Pathophysiology part 1


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  • A combination of genetic and environmental factors
  • Understanding these 3 factors can help cure disease.
  • Allergies, Asthma, Rheumatic fever
  • Quiz -
  • Quiz -
  • Test question – The type of shock resulting from arteries' losing tone and dilating is known as:
  • Quiz
  • Sepsis is the most common cause of MODS
  • Pathophysiology part 1

    1. 1. Disease—Causes and Pathophysiology
    2. 2. Part 1 Topics Disease Risk Hypoperfusion Shock Multiple Organ Dysfunction Syndrome
    3. 3. Genetics and OtherCauses of Disease
    4. 4. Many factors combine to cause disease. (1 of 3) Genetics Environment Life-style Age Gender
    5. 5. Many factors combine to cause disease. (2 of 3) Inherited traits are determined by molecules of deoxyribonucleic acid (DNA). Each somatic cell contains 46 chromosomes. Sex cells contain 23 chromosomes.
    6. 6. Many factors combine to cause disease. (3 of 3) An offspring receives 23 chromosomes from the mother and 23 chromosomes from the father. One or more chromosomes may be abnormal and may cause a congenital disease or a propensity toward acquiring a disease later in life.
    7. 7. Most disease processes are multifactorial in origin.
    8. 8. Disease Effects on IndividualsClinical Factors Host Agent Environment
    9. 9. Disease Effects on PopulationsEpidemiological Factors Incidence Prevalence Mortality
    10. 10. Family History andAssociated Risk Factors
    11. 11. Immunologic Disorders A number of immunologic disorders are more prevalent among those with a family history of the disorder.
    12. 12. Cancer Some types of cancer tend to cluster in families and seem to have a combination of genetic and environmental causes.  Breast cancer  Colorectal cancer
    13. 13. Endocrine Disorders The most common endocrine disorder is diabetes mellitus. Leading cause of:  Blindness  Heart disease  Kidney failure  Premature death Both Type I and Type II diabetes can be family related.
    14. 14. Hematologic Disorders There are many causes of hereditary hematological disorders such as gene alteration and histocompatibility (tissue interaction) dysfunctions.  Hemophilia  Hemochromatosis
    15. 15. Cardiovascular Disorders The cardiovascular system can be greatly affected by genetic disorders.  Elongation of the QT interval.  Mitral valve prolapse.  Coronary artery disease.  Hypertension.  Cardiomyopathy.
    16. 16. Renal Disorders Caused by a variety of factors, primarily hypertension. EMS is increasingly being called upon to deal with complications of dialysis including:  Problems with vascular access devices  Localized infection and sepsis  Electrolyte imbalances
    17. 17. Rheumatic Disorders Gout is a disorder both genetic and environmental characterized by the deposit of crystals in the joints, most commonly the great toe. The crystals form as a result of abnormally high levels of uric acid in the blood.
    18. 18. Gastrointestinal Disorders Lactose intolerance Crohn’s disease Peptic ulcers Cholecycstitis Obesity
    19. 19. Neuromuscular Disorders Diseases of the nervous and muscular systems include:  Huntington’s disease  Multiple sclerosis  Alzheimer’s disease
    20. 20. Psychiatric Disorders Genetic and biological causes of these disorders are being studied and increasingly understood.  Schizophrenia  Manic-depressive illness (Bipolar disorder)
    21. 21. Hypoperfusion
    22. 22. Hypoperfusion (shock)is inadequate perfusion of body tissues.
    23. 23. Shock occurs first at thecellular level and progressesto the tissues, organs, organ systems, and ultimately the entire organism.
    24. 24. Components of the Circulatory System (1 of 2) The pump (heart) The fluid (blood) The container (blood vessels) Any problem with the components can lead to inadequate perfusion.
    25. 25. Components of the Circulatory System (2 of 2)
    26. 26. The Pump The heart is the pump of the cardiovascular system. Receives blood from the venous system, pumps it to the lungs for oxygenation, and then pumps it to the peripheral tissues.
    27. 27. Stroke Volume (1 of 2) The amount of blood ejected by the heart in one contraction.
    28. 28. Stroke Volume (2 of 2) Factors affecting stroke volume:  Preload—amount of blood delivered to the heart during diastole.  Cardiac contractile force—the strength of contraction of the heart.  Afterload—the resistance against which the ventricle must contract.
    29. 29. The Frank-Starling mechanism statesthat the greater the stretch of cardiac muscle, up to a certain point, the greater the force of cardiac contraction.
    30. 30. Contractile ForceIs affected by circulatinghormones called catecholamines. Epinephrine – “Fight or Flight” Norepinephrine - Vasoconstriction
    31. 31. Cardiac Output Cardiac output is the amount of blood pumped by the heart in one minute. Stroke volume x Heart rate = Cardiac output
    32. 32. Blood Pressure Peripheral vascular resistance is the pressure against which the heart must pump. Blood Pressure = Cardiac Output x Peripheral Vascular Resistance
    33. 33. The Fluid Blood is thicker and more adhesive than water. Consists of plasma and the formed elements.  Red cells, white cells, platelets Transports oxygen, carbon dioxide, nutrients, hormones, metabolic waste products, and heat. An adequate amount is needed for perfusion, and must be adequate to fill the container.
    34. 34. The Container (1 of 2) Blood vessels serve as the container of the cardiovascular system. Under control of the autonomic nervous system they can adjust their size and selectively reroute blood through microcirculation. Microcirculation is comprised of the small vessels: arterioles, capillaries, and venules.
    35. 35. The Container (2 of 2) Capillaries have a sphincter between the arteriole and capillary called the pre-capillary sphincter. The pre-capillary sphincter responds to local tissue demands such as acidosis and hypoxia, and opens as more blood is needed.
    36. 36. Blood Flow Regulation Peripheral vascular resistance. Pressure within the system.
    37. 37. Post-capillary Sphincter At the end of the capillary between the capillary and venule is the post- capillary sphincter. The post-capillary sphincter opens when blood needs to be emptied into the venous system.
    38. 38. The Fick Principle (1 of 2) The movement and utilization of oxygen in the body is dependent upon the following conditions:  Adequate concentration of inspired oxygen.  Appropriate movement of oxygen across the alveolar/ capillary membrane into the arterial bloodstream.
    39. 39. The Fick Principle (2 of 2) Adequate number of red blood cells to carry the oxygen. Proper tissue perfusion. Efficient off-loading of oxygen at the tissue level.
    40. 40. Oxygen-HemoglobinDissociation Curve
    41. 41. Bohr Effect
    42. 42. The Pathophysiology of Hypoperfusion
    43. 43. Causes of Hypoperfusion (1 of 3) Inadequate pump  Inadequate preload.  Inadequate cardiac contractile strength.  Excessive afterload.
    44. 44. Causes of Hypoperfusion (2 of 3) Inadequate fluid  Hypovolemia.
    45. 45. Causes of Hypoperfusion (3 of 3) Inadequate container  Dilated container without change in fluid volume (inadequate systemic vascular resistance).  Leak in the container.
    46. 46. Shock at the Cellular Level Shock causes vary, however the ultimate outcome is impairment of cellular metabolism.
    47. 47. Impaired Use of Oxygen When cells don’t receive enough oxygen or cannot use it effectively, they change from aerobic to anaerobic metabolism.
    48. 48. Glucose breakdown. (A) Stage one, glycolysis, is anaerobic (doesnot require oxygen). It yields pyruvic acid, with toxic by-products such as lactic acid, and very little energy. (B) Stage twois aerobic (requires oxygen). In a process called the Krebs orcitric acid cycle, pyruvic acid is degraded into carbon dioxide andwater, which produces a much higher yield of energy.
    49. 49. Compensation and Decompensation  Usually the body is able to compensate for any changes. However when the various compensatory mechanisms fail, shock develops and may progress.
    50. 50. Compensation Mechanisms The catecholamines epinephrine and norepinephrine may be secreted. The renin-angiotensin system aids in maintaining blood pressure. Another endocrine response by the pituitary gland results in the secretion of anti-diuretic hormone (ADH).
    51. 51. Shock Variations (1 of 3) Compensated shock is the early stage of shock during which the body’s compensatory mechanisms are able to maintain normal perfusion.
    52. 52. Shock Variations (2 of 3) Decompensated shock is an advanced stage of shock that occurs when the body’s compensatory mechanisms no longer maintain normal perfusion.
    53. 53. Shock Variations (3 of 3) Irreversible shock is shock that has progressed so far that the body and medical intervention cannot correct it.
    54. 54. Types of Shock Cardiogenic Hypovolemic Neurogenic Anaphylactic Septic
    55. 55. Cardiogenic Shock The heart loses its ability to supply all body parts with blood. Usually the result of left ventricular failure secondary to acute myocardial infarction or CHF. Many patients will have normal blood pressures.
    56. 56. Evaluation The major difference between cardiogenic shock and other types of shock is the presence of pulmonary edema causing:  Difficulty breathing.  As fluid levels rise, wheezes, crackles, or rales may be heard.  There may be a productive cough with white or pink-tinged foamy sputum. Cyanosis, altered mentation, and oliguria.
    57. 57. Treatment (1 of 2) Assure an open airway. Administer oxygen. Assist ventilations as necessary. Keep the patient warm.
    58. 58. Treatment (2 of 2) Elevate the patient’s head and shoulders. Establish IV access with minimal fluid administration. Monitor the heart rate. Dopamine or dobutamine may be administered.
    59. 59. Hypovolemic Shock Shock due to loss of intravascular fluid.  Internal or external hemorrhage.  Trauma.  Long bones or open fractures.  Dehydration.  Plasma loss from burns.  Excessive sweating.  Diabetic ketoacidosis with resultant osmotic diuresis.
    60. 60. Evaluation (Signs 1 of 2) Altered level of consciousness. Pale, cool, clammy skin. Blood pressure may be normal, then fall.
    61. 61. Evaluation (Signs 2 of 2) Pulse may be normal then become rapid, finally slowing and disappearing. Urination decreases. Cardiac dysrhythmias may occur.
    62. 62. Treatment Airway control. Control severe bleeding. Keep the patient warm. Administer a bolus of crystalloid solution for fluid replacement. PASG if part of local protocol.
    63. 63. Intravenous Therapy
    64. 64. Fluid Replacement
    65. 65. Colloids Colloids remain in intravascular spaces for an extended period of time and have oncotic force.  Plasma protein fraction (Plasmanate).  Salt-poor albumin.  Dextran.  Hetastarch (Hespan).
    66. 66. Crystalloids Crystalloid solutions are the primary compounds used in prehospital care.  Isotonic solutions.  Hypertonic solutions.  Hypotonic solutions.
    67. 67. The effects of hypertonic,isotonic, and hypotonic solutions on red blood cells.
    68. 68. Most Commonly UsedSolutions in Prehospital Care Solution TonicityLactated Ringer’s Isotonic Normal Saline Isotonic D5W Hypotonic
    69. 69. Transfusion reactions occur when there is a discrepancy between the blood type of the patient and the type of the blood being transfused.
    70. 70. Signs and Symptoms of Transfusion Reactions Fever  Flushing of the skin Chills  Headache Hives  Loss of Hypotension consciousness Palpitations  Nausea Tachycardia  Vomiting  Shortness of breath
    71. 71. Treatment of Transfusion Reactions (1 of 2) IMMEDIATELY stop the transfusion. Save the substance being transfused. Rapid IV infusion.
    72. 72. Treatment of Transfusion Reactions (2 of 2) Assess the patient’s mental status. Administer oxygen. Contact medical direction. Be prepared to administer mannitol, diphenhydramine, or furosemide.
    73. 73. Neurogenic Shock Results from injury to brain or spinal cord causing an interruption of nerve impulses to the arteries. The arteries dilate causing relative hypovolemia. Sympathetic impulses to the adrenal glands are lost, preventing the release of catecholamines with their compensatory effects.
    74. 74. Evaluation Warm, dry, red skin. Low blood pressure. Slow pulse.
    75. 75. Treatment Airway control. Maintain body temperature. Immobilization of patient. Consider other possible causes of shock. IV access and medications that increase peripheral vascular resistance.
    76. 76. Anaphylactic Shock A severe immune response to a foreign substance. Signs and symptoms most often occur within a minute, but can take up to an hour. The most rapid reactions are in response to injected substances:  Penicillin injections.  Bees, wasps, hornets.
    77. 77. Evaluation (1 of 2) Because immune responses can affect different body systems, signs and symptoms vary widely:  Skin:  Flushing, itching, hives, swelling, cyanosis.  Respiratory system:  Breathing difficulty, sneezing, coughing, wheezing, stridor, laryngeal edema, laryngospasm.
    78. 78. Evaluation (2 of 2) Cardiovascular system:  Vasodilation, increased heart rate, decreased blood pressure. Gastrointestinal system:  Nausea, vomiting, abdominal cramping, diarrhea. Nervous system:  Altered mental status, dizziness, headache, seizures, tearing.
    79. 79. Treatment Airway protection, may include endotracheal intubation. Establish an IV of crystalloid solution. Pharmacological intervention:  Epinephrine, antihistamines, corticosteroids, vasopressors, inhaled beta agonists.
    80. 80. Septic Shock An infection that enters the bloodstream and is carried throughout the body. The toxins released overcome the compensatory mechanisms. Can cause the dysfunction of an organ system or result in multiple organ dysfunction syndrome.
    81. 81. EvaluationThe signs and symptoms are progressive. Increased to low blood pressure. High fever, no fever, or hypothermic. Skin flushed, pale, or cyanotic. Difficulty breathing and altered lung sounds. Altered mental status.
    82. 82. Treatment Airway control. IV of crystalloid solution. Dopamine to support blood pressure. Monitor heart rhythm.
    83. 83. Multiple Organ Dysfunction Syndrome MODS is the progressive impairment of two or more organ systems from an uncontrolled inflammatory response to a severe illness or injury.
    84. 84. MODS Stages
    85. 85. Primary MODS Organ damage results directly from a specific cause such as ischemia or inadequate tissue perfusion from shock, trauma, or major surgery. Stress and inflammatory responses may be mild and undetectable. During this response, neutrophils, macrophages, and mast cells are thought to be “primed” by cytokines.
    86. 86. Secondary MODS The next time there is an injury, ischemia, or infection the “primed” cells are activated, producing an exaggerated inflammatory response. The inflammatory response enters a self-perpetuating cycle causing damage and vasodilation. An exaggerated neuroendocrine response is triggered causing further damage.
    87. 87. MODS 24 Hours After Resuscitation Low grade fever. Tachycardia. Dyspnea. Altered mental status. General hypermetabolic, hyperdynamic state.
    88. 88. MODS Within 24 to 72 Hours Pulmonary failure begins.
    89. 89. MODS Within 7 to 10 Days Hepatic failure begins. Intestinal failure begins. Renal failure begins.
    90. 90. MODS Within 14 to 21 Days Renal and hepatic failure intensify. Gastrointestinal collapse. Immune system collapse.
    91. 91. MODS After 21 Days Hematologic failure begins. Myocardial failure begins. Altered mental status resulting from encephalopathy. Death.