Sarcoidosis<br /><ul><li>Is and autoimmune disease that attacks the body’s</li></ul> tissues. Described as Heightened Immunity, whereby <br /> the immune system overreacts resulting in tissue<br /> damage.<br /><ul><li>Groups of cells become inflamed where they take on</li></ul> a granular shape (granulomas).<br /><ul><li>When they form on an organ, they make affect the</li></ul> organs function.<br /><ul><li>It’s known that Sarcoidosis is an immune disorder but whether the Immune response is a cause or effect of the disease is unknown.</li></li></ul><li>SYMPTOMS and Diagnosis<br /><ul><li> May be related to an organ or organs or nonspecific</li></ul> such as weight loss , loss of appetite, fatigue, fever,<br /> chills, night sweats.<br /><ul><li> Symptoms may come and go and may mimic other</li></ul> diseases, so diagnosis may be the elimination of<br /> other possible diseases.<br /><ul><li> Diagnosed mainly by chest x-ray since most cases</li></ul> start in the lungs and lymph nodes of the chest, but,<br /> given the patient’s area of complaint other tests like<br /> blood, biopsy, lung function are used.<br />
Who Gets Sarcoidosis<br /><ul><li> In the U.S. it is most common among African Americans and people of</li></ul> Northern European descent, where African Americans are most affected<br /> with a risk as high as 2%. The risk is 2x higher for AA women than AA<br /> men.<br /><ul><li> 20-40 years old.
Risk of getting the disease is greater when someone in the family has it,</li></ul> which is why some believe there is a genetic link.<br />
Sarcoidosis can Affect:<br /><ul><li> Lungs: Sarcoidosis usually starts in the lungs or lymph nodes of the</li></ul> chest with inflamed alveoli (sacs where oxygen and carbon<br /> are exchanged). It may clear up or lead to granuloma<br /> formation and fibrosis (scarring). 90% of cases.<br /><ul><li> Skin: 25-35%
Musculoskeletal System: 2-38%</li></li></ul><li><ul><li> LUNGS: Cough that does not go away, shortness of breath, chest pain.
LYMPH NODES: Enlarged in neck mostly but also under chin, armpits</li></ul> and groin.<br /><ul><li> SKIN: Painful, red, raised bumps on legs or arms (erythemanodosum),</li></ul> discoloration of the nose, cheeks, lips and ears (lupus pernio)<br /> and small brown, painless skin patches.<br /><ul><li> EYES: Burning, itching, tearing, pain, red eye, sensitivity to light</li></ul> (photophobia, dryness, seeing black spots (floaters)<br /> and blurred vision.<br /><ul><li> LIVER: Enlarged (hepatomegaly) or changes in liver exzymes.
HEART: Weak heartbeat/shortness of breath, swelling in legs. </li></ul> Irregular heartbeat.<br /><ul><li> NERVOUS SYSTEM: Facial paralysis, headache, confusion, malaise.
MUSCULOSKELETAL SYSTEM: Arthritis, periarthritis, arthralgia. Most common</li></ul> that pain will be acute with swelling in lower legs<br /> and tenderness in joints.<br />
TREATMENT:<br />Is difficult because disease tends to come and go so many times there<br />Is no treatment. <br />If inflammation involved, initial treatment is usually corticosteroids like <br />Prednisone to reduce inflammation orally but also used topical<br />Corticosteroids.<br />Depends on organs affected. <br />In general, Sarcoidosis appears briefly and clears itself without relapse.<br />However, 20-30% are left with some lung damage, 10-15% have chronic<br />case and 5-10% can be fatal if vital organs are seriously affected. <br />Most people can lead a normal life.<br />