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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?
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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?

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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?- Biswapriya Biswavas Misra, Ph.D., CCB@USM, 23rd August, 2012

Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ?- Biswapriya Biswavas Misra, Ph.D., CCB@USM, 23rd August, 2012

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Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ? Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ? Presentation Transcript

  • Metabolic Pathways & Phyto-patho Interactions: Clues to Targets for Metabolic Engineered ‘Defense Bolstered Crops’ ? Biswapriya Biswavas Misra, Ph.D. CCB 23rd August, 2012
  • CASE STUDY: 1
  • Model Fungal Genomes Studied:1.Fusarium sps: Die backs, root rots etc.2. Phytophthora sps: Leaf drop/ fall3.Aspergillus sps: Collar rots Model Plant Genomes Studied:1.Arabidopsis thaliana [Model Plant]2.Physcomitrella patens [Primitive Plant]3.Chlamydomonas reinhardtii [UnicellularGreen Organism]
  • Generic ‘Terpenoid Metabolism’ in Living Organisms
  • Comparative Pathways Operative Across Various Kingdoms Plants Pathogens
  • Terpenoid Biosynthesis in …Arabidopsis thaliana 7 Essential proteins.
  • Terpenoid Biosynthesis in …Physcomitrella patents 8 Operative proteins.
  • Terpenoid Biosynthesis in …Chlamydomonas reinhardtii 8 [+ 1 OL] Operative Proteins
  • Terpenoid Biosynthesis in …Aspergillus species 8 [+2] Operative proteins.
  • Terpenoid Biosynthesis in …Fusarium species 6 Essential proteins !!!
  • Terpenoid Biosynthesis in …Phytophthora species 5 [ +2 OL] Operative proteins ??
  • Carbon Fixation Routes in Plants & PathogensTotal Number of Orthologs : 13 14 21 14 22 12 (reduced?) Differential Number of proteins !
  • CASE STUDY: 2
  • Let us study 3 Phytopathogens:1.Ganoderma sps.2.Phytophthora sps.3.Aspergillus sps.[All are Pathogenic to Rubber Tree!]
  • Case 1: Phytophthora sps- GO Distributions
  • Case 2: Ganoderma sps- GO Distributions
  • Case 3: Aspergillus sps- GO Distributions
  • Summary- GO Distributions for 3 Model Pathogens
  • CASE STUDY: 3
  • Number of Arabidopsis thaliana Unique Genes Responding To Stress [Biotic/ Abiotic]?Insect Bacterial/Viral Fungal Hormonal
  • Summarizing All Stress [Biotic/ Abiotic] Responsive Genes…….into Pathways
  • …..reflected in Biosynthesis of Secondary Metabolism Pathways…..
  • …..reflected in Starch and Sucrose Metabolic Pathways…..
  • Functions of genes Regulated in ABA Stress Response : (as 2nd Level of GeneBins Ontology)
  • Functions of genes Regulated in Pseudomonad[Pathogen] Challenge: (as 2nd Level of GeneBins Ontology) NO Difference ? Pathogen vs Abiotic Stress Challenges in terms of Functions !
  • GO Distribution Network for ABA Responsive Genes in Arabidopsis thaliana:
  • GO Distribution Network for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana: Huge Complexity & Networking of Cellular Localization of Proteins in Pathogenic Stress ?
  • GO Distribution for Pseudomonad[Pathogen] Challenged Arabidopsis thaliana:
  • GO Distribution for ABA Responsive Genes in Arabidopsis thaliana:
  • Thank YouNote: Study is based solely on Publicly available Databases, Platforms/ Softwares, Sequences, Codes, Programs and Information and are exclusively GENERATED. Appropriate sources are thanked. Follow the Ideas- as SKY is the Limit !More INTERESTING & RELEVANT ONES are on the Cards ! Happy Following!!!