Monoclonal Antibodies

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technique monoclonal antibodies, uses of monoclonal antibodies

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Monoclonal Antibodies

  1. 1. Describe: Monoclonal Antibodies b.stev
  2. 2. USES - <ul><li>REPRODUCIBLE WORLDWIDE - laboratories compare results </li></ul><ul><li>cleanses bone before transplantation </li></ul><ul><li>some disorders of the immune system are treatable </li></ul><ul><li>uses in studies of medicine </li></ul><ul><li>some tumours are treatable (only attack specific cells) </li></ul><ul><li>sensitised to target antigen </li></ul><ul><li>targets antigens on parasite external tissue (vaccine production) </li></ul><ul><li>cancer treatment (binds to cancer specific antigen) </li></ul>
  3. 3. PROCESS of PRODUCTION - <ul><li>MOUSE : injected with desired antigen that causes the </li></ul><ul><li>immune system within the mouse to produce antibodies </li></ul><ul><li>- MOUSE is then killed for it’s spleen (production site) </li></ul><ul><li>THIS IS THEN </li></ul><ul><li>MIXED: non-immunised cell from another mouse </li></ul><ul><li>& placed to certain tissue culture > 7-10 days </li></ul><ul><li>pool of antibodies form, many varieties can </li></ul><ul><li>be grown and separated - each with different </li></ul><ul><li>amino acid groups > these can produce endlessly </li></ul><ul><li>MIXED: tumour tissue - growth of fused cell known as, hybridoma , specific use in tumours </li></ul>(National Health Museum, 2008)
  4. 5. <ul><li>Chron’s disease & rheumatoid arthritis </li></ul><ul><li>ACUTE rejection of kidney transplants </li></ul><ul><li>prevent coagulation in coronary angioplasty </li></ul><ul><li>ACUTE myeloid leukaemia </li></ul><ul><li>B cell leukaemia </li></ul><ul><li>Non-Hodgkins lymphoma </li></ul><ul><li>Anti-cancer treatment for specific breast cancers </li></ul><ul><li>Rheumatoid arthritis </li></ul>MORE USES:
  5. 6. Bibliography National Health Museum. (2008). Monoclonal antibody technology – the basics . Retrieved October 23, 2008, from http://www.accessexcellence.org/ RC/VL/GG/monoclonal.php Wikipedia. (2008). Monoclonal antibodies – wikipedia, the free encyclopedia . Retrieved October 23, 2008, from en.wikipedia.org/wiki/ Monoclonal _ antibody - 94k -

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