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Cell cycle

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  • 12/16/11 Cyc : cyclin CDK : cyclin dependent kinase RNA : ribonucleic acid p53 : cell cycle control protein, MW 53kDa, also involved in other phases of cell cycle pRb : retinoblastoma protein DNA : deoxyribonucleic acid H1 : histone H1 Abl : Abelson interacting protein
  • 12/16/11 G 1 : gap phase 1 S : DNA synthesis phase G 2 : gap phase 2 M : mitosis Cdk : cyclin-dependent kinase
  • 12/16/11 CDK2 : cyclin dependent kinase 2 CE : cyclin E pRb : retinoblastoma protein E2F : transcription factor E2F DNA : deoxyribonucleic acid p53 : cell cycle control protein, MW 53 kDa p21 : protein, MW 21 kDa
  • 12/16/11

Transcript

  • 1. Cell Cycle
    • Presented by:
    • Muhammad Asif
    Muhammad Asif Pu Pakistan
  • 2. Cell Cycle Eric Niederhoffer SIU-SOM Muhammad Asif Pu Pakistan G1 G0 6-8 h DNA, RNA, Protein 3-4 h RNA, Protein 1 h Mitosis, Cytokinesis S G2 Cyc D’s CDK4,6 Cyc B/A CDK1 Cyc A CDK2 M Cyc E CDK2 6-12 h RNA, Protein p53 pRb Lamin H1 Abl
  • 3. Variation in Cell Cycle Cyclins Cell cycle phases Cyclin-dependent kinases cyclins Muhammad Asif Pu Pakistan M G 1 G 2 S M G 1 Start D E A B(A) Cdk4 Cdk2 Cdk1
  • 4. Cell Cycle Regulation pRb pRb CDK2 CE E2F Enzymes for DNA synthesis DNA damage 1. CDK phosphorylation 2. C degradation 3. C & CDK synthesis 4. CDK inhibition pRb Muhammad Asif Pu Pakistan Passage from G1 to S pRb P Active p53 p21
  • 5. Review Questions
    • What are and what happens during the phases of the cell cycle?
    • Which proteins are involved in the regulation of the cell cycle?
    • Which cyclins and cyclin-dependent kinases are most important in individual phases of the cell cycle?
    • What are four mechanisms for regulating cyclin-dependent kinase activity?
    • What role do p53, p21, and pRb play in the G1 to S transition?
    Muhammad Asif Pu Pakistan