Your SlideShare is downloading. ×
Mutationby madhuhewa&judygarza
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Mutationby madhuhewa&judygarza

612
views

Published on

Published in: Technology

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
612
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
104
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. Mutations
  • 2. • What is the definition ofmutation?-A mutation is a change or anymistake in DNA sequence
  • 3. Mutants…
  • 4. Types of mutations:• Point Mutations• Frameshift Mutations• Chromosomal Mutations
  • 5. Point mutations:• Point mutations are single-base changesin a gene’s DNA sequence.• These include:-Missense mutations-Nonsense mutations-Silent mutations
  • 6. Point mutations: Missensemutation• Missense mutation: Change in a singleamino acid within a protein.• This does change in protein.Example:Normal: THE DOG BIT THE CATMutated: THE DOG BIT THE CAR
  • 7. Point Mutations: Nonsensemutation• Nonsense mutation: Nonsensemutations make a premature stop codonthat causing the protein to be shortened.• Nonsense mutation does change theresulting protein.Example:Normal: THE DOG BIT THE CATMutated: THE DOG BIT
  • 8. Point Mutations: Silent mutation• Silent mutation: Silent mutations change theDNA sequence(not the amino acid sequence).• Silent mutation does not change the resultingprotein and no effect on an organism.Example:Normal: THE DOG BIT THE CATMutated: THE DOG BIT THE KAT
  • 9.
  • 10. Frameshift Mutations• Frameshift Mutations: Frameshift Mutation isinsertion or deletion of one or more bases into or fromthe DNA sequence.• This effect on every amino acid in the protein and itmakes protein nonfunctional.Example:
  • 11. Frameshift Mutation:
  • 12. Chromosomal Mutations:4 types of chromosomal Mutations:• Translocation: A chromosomal segment is transferredto a new position on the same or another chromosome• Deletion: the loss or absence of one or morenucleotides from a chromosome• Inversion: Part of a chromosome breaks out and isreinserted backwards• Insertion: Part of the chromosome is broken off andattaches to the sister chromatid.
  • 13. Chromosomal Mutations:
  • 14. Causes of Genetic Mutations:• Sometimes it happens for no reason(Spontaneous Mutations).• Environmental Causes:-UV light- Radiation- X-rays-Some Chemicals
  • 15. Genetic Disorders:
  • 16. Cystic Fibrosis
  • 17. OsteogenesisImperfecta
  • 18. Multiple Neurofibromastosis• genetically-inherited disorder• Multiple begins tumors that form in skin
  • 19. Klinefelter’s Syndrome• Males have XXY sex chromosomes:
  • 20. Twin-to-Twin Transfusion Syndrome• Due to placental abnormality, one twinreceives too much blood and the otherdoes not receive enough.
  • 21. Fragile X Syndrome