Neonatology MCQs
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Transcript

  • 1. 100 MCQs in Neonatology By Ayman Abu Mehrem, MD Assistant Consultant Department of Pediatrics King Abdulaziz Hospital, Al-Ahsa
  • 2. بسم الله الرحمن الرحيم
  • 3. Question 1 An infant has the following findings at 5 minutes of life: pulse 130 bpm, cyanotic hands and feet, good muscle tone, and a strong cry and grimace. This infant Apgar score is:
    • 6
    • 7
    • 8
    • 9
    • 10
  • 4. Question 2 Jaundice is most likely to be physiologic in a term infant in which of the following situations:
    • Jaundice at 12 hours of age
    • Serum bilirubin level increasing less than 5 mg/dL/24 hours in the first 2-4 days
    • Direct serum bilirubin greater than 2 mg/dL
    • Jaundice at 13 days of age
    • Serum bilirubin level 15 mg/dL at 7 days of age
  • 5. Question 3 Which of the following is most appropriate for treating hyperbilirubinemia (11.2 mg/dL) in a 3-week-old, breast-fed infant with normal growth and development?
    • Phototherapy
    • Exchange transfusion
    • Phenobarbital
    • Replace breast milk by formula for 48 hours
    • None of the above
  • 6. Question 4 Newborns are obligate nasal breathers for the first few months after birth. Of the following, the most common cause of neonatal nasal obstruction is:
    • Choanal atresia
    • Craniofacial malformations
    • Intranasal encephalocele
    • Lacrymal cyst
    • Mucosal inflammation
  • 7. Question 5 A term newborn appears dusky at rest, but becomes pink with crying. Attempts to pass a catheter through each nostril have failed. Physical examination of the infant reveals other congenital anomalies. Of the following, the most likely clinical syndrome in this infant is:
    • Apert syndrome
    • CHARGE association
    • Crouzon syndrome
    • Pfeiffer syndrome
    • Treacher-Collins syndrome
  • 8. Question 6 The following are accepted definitions Except
    • The neonatal period is the first 28 days of life of a newborn of any gestational age
    • Small for gestation infants have a birth weight less than 10 th centile
    • Infancy refers to the 1 st year of life
    • The fetal period is from the 12 th week of gestation to delivery
    • The perinatal mortality rate is the number of stillbirths and neonatal deaths per 1000 total births
  • 9. Question 7 The maternal serum screening test or “quadruple test” is done between 14 and 22 weeks gestation. It includes all of the following Except
    • Alpha-fetoprotein
    • β -hCG
    • Unconjugated pregninolone
    • Inhibin–A
    • Unconjugated esteriol
  • 10. Question 8 Neonatal hypercalcemia is associated with all of the following Except
    • Williams syndrome
    • Subcutaneous fat necrosis
    • Blue diaper syndrome
    • Familial hypercalciuric hypercalcemia
    • Primary hyperparathyroidism
  • 11. Question 9 The single greatest risk factor for necrotizing enterocolitis is
    • Prematurity
    • Patent ductus arteriosus
    • Indomethacin therapy
    • Polycythemia
    • Hypoxic-ischemic insult
  • 12. Question 10 You are called to the delivery of a boy at 42 weeks’ GA with thick meconium-stained fluid and type II decelerations. The obstetrician rapidly delivers the baby and hands him to you. The boy hypotonic, cyanotic, apneic, and bradycardic. The most appropriate action is to
    • Stimulate the infant to breath
    • Administer epinephrine
    • Provide positive-pressure bag-and-mask ventilation
    • Intubate and provide positive-pressure ventilation
    • Intubate and apply negative-pressure suction
  • 13. Question 11 You are called to see one-hour-old term baby in normal newborn nursery with ambiguous genitalia. Your plan includes all the following Except
    • Inform the parents that their baby’s genitalia are incompletely developed, and you need to do some investigation to identify their baby’s gender
    • Advise the parents to use unigender name
    • Urgent chromosomal analysis
    • Pelvic ultrasound
    • Serum electrolytes with daily monitoring
  • 14. Question 12 Incidence of respiratory distress syndrome increases with all of the following Except
    • Prematurity
    • Maternal diabetes
    • Black race
    • Male gender
    • Cesarean section delivery
  • 15. Question 13 Normal findings in a newborn baby includes all of the following Except
    • A mongolian blue spot
    • A strawberry nevus
    • Vaginal blood loss
    • Lanugo hair
    • Erythema toxicum
  • 16. Question 14 The pharmacologic effects of caffeine in the treatment of apnea of prematurity include stimulation of the medullary respiratory center, increased sensitivity to carbon dioxide, and enhanced diaphragmatic contractility. Of the following, caffeine exerts most of its effects by
    • Antagonism of prostaglandin activity
    • Blockage of adenosine receptors
    • Enhancement of catecholamine secretion
    • Stimulation of phosphodiesterase
    • Upregulation of gamma-amino-butyric acid receptors
  • 17. Question 15 When clinical zinc deficiency occurs in term and preterm infants, almost all affected infants are exclusively breastfed and receiving breast milk that has substantially lower-than-average zinc content. Of the following, the most common clinical manifestation of zinc deficiency in infants is
    • Alopecia
    • Diarrhea
    • Failure to thrive
    • Irritability
    • Rash
  • 18. Question 16 Assisted reproductive technology is associated with significant risks to the fetus and the mother. Of the following, the greatest risk to the fetus is related to
    • Cesarean section
    • Gestational diabetes
    • Maternal pre-eclampsia
    • Multiple gestations
    • Placental abruption
  • 19. Question 17 A term male newborn has severe intrauterine growth restriction, triangular face with broad forehead and pointed chin, leg length asymmetry, fifth finger clinodactyly, and cryptorchidism. Of the following, the most likely genomic imprinting disorder in this infant is
    • Albright hereditary osteodystrophy
    • Angelman syndrome
    • Beckwith-Wiedemann syndrome
    • Prader-Willi syndrome
    • Silver-Russell syndrome
  • 20. Question 18 A preterm newborn has multiple fractures of long bones, wormian skull, dark blue sclera, and beaked nose. Osteogenesis imperfecta type II is suspected. Genetic molecular tests are ordered for confirmation of the diagnosis. Of the following, the genetic mutation in this infant is most likely to involve the
    • ADAMTS2 gene
    • Collagen 1A1 gene
    • Fibrillin-1 gene
    • Filamin B gene
    • Transforming growth factor receptor 1 gene
  • 21. Question 19 Of the following, the nasal maldevelopment most likely to be associated with holoprosencephaly is:
    • Cepocephaly
    • Choanal atresia
    • Nasal agenesis
    • Piriform aperture stenosis
    • Proboscis lateralis
  • 22. Question 20 Regarding the head of a newborn infant (multiple choices)
    • A cephalohematoma will resolve within the first 24 hours of life
    • Caput is due to edema of the presenting part of the head
    • A cephalohematoma is due to bleeding into the skin
    • Overlapping of the skull bones is a normal finding
    • A cephalohematoma should be drained
  • 23. Question 21 The most prevalent clinical manifestation of late-onset group B Streptococcus disease is
    • Arthritis
    • Cellulitis
    • Meningitis
    • Osteomyelitis
    • Pneumonia
  • 24. Question 22 In contrast to “classic” bronchopulmonary dysplasia (BPD), the “new” BPD in the more contemporary clinical setting is characterized by different histopathologic findings on examination of the lung tissue. The most striking abnormality in the lungs of infants who have new BPD is
    • Decrease in alveolar septation
    • Diffuse leukocytic infiltration
    • Epithelial squamous metaplasia
    • Hypertrophy of airway smooth muscle
    • Lung parenchymal fibrosis
  • 25. Question 23 Several risk factors during prenatal, perinatal, and postnatal development have been proposed as predictors of cerebral palsy in preterm infants. Of the following, the highest rate of cerebral palsy among preterm infants is associated with
    • Bronchopulmonary dysplasia
    • Necrotizing enterocolitis requiring surgery
    • Parenchymal brain injury
    • Sepsis or meningitis
    • Severe retinopathy of prematurity
  • 26. Question 24 A 1700-g infant is born at 36 weeks’ gestation complicated by severe oligohydramnios. The Apgar scores are 3 and 5 at 1 and 5 min respectively. The baby required intubation as part of the resuscitation and continued MV to improve the ABGs. At 1 hour of age, the baby showed acute deterioration with cyanosis, bradycardia, and hypotension. The most likely diagnosis of this acute change is
    • Patent ductus arteriosus
    • Intraventricular hemorrhage
    • Hypoglycemia
    • Pneumothorax
    • Severe respiratory distress syndrome
  • 27. Question 25 A healthy newborn baby boy may (one incorrect)
    • have erythema of the umbilical skin extending on to the abdomen
    • produce breast milk
    • have a single palmar crease
    • have an umbilical hernia
    • vomit blood if breast feeding
  • 28. Question 26 A 14-day-old preterm infant, whose birthweight was 980 g at an estimated gestational age of 27 weeks, is receiving full enteral feedings of fortified human milk. The infant is breathing spontaneously in room air and has no evidence of cardiac, renal, or intracranial abnormalities. Of the following, the most desirable goal of enteral nutrition in this infant is to achieve
    • Fetal rate of body weight gain
    • Fetal rate of crown-heel length gain
    • Fetal rate of head circumference gain
    • Intrauterine body composition
    • Normal blood urea concentration
  • 29. Question 27 The interruption in the transfer of nutrients from the mother to the fetus that occurs following birth can be minimized by early administration of parenteral nutrition in VLBW neonates within the first 24 hours after birth. Of the following, the most common metabolic consequence of early parenteral nutrition with amino acids is
    • Hyperammonemia
    • Hyperglycemia
    • Hyperkalemia
    • Increase in blood urea nitrogen values
    • Metabolic acidosis
  • 30. Question 28 A 3600-g, breast-fed female, 42 weeks’ GA, is noted to have persistent hyperbilirubinemia at 2 weeks of age. On examination, the infant has not gained weight since birth and has decreased tone, an umbilical hernia, and an anterior fontanel measuring 4 x 6 cm. The most likely diagnosis is
    • Crigler-Najjar syndrome
    • Gilbert disease
    • Biliary atresia
    • Hypothyroidism
    • galactosemia
  • 31. Question 29 Fractured clavicle (multiple choices)
    • occurs more frequently in infants of diabetic mothers
    • requires treatment with a sling
    • is associated with Erb’s palsy
    • causes an asymmetric Moro reflex
    • is not painful
  • 32. Question 30 Minimal enteral feeding, also called gut priming or trophic feeding, is designed to improve gastrointestinal function and is used frequently in the nutritional management of VLBW neonates. The most accurate statement regarding minimal enteral feeding is that it
    • Increases plasma concentrations of gastrointestinal hormones
    • Is best avoided in infants weighing 500 to 600 g
    • Is contraindicated in the presence of assisted ventilation
    • Is contraindicated in the presence of indwelling umbilical catheters
    • Prevents necrotizing enterocolitis
  • 33. Question 31 The only inborn error of metabolism associated with neonatal hyperammonemia that is X-linked in inheritance is
    • Hyperinsulinism/hyperammonemia syndrome
    • Isovaleric acidemia
    • Medium-chain acyl-CoA dehydrogenase deficiency
    • Ornithine transcarbamylase deficiency
    • Pyruvate carboxylase deficiency
  • 34. Question 32 A 750-g black female experienced respiratory distress after a preterm delivery at 27 wks’ gestation. Pregnancy was uncomplicated, but labor was abrupt and therefore the mother did not receive steroid or penicillin therapy. The baby required intubation and MV with 100% O 2 . The possible causes of respiratory distress include (multiple choices)
    • Pneumothorax
    • Respiratory distress syndrome
    • Patent ductus arteriosus
    • Group B streptococcal sepsis
    • Transient tachypnea
  • 35. Question 33 The patient in Question 32 was also treated with endotracheal instillation of exogenous surfactant. This is likely to be beneficial by (multiple choices)
    • Preventing bronchopulmonary dysplasia
    • Reducing the incidence of pneumothorax
    • Reducing mortality
    • More rapid improvement of RDS
    • Preventing oligouria
  • 36. Question 34 Approximately 10% of infants born with congenital diaphragmatic hernia (CDH) have significant heart defects. The most common congenital heart defect associated with CDH is
    • Aortic arch obstruction
    • Tetralogy of Fallot
    • Total anomalous pulmonary venous return
    • Transposition of the great arteries
    • Ventricular septal defect
  • 37. Question 35 Contemporary management of gastroschisis is associated with a 10% to 25% incidence of postoperative intestinal and related complications. The most common postoperative complication of surgical repair of gastroschisis is
    • Abdominal compartment syndrome
    • Enterocutaneous fistula
    • Necrotizing enterocolitis
    • Renal ischemia
    • Short bowel syndrome
  • 38. Question 36 Amniotic fluid volume varies substantially at each week of human gestation, as reflected in the wide range of normal values. The largest variation in amniotic fluid volume occurs at the gestational age of
    • 26 to 27 weeks
    • 29 to 30 weeks
    • 32 to 33 weeks
    • 35 to 36 weeks
    • 38 to 39 weeks
  • 39. Question 37 You wish to determine the incidence and natural course of necrotizing enterocolitis in preterm neonates. Of the following, the best study design to address this question is a
    • Case-control study
    • Descriptive observational study
    • Prospective cohort study
    • Randomized clinical trial
    • Systematic meta-analysis
  • 40. Question 38 The most common fetal cause of polyhydramnios is
    • Decreased absorption of amniotic fluid due to gastrointestinal atresia
    • Decreased fetal swallowing from neuromuscular disorder
    • Excessive transudation of fluid from an abdominal wall defect
    • Increased fetal lung fluid secretion associated with gestational diabetes
    • Increased fetal urine output from hydrops associated with anemia
  • 41. Question 39 A 4-week-old, A-positive, African-American former 40-week’s-gestational age infant was born to an O-positive mother and experienced hyperbilirubinemia requiring 2 days of phototherapy in the NB nursery after birth. The infant appears apathetic and demonstrates pallor, a grade 2/6 ESM, and a HR 175 bpm. The most likely diagnosis is
    • Anemia of chronic disease
    • G-6-PD deficiency
    • Hereditary spherocytosis
    • Sicle cell anemia with hemolytic crisis
    • ABO incompatibility with continued hemolysis
  • 42. Question 40 The following predispose a baby to be small for gestational age (multiple choices)
    • Placental insufficiency
    • Twin pregnancy
    • Congenital infection
    • Maternal diabetes
    • Alcohol consumption
  • 43. Question 41 The small for gestational age newborn baby is at increased risk of (multiple choices)
    • Hypoglycemia
    • Polycythemia
    • Hypothermia
    • Hypothyroidism
    • Cardiac abnormalities
  • 44. Question 42 A term infant is born with Apgar score 5 and 7 at 1 and 5 min respectively. The infant has a HR 170 bpm and demonstrates pallor with hepatosplenomegaly. A Kleihauer-Betke test was positive. The most likely diagnosis is
    • Erythroblastosis fetalis
    • Hereditary spherocytosis
    • Chronic feto-maternal transfusion
    • ABO incompatibility
    • Blackfan-Diamond syndrome
  • 45. Question 43 The twin-twin transfusion is unique to twins that are
    • Dizygotic, dichorionic
    • Dizygotic, monoamnionic
    • Dizygotic, monochorionic
    • Monozygotic, dichorionic
    • Monozygotic, monochorionic
  • 46. Question 44 The amino acids derived from swallowed amniotic fluid are important for fetal gastrointestinal development. The amino acid considered conditionally essential for normal growth and maturation of the fetal gastrointestinal tract is
    • Alanine
    • Citrulline
    • Glutamine
    • Leucine
    • Valine
  • 47. Question 45 Respiratory distress syndrome is exacerbated by the following Except
    • Hypothermia
    • Acidosis
    • Hypoxia
    • Meconium aspiration
    • Withholding enteral feeds
  • 48. Question 46 The most important determinant of endotracheal tube resistance is
    • Airflow velocity
    • Biofilm coating
    • Gas density
    • Tube curvature
    • Tube diameter
  • 49. Question 47 Bilirubin conjugated in the liver and secreted into bile can be deconjugated in the gut, then reabsorbed into the bloodstream, resulting in enterohepatic bilirubin circulation. The enzyme most responsible for contributing to enterohepatic bilirubin circulation is
    • Beta-glucuronidase
    • Bilirubin hydrogenase
    • Bilirubin oxidase
    • Biliverdin reductase
    • Uridine diphosphoglucuronate glucuronosyltransferase
  • 50. Question 48 The most widely used and accurate method for estimating amniotic fluid volume is by
    • Determination of dye dilution by timed amniocentesis
    • Palpation of the fetus by the Leopold maneuver
    • Palpation of the uterus for fundal height
    • Ultrasonographic measurement of the amniotic fluid index
    • Ultrasonographic measurement of the largest vertical pocket
  • 51. Question 49 A NB female has a ventricular septal defect, cleft lip and palate, imperforate anus. All of the following tests would be appropriate Except
    • Karyotype analysis
    • TORCH titer
    • Renal US
    • Cranial US
    • Skeletal survey
  • 52. Question 50 A 2700-g, 36-wk’s-GA white male is born after 22 hrs of premature rupture of the amniotic membranes. The Apgar scores are 3 and 5. He immediately experienced respiratory distress and cyanosis requiring ET intubation and MV with 100% O 2 . Vital signs are T: 35.7 ˚ C, HR 195 bpm, mean BP 22 mm Hg. WBC 1500/ μ L, platelets 59,000/ μ L. The next most appropriate treatment for this baby is to administer
    • Surfactant by aerosol
    • IV ampicillin and gentamicin/cefotaxime
    • IV steroids
    • IV acyclovir
    • HFOV
  • 53. Question 51 The patient described in Question 50 is most likely suffering from
    • Respiratory distress syndrome
    • Diaphragmatic hernia
    • Congenital pneumonia with sepsis
    • Pneumothorax
    • TORCH infection
  • 54. Question 52 Transient tachypnea of the newborn (multiple choices)
    • occurs in 15% of full-term babies
    • can be diagnosed if onset occurs up to 48 hours post delivery
    • is caused by delayed absorption of fetal lung fluid
    • is more common in babies delivered by cesarean section
    • cannot be clearly differentiated from early pneumonia
  • 55. Question 53 A baby presents in heart failure at 5 days of age. The baby is not centrally cyanosed. The differential diagnosis includes (multiple choices)
    • Atrial septal defect
    • Fallot’s tetralogy
    • Hypoplastic left heart
    • Coarctation of the aorta
    • Tricuspid atresia
  • 56. Question 54 A well baby has difficulty sucking. Causes for this could be (multiple choices)
    • Micrognathia
    • Dystrophia myotonica
    • Cleft palate
    • Prader-Willi syndrome
    • Bulbar palsy
  • 57. Question 55 The causes for failure to pass meconium in the first 24 hours of life include (multiple choices)
    • Cystic fibrosis
    • Hyperthyroidism
    • Hirschsprung’s disease
    • Hiatus hernia
    • Galactosemia
  • 58. Question 56 Polycythemia in the neonatal period is associated with the following Except
    • Trisomy 21
    • The donor twin in a twin-twin transfusion
    • Maternal diabetes
    • Intrauterine growth restriction
    • Respiratory distress
  • 59. Question 57 A preterm baby of 30 week’s gestation is intubated and ventilated. On the 2 nd day of life he suddenly deteriorates. The differential diagnosis includes (multiple choices)
    • An intraventricular hemorrhage
    • A blocked endotracheal tube
    • A pulmonary hemorrhage
    • Pneumonia
    • Self-extubation
  • 60. Question 58 The blueberry muffin appearance in infants with TORCH infections most likely represents
    • Dermal erythropoiesis
    • Palpable purpura
    • Metastatic hepatic tissue
    • Viral lesions
    • None of the above
  • 61. Question 59 Necrotizing enterocolitis presents with (multiple choices)
    • A distended abdomen
    • Blood-stained feces
    • Septicemia
    • Bilious vomiting
    • Perforation of small bowel
  • 62. Question 60 When a newborn fails to achieve or sustain the normal decrease in pulmonary vascular resistance at birth, the result is hypoxemic respiratory failure or persistent pulmonary hypertension of the newborn (PPHN). Of the following, the mediator most responsible for normal pulmonary vascular transition at birth is
    • Asymmetric dimethylarginine.
    • Endothelin-1
    • Leukotriene
    • Nitric oxide
    • Thromboxane
  • 63. Question 61 The triggering mechanism that has become the standard of care in neonatal synchronized ventilation involves
    • Airflow trigger
    • Esophageal probe
    • Pressure trigger
    • Surface capsule
    • Thoracic impedance
  • 64. Question 62 The clinical and ultrasonographic feature most consistent with the compensated phase of fetal hypoxemia is
    • Abnormal biophysical profile
    • Absent fetal weight gain
    • Diminished cardiac ventricular compliance
    • Increased diastolic flow in middle cerebral artery
    • Lost fetal heart rate variability
  • 65. Question 63 Harlequin color changes is a sign of
    • Congenital ichthyosis
    • TORCH infection
    • Erythroderma
    • Normal physiology
    • Spinal cord trauma
  • 66. Question 64 The risk of developing necrotizing enterocolitis is increased in (multiple choices)
    • Breast-fed babies
    • Asphyxiated babies
    • Premature babies
    • Infants who have the umbilical artery catheterized
    • Infants who have had no milk feeds
  • 67. Question 65 A 2-day-old is noted to have conjunctival and retinal hemorrhage. The most likely etiology is
    • Child abuse
    • Maternal alloimmune thrombocytopenia
    • Maternal idiopathic thrombocytopenic purpura
    • Force of birthing process
    • Forceps delivery
  • 68. Question 66 Inhaled nitric oxide (iNO) has many of the characteristics of an ideal selective pulmonary vasodilator and, therefore, is used widely in the treatment of PPHN. Of the following, the lung disease most resistant to iNO is
    • Bacterial pneumonia
    • Congenital diaphragmatic hernia
    • Idiopathic PPHN
    • Meconium aspiration syndrome
    • Respiratory distress syndrome
  • 69. Question 67 The most common cause of nutritional intrauterine growth restriction is maternal
    • Chronic disease
    • Drug addiction
    • Hypertension
    • Infection
    • Malnutrition
  • 70. Question 68 Fetal undernutrition can have long-term effects on the occurrence of chronic adult diseases, a phenomenon described as fetal programming. Of the following, in addition to coronary heart disease and hypertension, the most common chronic adult disease attributed to fetal programming is
    • Chronic obstructive pulmonary disease
    • Diabetes mellitus
    • Malignancy
    • Osteoporosis
    • Retinal degeneration
  • 71. Question 69 A baby with Apgar scores of 1 and 2 at 1 and 5 minutes, respectively, appears hyperalert and has hyperactive deep tendon reflexes and mydriasis. The most likely diagnosis is
    • Stage I hypoxic-ischemic encephalopathy
    • Stage II hypoxic-ischemic encephalopathy
    • Stage III hypoxic-ischemic encephalopathy
    • Kernicterus
    • Intraventricular hemorrhage
  • 72. Question 70 The most typical inspiratory-to-expiratory time used with high-frequency oscillatory ventilation is
    • 1:2
    • 1:3
    • 1:4
    • 1:5
    • 1:6
  • 73. Question 71 Maternal chorioamnionitis is most likely to prevent the occurrence or severity of
    • Bronchopulmonary dysplasia
    • Cerebral palsy
    • Cystic periventricular leukomalacia
    • Intraventricular hemorrhage
    • Respiratory distress syndrome
  • 74. Question 72 The clinical manifestation most predictive of intestinal necrosis in necrotizing enterocolitis is:
    • Abdominal tenderness
    • Bloody stools
    • Erythema of the abdominal wall
    • Gastric residuals
    • Hemodynamic instability
  • 75. Question 73 A 2-week old preterm neonate (30 weeks) is experiencing recurrent episodes of apnea. The infant is well-oxygenated in room air between episodes and has no clinical or radiographic evidence of lung disease. Mechanical ventilation using the strategy of volume guarantee is started. The most appropriate positive end-expiratory pressure in this infant is
    • 0 cm H2O
    • 3 cm H2O
    • 5 cm H2O
    • 8 cm H2O
    • 10 cm H2O
  • 76. Question 74 Many identifiable factors contribute to human preterm birth. Of the following, the largest single category of causes associated with human preterm birth is
    • Idiopathic preterm labor
    • Multiple gestation pregnancy
    • Placental abruption
    • Prenatal infection
    • Substance abuse
  • 77. Question 75 The most likely syndrome in an infant who has thrombocytopenia and thumb anomalies is
    • Down syndrome
    • Fanconi syndrome
    • Kasabach-Merritt syndrome
    • Thrombocytopenia with absent radius syndrome
    • Turner syndrome
  • 78. Question 76 Transient neonatal diabetes mellitus is a rare disorder of genomic imprinting. Its clinical presentation includes intrauterine growth restriction, failure to thrive, hyperglycemia, and dehydration. Of the following, the imprinting defect in transient neonatal diabetes mellitus is most likely to involve
    • Chromosome 6
    • Chromosome 7
    • Chromosome 11
    • Chromosome 15
    • Chromosome 21
  • 79. Question 77 The plasma constituents most commonly implicated in the pathogenesis of transfusion-related acute lung injury are
    • ABO alloantibodies
    • Anti-IgA antibodies
    • Anti-neutrophil and anti-HLA antibodies
    • Anti-T agglutinins
    • Inflammatory interleukins
  • 80. Question 78 The first time the human fetus demonstrates swallowing ability is by the gestational age of
    • 11 weeks
    • 13 weeks
    • 15 weeks
    • 17 weeks
    • 19 weeks
    (Sucking at 18-20 weeks)
  • 81. Question 79 The function that plays a major role in regulation of the amniotic fluid volume is
    • Fetal lung fluid secretion.
    • Fetal swallowing
    • Fetal urine formation
    • Intramembranous absorption
    • Transmembranous flux
  • 82. Question 80 Direct-reacting hyperbilirubinemia on the 10 th day of life suggests all of the following Except
    • Cystic fibrosis
    • Galactosemia
    • Neonatal hepatitis
    • Byler syndrome
    • Gilbert disease
  • 83. Question 81 The ventilator variable most influential in avoiding atelectasis in mechanically ventilated neonates is
    • Inspiratory time
    • Peak inspiratory pressure
    • Positive end-expiratory pressure
    • Tidal volume
    • Ventilator rate
  • 84. Question 82 Nearly all preterm neonates are most likely to have passed meconium by the postnatal age of
    • 48 hours
    • 96 hours
    • 144 hours
    • 192 hours
    • 240 hours
  • 85. Question 83 The most accurate statement regarding gastrointestinal development and enteral feeding in preterm infants is that
    • Diluted milk empties more slowly from the stomach than does undiluted milk
    • Feeding intolerance is largely due to immaturity of mucosal function rather than motor function
    • Gastric emptying is influenced by the temperature of the milk
    • Large feeding volumes induce maturation of motor patterns of the gut more effectively than small feeding volumes
    • Motor function develops earlier in the stomach/small intestine than in the rectum/anal canal
  • 86. Question 84 Hemorrhagic disease of the newborn (multiple choices)
    • is secondary to low prothrombin
    • can present up to 6 months of life
    • is treated with protamine sulphate
    • is prevented by administering vitamin E to all newborn babies
    • can result in intracerebral hemorrhge
  • 87. Question 85 The most critical determinant of ventilator-induced lung injury in preterm neonates is excessive
    • Airway pressure
    • Gas flow
    • Oxygen concentration
    • Tidal volume
    • Time constant
  • 88. Question 86 The postmenstrual age at which preterm infants who have stable cardiopulmonary status and no neurologic abnormalities are likely to be introduced to oral feeding is closest to
    • 28 weeks
    • 30 weeks
    • 32 weeks
    • 34 weeks
    • 36 weeks
  • 89. Question 87 All of the following are problems of an infant of a recently diagnosed diabetic mother Except
    • Hypoglycemia
    • Hypocalcemia
    • Intrauterine growth restriction
    • Hypomagnesemia
    • hyperbilirubinemia
  • 90. Question 88 The most critical factor in the development of respiratory distress syndrome in the preterm neonate is
    • Immature composition and biophysical function of surfactant
    • Leaking epithelium/endothelium barrier from lung injury
    • Low lung gas volume with susceptibility to overdistention
    • Low surfactant lipid pool size
    • Saccular versus alveolar stage of lung development
  • 91. Question 89 A newborn baby has profound thrombocytopenia. The causes include all of the following Except
    • Cytomegalovirus infection
    • Autoimmune neonatal thrombocytopenia
    • Maternal ingestion of warfarin
    • Alloimmune neonatal thrombocytopenia
    • Gram-negative septicemia
  • 92. Question 90 The high-frequency ventilator variable most likely to influence oxygenation is
    • Amplitude
    • Frequency
    • Inspiratory-to-expiratory time ratio
    • Mean airway pressure
    • Tidal volume
  • 93. Question 91 A severely hydropic infant is about to be delivered. Complications to be prepared for include all of the following Except
    • Pulmonary hypoplasia
    • Abdominal ascites
    • Polycythemia
    • Heart failure
    • Laryngeal edema
  • 94. Question 92 You are called to see a tow-day-old jittery baby. The causes to consider are (multiple choices)
    • Maternal diabetes
    • Fetal alcohol syndrome
    • Maternal hyperparathyroidism
    • Maternal thyrotoxicosis
    • Congenital adrenal hyperplasia
  • 95. Question 93 The distribution of surfactant in the lungs is most efficient when surfactant is administered
    • After a period of mechanical ventilation
    • As an aerosolized preparation
    • At a slow rate of infusion
    • At birth in the presence of fetal lung fluid
    • Using a smaller volume of the drug
  • 96. Question 94 Infants at risk of hyperinsulinemic hypoglycemia include all of the following Except
    • Infants with nesidioblastosis
    • Infants of diabetic mothers
    • Infants with galactosemia
    • Infants with leucine sensitivity with hyperammonemia
    • Infants with Beckwith-Wiedemann syndrome
  • 97. Question 95 Neural tube defects
    • Occurs with frequency of 2 per 10,000 births
    • Have a genetic predisposition
    • Result from abnormal development of the neural tube at 3-4 months’ gestation
    • Can be detected antenatally by low maternal serum alpha-fetoprotein levels
    • Are treated with folic acid
  • 98. Question 96 Metabolic bone disease of prematurity (multiple choices)
    • Is associated with chronic respiratory distress
    • Is prevented by administration of vitamin D
    • Is less severe in infants fed with breast milk compared to formula-fed infants
    • Can result in spontaneous fractures
    • Is caused by a substrate deficiency
  • 99. Question 97 The most common limb defect associated with amniotic bands is
    • Amputation of digits
    • Congenital arthrogryposis
    • Preaxial polydactyly
    • Proximal syndactyly
    • Single bones in extremities
  • 100. Question 98 The aromatic amino acid most likely to be detected by tandem mass spectrometry is
    • Citrulline
    • Leucine
    • Methionine
    • Phenylalanine
    • Valine
  • 101. Question 99 Hydrops fetalis is associated with (multiple choices)
    • Beta-thalassemia
    • Diaphragmatic hernia
    • Paroxysmal supraventricular tachycardia
    • OA materno-fetal blood group incompatibility
    • Turner syndrome
  • 102. Question 100 The blood constituents most implicated in the pathogenesis of transfusion-associated graft versus host disease are
    • Anti-neutrophil antibodies
    • Anti-T agglutinins
    • Donor-derived lymphocytes
    • Erythrocytic RhD antigens
    • Inflammatory interleukins
  • 103. GOOD LUCK