Rbc

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Rbc

  1. 1. Peripheral Blood
  2. 2. Whole Blood
  3. 3. Hemopoiesis
  4. 4. Erythroid Lineage Myeloid Lineage
  5. 5. Erythropoiesis <ul><li>Formation or making of red blood cells </li></ul><ul><li>Life-span 120 days </li></ul><ul><li>New-born = old-death = 1 - 1.5 % </li></ul><ul><li>Bone marrow ==> macrophages (RE cells) </li></ul><ul><li>Fe, Proteins (amino acids), B12, Folate, etc. </li></ul>
  6. 6. Erythron Erythropoiesis
  7. 7. Blood Forming Organs <ul><li>Mesoblastic period </li></ul><ul><ul><li>yolk sac </li></ul></ul><ul><li>Hepatic period </li></ul><ul><ul><li>liver & spleen </li></ul></ul><ul><li>Myeloid period </li></ul><ul><ul><li>bone marrow (BM) </li></ul></ul>
  8. 8. Blood Forming Organs (cont.) <ul><li>Medullary Hemopoiesis </li></ul><ul><ul><li>bone marrow (BM) </li></ul></ul><ul><li>Extramedullary Hemopoiesis </li></ul><ul><ul><li>liver / spleen </li></ul></ul>
  9. 9. Blood Forming Organs
  10. 10. Stages of Erythron
  11. 12. E2 E1 E3 E4 E5 E3
  12. 13. Extrusion Polychromasia Reticulocytes Erythrocytes
  13. 14. Erythropoiesis Mechanism <ul><li>Proliferation </li></ul><ul><li>Differentiation </li></ul><ul><li>Maturation </li></ul><ul><li>Release </li></ul><ul><li>Functional RBC </li></ul><ul><li>Senile RBC </li></ul>
  14. 15. Erythropoiesis Mechanism
  15. 16. Characteristic of Erythron
  16. 17. Bone Marrow Structure
  17. 18. Bone Marrow Section
  18. 19. Bone Marrow Contour
  19. 20. Normal Red Blood Cells
  20. 21. Functional Blood Cells
  21. 22. Regulation of Erythropoiesis <ul><li>Hypoxia </li></ul><ul><li>Oxygen tension in blood </li></ul><ul><li>Peritubular cells in Kidney </li></ul><ul><li>Erythropoietin </li></ul><ul><li>Nutrients & raw materials </li></ul>
  22. 23. Regulation of Erythropoiesis
  23. 24. Erythropoietin (Epo) <ul><li>Chromosome 7 (q) </li></ul><ul><li>3000 kDa </li></ul><ul><li>165 Amino acids </li></ul><ul><li>60 % Proteins </li></ul><ul><li>40 % Carbohydrate </li></ul><ul><li>Peritubular cells in Kidney </li></ul>
  24. 25. Molecule of Erythropoietin
  25. 26. Factors Effecting Erythropoiesis <ul><li>Micro-environment </li></ul><ul><li>Stem cells </li></ul><ul><li>Nutrients / Erythropoietin / Etc. </li></ul>

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