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Normal Neuromuscular Junction Action
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Normal Neuromuscular Junction Action

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A slide show demonstrating normal neuromuscular junction action leading to muscle contraction

A slide show demonstrating normal neuromuscular junction action leading to muscle contraction

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Normal Neuromuscular Junction Action Normal Neuromuscular Junction Action Presentation Transcript

  • Neuromuscular Junction Normal Neuromuscular Junction Action
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
    • Depolarisation of end plate
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
    • Depolarisation of end plate
    • Action potential generated by depolarisation
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
    • Depolarisation of end plate
    • Action potential generated by depolarisation
    • Muscle contraction
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
    • Depolarisation of end plate
    • Action potential generated by depolarisation
    • Muscle contraction
    • Rapid removal of Ach
    By rapid diffusion & action of acetyl- cholinesterase
  • Normal Neuromuscular Junction
    • Electrical impulse arrives at motor terminal
    • Influx of Ca2+ at motor terminal
    • Release of Acetylcholine
    • Diffusion of Ach across synaptic cleft to nicotinic receptors on motor end plate
    • Depolarisation of end plate
    • Action potential generated by depolarisation
    • Muscle contraction
    • Rapid removal of Ach