TBX 3/5-forelimbs (ulnar/radius) and TBX2/4-hindlimbs (tibia/fibia) Photo : Malcolm Logan
Moskowitz etal. Cell (2007) 129:1365
Moody, Principles of Developmental Genetics, AP Press, 2007.
Published by AAAS E. N. Olson Science 313, 1922 -1927 (2006) Fig. 3. The heart of Drosophila
Horton etal. Dev Genes Evol (2008) 218:613
Chick embryos 4 Day Gestation, in situ hybridization. The cells expressing Tbx5 will form a wing; those expressing Tbx4 will form a leg. Tbx4 and Tbx5 code for related gene regulatory proteins, which are thought to dictate which type of limb develops. H. Ohuchi et al., Development (1998)125:51–60
Logan, M. Development 2003;130:6401-6410 (A) Representation of the prospective limb territories in a stage 15 chick embryo