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-{AIUARf-JUI{E,                                        r       ENGLISH                 UARTERLYThe First Abstract Jo urnal...
II    .          AAMRA enters 2it. les of its irczinot fle frst ad second *s1ta of $trm. - 2 se        -qU tog"6o fo, wsfl...
Ih. KC. CI{IEXAR                                Ih. PC_ CtloutltuRtcrll      n u-a!r4us Ri,V   (Delhi)             Fc.ns  ...
IIe udds......           ,4A,a U        it+!; g;n     it:                           Thc nntn obVtnue r bcttg at-          ...
iit a nore cortprehetsiue and effectiue   wal ltis dLo {dtifli gthat AAMM i pntid:ng1ab         I am well aaare af the dff...
2-1&2-AC-O0r    IN ITRO TESTING OF PLANTS USED IN TEE INI}IAN SUB-CONTINENT FOR                                     TREATI...
ln ali_ 1J3              {ca 90 p€rceni oiofcgm.pgunds thal rnulal indicate the degree ofroasting                         ...
rofo.m - ether erlrac! were subjected to IR spectrophotometer. Its abso4tlon psks and finger pdalrcgion ivere compared to ...
2-1&2-BK-010 EF9ECT O} STORAGE AND DOMESTIC PROCESSING ON THE CONTENT ANI)     COMPOSITION OF FL{VONOL GLUCOSIDES IN ONION...
2-l&2-BK-013     GOOB DIANUFACTURING FR{CTICNS (GMP) FOR AYURVEDIC, SIDDIIA .dD  {-N-dI F{}aDICINES: TRAFT PROPOSALg: REG....
Palygonatun ciththli tll, P wftiilaholt, I igna pilosa.l: turliata, ,Ial6is nrdfeta,     II ac      inata        and, Glyc...
2-l &   2-ItG-1,21)ANTIINFLA}I}IAIORY AND ANTIPYRETIC ACTIVITY OF MICHELTA CHAMPACA ,-.]V?V., (WIIITE VARIET,IXOM BNACHIAT...
/   Therr fu$ft cionnE $ill conslitute a ajor ad*nce Taste trmsduction !pica11t utilizes two or                           ...
2-t & z-DG-025   SELECTIIE GROWTH INEIBITION OF A EIMAN MALIGNANT MELANOMA                         CELL LTNN DY SESAME OIL...
2-l  PICROLIV R,OGULATES LIPID METABOLISM IN PLASMODIUM BEBGEEI IN                  DUCED LItsR IAMAGE IN MASTOMYS CAUCSA ...
t4e2sa2J       CARDIOVASCI]LAR EFFECTS INDUCED BY VENOM OF SCORPION (BUTEI]S                                        TAMULU...
slns oI bodv $€isht tb.$,t)r rwice a weekJ rdrceal acute hepatic nec..sis in liuss albino icc 0nil.5.s,t. l0 ams + 21. CcI...
2-1   & 2-DG-034            PHARMACOLOGICA]- PROrILE OT TENDER COCONUT 1VATER Hdju€t Singh Rahana & Motrpurkar, B.G. Dopl ...
-!:€;j.:                                                                              lllid?gTq t*dj ee.tiir de..€ases to ...
2-1&2-DG-039  STFTCT OF PICROLIV ON IMPAIRTD DRUG M{TABOLSM iN CARBON Ti]TRA-                                 CHLORIDE TOX...
femaleralsThelenaless!ro]e.Ircjecdonan.l€xhibiteil.lecfeasedloldoslswhenmalesattemPaedi":In"."i.n" itJ* "r teectiois ;diga...
i{a-                                                                      ABSORPTIONAN PERMEABtr-ITY CHARACTERISTICS OF PI...
2-t&2-DG-O47 ANTI-INFLAMMATORY AND ANTIMPAIOTOXIC AbTNTTIES OF THE ROOTS OF                            MORINGA PTf RYGOSPE...
c!|cnrrageenin-ndrced oedems inrats. If $as devoid of analgesic, s€dative and tnotor incoordiMriryactivities in mice. Hoi!...
and calrhsc (Udf) rcltlilics in nricc. Whilc l5 drr lrcinn,eol iLh Asirugrndhi rool po$derdid llol produce aoyiigrifidlrt ...
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Aamra v2-1&2

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Allied Ayurvedic Medical research abstracts, volume-2, Issue-1&2, January- June 1998

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  1. 1. -{AIUARf-JUI{E, r ENGLISH UARTERLYThe First Abstract Jo urnal Ayurveda rBESr9 Tl SRI VEI{KATARATIA PUBLICATIONS TlnuPAT|, aP. tNDta Strltr tt : (M nA nono Fitot http://ffl sll. gg0cltGs,c0tn/C0ll0!GParvLab/5l 41
  2. 2. II . AAMRA enters 2it. les of its irczinot fle frst ad second *s1ta of $trm. - 2 se -qU tog"6o fo, wsflt aJ j,r;r.ds snn fu{iti.s. It hop* tz sulsd$as mL nofurs will altnit it posinre?, We wprus pkaswe a actnowknge $e Do61r lntie Lti., DeIhi [q t!&1.t covetLl sttlpoft E cosponsotLng de AAMRA pbtia*ns. AAMRA i1.oryotut6 threz aswer co(umtLs iorn t6ir irsue. Ee atts k onz cotumn tkngk whnh erpe*s ant. esletizln?t in tU flcU .r<press th2it imytessions oni i^tllngs ftIotet a vemchhg in Atwdo, Dt. K.C. ChtneLeI, Glsu in DrE ydtul,lt v$onas, Intio has Ay fledL ftsearch. lfuy not or$ yrovi{e o ltecti.olt to dtr AALTRA altiliE fut ako mFarcts dE $ility scope oJ AAMRA. . "AAMRA Atlt, corsiJtr tie titlsr af dwzt stnirct at Pc irutilttioru. It oirns at fiifgiig 6. anong Ay|r,.elX iLstit tioflr, rfJelrcturl ont .aruJa!itrets. The "*it6og 9q .rlrdta/lirAriln gE is rconiry duptka;nn $ fts?aieh &,ML ift se,leryI Pc ir$riurtioru d AJlttrz&L TL cohnat oko irpx& to irlsdll i. tfi€ dorumefiatkn oJ rceatcfus contuttl at l.fi]otts A!1tfledn irutillti.ff, se1,em, ns6. ilsx sulmittel 4 d" yottg re:ettchtrs go a$o*d &. to tnsrftiEft doctLrri,er*atiofl fr.ititii, AAMRA is fod E introd.a ing tAe fist *- yttqftttt the csent tlses ti&s. n alryak to all the rost gtolllare ka&qs otd "!* "J sclohs to nait $e ti/,s att a6sfiaLts of {re d:esa< sulmiwt at &eir e:tentl ;:rs&tutions gtw lor ttls cohltrlll tn orls ta sqqft dE a.niE snd agrfli.et ftttanhing it AJ,ttr||.&. Eot txas cAnUt axalysx of Ayw,redX hsbs ts con&Et t .,igorou:ty in search urny moksth:. rle plrytocfienXal d **a aiuz offitsk ope&s ,esh vistas in &z {onoin of +wdt &!g staxdlddkatiafl, tPfrytaehetfltal Prerlelr" o&sts dE conbtus oJ Aluye& e qlarrn fon 6me to ttme. Tltzse chzmnats with o fuowt sfirf]trfle ftry yo1lide o quXE J hgi t 6$is 0* d1e e&leinafltal bt fot fs@idrE *u nodw oyerontl. oJ fu &bs AAMRA UAAMRA P&ron" schenL ant. tL{e tutrdcnptiotl foi ,tnoll]n{rs i#!i&!aG to nwsw a frorcral funlnt;nn, url en*re nsw:rl.ce fu df attl,iE kee yory. N.e). Altu W** to dr. ${ at.b a.lfl{f ?art[ieote ir its mirrion of organilet Fq6s E i.y,svefa for tirpensiig tt wa goo{s to eilhg a { hta{tIty in Mdving miqs11im, tu : 09-01-98 &. : -Tia{oli chi{ Elitat. ry4n-JALX 199t AAMM . II/II!2
  3. 3. Ih. KC. CI{IEXAR Ih. PC_ CtloutltuRtcrll n u-a!r4us Ri,V (Delhi) Fc.ns Piqd Roaess.r o{ Menicine&aS- 8l.U- rcnBg Col€ge tEil y S.itrc€s rrupat oa 0r- PJ RAJt}- L SIJ{.EEVA RAO Addilional Di€cb ( y.rEda)ClEiiE! R€daliofl Commiltee CCIM Govt oftrP,lttid€r*adCtEftlla! nryuvedjc Ph.fi aco?eia Commitl€sNd D€! Dr. s.P. olxrth_ sJ( SHAR A T.T.DS- S.V Ayurvedic Collese, Tin$ati Dr. CHS. SASTRIRed GDs Blildings, New Delhi Natonal hstitute of Ayuveda, Jaipu.OT. A SNARAI,KRISHNA Dr tl R GOYALSrs€on lo Gov€.no. ofA.P Di.ecLr CCRA & sRaFha$an, HydeEbad J.N.lnsliMe oi lS.M.. N* Delhi0r. C. SURYAPMXASH RAo Dr PREiI KISHOREDarecto{, SVIMS Dir.clorIirupaf Cental lndthle ofAyu edic Researcn, Nelv DelhiDT G FANDYE Dr. K.V DAKSHINA MURTHYAsst Dneclor lndian lnsliMe ol Drus Research Head, Oept of Neph@logyccRAs, Ranikhel (U.P) NIMS - MerabadDr. Vs. PAIIL Dr- M. SIVAIIANDAMRinchal. Ayurvedic Medical College Ex€dive Member, CCIM, New DelhiBidar (Kamalata) P6ident, All lndia Aywedic collese, A.P,D.- VK. JOSHIH€€d Dept d Dalyaguna Dr. c.K. XIATIYARh$tub ol lvledical Scienc.s, B.H.U., VaEnasi Dabur lndia Lld., New DelhiDr. A" JAGAllAlHAilAsso. Plofesso., AgDnomy 0r. s.l.{. YOGANARSIi/IHANGoit Agricultral College, i,tahan€ndi (Kumool) sr R.O. & Head RRc (Ay.lDr. D. GUNASEXI|AR Uedicinal Planl oivision Bangalorq Dr. V.Y PRASAoDr. APPARSI, RAJENDER Rti.rd lHe64 H. d l]rdr€eA< fd€sr, Co eg€ o, PtEmacy sV AI,vdc C{arge, Tnp{Sdft Dato& Univ€.dtyF!.liEs (SD) U.Sl, AyinEdc REIE Aeb CcEita-rtNLuw - Jwz t99t -4a)tl^ - E/t&2
  4. 4. IIe udds...... ,4A,a U it+!; g;n it: Thc nntn obVtnue r bcttg at- ^ ",o,,,/ 1",,.u1 ,,,p,,ut conplihed by proritling I to dak i f;rnat;an re&nling rcsearchet conducted all oter tbe p,ltituh,ly ,uorl.t u,it h rcktion to Indian nedicixe (Aturuetld) uhich is nostj based an herbal me,lutnc. l)te to adrttt rcactiott antl toticitl peapb are tffnin{ again tlanrd, onl fb me,llca I purposc butin ewry passiblrfeld conneaed ui th lfe. (Cosnetolugy, herbs not Agronontt. t, olng and Dt. et., et. ,t-4,4.{M jouna/ispra dingcanent iLJinnaaon bl which all bene/iciaries can utilisepropn$ the aseful pnperties ofherbs ttith utrnost carc. In our standard slttems ofmelictne, Le ger rcfrencet an/! t0 djiw hundtdphnx being utiliselfor medicines andfiods. Yheteas oar clunr! hat d Jlo,.a af uarious narute consisting of thausands of pknts uhlch can be utilisett afer ptoper scrutin1. Yefnd that thousand: ofphnx are s l being used fu tribalpeopb and ethnic graups dwellixg in the remotztt dre4s of oar country. Basetl on their ttaditional experince for htndteds of1earc, these phn* arc bei ng ,u fuccred ra t esent th. Thefa;tfil renk ILILA be utllted tu tElace thz clasial drugs and ued a; substinte drugs. Thb uill rcduce pressure on the tuell &noux cl.asical pknts. Alunerla Las recommelTdel toiJ. tubttitute if the oigixal it xot arailabb afer prcper tmdqt. Charalea sals that there rho trabtta?lcc tuhich l)dt fto medicinal oalue axd an1 plani subsmxce can be used aftet smtt1n1. A,4MM it prnidixg asefvl infamation uhich is quite eaE to tefer. h is agaix giumgenco*ngement for firther letealch and uouU dho preuent dupbcation af rcearch whichbas bcen a probbm for the difetent institations of aur coantrl. Na doubt, INSDOC iprouiding authenii ixfotmaior 6ut it it not easill accessibb for genenl worl<ers paticu-larly fot those aho are worlzing in post grad.aate depattment:t oflndian systems afmedianeanl Raearch irctitutes ofdiferext aancils urh asAymeda, Sidda, t-lnani and Honeopatlry.Thi joumal uould be utilied by thae ixstintions and unxecesnry repetiion in researchaouU be aooided. Research scholars wouldfnd it oery helpflfot sebcting *itabb probbmfor thcir thaes as disscrutions at difcrcnt leuels. Another uery important uil*aion of.4AMM In the Jear may be dt a eaching aid.1969, Ip blihed a booht t, VANAUSHADHI AIVLISANDHANA DANHIKA ndllixHindi,fotprwidingsuchrevarcltinformatiox.Nowlfeelthat,4.4.a.1RAisfl[ttingthe.IANUARY . JULY, 1991 AAMIA - I/1&2
  5. 5. iit a nore cortprehetsiue and effectiue wal ltis dLo {dtifli gthat AAMM i pntid:ng1ab I am well aaare af the dfficubies and obswclzs acadctnic as wclJ as fnancial fot ondettahm as honoraryjob l am abo teminlcdpetforning stkh b&tiogtdphicat wo* being"n.ii ,*-pt Arc lo,g bak i thi l1 $te semi-garnzncnt bodl *t!fy" norori qa/ lihe AAMM swf Crun"it *rt no obuious resulx It is onfi tle daotcd pcoptz boli6 *ho ,o, prr1o,- -orh *otb ;fful$ *sistcd b7 fzaflciat anl hcb fo/1 ofrcial I oz utlzt thc Minioy of Health btt abo sch othet hapz that the Cottncik not al hclp so that permanatt futly paid saf ,"/otu,/ boko .oot ! p*uidc stftirt ftuE liheconyter INTERNETfatiIiE ctc i iasti*tcd an.d*ch asefil ai t modern ameniies )ork *ouh ronnr* fo, etr uidt beazr raub. Thcsc go* bodia nz1 ako help b7 subscibixg zt voninal ?rit" tu their conccmel )-i* r,,i-r, "f ,*,, of AAMMfor d;str;ht;ag I heartill congrznhtc the flitarizl antl other for doizgap cxatlznt saf of AAMM pctfoming tht iob for the b"ne,m)t of manhind" Mal Lord Balaji shouer hb bissirys for umnre sa thnr hi oun oeaion beaefrcd i Vaaanasi, 2t 4.98 K.C, CHLNEKAR) DR.K,C,CHU{EKA& GURU IN DRAWAGL]N. VARANASI, INDIA AAML4.IM&2 JA.IIUARY . ]UIY,1993
  6. 6. 2-1&2-AC-O0r IN ITRO TESTING OF PLANTS USED IN TEE INI}IAN SUB-CONTINENT FOR TREATINC SNAKEBITE. Houglton, P.J Slari LP.; Tifese, S. (Pharnlcogoosy Rese{ch Irbonlories. Depanmeol of phamacv Lhp r olkee I oidon. [4bn.ee R@d L.ndor ss.n ot x ).updnkct ah.t poods. m? Ehlaphamncolosical Apploach. 2"d Europeablco a.tdrn on Ennophamacatog,, p. Aa,24-27 Marcb 1993. Heidelbere, cerhany Aqueous extncts of the roots of Rauv-oljia serpenttna (Saryogandha) and R.canesce t, Ophiatthiza nungas (Sarpaksi) Cassia tora (Chabandia) ,hjch alt hae a rcpularion of us€ ^nd against snalebite in the traditional medicine of India and Sii Lanka irere resred against carpel viper (Rajanaktha) (Echis carr?at s, and Najd species venomes. The e1ncts ofop hithizd mungos ad Carsia ldra both gale a decrease in cottncture and an incre3se in hme ro rwrrcl btockinduced by enom and so inhibitor] etrect on the cobra venom is srggested. The Ranouia enracts jnduced coltraction per se and so their ettect ill ihe prcscnce of venom could not be assessed. The test 1or proloryaaion of time to blood-cloting induced bt t.a/ttalrr shoFed that all foxr exUacis gave a dose related response. Cassja tora and Aphiarhiza n ngos exiacts gave the gr€atest efects when premixed $ith the e ou. The €fecr of the Rarla/t& exlracls was indcpendent of this taclor so lhey may inlefere with the blood-clotlirg cascade its€lt This indicate thar O . nungos and C.toru ext{acts counteracl thc enons of bolh trpcs of smkes inicstigated and the efect of the a1ro species of Ranafd an the blood clotting process i riatcd bt, Lchis carinarus rJnom indicate that compounds might bc prcsent in the erlract rrlich ha,e some neutratisirg cffect on the vcnom ofthjs snalc 2-1&2-BK-002 HERBAL REMEDIf, S THROUCH GMP/HACCP TECHrIQUf, S Nhvana D.BA: 8!hH B. dnJ Katitar (.K: lLhur Rcscrir t.unda on .ll ie V ahrb.bad. 2r I .t0ruP. hdib .|te trt.tu pt tn Thc need of classicnl rrcllrods and cood n,anutrciunng practrccs tCMCI rn AIrn€drc Hctatmedicincs .lle discussed ir)dci.]il The aurhors ha,e suggcstcd to ,dopr "Haard Analysis and Cntj;alConlrolPoir!" (HACCP) for AilJn edic dftgs n lso. HACCP has been madc a nundalory rEquircmenrfor thcproduction. handling. storage:rnd distribrtion ofproccsscd foods in their domesric as wcil asexporvjmpon markcts World srr ndnrd bodics such as Codcs Alimenhrius Comn ssion,WHOardintcmalional organisalions such :]s FAOruN. WTO ctc havc decicdcd lo use HACCP as ttrc.basiclool in quali4 assura cc,nd irspeclior ofproccsscd foods - The back grouod. principles. irplultillion ofHACCP arc discusscd in briel A ncwprcvcr-tie drug car bc dcvcloped b follorving F.rnn io consrnci .stralczv sugqcst€d to proccsscd foodsbeca s€ thc nnlo.ih ofllc Auncdjc dnrgs arc origincd in plrnrs ntikc foods 2-l&2-BK-003 ANALYSIS OF VOLATII,E COMPONANTS DERIVED FROM RT{W AND ROASTEI) FqRTH-ALVOND rC pentS rSCt LETt L.r. Cartakjo, ll.J.0)lRdnr Wild l.oundlllio. Iidcr re.1.69 8 hcidetbcE. cctuan) Ja na! .)f t,.,,,14,.,t ,,,. t.,.1 r.,,;r,r t,.. ftxi.r,y,., tr Voirl ilc aronrn conrponcnts ol ral} c.l fi h N h ond (rvrgdrar rsr., rnd those dcvctopcd rr aro?rsling p.occss 1 €rc :r nrlvT.d b gr s ch roIitogftrphrlnnss spccl ronrcl rr to dclenninc l he idenlitrJ.4 NL:,4R1 -.t Ut.y. I 9qt
  7. 7. ln ali_ 1J3 {ca 90 p€rceni oiofcgm.pgunds thal rnulal indicate the degree ofroasting as earth almotrd lolatiles for reported omponents,i," arjr i.otur"t n rr" poruvell ialenufred of $-hich I 18 are,ir.i,*i..it.*"i"n"ro..ompoundsIdenuledrnrareanialmorrdserealcoho;strhereaqin thet""*J"*f. t.*4 u" fiajoritliof the Yolatiles ilenlifrel suggest the flalor fodlatiofl is Yia ."""i"., tt:trt o,ra;ines contribudng directlv to the roasted flaror of earth alflond"rJii;i 2l&2-BK-001 lN Ef,ARTWOOD A RAPID TIIETI{OD OF ESTIMATTNG ESSXNTTAL OIL CONTENT OF SANTATUM AI-BUM LINN.- A Ni rbeag!mj:":^11 soznra,anararana. KH : Ansdi vG t Rsjchrohtr" uror) 1"-li ll: o".-.*... tn- n"uiture ol lYood Science ed Tecbnolog Bdgalo( i6Lrour KamaraNa ?:t4r :rl_ll: Cuaa Sa?4" P 1e97 Sandal ood (Ci ardat4 br I rs generall] obtained bt h_lro or sleam distillatron ofpoal d€red rr"u^tJJa. eo;uti"n oi oil in a s;[ quanti! of hezrtivood po$d€r is difiicult bv the conl en- nlate- ffi;i;;;*;;ii;;;;"tl"il HoBever estimarion of oil in a small quantit-! of heafl$ood ;;;;;;;i;;..1 ;g of oil is rcnilereil sirnPler quicker and fairl**i: LlIq1* .".,^ninn."r"rmeasuringoplicaldensltlal2lgnJntmas)onheaneellacrols$dJlpo$oer usetulin ratid ;fi.;;;;;.;;,;;;iim? ahe ampr correton selectionthismedlod liould be difierent ptor_ Hence oiplus trees amoflg ."."..i"" t""A"f pfrti" for their oil conreot an! in "i 2-l&2-BK-005 ROXB): FABRICA- CUIIINC OF L.ARGE CARI}AMOI4 (AMOMUM SUBULATUM oF lrs PERToRMANcf, r"l6x ot .c, xEw nnvER AND A CoMPARATTVE sruDY WITE OXISTING DRYf,RS. -!c.€nlr. J. Rash{,ah, B; Nrnjundiah. G: shanLamDar!}atra U l Ctrnal rcJd lechrroec"l t tot )t- Resl"r.h l rure Vtrcrc t?u 0li. Kamaba |J|din |una! JSpis dtd ttohnt . P 105_110_ 1996 I .in,.le nrrf,l convection dn€r that could be easily and trarspoted qas de_ ."", ;;;HJ;;;;." i"ii.Ji.li,,e. *,au** er (i ;nun subutetun) (Bi.h.a(aita) ptanta @ li$Lantled ;iil;i;kk#. il;. il;tr".*"l efficie;c-v orthe do 2 perceno was.much hlgher compared saving substantial tue1 The dr)€r had a i" ir" ,1"a]ii"i,ri"*lrg r,ouse alrver (1 3 percenu thus cap$jes to a 11,".",^: r. cardamtm capsules and tle dme taken for dr.ving the fiesh "ii,j,i "rGr ro p".cenr *as .zr* tllicli was much Iess comparcd to co ertionrr ;;::;;*:#;?;;;;, vas also superiot ro ffiroj. il;;"itg;;f;e diied proauct uith respect ro flaiour and colour rlnt oblained flcm drc other tiro methods of dryhg 2-r & 2-BK-006 MENTIFICAIION Of SOME AYIJRTDIC I}RUGS USING IRSPECTROPEOTOMXTIR 12-Sarclri Nddt .ln,rehdr sinrhr R,m PFktsh I A}!Fedrc & UMi LsboEro U PGovemm€nl " "" i*l*::b00l LfP Lndia) lndlin Ddsr t J4r6:P ioO-rbr 160r "i,^ as Ch*-11 Various sa"mples of drfferent Avurveilic drugs such lh:th:g Churna etacted bv cruo- lll:::l lasfrnufarisi. ,q.fttiaganaha{ist. Abhavdris! Tifala churtra Shibpladi ,1/!ML1 - I7/l &2 .|ANUARy -.lu,l. l99e
  8. 8. rofo.m - ether erlrac! were subjected to IR spectrophotometer. Its abso4tlon psks and finger pdalrcgion ivere compared to standard drugs and the same is aepoded. 2-t &2-8K407 SAIT.RON IN KASHMIR.II: A REVIEW OF DISTRIBUT]ON AND PRODUCTION.thar, A.Ki Mt, Gn4 Gegional Reseltch LtbostoDl CaDal Road, Jmmu l8A O01,IK,Indh) Jornal of Helbs, Spices & MedicihalPlmc v.4(4): p. 83-90, 1997. The proCuctior of safron (Craa$ sativu, (Kesatu, an impo(ant ingledient of Aprvedicand Utranj +slems ol medjcine. occurs prjmarily iD JaJnmu atrd Kashmjr Slale. The bolan]. disEi-butiotr and Eade ofrhis crop along lti eslrmales on production atd soooetonomjc impac,s inKasllmir are discr.lss€d. 2-l DETOXFICATON TECHNIQIJES OF TRADITIONA], TiFYSICIANS OF KERALA, INIIIA ON SOME TOXIC fiXRBAI, DRUGS. si. laskhr& A.E.i Btnu, S.; Umithan, C.M.; Santhoshkmr, E S.; PushPangd.n, P. (Irclical Boteic G€iden dd Rosearch Insutut€, Pscha-Pelode, Thiruvu4hapDrd 695 562, Kerala, India) Fitaterupia, !. 6A(1): p. 69-74, 1997 . ?echni$rcs used to detox8 ten herbal drugs vi., dliospernunt nantanun @anti) (tools,].a!es. seeds), Cdrrdrtr sa tiva (Bhanea) leaves, flo,$e..s, Conniphata iightii (Guggulu) (gam)Caton tieliun (talapaala) (toota slem. leaf, seed), ,arrla sftanoniltn (Datturu) (leaf, flowe!*Ei roatt), Gloriasa &tperba (Langav {tnbet), )uuana pruriehs (toos, (Kapiiaccir) seeds andtle baiis covering the pods, Plunbago ibdica (roots) (Chituka). Seneca/pus anacardiun (Seedk=il]F1s) (Bhaeataka) a1fl Strrchnos n x-,onicalKuprTr) (seeds) are described. Propefties oflhesefug are also en!meraled. 2-r&2-BK-009 EITTCT OT GRJNDING METHODS ON TIiE RETf,NTION OF BLACKPEPPER VOLATILf,S. tEtb]: c.t; Krishnahurthl, N.! Randsh, T.; Rao, PN.s. @(partncnl ol tood Fn8 ne*ri8, Cmtral :..r -chnological Resca.ch lnslitule. Mysore 570 013, Kdnalak^,Ind;^) Jattnal o.f Foad Sciesce md T.cl"tulos, . 3314): p.299-3o1 - 1996. Pipet nigrum (Ma cha) *as ground al four differenl feed temperatures viz. 40 degree C, (2J de$eec! 10 degre€ C and- 120 d€grce C. using hot or chi:led water circulation afuough-a:isr-= Srind€1jacketor direct injection oiliquid nilroge (l-N2) inlo the mill along rith the fccd. The::hi3 ail contert of dre pmducl indicaled thal chilled nater and IN2 cooled conditio retainedai=x s3me quaniry ofvoallil€s (e.56 rd/l{}0 g and 3.60 ml/1009, rcspectively) and powde. fine-!:s Fas grEaler in rhe case of tire latter The gas chromatogriphic analysis of the oils shoeediE:€: riefiion ofmonoteeenes under cryogenic (LN2) and tow tcmpe{ur9 (chilled valer) grind_ -rlirions rhan under ambient and high tenperrtue grinding colrditions.=l!!:tBf - JLL|-, 1998 AAMRA . II/I &2
  9. 9. 2-1&2-BK-010 EF9ECT O} STORAGE AND DOMESTIC PROCESSING ON THE CONTENT ANI) COMPOSITION OF FL{VONOL GLUCOSIDES IN ONION (AILIUM CEPA). Price, KR.i BacoL J.Ri Rhod6, !{-r.C (Bidhemistry DeParmenl. lfttitule ol Food R.s4ch.No.ich RMch Pdli. colDey: Norich NR4 ,ntA, UD Jtu;ot oJAsidfu tul @d Food Anisttv, ! 45(3): p.93&942, 199?. The stabiliry ofthe majo. flavonol glucosides, quercelir 3,4Odiglucoside (QDG) &d qu€r-cetin,l]o-monoglucoside (QMG), s"s s$di€d ia t{-o naie[es ofoll,on (PaId da) that were curedard stored for 6 monlhs inder notrnal commedcal conalrtions and anallzed at regllat inteiwlsOnions $ere also cboked by bioling in water and by ftying in oil tnder nolmd domestlc conditionsApan ftom a 50 perceflt Ioss oi quercelin 4-O_morcglBcosidb dnring the initial &yrng process,titile change in contefl! and composition wis obsewed oier 6 months of storage. Neither boiling norfrying resulted in intercoNersion of the quercetin conjugates or prcduction of fr€e quercetin, al-though a 25 perceni loss overall was rccorded for each process. 2-1&2-BK-011 PHYSTOLOGICAL AND BIOCHEMICAI- CHANGES IN POSTflARVEST GARLIC BULBS AND THE TECIINIQUE OT STORAGf,. Shu an. L.r Yuebiao, L.: Frne, C i Donglin, Z; Yrcning J (Soulh Chitu Ifftitute otBotanv;Academi! .inica- GuangTnou 510 650. chi;a) "/o!n./ ,/ Iropical ah.l S bboPical Botanv v 4(3) pA549, 1996. The g.rrlic bulbs -4l/ilrr! ., atiun (Lasun4 aftet awest *ere stored at low lemperature (l_jC). aorbi€nr lemperature and high lenrperature (35C), and the subsequent efects of storage onphlsiotogical and biochemical changes rvere eriamined Respiralory rale, prctein ard vila{in Caont€nts gr:lduiu incr*lsed as lhe slorage period of garlic bultrs ptogressed at ambient tempefalurc. $hile sugar and dn tnaiiel contents decreas€d mark€dly affer 2 months of sto.age, and ihegemrs of gartii tulbs began to sprou!. Cout.olied atnrpsphere storage (02:2_5 pqcent, CO2:8-10ferceng ai lo11 temperarure (1-5C) obviously i ribited lhe germinalion of garlic bdbs whirh did;ot spro aJlcr 8 Norths of storage. and about 95 perccnl of garlic bolbs obser"ed ere itl go{dcondrions. The slorag€ al high lemperalure in cornbinalion i{r polyethylene packagitg also showcda siNilar effect. 2-l&z-Bl(-t:i12 STANDARDISATION OF ELATICCUR{NAM. Sar.sNatht, A.t Satrk,ri, R.i PrPtn, Vi V€luchrm): G- (Dn.g Slardardisalion Research Unil (Siddtl3) caphin Sd;iv0sr Mlrli D B Rese;th inslitute lor Ar d.dr. Arulnbdkkan. Nladtas 600 106- TN, hdia) .tda A-&eda drd Siddha 15(i4):p 178-181 1994 d! o.f Reseagh nt Elalicflftnam. fl Siddha conpound fonlrulation cotlaining eigil herbal drugs tiz futgentaannatica (Laa st) (flowetb ds,Piper nietun @uncha) (t its). CinMnrcuu €lri, (flow-c$).Taxus baccata (Talisa)(leaves). utitisinn (Sakfianl) (thizomei. Zin.qibet olcinate6uurht) Ghizoncr- Elettaiia car.laDloxtltnt (Etu) (seed) and cine sugar, was prepared and chemi ^Ianihotcally annlyseal to lay dowu slandards- Thin hyer chromatographic techdque was also e ployed toclraracterize the respectire cl€mic1rl conslituenls. The evolved pa.amete* along wilh the chemicalnurkers can bc used for prescribing dcpendable slandrtds to this medicirc. J/INLi.4RY - .IULy, 1998 aavR,t - n/l&2 i I l
  10. 10. 2-l&2-BK-013 GOOB DIANUFACTURING FR{CTICNS (GMP) FOR AYURVEDIC, SIDDIIA .dD {-N-dI F{}aDICINES: TRAFT PROPOSALg: REG.NO,K 1102s/1/96-DOC(ISM) DATED ,,Ttr FEBRU.{RY, 1997Sha.Il::- ILL. (Depdtm€nr ofISM&H, Ministry of Heelth al1d lamilv Welfarc, Colrtun€nr otlidia, i.{.* DelhiI^ab) Phatua Tin.s. v 29{5):p 15-43. t99?. A coFI of Good Manufacturing Practiccs (Cl,,tP) for AJurveda, Siddha and Unari dl1lgs dull3pproyed by Chairnaq A. S.H D.A. B. has been presented- t-1&2-B t4 STANDARDISATION OF BR{IIMIGRITHAl1. Thankllm A.; Radhik!; L.G. (DruS Slabderdisli.n Unir. Ayu rdu ccll€se Urrr I.oj,ppura. Thirui?nanthrpunm. KeEla , lndia) Aryatuidra . . 1A(3) t.11 7 -1a2 1991 Brahmig.ilhaln is a campound consisting ofseveral medicinal pla s and is considded to b€= good brain tonic, according to Ajlrneda tct. GIle€ is used in this pr€paration. Tl,C nelhod is::s..ribcd for rhe detectior oturious ingrcdiems. The plants inglediet1ls include ihe following vr 7 .a.:-: tlis,unt (M.!ticha), tpanaea tutpeth (l htietit), Baliaspentnn nr tdnu (Drrtr, t:6,a -,:1 (Atagt6dha), Alsbnia s.holatls (Sqtapanrc) Enbelia ribe. (l4d niaa). Thc mellrod cm-:::r r.i .3n be used as ore of lhc clhods rbr slandardisation ofthe drug :-1&2-BK-0r5 ETTTCT OF Tf,LPERATUR]I AND pH ON THI EXTRACTION OF TOTAL ALKA- LOIDS FROM CATIIARANTHUS ROSEUS Lf,AVES. $ulh,l.N.i ArchaN Rari: Sushil Kuh$ (cenlral Inslilule ol Medicinsl and /lrcmaric Irlans.:-.i:r:r::6 015. Lr? rndia) Jo flnloIlledtcina! and Ar.ntdti. Pla t Sciencts. l9(2.r p 4-r!r,1ll i!9t The effecl of temperalurc on rhe isolation of lotal alkaloids frorr thc dricd lcacs oi ,-:-:..:hus rcse s (5tu1.!!r/.rrrd) using the mcllod olpartitioning ofalkaloid bascs and thcir s,rlLs:E-. cr:anlc ilnd aqueo spl ses has bcen shrdied Thc nudy rccalcdlhalas rhc tefipcratLrrc rl-::r =i.i.: isolation proc€ss was peforrned. rvas incrcased ihc vicld o[alkaloid also incrcilscd b : :E::.nt ro 0l8 percenr Isolaiion rvas also donc ai two difercnt pH 8.5 and 9.{) and a lnrlcf::-: i.:i obscned on the lield ofalkaloids: thc alkrloid yi€ld ras incr€ascd by 0.()7 pcrccnl ard r-Jnr r<.pe.ri(l JcrhcpH InJrcJ(cd Irorr d 5 lo /rr :-: $:-BPrl16-.f RPTS FRONl CHKITSAMANJARI-)XI TRATMENT OF II{ADATYAYA (ALCO- HOLISM). - Elihb!h. P {Pror Ps Vaier Arlrvedr Collcec. Kotlnlk.l. Ldrrikode 676 irll. Kdall lndia) t!,,rhx,.rI j,- f :":F.I r/-:-r::llr.nlolrhcdisenscscrtlscdduc10lheovcrrseolirloicrtingagentsisdcall ilh r! . nL: S:-r: re.ipi.s fornrad.r rnd moorcchn $ilh thcold lrdlrrcnl lcchniqucs againsl s:nnyrsa:ra Pl:rnt b:rscd ka$Da dtugs $hic[ cure nradaayr h,rs becn dealt xilh Solne oftlre::rj=r.:.: ::-:::n:l iirclndc: /*)/dJ/c,r,.r .l..korlien. l.riti/l.tti(t roylei, Lilliunt paltphrl/ n..,1.i-.]|j- jtll tte:r
  11. 11. Palygonatun ciththli tll, P wftiilaholt, I igna pilosa.l: turliata, ,Ial6is nrdfeta, II ac inata and, Glycyrrhiza slabrc €snb,adhu) eIc. 2-1&2-BP-017 SAVE ET{IIRONMENT-SAVE MEDICINAL TRf, f, S.SEARCH HARMLESS FORMU- LAf. sh.h. D.c.: chudharL B.G.: vlchharljani. Y.R. rDrus sL"nod,di/dt,oo Re"*r.h Prqert. c!l{l Guj&al Aruneda UnircFit! lemnagd 16 108. Gujsqt, irdia) sd./ttta hr,.?d. v 1?(12)r p 9?5-9i9 . 1995. Fomulas of alrugs coftaining leaes and bark heartood root and slems ofptants and prescribed in 2-l diferenl ailme s hate been descdbed. Piamsaring and plant-damaging formulas haye been enlisted s€paratelJ: Djferent kirds of preparations usirg leales for l€rbs iral€ been ubulated. Use ofplanis in difierenl dlseises as menlioned in 1? Sanskrit tels hai€ been enumer ateal. Bolanical namcs of 52 pianls rhos€ ieares ale mainll used and tlrcse of 6 l plants $ ho:€ roots root-ba*. stembark and heatl*ood etc are used. arc enlisted separatell: 2-r & 2-DG-018 OEDEIIA SUPPRESS-1.NT ACTIIITY OT THX STEII BARK OF TyOft1]f6: PTERYGOSPEMLA GAERTN Rdo KS., Mishra S.H., Phamact Deln Fdcull ol Tech & Eneg. Lalabh{van. M s Univ"sit ol B{oda VadodaE:390 001. rdtat Dnss 1997 13(3) 1168. Ponedered drug and the difiercnt e{racts ofthe slernbaftofIla"lnga ptengosper vGaet l fsig.lr). UrloringaceaeJ rlere studred for (herr oedema s ppressa act$il in albino €ts All rhe ertiac. ,lo*ca peal oedenra supplessanl aculrl tithin l$o houts ofcarrageenan rniellion l ln mcrh.rnor. ertrait shosed signlicanl fP)oedema supPrersanl acu rD simrlar lo lhal ofrndsmelhacin at the first hour ofcarrageenan irjection. These sludies, th€rfore. ofier scope for funher ilwesliga_ rions lo (ubslainlicle rhe cldims on dris bark 2-l&2-DG-019 CHEMICAI- INVESTIGATION OF MEDICINAI PI,ANTS Ram€htar Dayrl, CIe,,tJtl DDnion, Forcst ReQar.h Instihtrc Deh/a Dun (hdia) Ildia F testo Idch 1997 Since his eistence on tbrs planel man has had to depend on Natule for sustennce nd sun i al. Medicinal plants hav€ been used by him !o keep hiInself healthy Accordi g to rhe studies on ethnonedicine a;d folk medicine about 2000 species are ne*lj identified as drug yielding planls and are $eil knolvn for their use in about {000 drug industnes of vanous Indian lvst€ms of medi_ cine. Phtlochemical ciamination of a mmber ofthem has been carri€d oul and activc in$edicnts, isolated, identfied are being corently used as altugs. Chemical examination o! hilllcno nnenplor€d nedicinal planis $ill help itr discovering netl drugs The paper also rrclud.s lhe lisl olso re purc acli,e priniiples isolated fron plani sources ird used as drugs and chemicxl consriluents of so e r]^cdtc druEs .IANAARY ..IULL 1998 ,4,111R 4 - II/1&2
  12. 12. 2-l & 2-ItG-1,21)ANTIINFLA}I}IAIORY AND ANTIPYRETIC ACTIVITY OF MICHELTA CHAMPACA ,-.]V?V., (WIIITE VARIET,IXOM BNACHIATA ROXB. AND RHYNCHOSIA CANA (V]LLD.) D.C. TI,OWER EXTRACTR. Vimtla & s.Nag*rajun, DeBdtrrcrt ofchcmisttr: Ilhrtulhid.*n ltnrversil- Tiruch;.ppllli 5:0 014 India ard M- Al,n, T. Sustr & s. Jor! Cnft{h Stjriv sd M ni Drug R.s!rch lNtilltc fo. A}uFeda, Clinnai 500 106. irrdia /td; n J.tntal of tjxPeindlal BioL )gr. r1l 3 5 Decenbat 1997 PP. 13101 3 11 Merhanolrc c1racr. olrlrc floltcrs oll/ .ral/fa. a (l hutryIu), I brothnh(Bdrlh!jhabhedq) a1:d R. ,ard tcrc ftjund to possess antiinflsmNrlory activity aglri st cotlon pcllei grann_lofta ir rals at a dose levcl of 100 g^g bod] eiShl sc The larter tro drugs slored fighera.lriD (AlAl as conrpared lo lhal of.1/. .hatnDam The Iedrrccd lhe prolenl icid phoprlllcglutamate pynvate lransamilase anal glutamaie o:alo_aveiate transaminasd actilitics in iiYer andJer,rrn. A significant reduction in the ascorlric acid conlenl i adrenals lr"s also observcd in d.ug-treated ani;ls. R. cara lvas recorded to possess signficanl rntipyreic aalivi$ fiom lhe fitst lourofaalmidstration. These phlmucologicil properties may be lracetl lo the presenc€ offlaonoids rnthe flo}€n ofthesd planls. 2-t&2-DG-2r PHAR,IIACOLOCICAT ACTIONS OF AsIES PIDROW ROYL. LEAF sirgL a,Ki Gopal N3rt, GeL a-K & Bh.irschans, s.K Depanmenrs ol Phdmanlop h"c Mi;biolog!, Ilstitutc of Medidl Scienc.s, B{as Hiadu. UnireFiv. Vdesi 221 c05, Ihdia- Ildid Jdma! E p.,inatbl A@togt vol J6. Febdary I9q8 pP 187l9l PeEoleum ethet (PE), benzene (BE). Chloroform (CE), acetone (AE) and elhanolic (EE)e{racts (50-200 or 200 mg&g, ip or 200 mg/kg, po) oldnd4bies pindrc|1) (Ttlisa Lhed.l) learesgivetr 30-45 inin before showed lignifrc.anr anti-inflatuna1ory (both agai$t acute alld sub-acutemodels), analgesic, barbiturate h)lnosis potentiation and anti:ulcerogeric aclrvitres in rats All llee(racts except EE exhibit€d h]?otension in immobility in mice rndicating some deg.ee of arri-deFessant activit. Only PE extrinited hpolension ir dogs blocked by auoprne Chemicrlly,e;ractsshowedtheFese;ceofglycosiales,;teroids,terPenoidsandflavonoitls They h€s rc anti-bacte.ial efiect. Ho;eveq toxiciy snrdies indicatad tllat lh€ e1nicts had an er$€nded safery indeThe inveslgations are consonant wilh som€ oftl. e ses of0is plant in Ayrrveda 2-1&2-DG422 TASTE RNCEPTION Bo nd Lirdenanq Flculty of Phsiology, UnircFity of Sa.rmrdes, Homburslsd, Getmnv. Phlsiolasi Ml Raiews 6, No. j W 1996 ?P719766 Recent rcsearch ofl cellula. m€chaaiims o! peripheral last€ has Mmed tmnsiluclion path$a1s involviag inembrane rcceptors, Gprcieins, secold messelgBrs, ad irdn chamels Receptorsfor organic tasunts rc€eived much sttenlioD, b€cause they Fovide !h€ specificitJi of a lesponse.IANUARY . ]ULY, I99E ,44n481 Iv1&2
  13. 13. / Therr fu$ft cionnE $ill conslitute a ajor ad*nce Taste trmsduction !pica11t utilizes two or to mole patlrna)x in p;rallel For jnslance, str€eFsensitive taste celts ofthe mt appcai to respotd (CAMP) sucro; with;drzion ofadenyl, qclase, follo$edbvadenosine 35rcyclic monoptospnat aleperdent membrane evanls anal Ca?L upiake Tte sanle cell respond difelen to some y artificial sw;ercners, i.e., $ith acli"tron of phospholipase C (PlC) folor€d by inosirol l45-tisphosphate (lP.) dependert Car rel€ase from inEacellular stores some bilter lastads block Klchamrels or i*iiot" th" t"""ptor Gr protei4 PLG, lPr and ca relense or the cascde receplor d-guslducin ""u*d" Pholphodiestense (PDE). cAiMP decrease and opening of cAMP-blocked channels Membrane- pe;eant bittertasonts may elicit a cellular tsponse b) intencting wi(h G protertr PLC or PDE of ile :rtove eascades. Salt taste is initiated q cunent flo nng into the taste cell tfuough cation .hannels located in ihe apical membrane EYen thougt basolateral channels may also contribute component of ioiron"lng .urr anrtio" tr,.ough parac€llular palhwlys) ln rodents, iheNa specific less specfic ard nol salt ta$;s lpicilty mediared by apical amiloride-sensitive Na channels, but uroifola"-."*iriu" u.t" exist in addiliotr sour taste may ilr part be medialed by "ompottents Na chamels conalucting protons Brt other meclnnisms certaidy conttibote amiloriale-sensitive. Thus dre traffaluctior of tasle cells generally compnses Parallel pathways Fulhermore The coune adoss tmNaluction path*ays ry ldtl the locadon of taste buds one the tongue aad of speci"" of a"i-ats o ia"ifJ these Path way to understard hoil ihey are controlled and why they elolved to this complexity ar€ majo. goals of prcseft rcseT ch 2-r & 2-DG-023 AI}APTOGENS IN HIGE MOIINTAINS srna:rlta KKt Derence ue ol Pnv ologv & Al|ed Scieaces Jimatu Lutkno$ Road Delhi br Il}Os.Indidh Jotrtdl ofNaturdl ptoduds VAl ll - !995 Spl Isfle fond Area ofinterest in se€nl oiental fiealical system including Aprveda is that ofusing $pple;enb, dietary elements, irerbs anrl minerals for incrcasing phlsical endurance and mental p"riouo"n"". n"t" Itu* teer described as Adaptogens Easayarg & eji Karam of A)u€da) efiect of One e)Qermertal moalel is developed sith albim rats to study the adaptogenic herbal compo;nd. and Ashva gandha After observitrg encounsilg rc$its in r{l ftejyrcs arc gio"o to ZOb tolto had spent one year at higher altitudes (3000 - 6000 M hr) The studv ir. "otidi"t", rfro*" rftur pty"lto-phyiiological performance, physicd perfoflnance ard sensitive indices of to a!€dod oftliee o:,ygen availabiliry to die tissues werc inlrov€d by the h tate of adaPtogensxp .iitn. *uy in ttiift .o*tui"s (4800 - 6000 mtrs). As llese adaPtogens intate Fovided protection stuihes arc aom nigh attituie stress thqv have been suggested as he€lih food supPlemenls These also indicated that Alurvedic herbal Feparations iz. Rasapna ad rrajikarafl drugs as the prepa- rrtion of rca1 value. 2-l&2-DG424 REVIEW ON PH-{TOCSEMICAL AND PHARMACOLOGICAI" ASPECTS TRIBUU TERRESTNS L. ctrora S.K. Ztts R- & Ptb.* D. Deg of Phtinaoglow & Ph!4ochmis^ racul^ Phmtc) Jami Hi6d tl Handed t Divernrv New Delb ll0062 /,dian Dtu+s 3a dt AuEust 97 pP126 The Phtto chemical and pbaroacologic,l studies conduced onTribltles tetristrus (Goksura) 14 to 1986 have be€a reriew€d. IANUARY - laLv, 199E AAMRA - IM&2
  14. 14. 2-t & z-DG-025 SELECTIIE GROWTH INEIBITION OF A EIMAN MALIGNANT MELANOMA CELL LTNN DY SESAME OIL TN ,ITRO. Snith D,E. Salemo J.W., Dep{4ndi ofPhysjotosicai and Biologicd Sciences, Mahanshi rnteDariooal Univa6ity, Fdrfeld, Iowa 52556, Ptustaglan.lins L.tkottenes & Esennal Fdft! Acids. 46(2) : 145 - 50, 1992 Jua. Ayuveda, an ancient and comprchensive system of natural medicinq rccofimelds iegulaltopical application to the skin of sesame oi1 (fild dar), above all other oilE as a health+romotingproc€dure. We eMmined the efrect of sesame oil and sercral o €rvegetable oils and thefu najorcomponent fattyacis of,tlle proliferationrale ofhuman nor;ul and malignant melanocFes gr$oitrgal iimilar mtes in serum-free media. We fol]nd that sesame ard safilower oi!s, both of whichcofiain large amormis of linoleate ili triglycedde form, selecdvely inhinited malignalt melanomagrwoth o,Er lrormal melanoc]tes whercas coconu! olive alrd mineral oils, which conlain litile or nolinoleale as triglycerid€, didnot. These oils t{ere tested at a range of 10-300 micmgams/ml. W€found that of the fatty acids tesr:d, or[y liaoleic acid was selectively itrlinitory while palmitic adoleic wer€ not. These faltyacids n€re tested in the range ol3 -100 microgtamvml Thesercsultssugges! lhat cstaia vegetable oils ri.h in linoleic acid, such as the sesame oil, recoinmended fortopicrl us€ by Allnved4 may conlain selecti!€ antineoplastic properties which are similar to thosedemonstrated for €ss€ntial pollunsrturated fatt-v acids and tlet metaboliles. This suegests tharwbole vegetable oils fiay have poftntial elinical usefuhess. 2-t&2-DH26 ANTIALLERGIC ACTIIITY OF PICROREIZA KIJRROA Bd.b, c.c; c{pra, P.P: Amr Nlfh;?allaib G.K & Dhlean, B.N. Division of Phmacoloey, Cdt al Drue R6deh Irstitule, LDckno*.- 226 001,1rd. Jouftrl of Phnna.olos/ v 29n feb 1997. Picrothiza hlftta (Katuki) is used for dEtreatned lrcpati€ disorders anai allergic condi-dons itr A}]rryeda- PicrolivJ a srandardised fraction isolated fiom rcot and rhlzome of Picrorhizakurro4 consisting mainly ofiridiod glycosides. picroside I and ku&oside sas shown to be respon-sible lor its hepatoprolective and innunomodularcq act$itres Its arltl-pasvve flltaneous araphy-laxis and rnasl cefl stablising aclivities were invesligated in present srudy In order to filrtlrcrestablsh its antiallergic activilv, its efiect i{as sfudred in eryerimenE Lly induc€d a naph} lacijc reac-tion (Schultz-Dalle phenomenol) and on Konzett-Roessler preparation. At 12.5 mglkg p.o., itprolected mast cell fiom degra$iation by 5-85%, when i uced by comp. 48/80 and antigeh rc-spectively, cwparable to the standard drug sodium cromoglycate. Howele! picroliv (10 mg,&gp-o. x 5) could not inhibit Schultz-ale phenomenon n anlgen presensiused guin$ pig i leum. bur in rvitro studies with picroliv (1-5 pglnrl) showed inhibition (10.7070) ofantigetr irduced contracio.dose dependendy. The cont aclon induced by hislamine in lhe nonnal guirca pig ileuln remain€duryfected o]- Picroliv Similar!, in tlle Konzett-Roesseler preparation in normal gunea pig, itfailed to afec! the bronchocofftriction iflduced by histamine or acetylcholine indicating the lack ofetrect ofpicroliv al the posl-synaptic level. In the sensilised guinea pig the b.onchoco$trictionindua€dby egg albumi:n, rvas efi€ctivelybloakedbyPicroliy Tlns it carbe concluded lhat PicrolivShowed a promilrent anti-allergic activiry alrd dral tlle activiry could be due to jnlibifion of phe-nomenon of sensrtisation by irrmunomodulalionJ.4.^!UARY- JULY,l98
  15. 15. 2-l PICROLIV R,OGULATES LIPID METABOLISM IN PLASMODIUM BEBGEEI IN DUCED LItsR IAMAGE IN MASTOMYS CAUCSA chm.ler Rmesb Khama AK & Dha{a!, B.N. Bi@L4}islrv Division md ICMR centre for Ad_r-".a prt"-"cof.ei""l R"*arch on Tradiiional Remedies, cedisl Drug RestNh Instituie Lucktrow_ 225 00L, Ihd Jomdl .f Phatua@los) e 29/1 leb t997 Picrolii the st nalardied preparation ofiridold glycosidesl plcroside-l and kutkoside. fro$Pioorhiza kuftoa (trat ra) protects liler tom damage ca sed by urious hq)atoto$ns rnlndngir"pJ. a"*"g" f"ffo"ln! llasnoaium berghei (P berghei) infection in Mastomys Cauchanr,i cr,rctrar. ihe arrtiondant effects and membrane srablishing aoion of ptcmliv are rePo ed to.,;*t"t"i" ,o,o f.p",optolectire actrvity Picroliv sdmirlates hepatic cholest€rol_7A_hydroTlase -ih. ,"tioity by increasiry the bioslntiesis and secretion ofbite acids in infected"nJr".tor., ri-- -J"t:t is also acconpaiied bv abnormalides of tipid bioslathesis and me€bo-;;;;. "ttot".ai"fir* itf.i"ft tuy t" tiaicted i4 rhe plasrna lipoprolein specuum PrETr]lBork^rcports.tlAt Pil.grrlii.i""il* It u. Carrclta at to"/" parasitae*ia suppressed plasnu PHLA (30%) and LCAT l"dJJ its"A **"i"t d wilh the inc.;s€ in ile levels of lipid and apoprot€in corqo. nelrts of."** oity a"n.ltl t:6-980/d) and iowdensityliPoproleinsl ]0-88%)the liver showed increased forui*J. lipia ,t a pt*i. inhibition of Tc-lipase acliviry and suPFessron of teceptor mediated "icalabolisrioflow iensity llpoprotein Treatmenr with prroliv (6mg/kg p-o) simuitan€ouslyrf,itht"f"af"" i", *" .*l.. irenidcdnl reacuvated the plasma and liver lipol]tic enlnres sEriulaled l]_,rt.i ri:s 1"" d;si$ lipoPtole rn $ irh livei recepror and enhanced ue faecal excretion oliii"l"ia.. "rrr"." t "Jiru "l .ort"a in a return of circulatory lipoproteins towards rhe nolmal le!€l 2-1&2-DG-028 EITECTI!E RAT MODEL FOR TIIE EVAI-UATION OF ADAPTOGENIC . SUBSTANCES Shukla, V; Am!.|, R!Patbaih G-K & Dhawaa B N- ICMR Advarced Cedre Dilision & ?Ej!p!ti, Phsm&;bsy, c;nfal Dss Resch lnsritute, Lckno|.Ind Jumot of Phomacotos) | 29/1 feb 19e7"r I mod;fication cold-hlpoxia-reslraint rat model was de!€loped for ealuating improvement is an €ssen- work performanci_and enilurance iII adverse sLesSll environment which in Physical alti"i of aq adptongens educrance to a stress 1il conditior A nunber ofmedici "ir".r",*tti"i*"4 i" India;yslem of Medicine as adaptogens but due to pi"r" h""" t"* lack of sciontific iuut*rioq tottt clinical, these dflgs trave not achiv€ddue recogniJion ln pteseni anil ;;;$g;ti* 6,;s," ra cenosus iSaavari) toot rerninatia chebuta (Eafitdki) ad Enbtica "rye.ito""td pro_ ,rto^to*ii t*tts extrscts and their liacllon itelE €valuated fo positiie endulrarce "rn"-in" i"t;ne pt"p.ru.. in ,Li. *odel. where restrain€d rats tere er?osed lo iC al 480 trrn$8 atno_ lhemlonic .pr*.i? it.J*"," r" - i*31 deco mpresrure chanber Io such a $Jesstul en ironmml ii.p"*i,*" tl" *t beins to fall Attainmelrt of a oolonic temperatu{e of 23"C was take; "i """niually as the terrnination point ofihe ex?osure. At this point adrenal weigh! ascorbic acid, choles- for its rccovery at rcom terol and brain laclic acid was eshmated Yiah time 10 attain 23C and time i.;;;"i-;. Paaaxei sery(t) nEA<E Po x s d?)s tzs used as sundard lorcomparison- Cmde exrrrcr ol dl for < days shou€d signtlionl rne rhree planls stu.lied in a dos€ of 200 mg/kg p o iJo.oott itv tl5-80%) in all the Paramercrs Further work is in Fogress to l;crlize rhe"uptoe"*. ".ti in th€se plants actr e constituent IO AAMR4 - II/t&2 ]/NUARy. JALY, I9C3
  16. 16. t4e2sa2J CARDIOVASCI]LAR EFFECTS INDUCED BY VENOM OF SCORPION (BUTEI]S TAMULUS) TN DOG Patel BG; Bhr1&, I4l & DNe, Lc." Delt of Pnarnaeology, AR. Colega of Phamacy, Vailsbb Vrdl€{agai-388 l20.To!Mt Pharmaceulicsl ht Lfd.. dd Dept. of Pharmacolos/, Ssi N H L. Mur Med. colicsc dd VS. G€neral Hospital, Ahnedabad - 380 006 , Ind. Joumol of Phamocotost | 29/t feb 1997 The Caralqmscular ef€cts oflyophilized venom of Scoryion {Brl}rt lan r s, were itrves- ligated ir anaesthitized dogs. The Vercln (0-1-0.25 figJkgi.t.) produced$ark€d h]lertensive etrect withbradycardia. Bfadycardia caused by 1€mm was prevented by atropins bul not afiected bt hexarne{bonium or brlal€ral aqotomy. The pressor response c€used by lenort lvas nofatrected by hexamedroniurn. abolsbed in resemine kealed dogs or b) PhenoxybeMamin( Higherdose of venom (0.5- 1.5 rng,&g i.v) caused cardiac arrhlllmias, depressior of ST segmenl and inversion of T ll?ve. Th€ rcsulls suggest tilat tlrc hlpertelNive response folloiled by ir itjeciion of the 1enom in anaesthetized dogs Inay probably be due to release of catecholamifts irom the slmpathetic post ganglionic nefle erldr.Igs- The bradycardia produced qt the vercm which was prelefied in aEo- iia;breated dogs maybe as a consequence ofblocked ofmuscarinic recePtois in the hean Whlle ECG changes caused by vercm may probabl,v be due to direct myocardial injdies o{ due to srmul- taireous rclease of catecholamiaes fiom slmpalhelic and acetylcholine fiom patasympatl€tic nerye endings. .2-1&2-DG-030 PROTECTIW EFFECT OF PICROLIV AGAINST A]-COEOL INDUCEI) MPATOTXICITY IN RAT Slrsrq Bj YiseD P.KSi PatrsiL, G.K & Dh in, B N ICMR Cenh for Adqoc€d Pham@logical Res€eh bn Tmditional Remedies, Division of Phmacolosy, Central drug R€sqch Institute, Lucltow, Ind. JoMaI of Phanacolas/ | 29/l feb 1997. In order to d€!€lgp herba! heiatop protectiv€ agent fo( ueatment of irlcohol induced liver disorders. protective a€-tfldy ofpicroliv the acl "e cotlstituent isolaled form $eplarjJ PicrcthDa htrrca (Katuli) ]i..rase:."l]uated against ethanol jnducedhepadc injury Alcohol f€eding (l-75 g/kg x 45 da]s) produced 25 to 90% alteratiofl in selected bjochemical serum (GOl GPT and ALP) aid li.r€I markars @ipid, glyccgen and protein) Funher, il also rcsulted in 41 & 52% reductioa in viability (as assessed by trr?ar blue exclusion and rate of O! uptate) as well as in ADH aai ALDH levels of rat hepatocltes (€xvivor. Alcobal also induced c]rolgstasis (45-50yo) as indicated b,v rcn bile volome, biie selts and bile acids. Simultaneols teatment widr Picroliv (6m9,&g p.o x 45 dals) significardy rcstor€d (6?-94%) the altered biochemical parameters in senrm, liver end isolated hepatic cells. It also reslored the 14abitiry ofhepaloc-]tes. TheE was implo,ement itrbilialy secle- tion. Picroliv was found to be more poteddBn sil]:mariq a standard hepatoprctectlve agent. 2-1&2-DG.03r EEPATOPROTECTIVE IFIECT OF A PROTEIN DERIWD TROM O4"T,4,VUS .AIICUJ SPRNG ON CARBON Tf,TRACSLORJDE INDUCED HEPATOTOXICITY IN MICE Srmistha Datfa, Swati Sitrha & Printclt Bhtirach.rf,a, D€pt. of ChemtutrJ. Bose Institute. Calcutta- 7a0 oo9. Ind. Jarftal of Phaftacotas ! 29/1 leb 1997. Hepalotolticily by alifieftnl chcmicals is weli kno$rL Li€r has be.ome the primary larget as it is the major site for detoification. Treatmelrl widr carbol tetrachloride (CCl,) (0.1 nvl00i tzru,qnv - nlv, rggt 4,1MPG - Itt 42
  17. 17. slns oI bodv $€isht tb.$,t)r rwice a weekJ rdrceal acute hepatic nec..sis in liuss albino icc 0nil.5.s,t. l0 ams + 21. CcI. itrdu.ed hepatotoxicit-v ald rcn l toxicity irl albino mice caused significanlalreratioiin Lhe actn-rois of glutamii o$loaceuc uansamind{e (coT): glulamic PtTLr Ic lrinslmi-nase rcPT): {kaline and A--cid phosphatase and serum biiirubrn AdministBtion o[ the pmlcinfractotr isoiated fronr lhe ledver df arJd s mdi:us Sprcng (Aada&r Concorulanl tnh CCI,countemc-led lhe action of CCl,on transafiunases, phospbztase m4 rne showing hep3loplolecllonDaily rreatment with apuriied-protein fraction .)c isolaled fromthe abo!€ plant (0.5 n ip conc22-25 pglnf) for a peiod of 7. 14 alr(t ?i days respecrively showed dedeascd activities of seirmtransarnirasis (p<o.of); s€rum acid and alkaline phosphatases (p<o.01) and decr€ased levels ofserum triglyceri-des (p<0.05); serum bilirubin (p<0.001). Histopathological obsenatrons fiL1hd tiit the proriilr ftaction "X produced significa hepatoprotection agaiist CCIa induced"onfirmhepatotoxicitv 2-t&2-DC-O32 INF.LI]ENCE OF AZAI}IRA.CHTA fiI}ICA (NEEITf) LEAF EXTRACT ON TEE IMMI]NOTOXICITY OF STRESS AND XENOBIOTICS IN EXPERIMNTAI, ANIMALS. R!y, At Baoerji, BD; KoDer, B.c 3 Sen, P. DePt. of PlrrmasLogv dd Bi@hemistry, UCMS and G.T.B Hospital. Shahda6, D.ki - I lO 095. hd Jounal of Phamacolog 29/l feb I 997 Avgriety olenvirc nentals stresso$ aie kno*n to inlluence immune fimction and the presenlstualy evaluated tlle efects of leaf er.lracts of -4za dirachta indica (Ninba) (AI Neem) on theirmlunomodujation irduced by rcstrairt slress (RS) and th€ insecticide, DDT, iq rats and mice. Inra$.inrmunizeil irith sheep RBC (SRBC), RC (llvdal:r5) exposure $pprcssed the ant-SRBC antr-body titres, and inl niEathe ilcreasg in footpad thickness after SRBC challenge in mice Boththe;e etrecis were attenuated aft€r oral Al (100mg/kg xsdays) itrlibited ihe antitrody response afldsuppressed the leucoqte igralion iirlibition, intetanus toxoidirffnr]nized mts Alpr€treatment (x6 Week also appreciably reverc€d the DDT induced chaages in the tests for humoral and cellmeAareOimmuniS. In the interac[on strdies, prior RS er?ostre clearly potentrated tlrc othenrieinsignitcant efiec! ofa subtlreshould DDT (200 pPm x 4 weeks) eQosure on the itrmuno rcsporse A]aaalihis was aiso relersedby.Alpreftatment. The r€sulls ilrdicate tllat both shon a4d lollg temrtreatments attefluate the immunoloxicilv of enitronmentavxenobiotic stressors and higt ight theimmunopolentiaiing and adaplogcnic eFect of this itrdigenous medicinal plant- 2-1&2-DCJ)33 ANTMYPERGLYCAXMIC ACTIVTTY OF IiEEM LEAF EXTRACT IN STREPTOZOTOCIN INDUCED NONINSUL1N DEPf,NIENT DTABETf, S Mf, LLTTUS Kaplr Arlor & Srinivasan, B P D.pl of Phma@lorit. Colleee of Phmacv. New Delhi t11 Jonoi oJ Phatuacolos) r 29/ I feb 1997 The prcsent study explor€s the efiect ofN€em (Nimr4 Leaf E{ract (NLE) in Non-lnsuliDilependcnt diabeles ellilus (NIDDM). NIDDM $as iduced by interperitolcal injeclionsteptozotocin (STZ) a! a dose level of90 ffg/lg to 2 d2y old neonakl rals Afler 6 eeks ofSTZinjectron, lats rvere gmuped as nondiabctic, diabelic. fle€m leaferiuact (1 g,4<9. p q ), glibcnclaatde(0.025 mg/kg. p.o.) and lncforlntu (200 ng^g. p-o) treut€d groups The abovc treatmenl wascontinucd for 6 wecks try daily oral dosing cver! moming Tlrcredicr blood glucosc estimalion done by "glucose oidasc method". Bodr NLE and glibetr clamide showed an etenel! signjfi" cantfal G=0.000I.] $hile nlelforn nsho$eda verv sigdficanl lall (p={} 0002) in blood glucose le}el. lt is thus suggested llrt NLE has a potenilal rolc in trear entofNIDDM JANUAIIY. IULY 1998 t2
  18. 18. 2-1 & 2-DG-034 PHARMACOLOGICA]- PROrILE OT TENDER COCONUT 1VATER Hdju€t Singh Rahana & Motrpurkar, B.G. Dopl of Phma@logy PICHS, Dhdn NePal and LNJP Hospital. N€s Delhi, Id. Jouma! of Phanacalos | 29/t leb 1.997 Coca n(Nankela) ,!alet is cheap and easilt avarlable in coagal areas The high nT ttitiYevalue and streile nature suggests its valuable aherapeutic application. A tocievitrg increases the inshelf life withour affecting its nutritile value lnraleoous aallnir stration ofTCW (100 mL&g)<logs ilecreeseil senrm Na;levels and increased K atrd Ca ?* levels ECG l1o{ shoir anyei_deice of hlperkalemia. It diil noi shcw effecl on Psvchomotor And anal€esic alTily R?ealed hd etr€cli€administraGn also did not r€vbal ary allergr or anaph)1iNis. ll is nalurail,r available costhigl y nou.ish€d flui4 ideal for parenteral s bstilute flrid 2-1&2-DG-03s MODULTION OF SPACIFIC AND NON-SPECIFIC IMMUNE RESPONSE BY oe lrrrlu s-{tcTUM Kh.jurj,l, Ai Shanu, M. L & Shamra. O-P D.pt oi lharnacolo-s Res ionrl R$edh Laborulort lamlu aro6.pr. ot ejo*ielcei. Janor Lrivenitrr lan nx hld Jaunat al Phatbnalos v 29tt f b 1997 ac ru t sancfir (Tulai) a traalitionat medicinat plant hclps to creale conditidns favouiablefor the ho$ deferce nainll thtongll the augm€fia1ion of humoral as $eil as c€1l rnediared immrinit]: Besides th€se ellects, O..tdrclr,, (AEOS) slrenglheri the biological aclivities and is used as €alu3te the effectan adaptogen against stresseal conditions The present study $as underlaten 10of I O.ro,r-cr,n on immunc sr stem. It iras obsen ed that oral administation of aqueous etracl ofO .Sdrrt enhanced the anribodv production ifl strcssed rats. when compared 10 control lmmuno-logical d€fecls $1ich lre cannecled $ith the CNS strcss modei lras used in order lo sippress theheiper ceiis. lo increase lhe suppressor e.fect and to reduce fte an!jbo6titre The resulls oflhestudv lrave suggesred that lhe conlinued emploimenl clO rd,cn,t ihich dhetsely afect humoraland cellulaL immuniq {ill contribute to ameliorate lhe suppressiY€ etrect created by stressed condi_dons and qloloic drug. ln conclusion th€ findings otthis study impll thal oral administrauon of, rarcrun can cause tire resloradon ofthe humonl response in immtnosuppressi"e state therebl aLing then prolecti{e fro idections. 2-1&2-DG-036 LIVER REGINER{TiON IN R{TS AFTER PARTIAL HEPATDCTOIIY: INFLUENCL OF PICROLTV - Dh!$ar. B.N: Dntsion ollhamrcoloel and Biochemistn: Cenlnl Dlug Resarch lnstilule Luckno{ )26 001 . t,td JoMtul oJ Phanacolos, t 29 1 leb t997 Regencrnlion oflhe li€r afier panial hepatectom! is one of fie most popular and frequendvused mod;l for the studr ofcell. gNolh and cell diferentlaliofl. T$o stages ale inlporlant in theslud) ofregeneration. The inilial slage. Nhen the cell sritch to the proliferating pool and the endsrage rieithe cells return lo quiescent Go-phase The initral stage is charactenzed b) an rncr:a=in;umber ofceli diisions anal of all nlelabolic processes. The lasl slage dunng lhich mrrttE
  19. 19. -!:€;j.: lllid?gTq t*dj ee.tiir de..€ases to norntl lc1cls. has not bccrr rlrro ghlY irrvesltsrledo:.1!€l rccm::a.]1o:-!e:at* ier,rur-*g componcnls rrcrc es6ruled durilts the cnd sl;seffto.Eo-,l-;09; r;noval of this orsarr rnd the!rul l:P"tf1i"-::]:-lg^:lj on llrosc "n*t:t Mrcrosorril JrLrlrnc lrdro1rr(c impr.:cth {6.6 mgl(gt rvas rn!e(iSalcd onrponLrs Declrre rn glutatn]ofleLtqtioe a"-etf5fase, aclivilics Nas maxinrllv dccrc scd on dr! 2lrt...r,la enutUonci transf€rde act ! ! r as cvidcnt luximall] on dt i 0 Declinc in Picroriv c- I cv1ochrome ro rtrat or hYdroxrase/r.riroplrine dcrnerhvrasc;;;-;f,;;;;i;iJ-,"*"d "ntrre ghr- i-o. tr ,,l; .Lou,eal iirnun protccrioir rn hcp.rric gturrtt,rone ccnlenr foilorved,bro*iono.-or*i"t rnitine hydrolllse. tinrnoprn ne dcrnelh lise Jnd cJ loil]rtrme fr:ll l.rcse "."- :rddrtionil e rdencc thal rt stimu-ti"nio .*n"t tr," t"il""idaoi ;olcndrl olpicroh rnd pio rde lales Lirer regenerrl.rr 7-t &2-Dc-l:t3,l EFFECT OF EUGENOL ON CASTRIC RUNCTION IN RATS Discdse Owisi Med€al- nd viiaral,tshni, Ri ttl. Quad.i, ss & Deoslhle, Gitcntre 1bt iivct 19e7 tl,J.i c.t-. i-o,,-u,eh. IllLletubac 5t)0 25a hrd Jou at ot ]hrntactos v 2e/t leh E (Luv n!a) ts^tr eilcctre ccretdgozuc-rr:::-t:::g g€nol. an actilc princip lc of cloe. at a*" O"p"ia"tr"rgt*"iion oigastric secrclion Eugcnol $Len rdminireredrntrrgssincallv ma{rmurn s€crclol of gastnc frce acid and serum pepsmogcn iu,i,n mat t".i*nt. "rtnulnlcd,t t:ts un ;:;::";:,, t"*;";:;";o,ion errcct on sastnc s€cretion Lons tcrm or31 nr"nrro1 H#i:ff;;il;;; a"." liroo uete t"a ierght per dar ror nree $ecks srg ficatl-v add secrerron ir"t".*tit" t"it^ p"p.inogcn le!.is. which posrti!clv orre-altcd with gaslnc frce exami- il;;;1.;i **" ;,;""proteic :rnd --sntitrpsin renuined unchanged Histopatbological *""-"""n "r""p"rlnt"nur nimaL a;a no1 shor anv damagc to mucosal cell . Thus ircight and ""]u"""i ,"r.r,",." ,""."tion u, o lorv conc€ntralion of eugenot. i.e. pgr(g body "i,*"r" belo$. hoL,rd ldcrhr.llcdrgcrron ?-l&2-IlG-038 INDUCOD TOXICITY PROTECTI7E EFFECT OF PTCRdLW AGAINST RIFAMPICTN vi.en, P.KSi snrt{rari. a P.tnail G K & Dha$an Bl: rMR({uetur Adunf,d P}am&uloeF .,io"--r.-|adi or.dR-.cdcs.rr,rs,ror PFmd!.loF (c_ra DhugRecdch ln:riture Lwknow.Ittd Jouma! of Phaflacolos | 29/l Ieb 1997 Theantibioticrifanpiciniswidel-vusedinlhetrealmentoftuberculosisandlepros}Pro. u""a,* .iFi"-rii* i"! been r€po(ed to cause hepatoloxicrtv Prcroliv th" ili::l:tl::" "ilii"*pi"* n *L f*rftt has earlier be€n reponed to posscss poient hepatoproicctil e.activitv ;;;#;;;;;;"t;i;"tl uv reersing rtre ctranged biochemicallaraneters "9"f1:l:!--ll: paramelers oi nldmprcrn i r rt.a ,o see the c$e-iot picrolil on addtio1al €lclred "?"r."i r,fi *g^s. p o 6) aione rc(utred in 26 r2ol0 reduc- ;epar;i;;-ir""^;;;";i.""r.c,*p.i" ,so gxtnea pig ttalso ii." i"tif" t"ft*" it. major constituents incons:rouirat and rnaesthetized (519") rn ihe Bolated ml hqp o- **"i iicl""" ;t ""a -"urfB (500/) and rate of ovgen uplake ,rt" inbile .,". p.,nl,r re.rmcn( showed dose depenoenr rr-i: mg,/kg po xTi prolectle acdvlq r-rre or andlheir :1;"1;;::;:;:;;;"a-,r." i"".*..ir r. uiriq or-heplto-vesqas less acrive e2285dor in r:-orq" il;:;;;ii;,#!"; mgkgt a standard drug comparison. r.-i" *2" . JULU AAMM - II/1&2 .IANUARv 1998
  20. 20. 2-1&2-DG-039 STFTCT OF PICROLIV ON IMPAIRTD DRUG M{TABOLSM iN CARBON Ti]TRA- CHLORIDE TOXICATSD NATS Rarhui. R. & Dh,srh. B.. ICivtR Cenr,! lor sd,anced Phma@loscat Re*a,ch on T,adirionaj rcmed.er. B@chem sm D,qron. Central Drug R.rar} Lsdrie Llckn;q - :2o AOl. Ind. Jodmal of Phanocolos/ y 29/l feb 1997. Carbon reuachlonde (CClrr induced hepatolol--ity is a conmonl] used model for investFgating lipid-peroxidation related tissue injury In the preseft study, a alrastrc impairment in hepalicdrug metebolism $?s obse!!€d in rats 24 hr followiag admirisEarion di CCIa (1.0 rni^g, i.p..sirgte) as jndicrred b decre,rse tll rle adiviries ofvarious mic(osornal dnlg metabolisifg conpo-nents r iz . aminopyflne-N-demelhliase, ahiline hyd@r9ase, NADH-c!tochrome C-r€ductasc,NADPHqlochrofle C-reductase. cllmh.ome P10 and glutathione-S-transferase. Picroliv (aa iridoidgcoside fnction obtain€d from roots and {hizomes of Picrorhiza kwrca) (Kaluki) al a dose of 6-0Ing/(g G.o) for 7 dal s (6 days before and one day along wilh CCIr treatmeno, provides signitrcantprol€ction (25-8070) 10 nosl ofthgse altercdbiochemical paamet$s. No signilicafi pmtectiotr wajobsened in the activilv ofNADPH C]tochrome C-rcductase. 2-1&2-DG-0J0 EFFECT OT GNGERON CISPLATIN INDUCtrD DEIAY IN GASTRIC EMPTYING IN , RATS Shalm, S.si & Gupta" YK D€pt ofPhamacolost All India instiiuto ofM.dicsl Sciences, New Delhi- 110 t)29 - I)d. .lorht.! of Prdma..lost | 29/l leb 1997. Cisplarin causes nausea. onlitirg and sloFing in gasr.ic emptting. We have demonstratq,lanliemetic efiec.t of ginger ac€tone and ethanolic ent.acts against cislatin indoced emesis in dogs.ln the presenl sludy efect of gi..get (Atdnka) extracts and gingerjuice $usmvestigated in cisplatinrnduced delay in gastric empl_ying. Wistat rats of ei0ler sex Weighing 150-200 g were lsed Theanimals i€re depriKd of food 2+ hI prior to lhe experiment. Cisplatin 10 mg/kg, i.p. nasadministr€led l0 ndn before rhe lesl m€al. After 30 min of test meal adnunis!{ation. rals weresacrificed for determinatio! ofp€rce gastric cntptling Acerone and alcoholic extract ofginger itralitrerenl doses (100.200 and 500 ng/kg. p o.) and gingerjuice at rhe doses oI I and 2 flt&g, p.o_were dministered b€fore 60 nlin of cisplatin administralion. Cisplatin 10 ng/kg, i.p. producedsigrificant delay in gasdic enphing to 28 79% as compared to vehicle treted group 81.20% Ac-elone. 50o% ethanolic extra€t and ginger Juicc produced dos€ dependen! rclersa! nf cisplarin in-duced delay in gastric emptying in dose dependeit rnanne. The acetone artract and gingerjulceproduced better reversal, ho!ve!€r. bolh lvere less ef€ctiv€ lian to 5-I{T3 rec€ptors antagonist-ordanserron. The findings suggesl that ging€r may help in improving drc gasrraintesti&t slmp-toms ofcis!larin. 2-1&2-DC-041 - MUCUNA ?RURIENS DECRXASES SEXUAL ACTN,ITY IN Ff,MALE RATS. R&jendr.r Y J6cph q D.vid J., Dcpanm€nt ot Phhnna@locy. St. JohS Medi€l Colese Bosaloro - 560031. Indian Dtugs 1997, 4i(3) 136-9 Ilucwa pruriens (ltr) (Kap,.&rcra, seed ponder 3 g. cortaining 100 rng Ldopa G-D) shoireda more significant iniibitory efect than 100 rug LD on seual behaviour in ser.ralty rcceptiveIANVARY - JAL|. 1998 AAMRA . II/I&2
  21. 21. femaleralsThelenaless!ro]e.Ircjecdonan.l€xhibiteil.lecfeasedloldoslswhenmalesattemPaedi":In"."i.n" itJ* "r teectiois ;digated as a signitrclnt decreasetoarme"t quotient awith a in lordoslsi".,iir."i.e i;;" -;ection quoreiru The irme animal" on -rlh v"1ter 1ek L*i te maie widout an) rejection Thc resrits Indicalc rhat tPt !: o -b:9 oflD"rii#* *iri t fr"i"* in fenales, llle inbrbnory effecl of MP $"s more dla thatffi i.ili; ".*p,"a ttris eff€ctir.dicariag the presence ofother constriutent in MP contdbutilg to 2-1&2-DG442 (CUMINUJTI EXTRACTS FROM TWO FREQUNNTLY CONSIMED SPICES-CUMIN 6niltruo;rlru runrunRrc (cuRcuMA roNcA)- INHrBrr PLATELET AcGRf,- -irir-riin-iiry -lr-ron ErcosANorD BrosYxrrisls N FUMAN BLooD PLArE- LETS. Unive6iry Dotrn{k P/ortasldtdt6 Srivtst.vs Kc., Departnent of Envircmeilir Medicine, Oden$ Ldkatid! & Es;ntial Fary Acils 37(I) : 5764 I9E9 Jxl- spices and |erts are claimed ln the tladilional lndian system ofmedicine Ayneila sevenl antiadEroscl€Iouc h)pohpldemlc to possess meahcinal properties, sllch as being antithombotic *tt *. Earlier we have reported tlat e{racts from. several slices behave as "nti-ionu*a *"agg"g"r"ty *A inhbit sifiilar studies with e$acts pftpared eicosanoid rynthesis t*iZ"a fc|"g*" ".rminmt) (titskd) aIldt$rrltnc Cltrcuna tnea) (Eaidta were under- ", platelst ag$e- uken- gdle.eal exfad of both cumifl and tumeric inifuited amchidonate_induced (l4c) rriino. iio- *"ie s?ices infu teil thromloxane 82 pmductron ftom exogenous "*ou* fie formation oftipoxygEnas.- i.Jtii"r* *u to,n, i" *ashed plaelets. a sitrnrlaaeous incr€ase in samples tteateg rt t:ftenc i"i*i p."a*o ** "t.erved i-ess TxB2 was protluceil in bloolincofporatioa of (14c) AA into *r"a irr* trr"y 1{"r" ulor"a to clol. fumerice$mct inhiailed on simulation wi$ calcium nlalelet rhosDhoiioids and d€?clatlon ol AAJabelled phospholipidr i";;;;;ft; i;; *as a*oo "xna ors. ct efiects E*racs rrom the two spices rcd!rced ged wrth A2 3 I 87 iie fimation of (laO TXBZ from AA-labelleil plateleis when thev were challen pt"perty of turmeric ma3, in Par! be ex?lained bv ils effect on ercosaoid ii" *,i-J""tJ","ty bioslnfiess. 2-1&2-DG-043 Ff,D RATS ANTIPEROXIDE EFFECT OF GARLIC PROTf,IN IN A]-COHOL R.isre- C R. & Rzimnhan T: KT Auglsti Depdnten ol Bio(hmir^ Untren:No Kerala d u€lon vu I lrebr cem Medicarcorrese r.i"1iir"i"* ;;;;;-;;;;t; , Lrdib and {choor oi redicsr I "1lii .tndtaLl^ roun-t ofEPeinentat Biotocv 36 ranuary tees p! 606r ttt o abo 45 davs exhibited high levels oftissue Rats fed ethaml (3.-/6g,4ag body xl/daj, ior *rtonA"U"rya", rya.op"ro*la" uoi ai""" "o4ugates Activity of tissue superoxide dismutase $rlcr.oluble proleins ol garli( .utJose. anO elulad.ion. conlenl dereJs€d Admrnislralrotr ol irclease in antipemxide Z^rrr., tj-ot-^t^t *ol 11./dav) to alcohol fed rats show€d significanl transfense as com_ *a a*.L.i n,ft" actiliry of gtutathione peioxidase and glulathione "",i"iry a stafflard ilrug gugulipid (50 mg&g pareal lo body rltdav) l6 IAMR/ - U/142 .IANUARY. JALY, 199E
  22. 22. i{a- ABSORPTIONAN PERMEABtr-ITY CHARACTERISTICS OF PIPERINE ON ORAL lcine lrrelon FRo:{ PEPPERs AND A BroAvArLABrLrrY ENSANcER Re-giotral Resench,Lb"T1* Annu lftajoria. urha zutshi & BedL KL: lsolope SechonC"Jn*air*."-r""r lnCtra,Indian rottrnal oferyermental Biotag uol 16 January 1998 PP 46-50 Pioeflne. (i-t5-tl.]benzodioxol_5Jl)-l_oxo-2 4 pentadieny l) prperigm) ls a pung€Dl i*senr in P;perur iPru! (Maichd) arld P loaeun (Pippali) Li" II rs shorrn lo etnancerut;i rtif,o mi-io* st clurally aod tierapeuucally dietse drugs A cotrclse mecna $rrl-- ui"oiA;;;i;f;tG il""il"bilitv enhanong acoon isiitcsineundertood This smdv rs an efforl lo plpeflne in pobrlt on oral absorption lt eocomPass€strtrdersland tbe absomuon dyntmrcs ol qcble"imide teatment and exclusion of Na#;#;;;J;;;;-;;.p";*"dmoderliiiili-iii ii"*i:.ldium iere ttre vaiattes os;d Absorption haflfe !PlT," :::l-i-*" l""t-* ria "ppaJenl pcrm€abiliw co-€8ic-ienl moietvcompuled lrom il isdala tTen_ werc the a weal baseili",Ji.i"i# rr,"*"lJr,ernical characrensLics of rbrs medra lt e:Jribired passive-dttusnn ehibired thar ilhi ;;;;i;!;;r"* virh partial solubili[ in aqueous :-::i,:f"iil;;;hb,bsomrion kineucs. i.ropott otpip..io. *ot nor resrsed b1 [wL and i^i"r"*iJi" o. rG",*d du;gh Eanscelluiar palhwa) hdisplayed shon absorPuonrscleaJanceffiti;ffi;,;:;;;;iLv#il";i ll ma]oata as an apolar molecule and lorm apolar comPle_Fn f,ar rc..rs lhe lntesunal bamer act inus obiained suggesred fiar piperine absortiedJtir t^n. ,na solules. h m;y modulale m€rnbrane d)namics due to is eas- pa(rtlorung rnllshelprng i-n efiicient permeabilir] across the bamers 2-t &2-DG-045 EFTf,CT OF MORINGA OLf,IFf,RA LAlr-{ ON PARACETAMOLINDUCED UEPATOTOXICITYRucknlrl Li K.viman! S.i ADndm R & Jtyakaa E Pdvar Coilese of Ph maceulicsl Sc;enc6s 1-r ei,a", in"lrv zt . hai^ t pnatu Sci IggE 60(I) pP 33i5 AqoeousandalcoholicextractsoflootantlflowelofMolei|era(Siglu).weIes$eeet.fol on *,iL"prii"J -t"lt ; p- "etamol tr€ated albino (SGPT,Liver flmction was assessed based r:its phosphates€ (SALP) L"ti""t"ay t"d", *i.t" levels oftnnsaminase SGOT) alkaline "*n ertracts were found to have antihePatotoxic actrvity and bilirubin. .ilt 2-1&2-DG046 COMPLTX ANTIFERTILITY.ACTIVTIY OF NIOSOMAL MNCDPLI]MBAGIN KS. & Udupa, MDept ol Phmaceulics Collese olPhma€uliel ---- R.D.; sihgh, U.Yi Atth!|, l|9Kmatak^. hdian J Phamt Sci: 1998 60(l) pP i610 Soua i.i"r"".r, la*ipa 576 (HPICD I 1v119tee:Td lnclusion complex of alrug with hydro;,al propvl betacaciodexlrin lhe adl € consu tuent ot rt utnoago witl a vie! to increa;e the etEcacJ and soiubili ofplumbagin and evdualed tclahid!nt lChiDtk,t). The complex was enlrapped in the aqueous{a1er ofnjosomes Ttus intum u as cornpared $ith niosomes ofthe plaln drug YheE entrapment i"i *,ril^,if" *ri"...luf" in"l"lrty farer Grven I raperitoneally at a dose of 5 mg&g the triosomes of the tn" fio,a il;""*i;; ;i;; J;;;i;sog amrdtrrli a"tiuiry el lover entaPmertthe control and niosomes Ihen comparecl to eftciencv o"er dre plain il;;;-;;;;6*t. Alihough complex shoir increased otug ttre sta[itiq una attfertili! activilv $as ark€dly ] AAMXA - 1I/T&2 ttNUAFv - -tCtLv, 1998
  23. 23. 2-t&2-DG-O47 ANTI-INFLAMMATORY AND ANTIMPAIOTOXIC AbTNTTIES OF THE ROOTS OF MORINGA PTf RYGOSPERMA GAXRTN R.o. KS.r & Mishm. S.lt . Phmscv Depart6csl rauhy ol Technology & Engineenn& M.S Unierih ofBsrod! Vadodsr- 390 00l.GutML Indi;t J. Phan S.i.Iqs6.60tttpp l2-t6 The fiols of lIoinga pterygosperna Gnett t (Sigtu). (Moi^gaceae) in por*.der and e1l;}cll_orm were stlrdieal for ttreir artl-inllalnrnatory and antihepatotoxic activities. Among these. themer,hamlic extact ahowEd signiflcant (p<0.01) oedef,a supFessad acfiity against carageeninind[ced pav oedenu sirnilar to rai of indomcthacin, The aqueous exuact against carbgnteaachio{de, totrl aqueous er(ract against paracetamol and metbaiolic e).tact against rifampicinlrearmenls sho$ed signrficaJrl (p<0.0I) antiheparoroxic acti iiy. 2-r&2-DG-048 NEUROPSYCHOPSARMACOLOGICAT ETTTCTS OF TEE AYUR!EDIC NOOTROPIC MONNIERA LINN. (BRAETI0 .{COPI H-L singh, B.N. Dh.w!n, Celltal DruB Rcsdch iistitut , Lucknor - 225 001. India, Ihdiah Josrhol oI Phmtacolast 1997: 29: 53595365 Bacopa nontlierc Lin . (Brarrrrt has been usrd sirce 1imes ilnmemorial as nerve for rm- proveme{ of memory The authentiqttion oifle lraditiotral claims of bra}m i wrs in iCated by nvcs- rtigiting tlte etrect of an alcoholic e1ract oflhb plafi otr acquisirioq consolidation ald retentio! ofthree newly acquired behavioural rcsponses in ilbino rats, viz., a foct-shock moti?led brighbessdiscrimination response, active conditioned aioidarce response ard Sidman coninuous avoidanceresponse. The facilitatory etrecl ofthe brJ-bfti siract (40 mg/kg. p.o x 3d) was manifesl in all llleduee lea.ni g responses as il augm€nted both tlle cognitive function and mrntal retention capacity. The chemical coflstituent responsible for ihe facilitatory e{fec! ofbrai&i on leaming sched- ules vas identified as a nilure of $1o saponins designated as bacosi.les A and B. Thc bacosidcssignificai{ly i provcd the acquisition, consolidatjon and ietenlion in the shock,motiated bright-ness discriminatioil response. aclive conditioncd avoidance reslonse and produced a dose{ep€n-denl facilitation ofdiscrelion belweer rr aversive (ticl) and paiatable fluid (sucrose) in rhe condi-tioned Uste ave*ion (CTA) respoffe. Bacosides also atten ated dre retrograde amnenr prodircedb) imnrobilisalion induccd $ress. ECS and scopohrnine. Th€t al.o enh ced prole,,r kinase aflr!-ily and prcduced and increase in proi€ir in hippocampus. Bacosides n€re also fornd to be safe in regulatory phannacological ard loxicological strdiesand ere $ell lolerated b normal health nrale lunBn lolulccrs in single do.e U0.J0{r mg) andiNltipie doses (100 and 200 g) administercd for.l veeks in doubLe blr d pliLebo co rolled andnot-crossover regulalory Phasel clinical trial. 2-l&2-D{l-0{9 PI{ARI{ICODYNAMIC EFFf,CTS oF CEDRUS Df,oDARA wOoDISSENIAL oIL . . . TrndanS.K.chHrdrdS..Cuprrs.&LrlJ..Dsn.oilhdna.ul,.-d l,a.1,^ tnd;" LrJ:,dr) Rcsearch Irrstilrto. lzat,raBa 21l 122 (UP). htdidn Jo nrd! ol Illnee,ii. at Scien.es ],P JC :3 The Pharmacodrnanic cfects of Q.frus (ltnJnra (Der.r/d/r) iuodesenLnl orltvcre rn-csligated inrnice afld ffG. Thc oil Nas fo[nd 10 poss€ss sig illcr t iinl!,i {ln.rmirtory aclil,il! ]n.L,tNUA Rt -./Ut.t. t 99!l 1,|Mk4 - 0/1&2
  24. 24. c!|cnrrageenin-ndrced oedems inrats. If $as devoid of analgesic, s€dative and tnotor incoordiMriryactivities in mice. Hoi!€vet il caused a significant increase in penloba$itone-induced bTnosisrrhich ma, be due lo inJubrrion ofdrug merabolising en-,]mes. 2-1&2-DG-050 CYCLO-OXYGENASE INEIBI1ORS FROM SPICES Vob.laboi., Venkatesh$trlu, Unive6iw Collcee of Phamaceulical Sciences. Kakatilb UnivFitl WrMgal - 506 009, AP- lldia, lndia DtuS. 34(3) Atgttst l99T The crude e{racts offresh rhizames of Zingiber a$cinale (Snteet) (Axdtuk4, dned thizo es of Ctrcund longa (tnm.Letic) (Httridry) and dry fruits of Piper njgtxkt Olack pepeer)(M.!ichan),slwwedpolentinhibiloryactiviS againstprostaglandinbio nth€siziry ename (cyclo-og€nase, PG s] nftetase) in an i,? vilt? bioassay test The extncts rverc fractionaled bJ monitoringthe ;crilitv to yield I l0l-gingerol 1, [6]-gincerol 2 from Singer 1.7-bis (4"h]dro].a-3me1ho$ phenyl)l-6-heptadiene- 3,s-dione (curcumin) 3, ph!dro-rcinnamoylferulovlmedane-l- 6-heptadiene- 3 5-dione j from turneric and piperine 5 ftom black pepeer Conpounds 1-5 raere charaderizf,d on thebasis oftheir IR. NMR speclroscopic da1a. The qclo-ogenase inhibitory aclii! ofthese com-pounds 1-5 rvas deiemlltred b] an ,, vl,o sssav method in ho6e b1ood. Fluniin mcglunine rvasused as a srardard for comparing the c,Yclo-orr_genease inhibitory activit]l Radioimmunoassay ofthromboxane B. (TB-) ras used to ass€ss tie crncentmlion oltfuomtroxare A, CI,/r) in seruft 2-t&2-DG-051 HIPATO PROTICTIIE ACTI!ITY OF ETHYL ACETATE f,XTRA.CT OF ACACL{ CATECHU Jard.thaiP, iudhsnan.Pi Rarhinad K, Pd)adasini lnslitule oi Paran.dical Scicnces Medical co ee. Thru.uarhupura _ 695011 & Sre€ chilra Tirunal Institute lbr Mcdral scicnes andTechno;!r Biomedical Technolog! win€. Poojapun, TJrnuvanlthaputan - 69i01?- K"ala lidia ldrd Janul 4;l Phanacolag 1997: 29: Pp 126128 Hepatoprorec$-e actiilv of eth]] acetale enracl of -1 cacia catechu (Khadba) Q"aIa) isstudied ilrrats. The acc te li€r damage in altlino rats is inducedb,r a single subculanious administration of i lnl,&g dose of 509o 7 carbon tetrachlonde in oli€ oil and the chronic lir€r damagetr lnt/kgrr.rceaireekforIld s Tlie hilatoprotectiYe actiliq ras moniiered biochemicallybl esrLnralrng serunr lrrnsmnc se. se rum alkahne phosphslase and seum bili bin -in bolh th€ casesaherinrraperitoneal iajeclior ofethJl acelare €trircl of katha (250ng&g). Thehistopathological.hanges oflit.r sa-pi." tt ere compared riith that of conlrolr The exuact of kalha inhibited thecarb; telrachloride induced hlel darAage in aibino rats at 20mg,&g b $: as assessed bl thebiochenical and hisropadological .aiues. 2-1&2-DG052 XTDf,NCE FOR FREE RADICA]- SCAVENGING ACTIVITY OT ASHWAGANDHA ROOT POWDER IN MICE Sllnlld Panda ,hd AMnd Ka School ol Lit Srciences. DA Uni!e6it. Ve]h Bhard KnandNa 11 (1): PP J21126 Road- lddoi. - .151001- hdia - IndiatLtounolo! Phsiolag, a d Phamo.alaL- 997; 1 The effects ofAslN?gandha rool ponder (0.7 and 1l g,&gbt1./dal) administered (SOD for 15dals and 30 davs $as inrestieilleal on lipid perioldation (LPO). superoide dism iase J4^UlRt - lALy, l9a8 19 1AyM - Iyl&2
  25. 25. and calrhsc (Udf) rcltlilics in nricc. Whilc l5 drr lrcinn,eol iLh Asirugrndhi rool po$derdid llol produce aoyiigrifidlrt chrn8c.:10 drrls |rcrtt crl prod ccd:r significllnl dccr.rse nILPO.irnd rn increa$ in both SOD d CAL OuT lirdingas indicalc lhil Ash$agandha roolpo!der possesses frec r.rdic.rl sclvcngrrg irclilill. rvhich nrnl tc rcspo sible lbr il-r p|rnna-cological ec-ecll. ?-1&2-DC453 ANTIFILARIAL ACTIVIIY OF MALLOTUS PHTLLIPPINENSIS LAM. ON SETARL{ Cf,RVIE (Nf,M.ATOD-4.: FILAROTDEA) lN VITRO R{jcndcr Sinsh, sn,Ahal-Kc. & Nilam U. Klr.. l).p! al Phdn dJlog!. J N. Mcdi.ni collcst. Alisxrh 102002 & l)epr or Chcnrnk.r. AliSrlr lvirrslin UnicFi1t Al;errh _ 2tt2(lt)1 l11)i!, tr iM I,lt"dl Ll IhrsnlLs! und Ihanuun.g 1997: lllJ, : t)P lr7 t03 Thc clle.lol rq ucous r rrd alcoholicc c{ra€ls of{hc lcacsot^k lohts lhtiqPi,kntis (lu}tt r.l ell. ,1rE (Kanpitlaka!) was s{udicd on lhe spootaneous movcmclrls of thc $hole rornr ntdncnic-muscle (n.nl.) prcparalion ol.Vldlrd ccru r.d the suniil ofnicrofihriac in itro gothtc elracls caused infiibilion of sponl.rneous molility of rvhole 1|ann:indthen. t. prepanlidndf,tcer, cha.ecl€riscd by inlial slinruirlion follor€d by dcJrcssior ofampliirde. Thc lonc andrale olcontractions rcmajncd visibly uncltcclcd. Aqucous c)ilracl al highcr concentralion sho$edinnlediate reduction in lonc. Thc conccntratior requircd 10 inhjbil thc movemenls ofn.m.prcparalion il as i /51fi for aqucous and I / I 1 th for alcoholic elracl comp:rtcd to that for the $holen3r.r. suggesling a culicular pcr iabilit) barncr Theslimuhlory rcsponse of rcetllcholinews blocked by aqucous €rtracl on ]lholc worrn movemenls. Onlhe microfialriae the LC50 andLC90 !crc l8 and 20 nglnli ibr aqucous and 12 and 15 mg/ml tor alcoboiic crlracls respectirely. 2-l&?-oG-fl51 EFFf,CT OF PRUNUS AMYGDALUS SEEDS ON LIPD PROFILf, Sunlta T€oti,, M,r singb and P!I.M.C., CcnlF hr Bionedica Ensnreenng. Indiar LNslilule ol lrclinolog!: New Delhi 110016. India.l,i.liat Joumdl ofPlysoloet an.l Pliutu ac,b? t997: ;11(li, PP. 383 389 The efrecr af Prunus anyJdatus, (uutaia) which is .ich in uns,lturated fat, fibre diel andlon cholesrrol was studied i 36 normolipidemic male:tlbino rabbits for 60 days. ThrecdifI.rent doses i.e. lrhole sceds defattted and oil showed a decreas€ ir scrum tolal cholestrol.lrjgit ccndes, LDL ans HDL choleslrol. Thc maximum etrects were shown by.rvholc secds follo{ edb oil and defa(ed 2-i&2-DG-{r5s POTf,NTIAL ANTIDLABETIC AGENTS FROIIIPI-AI{T SOURCES : PHARMACO- LOGICALASPECTS Z.S.Hakim, &A-Bangdru, D.D.Santani md R.LGoya! Depannenl olPhrmacoloe)! L M collese ol PharMcy. Ahm€dabdd 38OOA9,India.l. Nat Ptud., lI Q),3 Diahetes nte llitts is z cofimon cfuonic endocrine disorder Sirce ancielt times a number ofhe6al medicines have been used in dre treatment of this disease. Many studies iave been canicdout in dre search of suitable plant drug that ould b e efrectre in Dtabetes meLlilrt l he pharmaco_Iogical actions of active principles obtained ftom variols plants have beeo strdied in lndia and . IUL, 1993 20INUARY

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