Anatomy Of Csf
1. Lateral ventricle
2. Interventricular foramen
(foramen of Monro)
3. Third ventricle(separating right
and left diencephalon)
4. Cerebral aqueduct of Sylvius
5. Fourth ventricle (between Pons
and cerebellum extending as far
caudal as medulla)
6. Foramen of Luschka
7. Foramen of Magendie
8. Subarachnoid space (between pia
9. Choroid plexus
• The cerebrospinal Fluid
[CSF] is a clear, colorless
transparent, tissue fluid
present in the cerebral
ventricles, spinal canal,
and subarachnoid spaces.
• CSF is produced in the brain by
modified “ Ependymal cells” in
the vascular choroid plexus
(approx. 50-70%), and the
remainder is formed around
blood vessels and along
ventricular walls. Both
filtration and secretion occurs
by epithelial cells.
FLOW OF CSF
Foramen of Monro [Interventricular foramen]
Subarachnoid space of Brain and Spinal cord
Foramen of Magendie and foramen of Luschka
Absorption Of Csf
• The main site of absorption is Arachnoid Villi (they are diverticula of
subarachnoid space) that project into superior sagittal sinus. Arachnoid
Villi have the fine tubules lined with endothelium permit a direct flow of
CSF into venous sinus.
COMPOSITION OF CSF
Proteins = 20-40 mg/100 ml
Glucose = 50-65 mg/100 ml
Cholesterol = 0.2 mg/100 ml
Na+ = 147 meq/Kg H2O
Ca+ = 2.3 meq/kg H2O
Urea = 12.0 mg/100 ml
Lactic acid = 18.0 mg/100 ml
Function Of Cerebrospinal Fluid
1. Removes metabolites from neuronal tissue.
2. Acts as shock absorber.
3. Acts as cushion between CNS & surrounding bones.
4. Transport medicine in some diseases.
5. Provide a fluid medium in which brain floats, so the weight reduces.
6. Protects the brain from the Trauma.
7. Helps in hormonal transport.
8. Serve as a reservoir and assist in regulation of content skull.
9. Take active part in nourishment of Nervous Tissue.
10. Helps in clinical diagnosis of diseases.