Plants & Agriculture
IBERS, Aberystwyth
Public Good Plant Breeding
Agriculture the most important event
in human history
‘The original biotechnology, fundamental to culture, health,
quality...
Agriculture is at the Center of Many of Society’s
Most Important Debates
Exciting time for Agriculture & Plant Breeding
• ...
Holistic Research
“No matter how excellent the
research done in one scientific
discipline is, its application in
isolation...
Doubly Green Revolution
• The aim
•repeat the success of the Green
Revolution
•on a global scale to include
Africa!!
•in m...
sunlight
plants
plant power
science Agriculture, Land
Use & Society
Plants provide sustainable solutions
‘ultimate green &...
fossil reserves biorenewables
oil...refineries bio...refineries
CHEMICALS MATERIALS FUELS
yesterday today and tomorrow
sun...
Agriculture critical to the future of
our planet and humanity
•FOOD,
•FEED,
•FUEL
•CHEMICALS
Daily calorie intake in developing world
Rice 45%
Wheat 29%
Maize 11%
Cassava 3%
Sorghum 2%
Potato 2%
Sweet potato 2%
Mill...
Courtesy Tobert Rocheford and
Catherine Bermudez Kandianis
Keith Weller
Doug Wilson
Scott Bauer
Keith Weller
•DuPont Food security index
http://foodsecurity.eiu.com
•Father Green revolution: Norman
Borlaug.
•Civilization founded on...
Charles Darwin
Evolution is driven by natural selection
Darwin’s mentor
Great Teachers often feature in the development of Great People!
Fundamental role of Diversity &
Selection
Reference: Michael Balter (2007) Seeking Agriculture’s Ancient Roots, Science 31...
Selective breeding is a powerful tool
ESEB Congress, Uppsala,
Sweden, August 2007
Domestication
traits: traits that
distinguish seed &
fruit crops from
their progenitors
Vavilov 1887-1943
•Soviet botanist & geneticist
•Discovered and identified
centres of origin/cultivated
plants
•Criticised...
Crop origins and diversification: multiple births
Science 316, 1830-1835
ESEB Congress, Uppsala,
Sweden, August 2007
Little overlap between centres of origin & today’s
productive agriculture.
ESEB Congress, Uppsala,
Sweden, August 2007
Nat...
Why is this important?
Nature Vol 418, 700-707
Drought in Africa between now and 2090
Red, Orange =
More prone to
drought
Blue =
Wetter and less
prone to
drought
Hadley ...
Crop Biodiversity
The Seed Vault at Svalbard
Global Crop Diversity Trust
Sexual reproduction in plants
Maize
Artificial cross pollination
Crossing
Distribution of Miscanthus Species
after Hodkinson & Renvoize et al. 2001
N 55°
N 24°
S 9°
China
Japan
Taiwan
IGER’s hunt for Asian elephant grass
http://www.iger.bbsrc.ac.uk/News/9march2007miscanthus.htm
Crossing
• Hybridisation Strategy
• 2n M. sinensis x 2n M.
sinensis from wide
geographical origins
• 4n M. sacchariflorus ...
Selection
Diverse Genetic Pool Increases Depth and
Breadth of Germplasm
• Increased Yield
• Disease Resistance
• Stress Tolerance
• ...
Crossing
Serendipity Natural Hybridisation
Many modern crop species are the result of ancient (or
recent) hybridisation events.
Cot...
Wheat a classic allo-hexaploid
ESEB Congress, Uppsala,
Sweden, August 2007
Science Vol 316, 1862-1866
Wheat a classic allo-hexaploid
ESEB Congress, Uppsala,
Sweden, August 2007
The New Rice for Africa
Monty Jones
2004
• Organisation and importance of Diversity
• Selection is a powerful tool but need to
understand & know what to select for...
Breeding major technology platform for
food, water & energy security
Next steps ?
Proteomics
Genomics
Analytical Technolog...
F1 Hybrids
ESEB Congress, Uppsala,
Sweden, August 2007
Hybrid vrs Open pollinated maize
On the right a
new, hybrid
maize variety
developed by
CIMMYT
with PASS
funding.
On the le...
To put your footer here go to View > Header and Footer 49
USA: Historic Maize Yields
Yield
(tonnes/ha)
6
5
4
3
2
1
0
1875 ...
Gregor Johann Mendel,
(b. 22 July 1822; d. 6 January 1884)
Moravia, Austro-Hungarian Empire
Originator of the concept of t...
A pea flower with the keel cut and opened
to expose the reproductive parts
The seven character differences studied by Mendel
purple-flowered (f) x white flowered (m)
May 2000
Life Science Companies
SeedCompanies
Joint Ventures
Cooperatives
Other Companies
GarstGarstSeed Co.Seed Co.
Decem...
Importance Genetics
Market Identification
by Trait, Crop,
species
Transgenic Plant
Development
Cell Culture
Molecular Biol...
Genetic software & Hardware
ALL THREE ARE CRITICAL IN DELIVERING YIELD TODAY – AND TOMORROW
BREEDING
Strategically breed plants
to create new, more ro...
Wamalwa Farm, Siritanyi FFS, Kanduyi.
Maize-groundnut intercrop providing 5330
kg maize and 1203 kg groundnut per ha.
Thes...
Feeding future populations means doubling the productivity of neglected but
nutritious crops such as yams and green bananas
“Selection works.”
JW Dudley Crop Sci (2007) 47(S3)S20–S31
Eco-systems based approach to
plant breeding
Grass crop domestication – increasing
forage quality
(Mean WSC over 5 years data)
Cultivar Mean Water Soluble
Carbohydrate...
High sugar ryegrass (Environmental/ Quality Trait)
Economic benefits – live weight gain
Environmental benefits – reduced d...
New traits-new sources genetic diversity
Redirection of metabolic hydrogen
Methods of methane mitigation:
Feed
CH4
CO2
Met...
Science has provided the
key to unlocking the
potential of food
Sugar keeps sheep happy, and has
revolutionised food produ...
Conversion of high sugar
grasses to alcohol based
transport fuel
Image courtesy of Steve Martin, TMO Renewables
Harvest
Pr...
Natural Products Biotransformation &
composites
Biorefining Centre of Excellence
The Life sciences revolution
Molecular biology
Computer science
Mathematics
Exciting time
Unlocking the genetic potential
...
ATGGATCTATCCCTGGCTCCGACAACAACAACAAGTTCCGACCAAGAACAAGACAGAGACCAAGAATTAACCTCCAACATGGAGCAAGCAGCAGCTCCGGTCCCAGCGGAAACAACAACAAC...
Democratisation genomics
Roche 454: Metagenomics,
amplicon sequencing, BAC
sequencing
Illumina: HiScanSQ for genomes, tran...
Genes provide the foundation of new products for
farmers
biomass utility?
improved agronomy?
tolerance to cold?
yield?
tol...
Marker- Aided Selection
• Locating
and
tagging the
genes for
drought
tolerance
© ISTOCKPHOTO
DAVID MARCHAL
Genomics and the People Century
Genomics-based research will make a difference but
only if there is integration across soc...
Iowa maize yield 61-90; 90-08
1960 1970 1980 1990 2000 2010
0
3
6
9
12
b=95 kg/ha/yr
R2
=0.51***
b=206 kg/ha/yr
R2
=0.61**...
US maize yields still rising –
why?
-1.0
-0.5
0.0
0.5
1.0
1.5
2.0
1986
1988
1990
1992
1994
1996
1998
2000
2002
2004
2006
S...
78
Scarcity The green revolution
Set aside, CAP changesSubsidy and Surplus
Security
Set Aside
Biofuels
Food Prices
Food Se...
79
Energy
Climate Change
Water (the new oil)
Food Security
Diet and Health
< 1000 1000 - 2000 > 2000
Estimated global wate...
sunlight
plants
plant biodiversity
science Agriculture, Land
Use & Society
Plants provide sustainable solutions
‘ultimate ...
Sydney Brenner
“Which type of science to
fund is simple:
all science is problem
driven and should be
judged by the importa...
In Era of Gene-Based Breeding, Amount of Data Explodes, Accelerating
Ability to Realize Step-Change Improvements
Reference...
In Era of Gene-Based Breeding, Amount of Data Explodes, Accelerating
Ability to Realize Step-Change Improvements
Reference...
Meeting the Demands of a Growing Global Market
• World population continues to increase
• Per capita food consumption cont...
Growth rates due to early years of the
Green Revolution (1961-1980)
0
0.5
1
1.5
2
2.5
3
3.5
Latin America Asia Middle East...
Growth rates due to late years of the
Green Revolution (1981-2000)
-0.5
0
0.5
1
1.5
2
2.5
Latin America Asia Middle East A...
Public good plant breeding requiresPublic good plant breeding requires
introduction of new sources diversityintroduction o...
Performance under
farmers’ conditions
and farmers’
acceptance
Participatory maize breeding in Africa
• Prioritize most imp...
IMPROVED
GERMPLASM
GENES
GenomicsGenetic Resources
Genetic
Engineering
Marker-assisted
Selection
Conventional
Selection
Ge...
Crop Breeding Technology
Options
Ghana’s
Success
Story
• MDG 1 achieved
• Malnourished - 5.8m in
1993 to 2.7 m in 2003.
• Declines in %
underweight childre...
All this is threatened by
Climate Change
• Higher
temperatures
• Greater & more
intense rainfall
• Greater droughts
• Rive...
biology is the science of thebiology is the science of the
natural world & critical to thenatural world & critical to the
...
The biosphere – nature’s solutions
Separate Niches
Source: Naylor R. and Battisti D. 2008 (pers comm)
Source: Global Biodiversity Trust
Maize has more molecular diversity than
humans and apes combined
Silent Diversity (Zhao PNAS 2000; Tenallion et al, PNAS 2...
Selective Breeding is a Powerful Tool
Picture courtesy of Roslin Institute
Projected losses of food caused by
the adverse effects of climate change
(2080)
The idea of blending inheritance
Spermatozoon and egg
contained essences from
various parts of the body;
at conception, th...
Reasons for choosing to study garden pea
• No morals involved
• Can be grown in a small area
• Produce lots of offspring
•...
Summary and conclusions of Mendel’s experiments
•After crossing pure parental strains, the
F1 produced 100% of one charact...
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
Plants and Agriculture - Nigeria - September 2012
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Plants and Agriculture - Nigeria - September 2012

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Presentation by Prof Wayne Powell, University of Aberystwyth, UK
Delivered at the B4FA Media Dialogue Workshop, Ibadan, Nigeria - September 2012
www.b4fa.org

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Plants and Agriculture - Nigeria - September 2012

  1. 1. Plants & Agriculture
  2. 2. IBERS, Aberystwyth Public Good Plant Breeding
  3. 3. Agriculture the most important event in human history ‘The original biotechnology, fundamental to culture, health, quality environment & biodiversity.’
  4. 4. Agriculture is at the Center of Many of Society’s Most Important Debates Exciting time for Agriculture & Plant Breeding • Global food security •Enhanced productivity •Increased yield •Sustainable production • Water availability •Drought-tolerant crops • Biofuels •Yield technologies to help meet demand for both food and fuel • Global warming •CO2 footprint •Fertilizer use
  5. 5. Holistic Research “No matter how excellent the research done in one scientific discipline is, its application in isolation will have little positive effect on crop production. What is needed are venturesome scientists who can work across disciplines to produce appropriate technologies and who have the courage to make their case with political leaders to bring these advances to fruition. ” Norman E. Borlaug
  6. 6. Doubly Green Revolution • The aim •repeat the success of the Green Revolution •on a global scale to include Africa!! •in many diverse localities • and be •equitable •sustainable •and environmentally friendly
  7. 7. sunlight plants plant power science Agriculture, Land Use & Society Plants provide sustainable solutions ‘ultimate green & clean technology’
  8. 8. fossil reserves biorenewables oil...refineries bio...refineries CHEMICALS MATERIALS FUELS yesterday today and tomorrow sunlight plant biomass a solar energy source for manufacturing
  9. 9. Agriculture critical to the future of our planet and humanity •FOOD, •FEED, •FUEL •CHEMICALS
  10. 10. Daily calorie intake in developing world Rice 45% Wheat 29% Maize 11% Cassava 3% Sorghum 2% Potato 2% Sweet potato 2% Millet 2% Soybean 2% Bean 1%
  11. 11. Courtesy Tobert Rocheford and Catherine Bermudez Kandianis Keith Weller Doug Wilson Scott Bauer Keith Weller
  12. 12. •DuPont Food security index http://foodsecurity.eiu.com •Father Green revolution: Norman Borlaug. •Civilization founded on crops •Importance of diversity
  13. 13. Charles Darwin Evolution is driven by natural selection
  14. 14. Darwin’s mentor Great Teachers often feature in the development of Great People!
  15. 15. Fundamental role of Diversity & Selection Reference: Michael Balter (2007) Seeking Agriculture’s Ancient Roots, Science 316, 1830-1835 ESEB Congress, Uppsala, Sweden, August 2007
  16. 16. Selective breeding is a powerful tool ESEB Congress, Uppsala, Sweden, August 2007
  17. 17. Domestication traits: traits that distinguish seed & fruit crops from their progenitors
  18. 18. Vavilov 1887-1943 •Soviet botanist & geneticist •Discovered and identified centres of origin/cultivated plants •Criticised the non- Mendelian concepts of Lysenko •Arrested in 1940, died of malnutrition in prison in 1943.
  19. 19. Crop origins and diversification: multiple births Science 316, 1830-1835 ESEB Congress, Uppsala, Sweden, August 2007
  20. 20. Little overlap between centres of origin & today’s productive agriculture. ESEB Congress, Uppsala, Sweden, August 2007 Nature Vol 418, 700-707
  21. 21. Why is this important? Nature Vol 418, 700-707
  22. 22. Drought in Africa between now and 2090 Red, Orange = More prone to drought Blue = Wetter and less prone to drought Hadley Centre, Met Office, UK
  23. 23. Crop Biodiversity The Seed Vault at Svalbard Global Crop Diversity Trust
  24. 24. Sexual reproduction in plants
  25. 25. Maize
  26. 26. Artificial cross pollination
  27. 27. Crossing
  28. 28. Distribution of Miscanthus Species after Hodkinson & Renvoize et al. 2001 N 55° N 24° S 9°
  29. 29. China Japan Taiwan IGER’s hunt for Asian elephant grass http://www.iger.bbsrc.ac.uk/News/9march2007miscanthus.htm
  30. 30. Crossing • Hybridisation Strategy • 2n M. sinensis x 2n M. sinensis from wide geographical origins • 4n M. sacchariflorus x 2n M. sinensis to produce 3n M. x giganteus types
  31. 31. Selection
  32. 32. Diverse Genetic Pool Increases Depth and Breadth of Germplasm • Increased Yield • Disease Resistance • Stress Tolerance • Grain Quality / Added Value • Build on strength of current germplasm as well as Molecular Breeding and Crop Analytics Capabilities
  33. 33. Crossing
  34. 34. Serendipity Natural Hybridisation Many modern crop species are the result of ancient (or recent) hybridisation events. Cotton Wheat Oilseed Rape Maize
  35. 35. Wheat a classic allo-hexaploid ESEB Congress, Uppsala, Sweden, August 2007 Science Vol 316, 1862-1866
  36. 36. Wheat a classic allo-hexaploid ESEB Congress, Uppsala, Sweden, August 2007
  37. 37. The New Rice for Africa Monty Jones 2004
  38. 38. • Organisation and importance of Diversity • Selection is a powerful tool but need to understand & know what to select for. • Importance engagement. – Journalists to articulate and sell stories!
  39. 39. Breeding major technology platform for food, water & energy security Next steps ? Proteomics Genomics Analytical Technology Transgenic Traits Molecular Engineering Winter Nurseries Computer Technology Plot Mechanisation Quantitative Genetics Statistics Pedigree Breeding Hybridisation Open Pollinated Selection GermplasmImprovement (HigherSustainableYields) Time Plant Breeders use any combination of these technologies to develop enhanced products for customers, and continue to explore technologies to enhance this process New Opportunities for Agriculture
  40. 40. F1 Hybrids ESEB Congress, Uppsala, Sweden, August 2007
  41. 41. Hybrid vrs Open pollinated maize On the right a new, hybrid maize variety developed by CIMMYT with PASS funding. On the left, a local landrace variety
  42. 42. To put your footer here go to View > Header and Footer 49 USA: Historic Maize Yields Yield (tonnes/ha) 6 5 4 3 2 1 0 1875 1925 1975
  43. 43. Gregor Johann Mendel, (b. 22 July 1822; d. 6 January 1884) Moravia, Austro-Hungarian Empire Originator of the concept of the gene (autosomal inheritance) Birthplace of Modern Genetic Analysis Augustinian monastry garden, St. Thomas, Brünn, Austria Brno (Czech Rep.) Experimemts, 1856-1870
  44. 44. A pea flower with the keel cut and opened to expose the reproductive parts
  45. 45. The seven character differences studied by Mendel
  46. 46. purple-flowered (f) x white flowered (m)
  47. 47. May 2000 Life Science Companies SeedCompanies Joint Ventures Cooperatives Other Companies GarstGarstSeed Co.Seed Co. December 1997 20% Equity ExSeedExSeedGenetics LLCGenetics LLC AstraZeneca PLC United Kingdom Mogen International NVMogen International NV The Netherlands Cooperatie CosunCooperatie CosunUA UA The Netherlands InterstateInterstatePayco Payco August 1996 50% Equity August 1996 50% Equity June 1997 $78 M 100% Equity 100%Equity August 1996 100%Equity August 1996 100%Equity Advanta BVAdvanta BV The Netherlands RoyalVanderHaveRoyalVanderHaveThe Netherlands KoipesolKoipesol//AgrosemAgrosem//AgraAgra Spain ItalyFrance ZimmermanZimmerman Hybrids, Inc.Hybrids, Inc. 1998 100%Equity France April 1998 100%Equity November 1998 50% Equity Land O’ Lakes November 1998 50% Equity December 1998 40% Equity August 1998 100%Equity July 1999 100%Equity July 1999 80% Equity U.S. CooperativeU.S. Cooperative System:System:CroplanCroplanGenetics, FFR,Genetics, FFR, GrowMarkGrowMark, etc., etc. Wilson Seeds, Inc.Wilson Seeds, Inc. Sturdy Grow Hybrids, Inc.Sturdy Grow Hybrids, Inc. MaisadourMaisadourSemencesSemencesSASA Novartis AGNovartis AG (SyngentaAG) Switzerland AgritradingAgritradingItaly EridaniaEridaniaBeghinBeghin-Say-Say France July 1999 20% Equity SyngentaSyngenta AGAGDiversa Corp.Diversa Corp. CalgeneCalgene, Inc., Inc. July 1996 100%Equity May 1998 $100 M50% Equity Joint Venture 1982 100%Equity AgriProAgriProSeedSeed WheatWheatDivisionDivision Cargill Hybrid SeedsCargill Hybrid Seeds North AmericaNorth America May 1998 $100 M50% Equity Joint Venture HybriTechHybriTechEurope SAEurope SA France February 1996 90% Equity February 1996 10% Equity PauPauEuralisEuralisFrance CargillCargill, Inc., Inc. RenessenRenessen Cargill’sCargill’sInternationalInternational Seed DivisionSeed Division Corn States Hybrid Service, Inc.Corn States Hybrid Service, Inc. Corn States InternationalCorn States InternationalSarlSarl.. AsgrowSeedAsgrowSeed Company LLCCompany LLC July 1998 $525 M100%Equity July 1998 $1.4 B(est) March 1996 $1.2 B 40% Equity May 1998 $2.5 B 100%Equity Total cost $3.7 Billion November 1996 $240 M100%Equity January 1997 $1.02 B 100% Equity November 1997 $150 M100%Equity April 1996 $30 M 50%Equity November 1996 $50 M 5% Equity May 1997 $242 M45% Equity Total cost $322 Million April 1996 $150 M100%Equity November 1997 JV with FT Sementes June 1998 DeKalb GeneticsDeKalb Genetics CorporationCorporation AgracetusAgracetus, Inc., Inc. Plant BreedingPlant Breeding InternationalInternational Cambridge,Cambridge,LtdLtd.. United Kingdom First Line Seeds,First Line Seeds,LtdLtd.. Canada MonsoyMonsoy Brazil JacobJacobHartzHartz Seed Co., Inc.Seed Co., Inc. 1983 100%Equity Holden’sHolden’s FoundationFoundation SeedsSeeds Monsanto/ Pharmacia Monsanto/ Pharmacia Sementes AgroceresSementes AgroceresSASA Brazil HybriTechHybriTechSeedSeed Int’l., Inc.Int’l., Inc. CustomFarm SeedCustom Farm Seed July 1997 CereonCereon Mendel BiotechMendel Biotech ParadigmGeneticsParadigmGenetics March 1999 16.4% Equity UnitedUnitedAgriseedsAgriseeds, Inc., Inc. Morgan SeedsMorgan Seeds Argentina AdvancedAdvancedAgriTraitsAgriTraits December 1996 $9.4 M18.75% Equity March 1999 83.6% Equity March 1999 $15 M 25% Equity April 1998 $32 M 100%Equity September 1996 $34.6 M 100%Equity February 1996 $72 M 100%Equity September 1998 100%Equity October 1998 $322 M100%Equity MycogenMycogen CorporationCorporation Illinois Foundation Seed, Inc.Illinois Foundation Seed, Inc. Dow Agrosciences Dow Agrosciences VerneuilVerneuil Holding SAHolding SA France HibridosHibridosColoradoColoradoLtdaLtda FTFTBiogeneticsBiogeneticsdedeMilho LtdaMilho Ltda Brazil DinamilhoDinamilhoCarolCarol Productos Agricolas LtdaProductos Agricolas Ltda Brazil Large Scale Biology (BioSource)Large Scale Biology (BioSource) DiversaDiversa) BayerBayerParadigm Incyte LION Exelixis BASFBASF Lynx Lexicon Incyte Exelixis Ag Chem & Seed Industry December 1999 24% Equity 1993 80% Equity December 1999 76% Equity March 1998 50% Equity March 1998 50% Equity 12% Equity BiotechnicaBiotechnica International, Inc./International, Inc./ LG SeedsLG Seeds Akin Seed Co.Akin Seed Co. CallahanCallahan SeedsSeeds October 1993 80% Equity March 1994 100%Equity July 1994 85% Equity June 1994 100%Equity October 1990 100%Equity 99% Equity 1997 55% Equity Aventis CropScienceAventis CropScience AgrEvoAgrEvo Aventis SAAventis SA France ScheringScheringAGAG Germany 1997 25% Equity KWSKWS SaatSaat Mais AngevinMais Angevin France BiogemmaBiogemma France RhoBioRhoBioFrance France PauPau EuralisEuralis France NickersonNickerson SeedsSeeds United Kingdom Great LakesGreat Lakes Hybrids, Inc.Hybrids, Inc. Canada KingKingAgroAgroInc.Inc. Canada GroupeGroupe LimagrainLimagrain France ProagroGroupProagroGroup India Plant Genetic SystemsPlant Genetic Systems International (PGS)International (PGS) February 1999 100%Equity August 1996 75% Equity- $550M Germany Sementes Ribeiral LtdaSementes Ribeiral Ltda.. Sementes Fartura LtdaSementes Fartura Ltda Mitla Pesquisa Agricola LtdaMitla Pesquisa Agricola Ltda Brazil July 1999 100%Equity Plantec BiotechnologiePlantec Biotechnologie Germany 1996 95% Equity 15% Equity Nidera SemillasNidera Semillas Argentina Pending Up to 25% Equity Agritope/Agrinomics Diversa Brazil DoisDois MarcosMarcos March 1999 100%Equity Protein TechnologiesProtein Technologies InternationalInternational December 1997 $1.5 B100%Equity OptimumQualityOptimumQuality Grains, LLCGrains, LLC HybrinovaHybrinovaSASA April 1998 100%Equity August 1997 50% Equity E.I. DuPont deE.I. DuPont de Nemours & Co.Nemours & Co. Pioneer Hi-Bred International, Inc. Pioneer Hi-BredPioneer Hi-Bred International, Inc.International, Inc. October 1999 100%Equity August 1997 50% Equity Lynx OGS AffymetrixCuraGen Maxygen
  48. 48. Importance Genetics Market Identification by Trait, Crop, species Transgenic Plant Development Cell Culture Molecular Biology Genetics Variety Development Yield Trials Product Testing Products Genetic diversity Analytical Screens Biochemistry Germplasm Development Traditional & Molecular Breeding Genetics Molecular Genetics • 24 ABI 377 Automated sequencers • 20,000 Lane per week capacity Gene Discovery Plant Biology Genomics
  49. 49. Genetic software & Hardware
  50. 50. ALL THREE ARE CRITICAL IN DELIVERING YIELD TODAY – AND TOMORROW BREEDING Strategically breed plants to create new, more robust seeds that perform better – and longer – in the field. AGRONOMICS Use precision ag, planting density, plant health protection, and conservation tillage to make acres more productive. BIOTECHNOLOGY Supplement breeding advancements by adding special beneficial genes to the plant. “The Three Pillars of Yield”
  51. 51. Wamalwa Farm, Siritanyi FFS, Kanduyi. Maize-groundnut intercrop providing 5330 kg maize and 1203 kg groundnut per ha. These results indicate that MBILI can produce significant food surpluses. Rasike Farm, Chililila WG. MBILI maize-soyabean intercrop providing 1215 kg maize and 545 kg soyabean per ha when conventional intercrops failed. These results indicate that MBILI is a means toward greater food security.
  52. 52. Feeding future populations means doubling the productivity of neglected but nutritious crops such as yams and green bananas
  53. 53. “Selection works.” JW Dudley Crop Sci (2007) 47(S3)S20–S31
  54. 54. Eco-systems based approach to plant breeding
  55. 55. Grass crop domestication – increasing forage quality (Mean WSC over 5 years data) Cultivar Mean Water Soluble Carbohydrate Content S23 17.1% AberDart 20.6% AberAvon 20.6% AberStar 21.5% AberMagic 23.7%
  56. 56. High sugar ryegrass (Environmental/ Quality Trait) Economic benefits – live weight gain Environmental benefits – reduced diffuse pollution - reduced GHG emissions
  57. 57. New traits-new sources genetic diversity Redirection of metabolic hydrogen Methods of methane mitigation: Feed CH4 CO2 Methanogens Protozoa Microbial cells
  58. 58. Science has provided the key to unlocking the potential of food Sugar keeps sheep happy, and has revolutionised food production, says Steve Jones. Steve Jones is professor of genetics at University College London
  59. 59. Conversion of high sugar grasses to alcohol based transport fuel Image courtesy of Steve Martin, TMO Renewables Harvest Primary Processing (screw press) Juice Fibre Fermentation Digestion Co-Products Co-Products Ethanol potential: ~ 5000 litres/Ha/yr Ethanol potential: ~ 5000 litres/Ha/yr Alternative uses Alternative uses Single enzyme
  60. 60. Natural Products Biotransformation & composites Biorefining Centre of Excellence
  61. 61. The Life sciences revolution Molecular biology Computer science Mathematics Exciting time Unlocking the genetic potential of the biosphere Sustainable food production Plant Breeding
  62. 62. ATGGATCTATCCCTGGCTCCGACAACAACAACAAGTTCCGACCAAGAACAAGACAGAGACCAAGAATTAACCTCCAACATGGAGCAAGCAGCAGCTCCGGTCCCAGCGGAAACAACAACAACCTTCCGATGATG ATGATTCCACCTCCGGAGAAAGAACACATGTTCGACAAAGTGGTAACACCAAGCGACGTCGGAAAACTCAACAGACTCGTGATCCCTAAACAACACGCTGAGAGTATTTCCCTCTAGACTCCTCAAACAACCAAA ACGGCACGCTTTTGAACTTCCAAGACAGAAACGGCAAGATGTGGAGATTCCGTTACTCGTATTGGAACTCTAGCCAGAGCTACGTTATGACCAAAGGATGGAGCCGTTTCGTCAAAGAGAAAAAGCTCGATGCA GGAGACATTGTCTCTTTCCAACGAGGCATCGGAGATGAGTCAGAAAGATCCAAACTTTACATAGATTGGAGGCATAGACCCGACATGAGCCTCGTTCAAGCACATCAGTTTGGTAATTTTGGTTTCAATTTCAATT TCCCGACCACTTCTCAATATTCCAACAGATTTCATCCATTGCCAGAATATAACTCCGTCCCGATTCACCGGGGCTTAAACATCGGAAATCACCAACGTTCCTATTATAACACCCAGCGTCAAGAGTTCGTAGGGTA TGGTTATGGGAATTTAGCTGGAAGGTGTTACTACACGGGATCACCGTTGGATCATAGGAACATTGTTGGATCAGAGCCGTTGGTTATAGACTCAGTCCCTGTGGTTCCCGGGAGATTAACTCCGGTGATGTTAC CGCCGCTTCCTCCGCCTCCTTCTACGGCGGGAAAGAGACTAAGGCTCTTTGGGGTGAATATGGAATGTGGCAATGACTATAATCAACAAGAAGAGTCATGGTTGGTGCCACGTGGCGAAATTGGTGCATCTTCT TCTTCTTCTTCAGCTCTACGACTAAATTTATCGACTGATCATGATGATGATAATGATGATGGTGATGATGGCGATGATGATCAATTTGCTAAGAAAGGGAAGTCTTCACTTTCTCTCAATTTCAATCCATGA DNA – a common language across living organisms in the biosphere genome programmes link understanding of biology to agriculture implications for: - forestry - aquaculture - livestock - arable Contemporary Science
  63. 63. Democratisation genomics Roche 454: Metagenomics, amplicon sequencing, BAC sequencing Illumina: HiScanSQ for genomes, transcriptomes or GBS / MiSeq for amplicons, small genomes, focused GBS and pilot experiments Ion Torrent: PGM for metagenomics, small genomes, BACS / Proton (due Sep ‘12!) for genomes, transcriptomes
  64. 64. Genes provide the foundation of new products for farmers biomass utility? improved agronomy? tolerance to cold? yield? tolerance to drought? flowering time? Genes Protein Trait Product
  65. 65. Marker- Aided Selection • Locating and tagging the genes for drought tolerance
  66. 66. © ISTOCKPHOTO DAVID MARCHAL
  67. 67. Genomics and the People Century Genomics-based research will make a difference but only if there is integration across social & natural sciences.
  68. 68. Iowa maize yield 61-90; 90-08 1960 1970 1980 1990 2000 2010 0 3 6 9 12 b=95 kg/ha/yr R2 =0.51*** b=206 kg/ha/yr R2 =0.61*** Year Maizeyield(t/ha) GMOs
  69. 69. US maize yields still rising – why? -1.0 -0.5 0.0 0.5 1.0 1.5 2.0 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 Source: Defra & USDA t/ha
  70. 70. 78 Scarcity The green revolution Set aside, CAP changesSubsidy and Surplus Security Set Aside Biofuels Food Prices Food Security
  71. 71. 79 Energy Climate Change Water (the new oil) Food Security Diet and Health < 1000 1000 - 2000 > 2000 Estimated global water scarcity in 2050 (from Wallace, 2000) per capita annual renewable freshwater resource (m3/person/year).
  72. 72. sunlight plants plant biodiversity science Agriculture, Land Use & Society Plants provide sustainable solutions ‘ultimate green & clean technology’
  73. 73. Sydney Brenner “Which type of science to fund is simple: all science is problem driven and should be judged by the importance of the problem and the quality of the solutions provided.” A Life in Science
  74. 74. In Era of Gene-Based Breeding, Amount of Data Explodes, Accelerating Ability to Realize Step-Change Improvements Reference genomes for each crop Genomes targeted for specific traits (disease) Genome for every yield plot GENOMES/YEAR
  75. 75. In Era of Gene-Based Breeding, Amount of Data Explodes, Accelerating Ability to Realize Step-Change Improvements Reference genomes for each crop Genomes targeted for specific traits (disease) Genome for every yield plot GENOMES/YEAR
  76. 76. Meeting the Demands of a Growing Global Market • World population continues to increase • Per capita food consumption continues to rise • Consumers continue to demand improved taste, convenience, and nutrition GROWING WORLD POPULATION (B) Source: FAO, WHO RISING CEREAL DEMAND (MMT) 1 2 3 4 5 6 7 8 9 1981 1999 2015 2030 500 1000 1500 2000 2500 3000 1981 1999 2015 2030 TRANSITION NATIONS DEVELOPED NATIONS DEVELOPING NATIONS “To feed the eight billion people expected by 2025, the world will have to double food production…” CSIS - Seven Revolutions
  77. 77. Growth rates due to early years of the Green Revolution (1961-1980) 0 0.5 1 1.5 2 2.5 3 3.5 Latin America Asia Middle East Africa Other inputs Cultivars
  78. 78. Growth rates due to late years of the Green Revolution (1981-2000) -0.5 0 0.5 1 1.5 2 2.5 Latin America Asia Middle East Africa Other inputs Cultivars
  79. 79. Public good plant breeding requiresPublic good plant breeding requires introduction of new sources diversityintroduction of new sources diversity DiversityDiversity BreedingBreeding MethodologyMethodology Traits &Traits & ProductsProducts OatsOats Forage grassesForage grasses Turf grassTurf grass LegumesLegumes MiscanthusMiscanthus New Opportunities but also complexityNew Opportunities but also complexity
  80. 80. Performance under farmers’ conditions and farmers’ acceptance Participatory maize breeding in Africa • Prioritize most important stresses under farmers’ conditions • Manage trials on experiment station and evaluate large numbers of cultivars, • Select the best, and … • Involve farmers – Mother trials in center of farming community grown under best-bet input conditions – Farmer-representative input conditions – Farmer-managed baby trials • Partnership with extension, NGOs, rural schools, and farmer associations The Mother / Baby trial design Collaborative, on-farm evaluation of maize cultivars
  81. 81. IMPROVED GERMPLASM GENES GenomicsGenetic Resources Genetic Engineering Marker-assisted Selection Conventional Selection Genebank accessions Segregating populations Forward/reverse genetic systems Structural Functional Plant Breeding Options
  82. 82. Crop Breeding Technology Options
  83. 83. Ghana’s Success Story • MDG 1 achieved • Malnourished - 5.8m in 1993 to 2.7 m in 2003. • Declines in % underweight children and mortality • Strong agricultural growth since 80s • 25% increase due to area expansion • Maize yield up by 36%, cassava by 50% • New maize, yam, rice and cassava varieties • A pest resistant cassava. • Strong growth in smallholder cocoa & pineapples • Market liberalisation • New rural infrastructure Sources: Development Outreach, October, 08;Coulombe & Wodon, World Bank; Irish Hunger Report
  84. 84. All this is threatened by Climate Change • Higher temperatures • Greater & more intense rainfall • Greater droughts • River bank erosion • Rising sea levels • More intense cyclones • Salt water incursions
  85. 85. biology is the science of thebiology is the science of the natural world & critical to thenatural world & critical to the future of agriculture.future of agriculture. ‘all life depends on sunlight and a green leaf’
  86. 86. The biosphere – nature’s solutions
  87. 87. Separate Niches Source: Naylor R. and Battisti D. 2008 (pers comm) Source: Global Biodiversity Trust
  88. 88. Maize has more molecular diversity than humans and apes combined Silent Diversity (Zhao PNAS 2000; Tenallion et al, PNAS 2001) 1.34% 0.09% 1.42%
  89. 89. Selective Breeding is a Powerful Tool Picture courtesy of Roslin Institute
  90. 90. Projected losses of food caused by the adverse effects of climate change (2080)
  91. 91. The idea of blending inheritance Spermatozoon and egg contained essences from various parts of the body; at conception, these essences somehow blended to form a pattern for the new individual Ideas in Science come in fashions called paradigms
  92. 92. Reasons for choosing to study garden pea • No morals involved • Can be grown in a small area • Produce lots of offspring • Easily identifiable traits • Produce true-to-type when allowed to self- pollinate over several generations • Can be artificially cross- pollinated
  93. 93. Summary and conclusions of Mendel’s experiments •After crossing pure parental strains, the F1 produced 100% of one character. •After self-pollinating the F1, both characters showed up in a 3:1 ratio. •Because the same types of ratio kept coming up, Mendel believed that there must be some mathematical formula or explanation for the observed data •The first assumption made by Mendel was that there must be a ”pair of factors” that controls the trait in pea plant. This “pair of factors” idea helped him formulate his principles

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