What is It?? Any malignant tumor of the breast Almost all tumors of the breast are carcinomas, therefore breast cancer usually applies to a malignancy of the breast ducts or glands. Sarcomas are rare; angiosarcoma being the most common, and arises from radiation therapy.
Are there different kinds?? Ductal Carcinoma 1.) Arises from epithelium lining the breast ducts 2.) Accounts for 75-80% of breast cancers Lobular Carcinoma 1.) Epithelium of smallest ducts or milk glands themselves 2.) Accounts for 10-15% of breast cancers
Microscopic Types and Frequenciesof Breast Cancer Histologic Type % of all Breast Cancers Carcinoma in situ 15-30% Ductal 80% Lobular 20% Invasive 70-85% Ductal 80% Lobular 10% Other 10%
Is it Lobular Carcinoma? Difficult to diagnose by mammography Often seen at multiple sites in the affected breast Tend to see cancer in both of the breasts occur (still in question).
What about Ductal Carcinoma?? Most common cancer of the breast. Also the most aggressive when its invasive. Less likely to see another cancer in the opposite breast (theory still in question) Cause growth of a very dense, scar like tissue
Can men get Breast Cancer YES Gynecomastia describes male breast cancer Usually bilateral Caused by high levels of estrogen Account for 1% of all breast cancers
Risk Factors Women are at 100x more of a risk then men Lobular Carcinoma Family History (BRAC-1, BRAC-2) Age Estrogen Obesity, alcoholism, and cigarette smoking
Prognosis 5 year survival can vary from 10% to 100%Important Risk Factors Carcinoma in situ v. Invasive Carcinoma Lymph node metastasis Tumor size Invasion of skin or chest wall
Prognosis Continued…Less important prognostic factors Histological type of carcinoma Histological grade of the carcinoma Rate of tumor cell division and aneupodiy Presence or absence of receptors on tumor cells
Prevention Maintain a healthy body weight(BMI less than 25) throughout your life Minimize or avoid alcohol. Consume as many fruits and vegetablesas possible. Exercise regularly the rest of your life Do your fats right! Do your carbs right! Consume whole food soy productsregularly Minimize exposure to pharmacologicestrogens and xeno-estrogens Take your supplements daily
Citations American Cancer Society. 2011. Cancer Facts and Figures 2011. p. 4. NW, Atlanta, GA Mayo Foundation for Medical Education and Research, 11/30/2011, Ductal carcinoma in situ (DCIS), http://www.bing.com/health/article/mayo-MADS00983/Ductal-carcinoma-in-situ- DCIS?q=ductal+carcinoma McConnell,Thomas H., 2007.The Nature of Disease, p. 571-577. Lippincott Williams & Wilkins, Baltimore , MD 21201. Webmd, 11/27/2011, Lobular Carcinoma (Invasive and In Situ), http://www.webmd.com/breast- cancer/lobular-carcinoma-invasive-and-in-situ, 02/08/2010 Weninger, Jessica, 12/01/2011, BSGI: The Best for Your Bust, http://imaging-radiation- oncology.advanceweb.com/Student-and-New-Grad-Center/Student-Papers/BSGI-The-Best- for-Your-Bust.aspx, 11/02/2010 Womens Health, 12/05/2011, Dr. Anns 10-Steps to Prevent Breast Cancer, http://womenshealth.about.com/od/cancerprevention/a/10stepsprevbcan.htm, Octob er 30, 2009