Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for  Metabolic Engineered ‘Defense        Bolstered Crops’...
CASE STUDY: 1
Model Fungal Genomes Studied:1.Fusarium sps: Die backs, root rots etc.2. Phytophthora sps: Leaf drop/ fall3.Aspergillus sp...
Generic ‘Terpenoid Metabolism’ in Living Organisms
Comparative Pathways Operative Across Various Kingdoms                            Plants                             Patho...
Terpenoid Biosynthesis in …Arabidopsis thaliana                                                  7 Essential              ...
Terpenoid Biosynthesis in …Physcomitrella patents                                                    8 Operative          ...
Terpenoid Biosynthesis in …Chlamydomonas reinhardtii                                                       8 [+ 1 OL]     ...
Terpenoid Biosynthesis in …Aspergillus species                                                   8 [+2]                   ...
Terpenoid Biosynthesis in …Fusarium species                                              6 Essential                      ...
Terpenoid Biosynthesis in …Phytophthora species                                                   5 [ +2 OL]              ...
Carbon Fixation Routes in Plants & PathogensTotal Number of Orthologs   :   13   14   21   14   22   12 (reduced?)        ...
CASE STUDY: 2
Let us study 3 Phytopathogens:1.Ganoderma sps.2.Phytophthora sps.3.Aspergillus sps.[All are Pathogenic to Rubber Tree!]
Case 1: Phytophthora sps- GO Distributions
Case 2: Ganoderma sps- GO Distributions
Case 3: Aspergillus sps- GO Distributions
Summary- GO Distributions for 3 Model Pathogens
CASE STUDY: 3
Number of Arabidopsis thaliana Unique Genes Responding                To Stress [Biotic/ Abiotic]?Insect                  ...
Summarizing All Stress [Biotic/ Abiotic] Responsive           Genes…….into Pathways
…..reflected in Biosynthesis of Secondary Metabolism                     Pathways…..
…..reflected in Starch and Sucrose Metabolic Pathways…..
Functions of genes Regulated in ABA Stress Response :          (as 2nd Level of GeneBins Ontology)
Functions of genes Regulated in Pseudomonad[Pathogen] Challenge: (as 2nd Level of GeneBins Ontology)                      ...
GO Distribution Network for ABA Responsive Genes in                 Arabidopsis thaliana:
GO Distribution Network for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana:                                        ...
GO Distribution for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana:
GO Distribution for ABA Responsive Genes in             Arabidopsis thaliana:
Thank YouNote: Study is based solely on Publicly available Databases,  Platforms/ Softwares, Sequences, Codes, Programs an...
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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?

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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?- Biswapriya Biswavas Misra, Ph.D., CCB@USM, 23rd August, 2012

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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?

  1. 1. Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ? Biswapriya Biswavas Misra, Ph.D. CCB 23rd August, 2012
  2. 2. CASE STUDY: 1
  3. 3. Model Fungal Genomes Studied:1.Fusarium sps: Die backs, root rots etc.2. Phytophthora sps: Leaf drop/ fall3.Aspergillus sps: Collar rots Model Plant Genomes Studied:1.Arabidopsis thaliana [Model Plant]2.Physcomitrella patens [Primitive Plant]3.Chlamydomonas reinhardtii [UnicellularGreen Organism]
  4. 4. Generic ‘Terpenoid Metabolism’ in Living Organisms
  5. 5. Comparative Pathways Operative Across Various Kingdoms Plants Pathogens
  6. 6. Terpenoid Biosynthesis in …Arabidopsis thaliana 7 Essential proteins.
  7. 7. Terpenoid Biosynthesis in …Physcomitrella patents 8 Operative proteins.
  8. 8. Terpenoid Biosynthesis in …Chlamydomonas reinhardtii 8 [+ 1 OL] Operative Proteins
  9. 9. Terpenoid Biosynthesis in …Aspergillus species 8 [+2] Operative proteins.
  10. 10. Terpenoid Biosynthesis in …Fusarium species 6 Essential proteins !!!
  11. 11. Terpenoid Biosynthesis in …Phytophthora species 5 [ +2 OL] Operative proteins ??
  12. 12. Carbon Fixation Routes in Plants & PathogensTotal Number of Orthologs : 13 14 21 14 22 12 (reduced?) Differential Number of proteins !
  13. 13. CASE STUDY: 2
  14. 14. Let us study 3 Phytopathogens:1.Ganoderma sps.2.Phytophthora sps.3.Aspergillus sps.[All are Pathogenic to Rubber Tree!]
  15. 15. Case 1: Phytophthora sps- GO Distributions
  16. 16. Case 2: Ganoderma sps- GO Distributions
  17. 17. Case 3: Aspergillus sps- GO Distributions
  18. 18. Summary- GO Distributions for 3 Model Pathogens
  19. 19. CASE STUDY: 3
  20. 20. Number of Arabidopsis thaliana Unique Genes Responding To Stress [Biotic/ Abiotic]?Insect Bacterial/Viral Fungal Hormonal
  21. 21. Summarizing All Stress [Biotic/ Abiotic] Responsive Genes…….into Pathways
  22. 22. …..reflected in Biosynthesis of Secondary Metabolism Pathways…..
  23. 23. …..reflected in Starch and Sucrose Metabolic Pathways…..
  24. 24. Functions of genes Regulated in ABA Stress Response : (as 2nd Level of GeneBins Ontology)
  25. 25. Functions of genes Regulated in Pseudomonad[Pathogen] Challenge: (as 2nd Level of GeneBins Ontology) NO Difference ? Pathogen vs Abiotic Stress Challenges in terms of Functions !
  26. 26. GO Distribution Network for ABA Responsive Genes in Arabidopsis thaliana:
  27. 27. GO Distribution Network for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana: Huge Complexity & Networking of Cellular Localization of Proteins in Pathogenic Stress ?
  28. 28. GO Distribution for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana:
  29. 29. GO Distribution for ABA Responsive Genes in Arabidopsis thaliana:
  30. 30. Thank YouNote: Study is based solely on Publicly available Databases, Platforms/ Softwares, Sequences, Codes, Programs and Information and are exclusively GENERATED. Appropriate sources are thanked. Follow the Ideas- as SKY is the Limit !More INTERESTING & RELEVANT ONES are on the Cards ! Happy Following!!!

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