2013-05-22 Atul Butte's presentation at the Big Data in BioMedicine Conference

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Atul Butte's presentation at the Big Data in BioMedicine Conference
2013-05-22 Atul

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2013-05-22 Atul Butte's presentation at the Big Data in BioMedicine Conference

  1. 1. KiloMegaGigaTeraPetaExaZetta
  2. 2. Total 1.2 million microarrays availableDoubles every 2-3 yearsButte AJ. Translational Bioinformatics:coming of age. JAMIA, 2008.
  3. 3. ~300 Diseasesand Conditions20k+ GenesBlue: gene goes downin diseaseYellow: gene goes upin diseaseHuman DiseaseGene Expression CollectionButte AJ, Kohane IS. Nature Biotechnology, 2006, 24:55.Butte AJ, Chen R. Proc AMIA Fall Symposium, 2006.Chen R, Butte AJ. Nature Methods, 2007.Dudley J, Tibshirani R, Deshpande T, Butte AJ. MolecularSystems Biology, 2009.Shen-Orr S, ... Davis MM, Butte AJ. Nature Methods, 2010.Joel Dudley
  4. 4. Lamb J, ..., Golub TR. Science, 2006.Sirota M, Dudley JT, ..., Sweet-Cordero A, Sage J, Butte AJ.Science Translational Medicine, 2011.Marina SirotaJoel Dudley
  5. 5. Rat colonoscopy Rat withInflammatoryBowel DiseaseInflammatoryBowel DiseaseAfterAnti-seizure DrugDudley JT, Sirota M, ..., Pasricha J, Butte AJ. Science Translational Medicine, 2011.Anti-seizure drug works against a rat model ofinflammatory bowel disease
  6. 6. Data-drivenSystems Medicine
  7. 7. What next?Let’s figure that outtogether!
  8. 8. Thanks• Kristin Goldthorpe• Michelle Christierson• Priya Singh• Michele Schiele and Ted Tussing• Carlos Bustamante, Euan Ashley, Russ Altman,Alan Yeung, Phil Lavori• All our helpers and volunteers• Phil Pizzo• Lloyd Minor• John Bell• Li Ka Shing Foundation

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