Breast cancer
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  • 1. What is It?? Any malignant tumor of the breast Almost all tumors of the breast are carcinomas, therefore breast cancer usually applies to a malignancy of the breast ducts or glands. Sarcomas are rare; angiosarcoma being the most common, and arises from radiation therapy.
  • 2. Are there different kinds?? Ductal Carcinoma  1.) Arises from epithelium lining the breast ducts  2.) Accounts for 75-80% of breast cancers Lobular Carcinoma  1.) Epithelium of smallest ducts or milk glands themselves  2.) Accounts for 10-15% of breast cancers
  • 3. Microscopic Types and Frequenciesof Breast Cancer Histologic Type % of all Breast Cancers Carcinoma in situ 15-30% Ductal 80% Lobular 20% Invasive 70-85% Ductal 80% Lobular 10% Other 10%
  • 4. Is it Lobular Carcinoma? Difficult to diagnose by mammography Often seen at multiple sites in the affected breast Tend to see cancer in both of the breasts occur (still in question).
  • 5. What about Ductal Carcinoma?? Most common cancer of the breast. Also the most aggressive when its invasive. Less likely to see another cancer in the opposite breast (theory still in question) Cause growth of a very dense, scar like tissue
  • 6. Can men get Breast Cancer YES Gynecomastia describes male breast cancer Usually bilateral Caused by high levels of estrogen Account for 1% of all breast cancers
  • 7. Risk Factors Women are at 100x more of a risk then men Lobular Carcinoma Family History (BRAC-1, BRAC-2) Age Estrogen Obesity, alcoholism, and cigarette smoking
  • 8. Prognosis 5 year survival can vary from 10% to 100%Important Risk Factors Carcinoma in situ v. Invasive Carcinoma Lymph node metastasis Tumor size Invasion of skin or chest wall
  • 9. Prognosis Continued…Less important prognostic factors Histological type of carcinoma Histological grade of the carcinoma Rate of tumor cell division and aneupodiy Presence or absence of receptors on tumor cells
  • 10. Treatments Bilateral mastectomy Simple mastectomy Lumpectomy Chemotherapy Radiation
  • 11. Prevention Maintain a healthy body weight(BMI less than 25) throughout your life Minimize or avoid alcohol. Consume as many fruits and vegetablesas possible. Exercise regularly the rest of your life Do your fats right! Do your carbs right! Consume whole food soy productsregularly Minimize exposure to pharmacologicestrogens and xeno-estrogens Take your supplements daily
  • 12. Citations American Cancer Society. 2011. Cancer Facts and Figures 2011. p. 4. NW, Atlanta, GA Mayo Foundation for Medical Education and Research, 11/30/2011, Ductal carcinoma in situ (DCIS), http://www.bing.com/health/article/mayo-MADS00983/Ductal-carcinoma-in-situ- DCIS?q=ductal+carcinoma McConnell,Thomas H., 2007.The Nature of Disease, p. 571-577. Lippincott Williams & Wilkins, Baltimore , MD 21201. Webmd, 11/27/2011, Lobular Carcinoma (Invasive and In Situ), http://www.webmd.com/breast- cancer/lobular-carcinoma-invasive-and-in-situ, 02/08/2010 Weninger, Jessica, 12/01/2011, BSGI: The Best for Your Bust, http://imaging-radiation- oncology.advanceweb.com/Student-and-New-Grad-Center/Student-Papers/BSGI-The-Best- for-Your-Bust.aspx, 11/02/2010 Womens Health, 12/05/2011, Dr. Anns 10-Steps to Prevent Breast Cancer, http://womenshealth.about.com/od/cancerprevention/a/10stepsprevbcan.htm, Octob er 30, 2009
  • 13.  Breast 232,620 2,140 230,480 39,970 450 39,520