Cronhs Disease

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  • 1. REGIONAL ENTERITIS (CROHN’S DISEASE)
  • 2. CRONH’S DISEASE
    • is a lifelong inflammatory bowel disease (IBD).
    • is a chronic, recurrent inflammatory disease of the intestinal tract.
  • 3. ANATOMY
  • 4. CAUSES
    • The exact cause of Crohn disease remains unknown.
    • Current theories suggest that genetics, environment, diet, blood vessel abnormalities, and/or even psychosocial factors cause Crohn disease.
    • Probably the most popular theory is that Crohn disease is caused by the immune system overreacting to infection by a virus or bacterium.
  • 5.
    • Crohn disease apparently is not caused by emotional distress.
    • Crohn disease definitely runs in families. People who have Crohn disease may have an inherited predisposition to abnormal immunologic response to one or more provoking factors.
  • 6.  
  • 7. CLINICAL MANIFESTATION
    • Prominent abdominal pain & diarrhea.
    • Crampy pains occur after meal.
    • Blood in your stool.
    • Fever and Leukocytosis occur.
    • Symptoms extend beyond the GI tract to include joint problems, skin lesions, ocular disorders and oral ulcers.
    • Reduced appetite and weight loss.
  • 8. DIAGNOSTIC PROCEDURE
    • Barium X-rays studies.
    • Colonoscopy or flexible sigmoidoscopy .
    • Biopsy .
    • Stool analysis.
    • Complete blood count (CBC).
    • Computerized tomography (CT).
  • 9. MEDICAL MANAGEMENT
    • TREATMENT:
    • Anti-inflammatory drugs
    • Sulfasalazine
    • Mesalamine
    • Corticosteroids.
    • 2. Immune system suppressors
    • a. Cyclosporine
  • 10.
    • b. Methotrexate.
    • c. Infliximab.
    • d. Azathioprine.
    • 3. Antibiotics
    • Metronidazole (Flagyl).
    • Ciprofloxacin (Cipro).