Rbc
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Rbc Presentation Transcript

  • 1. Peripheral Blood
  • 2. Whole Blood
  • 3. Hemopoiesis
  • 4. Erythroid Lineage Myeloid Lineage
  • 5. Erythropoiesis
    • Formation or making of red blood cells
    • Life-span 120 days
    • New-born = old-death = 1 - 1.5 %
    • Bone marrow ==> macrophages (RE cells)
    • Fe, Proteins (amino acids), B12, Folate, etc.
  • 6. Erythron Erythropoiesis
  • 7. Blood Forming Organs
    • Mesoblastic period
      • yolk sac
    • Hepatic period
      • liver & spleen
    • Myeloid period
      • bone marrow (BM)
  • 8. Blood Forming Organs (cont.)
    • Medullary Hemopoiesis
      • bone marrow (BM)
    • Extramedullary Hemopoiesis
      • liver / spleen
  • 9. Blood Forming Organs
  • 10. Stages of Erythron
  • 11.  
  • 12. E2 E1 E3 E4 E5 E3
  • 13. Extrusion Polychromasia Reticulocytes Erythrocytes
  • 14. Erythropoiesis Mechanism
    • Proliferation
    • Differentiation
    • Maturation
    • Release
    • Functional RBC
    • Senile RBC
  • 15. Erythropoiesis Mechanism
  • 16. Characteristic of Erythron
  • 17. Bone Marrow Structure
  • 18. Bone Marrow Section
  • 19. Bone Marrow Contour
  • 20. Normal Red Blood Cells
  • 21. Functional Blood Cells
  • 22. Regulation of Erythropoiesis
    • Hypoxia
    • Oxygen tension in blood
    • Peritubular cells in Kidney
    • Erythropoietin
    • Nutrients & raw materials
  • 23. Regulation of Erythropoiesis
  • 24. Erythropoietin (Epo)
    • Chromosome 7 (q)
    • 3000 kDa
    • 165 Amino acids
    • 60 % Proteins
    • 40 % Carbohydrate
    • Peritubular cells in Kidney
  • 25. Molecule of Erythropoietin
  • 26. Factors Effecting Erythropoiesis
    • Micro-environment
    • Stem cells
    • Nutrients / Erythropoietin / Etc.