle Anatomy
• http://www.bmb.psu.edu/courses/bisci004a/  muscle/b4muscle.htm
Skeletal Muscle Connections• Direct connection to Bone• Indirect connection via TENDON• ORIGIN: bone that does NOT move wh...
Microscopic Structure of                 Muscle Fiber•   Cell membrane = Sarcolemma•   Cytoplasm = Sarcoplasm•   Multiple ...
Sarcoplasmic Reticulum• Specialized ER connected to cell surface by T-  tubules• Surrounds each myofibril• At rest, filled...
Actin (thin) filament                  Composition• Long chains of actin globules in double spiral  arrangement• Each acti...
Actin Filament
Myosin (thick) filament               Composition• Contains 2 tails each with globular heads• Heads have ATP binding sites...
Myosin Filament
Multiple Myosin Filaments
Sarcomere structure• Alternating dark and light bands• Central H-zone contains MYOSIN only• Lateral A-bands  contain bot...
SARCOMERE STRUCTURE
Sarcomere
Nerve supply              to Muscle Fiber• Each muscle fiber served by a motor neuron• Motor neuron ends in a pad filled w...
Neuron pad + motor end plate =    Neuromuscular       junction(Space between called synaptic cleft )
Sliding Filament Theory of                Muscle ContractionSequence of Steps:1. Neuron releases neurotransmitter, acetylc...
Generation of              Action Potential• RMP = -70 Mv• Sudden influx of Na+ generates  Action Potential• RMP later res...
5. Action potential carried along the   sarcolemma to transverse (“T”) tubules   connected to Sarcoplasmic Reticulum6. SR ...
8. Ca++ binds to troponin9. Ca/Troponin pulls tropomyosin out of the  way, unmasks active site on actin molecules10. Myosi...
13. Myosin splits ATP to recharge14. Continues until Action Potential is restored  and Ca++ is pumped back into SR15.All s...
16. Shortening cell pulls on tendons attached to  bones, moving bone at articulation17. Contraction of opposite muscle req...
Reminders:• Refractory Period• All or None Effect• Breakdown of ACh by ACh-esterase
Disorders/Conditions of the Muscular              System• Duchenne’s Muscular Dystrophy  – Sex linked inheritance  – Dystr...
Tetanus
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
Musculoskeletal systems
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Musculoskeletal systems

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Musculoskeletal systems

  1. 1. MOVEMENT
  2. 2. MAJOR FUNCTIONS1. SUPPORT framework for body2. MOVEMENT ~point of attachment for skeletal muscles ~joints
  3. 3. 3. PROTECTION ~ soft tissues (brain, spinal cord, heart, etc.)
  4. 4. 4. STORAGE ~ minerals: (Ca, P, Na, K ) for use when needed…
  5. 5. 5. FORMATION OF BLOOD CELLS ~Hematopoiesis: red marrow produces blood cells for circulation
  6. 6. TWO MAJOR TYPES OF BONE TISSUE• COMPACT BONE –Give bone hard, durable quality –Outer layers of bone –Functions served? –Composed of osteocytes packed into lacunae.
  7. 7. COMPACT BONE
  8. 8. • SPONGY BONE - Less dense than compact bone – Contains red marrow: stem cellsblood cell components – Yellow marrow: fat storage centers
  9. 9. Types of Joints• The type of joints that are particularly important for physical activity and sport are: – BALL AND SOCKET JOINT - allows a full range of movement. E.g. the hip and shoulder joints – HINGE JOINT - movement in one plane: flexion and extension.
  10. 10. – GLIDING JOINT - these occur in the many small bones of the hand and feet. They allow a slight sliding motion forwards and backwards and from side to side.– PIVOT JOINT - allows rotation. E.g. atlas and axis in the neck.
  11. 11. • TASK:• the picture shows:• 1: Shoulder joint -ball and socket• 2: Elbow joint - hinge joint• can you name another ball and socket and hinge joint?
  12. 12. FOUR MAJOR TYPES OF BONES1. LONG BONES2. SHORT BONES3. FLAT BONES4. IRREGULAR BONES
  13. 13. LONG BONES• Greater in length than width• Absorb stress from body weight• Upper/lower appendages
  14. 14. Long bone structure1. Diaphysis- shaft with compact bone & medullary cavity2. Epiphysis- ends, articular cartilage & compact bone covering cancellous bone3. Epiphyseal line- between epiphysis & diaphysis- region of bone growth (epiphyseal plate)4. Medullary cavity- central cavity within diaphysis
  15. 15. SHORT BONES• ~ equal length/width• Wrists, ankles
  16. 16. FLAT BONES• Thin, flat in structure• Skull, ribs, sternum
  17. 17. IRREGULAR BONES• Variety of shapes• Vertebral column / bones of face
  18. 18. The Muscular System
  19. 19. Muscular System Functions• MOVEMENT• Maintain Posture• Stabilize Joints• Generate HEAT – 40% body mass – 80% body heat – Endothermy!
  20. 20. Muscle Tissue• Tissue Review: – Cardiac Cardiovascular System • Involuntary, Striated – Smooth  Cardiovascular, Digestive, Reproductive, etc. • Involuntary, non-striated – Skeletal* MUSCULAR SYSTEM • Voluntary, striated
  21. 21. Muscles are…• Excitable (irritable)• Contractile• Extensible• Elastic• Myo-, Mys, Sarco- (muscle prefixes)
  22. 22. Skeletal Muscle Tissue• MUSCLE CELL STRUCTURE – Arrangement: large, long FIBERS • Fiber = muscle cell – Two major protein filaments present: • Actin • Myosin myofilaments
  23. 23. Skeletal Muscle Structure• Striated – Due to actin/myosin• Elongated – Varied lengths• Multinucleated
  24. 24. Muscle Anatomy
  25. 25. • http://www.bmb.psu.edu/courses/bisci004a/ muscle/b4muscle.htm
  26. 26. Skeletal Muscle Connections• Direct connection to Bone• Indirect connection via TENDON• ORIGIN: bone that does NOT move when muscle contracts• INSERTION: bone that MOVES when muscle contracts
  27. 27. Microscopic Structure of Muscle Fiber• Cell membrane = Sarcolemma• Cytoplasm = Sarcoplasm• Multiple Mitochondria = High E output• Fiber is filled with long myofibrils• Myofibrils filled with filaments arranged in contractile units called SARCOMERES. – Myosin (thick filament) – Actin (thin filament)
  28. 28. Sarcoplasmic Reticulum• Specialized ER connected to cell surface by T- tubules• Surrounds each myofibril• At rest, filled with Ca++ maintained by a calcium “pump”, uses ATP• When activated, pores open and release calcium, initiating contraction
  29. 29. Actin (thin) filament Composition• Long chains of actin globules in double spiral arrangement• Each actin contains binding site for myosin• Tropomyosin spiral around chain – blocks active site on actin• Troponin clustered along spiral – Binding site for calcium!
  30. 30. Actin Filament
  31. 31. Myosin (thick) filament Composition• Contains 2 tails each with globular heads• Heads have ATP binding sites and ATPase for splitting ATP• Heads attracted to active sites on actin molecules• Heads form cross-bridges with actin
  32. 32. Myosin Filament
  33. 33. Multiple Myosin Filaments
  34. 34. Sarcomere structure• Alternating dark and light bands• Central H-zone contains MYOSIN only• Lateral A-bands  contain both ACTIN and MYOSIN filaments• End in I-bands contain ACTIN only (with Z-line in center) Z LINE TO Z LINE = 1 SARCOMERE
  35. 35. SARCOMERE STRUCTURE
  36. 36. Sarcomere
  37. 37. Nerve supply to Muscle Fiber• Each muscle fiber served by a motor neuron• Motor neuron ends in a pad filled with vacuoles packed with neurotransmitter• Pad sits above specialized piece of sarcolemma called motor end plate
  38. 38. Neuron pad + motor end plate = Neuromuscular junction(Space between called synaptic cleft )
  39. 39. Sliding Filament Theory of Muscle ContractionSequence of Steps:1. Neuron releases neurotransmitter, acetylcholine (ACh) into synaptic cleft2. ACh diffuses to motor end plate3. ACh binds to receptor on motor end plate4. Gated channel protein opens, Na+ rushes into cell interior, upsets RMP!
  40. 40. Generation of Action Potential• RMP = -70 Mv• Sudden influx of Na+ generates Action Potential• RMP later restored to normal by sodium-potassium pump
  41. 41. 5. Action potential carried along the sarcolemma to transverse (“T”) tubules connected to Sarcoplasmic Reticulum6. SR membrane becomes permeable to calcium7. Sarcoplasm is flooded with calcium ions
  42. 42. 8. Ca++ binds to troponin9. Ca/Troponin pulls tropomyosin out of the way, unmasks active site on actin molecules10. Myosin heads attach to actin11. Heads rotate, pull actin in to H-zone12. Z lines get closer…
  43. 43. 13. Myosin splits ATP to recharge14. Continues until Action Potential is restored and Ca++ is pumped back into SR15.All sarcomeres shorten, shortening muscle cell
  44. 44. 16. Shortening cell pulls on tendons attached to bones, moving bone at articulation17. Contraction of opposite muscle required to fully elongate shortened muscle
  45. 45. Reminders:• Refractory Period• All or None Effect• Breakdown of ACh by ACh-esterase
  46. 46. Disorders/Conditions of the Muscular System• Duchenne’s Muscular Dystrophy – Sex linked inheritance – Dystrophin protein deficiency – Tearing of sarcolemma – Accumulation of CT/fat – Muscular ATROPHY
  47. 47. Tetanus
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