18 Total Patents3 Awards Received8 Published Scientific ArticlesAGELOC SCIENCEIS A GLOBALPHENOMENON14 Oral Presentations26 Scientific Posters
“Nu Skin, with ageLOC science, stands apart from the competition becauseour approach is based upon 30 years of breakthrough anti-aging research.Our research continues to gain recognition and is validated throughpresentations at global scientific conferences.”—Joe Chang, Ph.D. Brussels, Belgium Hangzhou, China Wuhan, China Taipei, Hong Kong, China Taiwan Buenos Aires, Argentina
“Nu Skin, with ageLOC science, stands apart from the competition because our approach is based upon 30 years of breakthrough anti-aging research. Our research continues to gain recognition and is validated through presentations at global scientific conferences.”—Joe Chang, Ph.D. Helsinki, Finland Berlin, Germany Brussels, Belgium Corvallis, OR USA New York, NY USA Paris, Les Diablerets, France Switzerland Sapporo, Santa Barbara, Tokyo, Japan CA Washington D.C, Hangzhou, Japan Phoenix, USA Barcelona, Siena, ChinaVentura, AZ USA Spain Italy Wuhan, ChinaCA Atlanta, GA, USA Anaheim, CA USA Taipei, Hong Kong, China Taiwan New Orleans, LA USA Bangkok, Thailand Singapore Buenos Aires, Argentina
“This research identifying groups of genes and genetic pathways that change in expression as we age is essential to building our proprietary ageLOC science that targets the sources of aging.”— Joseph Chang, Ph.D., Nu Skin Chief Scientific Officer and Executive VP of Product Development2011
2 Presented “This research identifying at Fifth International groups of genes and genetic Symposium on Health andpathways that change in expression as we age is the Environment essential to building our proprietary ageLOC science that targets the sources of aging.”— Joseph Chang, Ph.D., Nu Skin Chief Scientific Officer and Executive VP of Product Development FEBRUARY MARCH 2011Published PresentedArticle in Cosmetics and at Gordon ResearchToiletries ConferencePresentedat American Academy ofDermatology’s 69th AnnualMeeting
2011 Released The Aging Myth, a book by Joseph Chang, Ph.D.
Presented at Society for Investigative Dermatology Awarded Utah Innovation Award for ageLOC Vitality: Natural Products CategoryAPRIL MAY JUNE 20114 Presented Releasedat Federation of American The Aging Myth, a bookSocieties of Experimental by Joseph Chang, Ph.D.Biology Presented Gene Expression Research in Paris, France
2011The Aging MythBecame a New YorkTimes Best Seller
Presented Presentedat Tenth Symposium of at Linus Pauling Institute DietMycology Societies and Optimum Health ConferencePublished 2 PresentedArticle in Central China at European Society forAgriculture University Dermatological ResearchJournal FiledJULY SEPTEMBER OCTOBER2011The Aging Myth PresentedBecame a New York ageLOC R2 Research atTimes Best Seller Second International Conference on Environmental Stressors in Biology and Medicine Launched Nutritional Product ageLOC R2
Presentedat Fourth InternationalConference and Exhibition Presentedfor Nutraceuticals and at Society of CosmeticFunctional Foods Chemists Annual Scientific SeminarPresentedat 2011 InternationalConference on Food Nu Skin AcquiredFactors LifeGen TechnologiesNOVEMBER DECEMBER 2011Presented Publishedat New TCM Product Online article inDevelopment and Industrial Dermatological SurgeryDevelopment Strategy PresentedSummit at International FederationPublished of Societies of CosmeticArticle in Zhejiang ChemistsUniversity Journal
FULL LISTPatents AwardsMultiple Patents in the following Angela Mastaloudis,categories: Senior Scientist, Received the DSM NutraceuticalLicensed Patents-Pending on Research AwardFormulation or Ingredients Remona Gopaul, Associate SeniorNu Skin-Developed Patents- Scientist, Named Young Scientist ofPending on Formulation or the Year by the Society of CosmeticIngredients ChemistsLicensed Patent on Method Nu Skin Awarded Utah Innovation Award for ageLOC Vitality: NaturalNu Skin-Developed Patent- Products category, 2011Pending on Method
FULL LIST2011 Published ArticlesFebruary 2011 November 2011Gopaul, R., Knaggs, H., Wickett, R. “A Li, C., Tan, N., Barger, J., Zhang, Y., Ferguson, S., Prolla,Review of Genomic Techniques in T., Zhu, J. “Combined use of ageLOC whole-geneCosmetic Testing.” Cosmetics & expression profiling technology and mouse lifespan test inToiletries. February 2011, pp. 112-117. anti-aging herbal product study.” Proceeding of New TCM Products Innovation and Industrial Development Summit,July 2011 Zhejiang University Publishing, Hangzhou. 27 Nov. 2011.Tan, N., Barger, J., Zhang, Y., Prolla, T., (in press)Weindruch, R., Zhao, C., Bartlett, M.,Zhu, J. “CordyMax Cs-4 restores aging- December 2011associated changes in gene expression Chang, A., Lingala, B., Chang, T., Kern, D., Wood, S.,and extends lifespan in normal aged Toyoda, H., Knaggs, H. “An Exploratory Study tomice.” Proceeding of the 10th Determine the Association Between Assessed Facial SkinSymposium of Mycology Societies Aging and Plasma Isoprostane Levels in Middle-AgedAcross Taiwan Strait, Central China Japanese Women.” Article first published online: 5 Dec.Agriculture University Publishing. 2011, 2011 Dermatological Surgery. http://pp 255-256. onlinelibrary.wiley.com/doi/10.1111/j. 1524-4725.2011.02235.x/abstract
FULL LIST2011 Oral PresentationsJune 2011 October 2011“Transcriptional biomarkers of calorie restriction “A unique nutritional formulation to “Whole-gene transcriptional profilingand their modulation by dietary interventions.” promote cellular protection and purification to detect aging-associatedInvited Speaker: Free Radicals, Nutrition and via induction of the Nrf2-mediated ARE/ mitochondria dysfunction and toAging: From Fundamental Aspects to Clinical Phase II detoxification pathways.” Invited develop an anti-aging product.” InvitedApplications. Paris, France, June 15-17, 2011. Speaker: Second International Conference Speaker: The 2011 InternationalBarger, J. on Environmental Stressors in Biology and Conference on Food Factors, Taiwan, Medicine. Centro Didattico, Policlinico Le November 20-23, 2011. Zhu, J., Dong, Scotte Siena, Italy. October 5-7, 2011. Y., Barger, J., Lu, J., Tan, N., Prolla, T.,July 2011 Mastaloudis, A. Weindruch, R., Bartlett, M.“CordyMax Cs-4 restores aging-associatedchanges in gene expression and extends November 2011 “Combination of ageLOC biochiplifespan in normal aged mice.” The 10th “Restructuring of the ECM in Human Skin whole-gene expression profiling andSymposium of Mycology Societies Across by Equol: A Plant and Soy-Derived mouse lifespan test in CM anti-agingTaiwan Strait, Wuhan, China, July 17, 2011. Tan, Isoflavonoid.” Gene Expression and study.” Invited Speaker: Summit ofN., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Protein Evidence presented at the 4th New TCM product Development andZhu, J. International Conference and Exhibition for Industrial Development Strategy, Nutraceuticals and Functional Foods, Hangzhou, China, November 25-27,September 2011 Sapporo, Japan, November 2011. Gopaul, 2011. Li, C., Tan, N., Barger, J.,“Transcriptional biomarkers of calorie restriction R., Knaggs, H., Lephart, E. Ferguson, S., Zhang, Y., Prolla, T.,in adipose tissue and modulation by dietary Zhu, J.interventions.” Invited Speaker: Linus PaulingInstitute Diet and Optimum Health Conference.Corvallis, OR, September 13-16, 2011. Barger,J.
FULL LISTPosters 2011February 2011 July 2011 April 2011“Exploratory Study to Assess Association of Skin Aging with “CordyMax Cs-4 restores aging-associated changes in gene “The lifespan-prolonging effect of Cordyceps sinensis Cs-4 inPlasma Isoprostane Levels in Healthy Middle-Aged expression and extends lifespan in normal aged mice.” normal mice and its molecular mechanisms.” FASEB J 2011Japanese Women.” The American Academy of Proceeding of the 10th Symposium of Mycology Societies 25(1): 599.1. FASEB EB2011, Washington, DC, Apr. 10,Dermatology’s 69th Annual Meeting, February 2011, New cross Taiwan Strait, Central China Agriculture University. 2011, 2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R.,Orleans, LA. Chang, A., Chang, T., Lingala, B., Kern, D., pp 255-256. Oral presentation at: The 10th Symposium of Zhao, C., Bartlett, M., Zhu, J.Wood, S., Toyoda, H., Knaggs, H. Mycology Societies Cross Taiwan Strait, Wuhan, China, July “ageLOC Vitality improves endurance exercise, exercise 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla,March 2011 glucose metabolism and antioxidant capacity in an aging T., Zhu, J.“A PCR-based screen to identify natural compounds with the model.” FASEB J 2011 25(1): 1049.2. FASEB EB2011,ability to influence Nrf2-mediated transcriptional induction of Washington, DC, Apr. 12, 2011. Yang, J., Dong, Y., Zhao, C., September 2011detoxification/antioxidant genes.” Gordon Research Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M., Zhu, J. “A Multifactorial Approach to Addressing Body AppearanceConference: Oxidative Stress & Disease. Emerging Aging.” European Society for Dermatological ResearchResearch Areas in the Study of Oxidative Stress and “Cordyceps sinensis Cs-4 restores aging-associated (ESDR) September 2011, J. Invest Dermatol 131. S. 54 (2011).Disease. March 13-18, 2011, Ventura, CA. Mastaloudis, A., changes in gene expression and extends lifespan in normal Knaggs, H., Kern, D., Gopaul, R., Langerveld, A.Barger, J., Prolla, T., Weindruch, R., Ferguson, S., Wood, S. aged mice.” FASEB J 2011 25(1): 1090.13. FASEB EB2011, Washington, DC, Apr. 13, 2011. Tan, N., Barger, J., Zhang, “A Multifactorial Gene Expression Approach to Understanding“Cordyceps sinensis Cs-4 restores aging-associated Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J. Skin Aging.” J. Invest Dermatol 131. S. 57, September 2011.changes in gene expression and extends lifespan in normal Knaggs, H., Kern, D., Bartlett, M., Wood, S., Mastaloudis, A.,aged mice.” Progress in Nutrition 2011. The 5th International “An ageLOC Vitality formula improves endurance exercise in Ferguson, S., Langerveld, A.Symposium, “Promoting Good Health and Developing a aged mice and energy metabolism in muscle mitochondria.”Sustainable Environment,” Hong Kong, March 10-11, 2011. FASEB J 2011 25(1): 1114.9. FASEB EB2011, Washington, “A Systematic Approach to Evaluate and Rank NaturalZhu, J., Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, DC, Apr. 13, 2011. Dong, Y., Lu, J., Yang, J., Zhao, C., Tan, Ingredients Based on Their Ability to Oppose Age-RelatedR., Zhao, C., Bartlett, M. N., Wu, Z., Zhang, Y., Gao, L., Bartlett, M., Zhu, J. Changes in Gene Expression.” Linus Pauling Institute Diet and Optimum Health Conference. Corvallis, OR. September 13-16,“ageLOC Vitality improves exercise endurance, glucose May 2011 2011. Wood, S., Mastaloudis, A., Barger, J., Prolla, T.,metabolism and antioxidant capacity in an aging model.” “Association of skin aging severity with blood isoprostane Weindruch, R.Progress in Nutrition 2011. The 5th International Symposium, levels in healthy middle-aged Japanese women.” Society for“Promoting Good Health and Developing a Sustainable Investigative Dermatology (SID) May 2011, J. InvestEnvironment,” Hong Kong, March 10-11, 2011. Zhu, J., Yang, Dermatol 131. S. 85 (2011). Chang, T., Lingala, B., Kern, D.,J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J., Wood, S., Toyoda, H., Knaggs, H., Chang, A.Bartlett, M.
FULL LISTPosters 2011October 2011 “Whole-gene transcriptional profiling to detect“A unique blend of natural compounds with the ability to aging-associated mitochondria dysfunction and tooppose age-related changes in gene expression related develop an anti-aging product.” Proceeding ofto dysregulation of removal of cellular debris, cellular 2011 International Conference on Food Factors.detoxification, antioxidant protection and inflammatory Zhu, J.S., Dong, Y.Z., Barger, J.L., Lu, J.H., Tan,balance.” Second International Conference on N.Z., Prolla, T.A., Weindruch, R., Bartlett, M.Environmental Stressors in Biology and Medicine. Invited Speaker at: The 2011 InternationalOctober 5-7, 2011, Centro Didattico, Policlinico Le Scotte Conference on Food Factors, Taiwan, NovemberSiena, Italy. Mastaloudis, A., Barger, J., Prolla, T., 20-23, 2011.Weindruch, R., Bartlett, M., Wood, S. December 2011November 2011 “Influencing the Expression of Genes Associated“Combination of ageLOC biochip whole-gene expression with Skin Inflammation by Combining Narcissusprofiling and mouse lifespan test in CM anti-aging study.” Tazetta Bulb Extract and Schizandra ChinensisProceeding of Summit of New TCM product Development Fruit Extract—an in vitro Analysis.” Society ofand Industrial Development Strategy, China J Chinese Cosmetic Chemists Annual Scientific Seminar,Materia Medica Publishing. 2011. Li, C.L., Tan, N., New York, NY, December 2011. Gopaul, R.,Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J. Knaggs, H., Kern, D.Invited Speaker at: Summit of New TCM productDevelopment and Industrial Development Strategy, “So Why Don’t I Look Younger?” InternationalHangzhou, China, November 25-27, 2011. Federation of Societies of Cosmetic Chemists, Bangkok, Thailand, December 14-15, 2011. Kern, D., Chang, A., Wood, S., Gopaul, R., Lephart, J., Knaggs, H.
summaryWe believe Nu Skin’s ongoing research, combined with the acquisition ofLifeGen Technologies, will deepen the company’s understanding of geneexpression and its impact on reversing the effects of aging even later in life.With our exclusive focus on identifying, targeting, and resetting YouthGene Clusters, we believe ageLOC science is the answer to anti-aging. It’sa scientific breakthrough that goes beyond the signs to target the ultimatesources of aging.For more information about ageLOC science, please visit ageloc.com.