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Cyazypyr

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  • 1. Technical Presentation Introducing DuPont™ Verimark™ and Exirel™ New Insect Control Products for Pest Management and Optimizing Yield in FL Citrus DuPont™ Cyazypyr™, Verimark™, Exirel™ and Benevia™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 2. Grower Benefits of Products powered by Cyazypyr™DuPont™ Cyazypyr™ helps improve early crop establishment forvisibly vigorous plants from start to finish, to help growers produce astronger crop in the field for a more appealing crop at harvest. • Applications early in the crop cycle protect tender seedlings from feeding damage and transmission of some pest-vectored diseases • Reducing biotic stresses improves crop establishment and gets the crop off to a strong start • Getting the crop off to a strong start with a program including Cyazypyr™ consistently creates an opportunity for improved yield at harvest DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 3. Designed for Optimal PerformanceProducts powered by Cyazypyr™ Verimark™ is designed for soil applications • For optimized root uptake and crop safety to tender roots and shoots, protecting both older leaves and new growth from a cross-spectrum of pests and helping provide consistently better yield and quality results at harvest. Exirel™ and Benevia™ are designed for foliar applications • For optimized leaf penetration and locally systemic movement, improving coverage and protection from a cross-spectrum of pests and potentially improving a plant’s resilience to stress.DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 4. What is Cyazypyr™? The second active ingredient in the anthranilic diamide class and the first to control a cross-spectrum of chewing and sucking pests whiteflies aphids Source: DuPont, USA Source: DuPont, USA leafminers Cyazypyr™ thrips (cyantraniliprole)Source: DuPont, The Netherlands Source: DuPont, Spain fruit flies Leps beetles weevils hoppers psyllids Source: DuPont, FranceSource: http://www.ars.usda.gov/is/graphics/photos/mar09/d1032-1.jpg Source: Source: Sylvia Villareal/IRRI Source: DuPont, Poland Source: DuPont, Poland Source: http://gardening- http://www.fotosearch.com coaches.com/CommunityGarden/gardening/asian -citrus-psyllid-reaches-ventura-county/ DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 5. Crop Uses Targeted in the US Products powered by Cyazypyr™ Products powered by Cyazypyr™ are effective on a wide range of crops* OR• Fruiting vegetables • Bulb vegetables • Fruiting vegetables• Cucurbits • Cotton • Cucurbits• Brassica • Potatoes • Brassica• Leafy vegetables • Oil seed crops • Leafy vegetables• Bulb vegetables • Tuberous & corm vegetables• Citrus • Including potatoes• Pome fruit • Citrus (small trees)• Stone fruit• Bushberries• Tree nuts * Not all crops are listed. Consult your local label. DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 6. Uniqueness ofProducts powered by Cyazypyr™ DuPont™ Cyazypyr™ insect control features a unique combination of product attributes Cyazypyr™ Feature Product Attribute Cross-spectrum Controls mixed pest populations Fast-acting Protects crops from feed damage and transmission of some diseases Translaminar Rainfastness and improved availability of Cyazypyr™ to different kinds of pests Root systemic Controls foliar pests when applied to the roots New MOA for sucking pests Controls pests resistant to other MOAs Selective for beneficial arthropods Strong fit in IPM programs; non-disruptive Low mammalian toxicity Convenient to use Excellent environmental profile Sustainable useDuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 7. Mode of Action of Cyazypyr™:The basis for rapid feeding cessation and plant protection Muscle Muscle fiber fibril RyRMuscle Depleted Internal Ca++ store Internal Ca++ store SYMPTOMS OF INSECT TOXICITY • Rapid feeding cessation Cyazypyr™ impacts insect behavior • General lethargy by impairing muscle function • Paralysis • Regurgitation (Lep larvae) • Eventual pest mortality Source: DuPont Stine-Haskell Research Center, Delaware, USA (2009)DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 8. Cyazypyr™ — Receptor Selectivity Excellent Mammalian Toxicological Profile As a Result of Selective Affinity for Insect Ryanodine Receptors (RyR) No response was observed in the human cell lineDuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 9. Cyazypyr™ — Mammalian Toxicology Excellent Mammalian Toxicological Profile All regulatory toxicology studies have shown low toxicity to mammals.DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 10. Acute Toxicity of Cyazypyr™ Productsvs. Other Insecticides The excellent mammalian toxicological profile of Cyazypyr™ is comparable to the best available in the marketplace.DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 11. Cyazypyr™ Selectivity to BeneficialArthropods Non-disruptive - Cyazypyr™ has moderate to no impact on pollinators, parasitoids and predatorsDuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 12. DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 13. Crops Covered DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 14. US Registration Anticipated Timeline Summary Initial EPA Submission (OECD dossier for Global Joint Review) •Submission to EPA • Jun 29, 2011 •Anticipated EPA approval • 1st quarter 2013 •Anticipated FL approval • 2nd quarter 2013 •State approvals • Most within 90 days of submission following EPA approvalDuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 15. Summary: DuPont™ Cyazypyr™ improves early crop establishment for visibly vigorous plants from start to finish, to help growers produce a stronger crop in the field for a more appealing crop at harvest.DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
  • 16. DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013. The information contained in this presentation is based on the latest-to-date technical information available to DuPont and DuPont reserves the right to update the information at any time. AgriMek, Asana® XL, Guthion, Karate, Lannate® and Monitor are restricted-use pesticides. The DuPont Oval Logo, DuPont™, The miracles of science™, Altacor®, Asana®, Avaunt®, Benevia™, Coragen®, Cyazypyr™, Exirel™, Lannate®, Steward® and Verimark™ are trademarks or registered trademarks of DuPont or its affiliates. Admire, Monitor, Movento, Oberon and Provado are registered trademarks of Bayer CropScience. AgriMek, Karate, Proclaim, Trigard and Warrior are registered trademarks of a Syngenta Group Company. Lorsban, Radiant, Spintor and Success are trademarks or registered trademarks of Dow AgroSciences LLC. Guthion is a registered trademark of Makhteshim Agan of North America, Inc. Confirm is a registered trademark of Nippon Soda Co., LTD. Dipel is a registered trademark of Makhteshim Chemical Works, LTD. Induce is a registered trademark of Helena Holding Company. Copyright © 2012 E.I. du Pont de Nemours and Company. All Rights Reserved.DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permittedprior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.