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Current status:Pre-erythrocytic vaccines• RTS,S (U.S. Army & GlaxoSmithKline)–Recombinant CSP combined with hepatitisB sur...
4 . / 54 . %!6.766 8 9! / :;</ 9=<! 8=3 1 6779. 677;
8 6 : 9 ; > ? = @ 87 88 86 8: 89 8; 8>A B/8@ CD5 8 /5 8 / 889696! 8! !1# > D 8>99 ,E F*-. 8>@8 ,CF -. 8>@@, FD-. 8?77 ,DF ...
896  +# ! !  H 4 3 ) !4&! 4 . ,3 763-# ! !  G + C AH . ! 8 26 !// 889696
Bandiagara Malaria Project• Started 1997• University of Bamako / Faculty of Medicine– Malaria Research & Training Center• ...
8 +8 +6 ! C8 98 4 ! + +) . 4 .
Malaria vaccine AMAMalaria vaccine AMA--11• P. falciparum apical membrane antigen-1• Expressed on merozoite surface,involv...
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Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
Fac 2006 plowe 1
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Fac 2006 plowe 1

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Transcript of "Fac 2006 plowe 1"

  1. 1. ! "# $ ! %! & () *+) ! , * -..! ! ! !.
  2. 2. / 0 1 ! ! /##) ! !2*+3
  3. 3. ! , -
  4. 4. Current status:Pre-erythrocytic vaccines• RTS,S (U.S. Army & GlaxoSmithKline)–Recombinant CSP combined with hepatitisB surface antigen– Immune boosting agents (adjuvant)• AS02A: QS21, monophosporyl lipid A
  5. 5. 4 . / 54 . %!6.766 8 9! / :;</ 9=<! 8=3 1 6779. 677;
  6. 6. 8 6 : 9 ; > ? = @ 87 88 86 8: 89 8; 8>A B/8@ CD5 8 /5 8 / 889696! 8! !1# > D 8>99 ,E F*-. 8>@8 ,CF -. 8>@@, FD-. 8?77 ,DF -. 8?78 ,G F4-. 8?8> ,1F5-3 8@ B B.
  7. 7. 896 +# ! ! H 4 3 ) !4&! 4 . ,3 763-# ! ! G + C AH . ! 8 26 !// 889696
  8. 8. Bandiagara Malaria Project• Started 1997• University of Bamako / Faculty of Medicine– Malaria Research & Training Center• University of Maryland– Center for Vaccine Development• US National Institutes of Health• 20 scientific papers published• 2 malaria vaccine trials completed
  9. 9. 8 +8 +6 ! C8 98 4 ! + +) . 4 .
  10. 10. Malaria vaccine AMAMalaria vaccine AMA--11• P. falciparum apical membrane antigen-1• Expressed on merozoite surface,involved in erythrocyte invasion• Antibodies block invasion of merozoitesinto erythrocytes
  11. 11. 3 3 83 3 8 +! !
  12. 12. 3 33 3 8 +8 +8 68 >3 3 8 8 677>6 677?
  13. 13. ! ! "# !# !I I +!D3 "1 . !
  14. 14. / !1 4 .A!3 ;)3 ! !# A . ) . .
  15. 15. B3 0 !C 1 BD *J ! 3B4 A!1 41 !1 !1 A* !40 ! ! 3 ! C3 G !C3 ! &AD)K )3 D1 KH 43)4G K3* 3J 1G C3 13D)K 5)D)K A!D)K D783)=;:9>D)K ) ) 43) , -H 43)4 , -G C , &! -
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