Desire to identify tumor markers, and markers of disease progression. Hope to distinguish tumor stage and outcomes. Used a sample pooling strategy, prior to gene expression profiling. Differs from clustering individual samples expression profiles, and loses distinction of gene expression profiles between samples. Comparison of gene expression values relative to normal were calculated as ratios (i.e. fold change). Candidate tumor markers were selected based on more than 2-fold expression difference vs. normal mucosa. Candidate tumor progression markers were selected based on overall pattern of progressively increasing expression in line with advancing tumor stage, with overall 2-fold change considered minimum required to be significant. Similar analysis was done to identify those genes progressively decreasing with tumor stage. Osteopontin most consistently progressive, and greatest differential expression.
Treatment combinations are different based on specific diagnosis of sub-type. Remissions can be achieved using corresponding treatments, however cure rates are greatly reduced, and unwarranted toxicities occur. Created an expression vector, highlighting an idealized expression pattern that would uniformly distinguish between the two classes. Training set identifies correlation of each gene’s expression level with the class distinction (AML vs. ALL). Identified genes that were more highly correlated with the class distinction than would be expected by chance. Used set of known samples (training set) to identify genes most strongly correlated with the class distinction. Cross-validation: Withhold 1 training sample; build predictor; test if withheld sample is correctly classified; repeat with a different test sample. Somewhat arbitrarily selected 50 most strongly correlated genes, but discovered that predictors based on 10 – 200 samples were as accurate. Some genes confirmed with independent knowledge; e.g. surface proteins for which monoclonal antibodies have been used to distinguish lymphoid from myeloid lineage cells. Others correlated with pathogenesis (e.g. chromatin remodeling, or known oncogenes) or pharmacology (e.g. topoisomerase II, target of etoposide).
Provides further validation, substantiation that the conclusions drawn from the individual models are accurate; if models work in concert, and agree, adds evidence that conclusions are valid.
Beginning Embedded Analytics: Scenario: A patient is admitted with a presumptive diagnosis of community-acquired pneumonia (CAP). Assuming a standard (uncomplicated) course of treatment, all of the resources required and their required displacement over time and space can be projected. This enables: An ongoing assessment: Is the patient on-track, on-protocol, on-standard of care? If not, why? And what factors are contributing to their deviating from standard? Looking at all similar patients in the aggregate, and considering their individual positions and distribution along their care pathways, are we adequately and appropriately deployed to meet the forecast and emerging resource needs of this patient population? If not, are we able to forecast and anticipate shortfalls, or overages? Can we exploit this information to re-deploy? This capabilities will also provide for LOS monitoring: are we achieving the required progress in the care of these patients, that we can anticipate achieving the required LOS and therefore the appropriate costs of care? Is our discharge planning keeping pace with the anticipated and/or desired course of care?
Process issues such as cross-specialty communications and hand-offs. Identify participant’s role in the process, in the incident, and their relationship to the provider enterprise, to determine risk and exposure.
Requires a core foundation of good, high quality, well-understood data
Gmb Gbs Presentation Template
Group Benefit Services, LLC Prepared by Brent Blakely
GMB Group Benefit Services <ul><li>Who we are… </li></ul><ul><li>GMB Group Benefit Services is an independent consulting firm focusing primarily on employer sponsored benefit programs such as: </li></ul><ul><li>Group Medical </li></ul><ul><li>Group Dental and Life Insurance </li></ul><ul><li>Group Disability </li></ul><ul><li>Buy Up benefit coverage’s </li></ul><ul><li>Our Mission… </li></ul><ul><li>We are dedicated to providing our clients with a unique benefit strategy tailored to their specific needs based on their demographics and goals. This strategy is not an annual transaction, but an ongoing program that will allow each client to keep up with market trends and changes. </li></ul><ul><li>Our Focus… </li></ul><ul><li>Our goal at GMB Group Benefit Services is to provide seamless administration, as well as employee communication for each and every client. Each employee deserves one on one education in order to both understand and appreciate the benefit programs that their employer provides. </li></ul><ul><li>This understanding is paramount in today’s insurance environment. Benefit Costs are always grabbing headlines, but understanding of benefits and the impact to lifestyle as well as paycheck help to improve employee morale and appreciation for what their company provides for them on a daily basis…. </li></ul>
Total Benefit Strategy TEXT TEXT TEXT TEXT TEXT Your Business Here! Supplemental Insurance Property / Casualty Workers Comp Group Retirement Planning Individual Planning Services Personal Lines Major Medical Ancillary Benefits Retirement Planning
Our Team Employee Benefits Commercial Lines Individual Planning Office Locations Brent Blakely Benefit Advisor Mooresville [email_address] Kate Overton Customer Service Mooresville, [email_address] Lynn Williams Administrative Assistant Mooresville [email_address] Ashton Loyd Commercial Lines Gasoline Alley [email_address] Rob Griffin Workers Comp Gasoline Alley [email_address] Charles Moore, III Executive Benefits Plaza Office firstname.lastname@example.org Lynn Williams Customer Service Plaza Office [email_address] Group Benefit Services 227 West Plaza Drive, Mooresville, NC 704-664-9111 ext .255 Griffin Moore Ins. Agency 227 West Plaza Drive, Mooresville, NC 704-664-9111 ext.239 Griffin Insurance Agency 135 Gasoline Alley, Mooresville, NC 704-664-9111 Tarheel Insurance Agency 135 Gasoline Alley, Mooresville, NC 704-768-2001 Griffin Insurance Agency 125 E. Front St, Statesville, NC 704-871-8002 Griffin Insurance Agency 208 Stanford Road, Lincolnton, NC 704-732-6856 Griffin Insurance (Hispanic) 227 West Plaza Drive, Mooresville, NC 704-664-9111 ext. 147
Stage III - Implementation This stage consists of all the necessary steps to make the right vendor and product selections, insure a smooth and successful rollout, and put in place the appropriate resources for ongoing support: Benefits Analysis & Recommendations Report — A report containing a detailed cost and bid analysis of the required products and resources Benefits & Systems Rollout — Professional resources and assistance to insure the effective implementation of your plan Stage II - Planning Here, we hold sessions with HR & benefits management to develop a strategic benefits plan: The Benefits & Systems Assessment Session — A detailed assessment of your current employee benefits programs, communication and needs. The Benefits Blueprint Session — Helps you develop a step-by-step blueprint for the appropriate products, strategies and time required to achieve your goals Stage IV - Review Finally, we provide periodic reviews to make sure your current programs and plans are still in synch with the business as it grows and changes: Wrap-Up Review Mid-Year Review Pre-Renewal Review Stage I - Discovery We help you assess your current situation and develop a clear and powerful vision for your benefits programs. The first step is to rate the effectiveness of your company's employee benefits program. We will also evaluate short term objectives and review long term goals. <ul><li>After you have worked with GMB Group Benefit Services </li></ul><ul><li>you will: </li></ul><ul><li>Have comprehensive benefit coverage that your employees will understand </li></ul><ul><li>Have a multi-year benefits strategy that will insure your needs as markets change </li></ul><ul><li>Have assurance that concepts in marketplace are understood </li></ul><ul><li>Save Time and Money </li></ul>Discovery Planning I Implementation Review
Benefit Survey <ul><li>Asking the right questions… </li></ul><ul><li>Employee benefits contribute significantly to an employee’s commitment and loyalty to an organization. Due to the expense of these products, it is critical that employers use their benefit dollars wisely. </li></ul><ul><li>The Benefit Survey is the first step in assessing the needs of your employees and their overall commitment to your organization. </li></ul><ul><li>Your representative will work with you to design a tailor made survey specific to the information we need to extract. </li></ul><ul><li>Surveys are designed to address areas such as: </li></ul><ul><li>Current benefits package </li></ul><ul><li>Employee budgets or financial constraints </li></ul><ul><li>Future product offerings </li></ul><ul><li>Retirement benefits </li></ul><ul><li>Communication of benefits </li></ul><ul><li>Employee morale </li></ul>Critical… As the importance of benefits in fostering employee loyalty grows, providing the right package is critical to organizational success. Designing the right benefits package requires the direction and focus that only a tested, validated assessment can provide.
<ul><li>Why do you offer Employee Benefits? </li></ul><ul><li>Employee Benefits are often put in place as a recruitment and retention tool. Without effective communication, this can become an inefficient program to hire and maintain key employees. </li></ul><ul><li>A good program poorly communicated is a poor program in the eyes of the employee. </li></ul><ul><li>A recent study found that 63% of employees underestimate the total costs of healthcare and 69% overestimate the percentage they pay. </li></ul><ul><li>GMB Group Benefit Services works with employers to develop a tailor-made communications plan that helps increase employee’s understanding and appreciation of their benefits while reducing the administrative burden for the HR and benefit staff. </li></ul><ul><li>Some of the communication services available from GMB include: </li></ul><ul><li>Custom communications and benefit education plans for employees. </li></ul><ul><li>Pre-filled enrollment and communication pieces designed to make the enrollment more efficient and easier to understand. </li></ul><ul><li>One-on-one communications with employees, to help them better understand their benefits. </li></ul><ul><li>Multi-state enrollments with professional, trained enrollers. </li></ul><ul><li>Employee benefit surveys, benefit statements & benefit fairs. </li></ul><ul><li>The more employees understand about their benefits program, the more value they will see in both the benefits and their employment with their company. </li></ul>Communication
At Group Benefit Services , we bring years of combined experience that includes developing working relationships and strategic alliances with some of the industry's leading insurance carriers and service providers. Through these relationships, Group Benefit Services offers comprehensive solutions to your benefit needs. We seek relationships with providers who share our goals and demonstrate financial stability, superior service commitments and high industry ratings. Our Partners